{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T21:27:55Z","timestamp":1789421275606,"version":"build-2803163510"},"reference-count":84,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T00:00:00Z","timestamp":1589587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Vitamin D (25OHD) pleiotropic effects are widely recognized and studied. Recently, vitamin D cardiovascular effects are gaining interest, especially in children, although the studies present conflicting data. Some randomized controlled trials (RCTs) have demonstrated that cardiovascular risk markers, such as lipid parameters, inflammation markers, blood pressure, and arterial stiffness, are unaffected by vitamin D supplementation. By contrast, other studies show that low vitamin D levels are associated with higher risk of cardiovascular disease (CVD) and mortality, and support that increased risk of these diseases occurs primarily in people with vitamin D deficiency. An update on these points in pediatric patients is certainly of interest to focus on possible benefits of its supplementation.<\/jats:p>","DOI":"10.3390\/ijms21103536","type":"journal-article","created":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T02:43:42Z","timestamp":1589769822000},"page":"3536","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Vitamin D and Cardiovascular Risk: Which Implications in Children?"],"prefix":"10.3390","volume":"21","author":[{"given":"Silvia","family":"Savastio","sequence":"first","affiliation":[{"name":"SCDU of Pediatrics, Azienda Ospedaliero-Universitaria Maggiore della Carit\u00e0, University of Piemonte Orientale, 28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Pozzi","sequence":"additional","affiliation":[{"name":"SCDU of Pediatrics, Azienda Ospedaliero-Universitaria Maggiore della Carit\u00e0, University of Piemonte Orientale, 28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Tagliaferri","sequence":"additional","affiliation":[{"name":"SCDU of Pediatrics, Azienda Ospedaliero-Universitaria Maggiore della Carit\u00e0, University of Piemonte Orientale, 28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Degrandi","sequence":"additional","affiliation":[{"name":"SCDU of Pediatrics, Azienda Ospedaliero-Universitaria Maggiore della Carit\u00e0, University of Piemonte Orientale, 28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6338-4166","authenticated-orcid":false,"given":"Roberta","family":"Cinquatti","sequence":"additional","affiliation":[{"name":"SCDU of Pediatrics, Azienda Ospedaliero-Universitaria Maggiore della Carit\u00e0, University of Piemonte Orientale, 28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4173-146X","authenticated-orcid":false,"given":"Ivana","family":"Rabbone","sequence":"additional","affiliation":[{"name":"SCDU of Pediatrics, Azienda Ospedaliero-Universitaria Maggiore della Carit\u00e0, University of Piemonte Orientale, 28100 Novara, Italy"},{"name":"Department of Health Sciences, University of Piemonte Orientale, 28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianni","family":"Bona","sequence":"additional","affiliation":[{"name":"SCDU of Pediatrics, Azienda Ospedaliero-Universitaria Maggiore della Carit\u00e0, University of Piemonte Orientale, 28100 Novara, Italy"},{"name":"Department of Health Sciences, University of Piemonte Orientale, 28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,5,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Al-Ishaq, R.K., Kubatka, P., Brozmanova, M., Gazdikova, K., Caprnda, M., and B\u00fcsselberg, D. 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