{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T15:35:45Z","timestamp":1781796945487,"version":"3.54.5"},"reference-count":46,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T00:00:00Z","timestamp":1590105600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1058175"],"award-info":[{"award-number":["1058175"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Australian Postgraduate Award","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Cyclophilin A (CypA) is a highly abundant protein in the cytoplasm of most mammalian cells. Beyond its homeostatic role in protein folding, CypA is a Damage-Associated Molecular Pattern which can promote inflammation during tissue injury. However, the role of CypA in kidney disease is largely unknown. This study investigates the contribution of CypA in two different types of kidney injury: acute tubular necrosis and progressive interstitial fibrosis. CypA (Ppia) gene deficient and wild type (WT) littermate controls underwent bilateral renal ischaemia\/reperfusion injury (IRI) and were killed 24 h later or underwent left unilateral ureteric obstruction (UUO) and were killed 7 days later. In the IRI model, CypA\u2212\/\u2212 mice showed substantial protection against the loss of renal function and from tubular cell damage and death. This was attributed to a significant reduction in neutrophil and macrophage infiltration since CypA\u2212\/\u2212 tubular cells were not protected from oxidant-induced cell death in vitro. In the UUO model, CypA\u2212\/\u2212 mice were not protected from leukocyte infiltration or renal interstitial fibrosis. In conclusion, CypA promotes inflammation and acute kidney injury in renal IRI, but does not contribute to inflammation or interstitial fibrosis in a model of progressive kidney fibrosis.<\/jats:p>","DOI":"10.3390\/ijms21103667","type":"journal-article","created":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T10:18:18Z","timestamp":1590142698000},"page":"3667","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Cyclophilin A Promotes Inflammation in Acute Kidney Injury but Not in Renal Fibrosis"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1944-9663","authenticated-orcid":false,"given":"Khai Gene","family":"Leong","sequence":"first","affiliation":[{"name":"Department of Nephrology, Monash Health, Monash Medical Centre, Clayton, Victoria 3168, Australia"},{"name":"Monash University Centre for Inflammatory Diseases, Monash Medical Centre, Clayton, Victoria 3168, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elyce","family":"Ozols","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Monash Health, Monash Medical Centre, Clayton, Victoria 3168, Australia"},{"name":"Monash University Centre for Inflammatory Diseases, Monash Medical Centre, Clayton, Victoria 3168, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Kanellis","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Monash Health, Monash Medical Centre, Clayton, Victoria 3168, Australia"},{"name":"Monash University Centre for Inflammatory Diseases, Monash Medical Centre, Clayton, Victoria 3168, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5734-2931","authenticated-orcid":false,"given":"David J.","family":"Nikolic-Paterson","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Monash Health, Monash Medical Centre, Clayton, Victoria 3168, Australia"},{"name":"Monash University Centre for Inflammatory Diseases, Monash Medical Centre, Clayton, Victoria 3168, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank Y.","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Monash Health, Monash Medical Centre, Clayton, Victoria 3168, Australia"},{"name":"Monash University Centre for Inflammatory Diseases, Monash Medical Centre, Clayton, Victoria 3168, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,5,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"728673","DOI":"10.1155\/2014\/728673","article-title":"The roles of CD147 and\/or cyclophilin A in kidney diseases","volume":"2014","author":"Qu","year":"2014","journal-title":"Mediat. 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