{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T14:25:08Z","timestamp":1791469508515,"version":"4.3.4"},"reference-count":238,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T00:00:00Z","timestamp":1590364800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["\u201cDipartimenti di Eccellenza 2018\u20132022\u201d to Department of Neuroscience \u201cRita Levi Montalcini"],"award-info":[{"award-number":["\u201cDipartimenti di Eccellenza 2018\u20132022\u201d to Department of Neuroscience \u201cRita Levi Montalcini"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007364","name":"Fondazione CRT","doi-asserted-by":"publisher","award":["RF 2017.2052"],"award-info":[{"award-number":["RF 2017.2052"]}],"id":[{"id":"10.13039\/100007364","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Mitochondria play a central role in a plethora of processes related to the maintenance of cellular homeostasis and genomic integrity. They contribute to preserving the optimal functioning of cells and protecting them from potential DNA damage which could result in mutations and disease. However, perturbations of the system due to senescence or environmental factors induce alterations of the physiological balance and lead to the impairment of mitochondrial functions. After the description of the crucial roles of mitochondria for cell survival and activity, the core of this review focuses on the \u201cmitochondrial switch\u201d which occurs at the onset of neuronal degeneration. We dissect the pathways related to mitochondrial dysfunctions which are shared among the most frequent or disabling neurodegenerative diseases such as Alzheimer\u2019s, Parkinson\u2019s, and Huntington\u2019s, Amyotrophic Lateral Sclerosis, and Spinal Muscular Atrophy. Can mitochondrial dysfunctions (affecting their morphology and activities) represent the early event eliciting the shift towards pathological neurobiological processes? Can mitochondria represent a common target against neurodegeneration? We also review here the drugs that target mitochondria in neurodegenerative diseases.<\/jats:p>","DOI":"10.3390\/ijms21103719","type":"journal-article","created":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T11:42:02Z","timestamp":1590406922000},"page":"3719","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":87,"title":["Mitochondrial Dysfunctions: A Red Thread across Neurodegenerative Diseases"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1454-0713","authenticated-orcid":false,"given":"Serena","family":"Stanga","sequence":"first","affiliation":[{"name":"Department of Neuroscience Rita Levi Montalcini, University of Turin, 10126 Turin, Italy"},{"name":"Neuroscience Institute Cavalieri Ottolenghi, University of Turin, 10043 Orbassano (TO), Italy"},{"name":"National Institute of Neuroscience (INN), 10125 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Caretto","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Rita Levi Montalcini, University of Turin, 10126 Turin, Italy"},{"name":"Neuroscience Institute Cavalieri Ottolenghi, University of Turin, 10043 Orbassano (TO), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1211-1552","authenticated-orcid":false,"given":"Marina","family":"Boido","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Rita Levi Montalcini, University of Turin, 10126 Turin, Italy"},{"name":"Neuroscience Institute Cavalieri Ottolenghi, University of Turin, 10043 Orbassano (TO), Italy"},{"name":"National Institute of Neuroscience (INN), 10125 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5909-2128","authenticated-orcid":false,"given":"Alessandro","family":"Vercelli","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Rita Levi Montalcini, University of Turin, 10126 Turin, Italy"},{"name":"Neuroscience Institute Cavalieri Ottolenghi, University of Turin, 10043 Orbassano (TO), Italy"},{"name":"National Institute of Neuroscience (INN), 10125 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,5,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1146\/annurev.genet.39.110304.095751","article-title":"A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: A dawn for evolutionary medicine","volume":"39","author":"Wallace","year":"2005","journal-title":"Annu. 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