{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T07:51:21Z","timestamp":1786866681051,"version":"build-2736575974"},"reference-count":50,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T00:00:00Z","timestamp":1590019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003848","name":"Industrial Technology Research Institute","doi-asserted-by":"publisher","award":["J356EX3200"],"award-info":[{"award-number":["J356EX3200"]}],"id":[{"id":"10.13039\/501100003848","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The interference screw fixation method is used to secure a graft in the tibial tunnel during anterior cruciate ligament reconstruction surgery. However, several complications have been reported, such as biodegradable screw breakage, inflammatory or foreign body reaction, tunnel enlargement, and delayed graft healing. Using additive manufacturing (AM) technology, we developed a titanium alloy (Ti6Al4V) interference screw with chemically calcium phosphate surface modification technology to improve bone integration in the tibial tunnel. After chemical and heat treatment, the titanium screw formed a dense apatite layer on the metal surface in simulated body fluid. Twenty-seven New Zealand white rabbits were randomly divided into control and additive manufactured (AMD) screw groups. The long digital extensor tendon was detached and translated into a tibial plateau tunnel (diameter: 2.0 mm) and transfixed with an interference screw while the paw was in dorsiflexion. Biomechanical analyses, histological analyses, and an imaging study were performed at 1, 3, and 6 months. The biomechanical test showed that the ultimate pull-out load failure was significantly higher in the AMD screw group in all tested periods. Micro-computed tomography analyses revealed early woven bone formation in the AMD screw group at 1 and 3 months. In conclusion, AMD screws with bioactive surface modification improved bone ingrowth and enhanced biomechanical performance in a rabbit model.<\/jats:p>","DOI":"10.3390\/ijms21103628","type":"journal-article","created":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T11:31:18Z","timestamp":1590060678000},"page":"3628","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Three-Dimensional Printed Porous Titanium Screw with Bioactive Surface Modification for Bone\u2013Tendon Healing: A Rabbit Animal Model"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7059-4498","authenticated-orcid":false,"given":"Yu-Min","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, National Taiwan University, Taipei 106, Taiwan"},{"name":"Department of Orthopedics, Shuang Ho Hospital, Taipei Medical University, Taipei 100, Taiwan"},{"name":"Department of Orthopedics, School of Medicine, College of Medicine, Taipei Medical University, Taipei 100, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Chieh","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering, National Chiao-Tung University, Hsinchu 300, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3516-3120","authenticated-orcid":false,"given":"Pei-I","family":"Tsai","sequence":"additional","affiliation":[{"name":"Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Hsinchu 310, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo-Yi","family":"Yang","sequence":"additional","affiliation":[{"name":"Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Hsinchu 310, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-I","family":"Huang","sequence":"additional","affiliation":[{"name":"Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Hsinchu 310, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-Hsin","family":"Shen","sequence":"additional","affiliation":[{"name":"Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Hsinchu 310, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Jen","family":"Lai","sequence":"additional","affiliation":[{"name":"Material and Chemical Research Laboratories, Industrial Technology Research Institute, Hsinchu 310, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Wei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, National Taiwan University, Taipei 106, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"San-Yuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering, National Chiao-Tung University, Hsinchu 300, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2994-6671","authenticated-orcid":false,"given":"Feng-Huei","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, National Taiwan University, Taipei 106, Taiwan"},{"name":"Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli County 360, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Shuang Ho Hospital, Taipei Medical University, Taipei 100, Taiwan"},{"name":"Department of Orthopedics, School of Medicine, College of Medicine, Taipei Medical University, Taipei 100, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,5,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"292","DOI":"10.2106\/JBJS.L.01713","article-title":"Does ACL reconstruction alter natural history?: A systematic literature review of long-term outcomes","volume":"96","author":"Chalmers","year":"2014","journal-title":"J. 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