{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:55:38Z","timestamp":1781744138773,"version":"3.54.5"},"reference-count":19,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T00:00:00Z","timestamp":1590019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["MINECO-17-PCIN-2016-164"],"award-info":[{"award-number":["MINECO-17-PCIN-2016-164"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>During the last 25 years we have accomplished great advances in melatonin research, regarding antioxidant or anti-inflammatory functions, oncostatic actions, glucose metabolism regulation or plant physiology, among others. Of course, we should not forget the classical, circadian-related functions of the indole, which has recently brought up new and important findings. All together these new discoveries will likely lead the way in the next decade in terms of melatonin research. This special issue collects some of these new advances focused on different aspects of the indole<\/jats:p>","DOI":"10.3390\/ijms21103645","type":"journal-article","created":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T11:31:18Z","timestamp":1590060678000},"page":"3645","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Melatonin from an Antioxidant to a Classic Hormone or a Tissue Factor: Experimental and Clinical Aspects 2019"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0882-2047","authenticated-orcid":false,"given":"Juan C.","family":"Mayo","sequence":"first","affiliation":[{"name":"Departamento de Morfolog\u00eda y Biolog\u00eda Celular, Redox Biology Group, Instituto Universitario Oncol\u00f3gico del Principado de Asturias (IUOPA), School of Medicine, University of Oviedo. C\/ Juli\u00e1n Claver\u00eda 6, 33006 Oviedo, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), Avda. Roma s\/n, 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3048-5582","authenticated-orcid":false,"given":"Rosa M.","family":"Sainz","sequence":"additional","affiliation":[{"name":"Departamento de Morfolog\u00eda y Biolog\u00eda Celular, Redox Biology Group, Instituto Universitario Oncol\u00f3gico del Principado de Asturias (IUOPA), School of Medicine, University of Oviedo. C\/ Juli\u00e1n Claver\u00eda 6, 33006 Oviedo, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), Avda. Roma s\/n, 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,5,21]]},"reference":[{"key":"ref_1","first-page":"57","article-title":"Melatonin a potent endogenous hydroxyl radical scavenger","volume":"1","author":"Tan","year":"1993","journal-title":"Endocrine"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Reiter, R.J., Mayo, J.C., Tan, D.X., Sainz, R.M., Alatorre-Jimenez, M., and Qin, L. (2016). Melatonin as an antioxidant: Under promises but over delivers. J. Pineal Res., 253\u2013278.","DOI":"10.1111\/jpi.12360"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jneuroim.2005.05.002","article-title":"Anti-inflammatory actions of melatonin and its metabolites, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) and N1-acetyl-5-methoxykynuramine (AMK), in macrophages","volume":"165","author":"Mayo","year":"2005","journal-title":"J. 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