{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:35:17Z","timestamp":1790534117832,"version":"4.1.0"},"reference-count":79,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T00:00:00Z","timestamp":1590451200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GA-2052"],"award-info":[{"award-number":["GA-2052"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"German Research Foundation","award":["GA-2052"],"award-info":[{"award-number":["GA-2052"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The deubiquitination of histone H2A on lysine 119 by 2A-DUB\/MYSM1, BAP1, USP16, and other enzymes is required for key cellular processes, including transcriptional activation, apoptosis, and cell cycle control, during normal hematopoiesis and tissue development, and in tumor cells. Based on our finding that MYSM1 colocalizes with \u03b3H2AX foci in human peripheral blood mononuclear cells, leukemia cells, and melanoma cells upon induction of DNA double-strand breaks with topoisomerase inhibitor etoposide, we applied a mass spectrometry-based proteomics approach to identify novel 2A-DUB\/MYSM1 interaction partners in DNA-damage responses. Differential display of MYSM1 binding proteins significantly enriched after exposure of 293T cells to etoposide revealed an interacting network of proteins involved in DNA damage and replication, including factors associated with poor melanoma outcome. In the context of increased DNA-damage in a variety of cell types in Mysm1-deficient mice, in bone marrow cells upon aging and in UV-exposed Mysm1-deficient skin, our current mass spectrometry data provide additional evidence for an interaction between MYSM1 and key DNA replication and repair factors, and indicate a potential function of 2A-DUB\/MYSM1 in DNA repair processes.<\/jats:p>","DOI":"10.3390\/ijms21113762","type":"journal-article","created":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T05:35:52Z","timestamp":1590557752000},"page":"3762","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Interaction of Deubiquitinase 2A-DUB\/MYSM1 with DNA Repair and Replication Factors"],"prefix":"10.3390","volume":"21","author":[{"given":"Carsten","family":"Kroeger","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Ulm, 89081 Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhild","family":"Roesler","sequence":"additional","affiliation":[{"name":"Mass Spectrometry Core Facility, University of Ulm, 89081 Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Wiese","sequence":"additional","affiliation":[{"name":"Mass Spectrometry Core Facility, University of Ulm, 89081 Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelheid","family":"Hainzl","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Ulm, 89081 Ulm, Germany"},{"name":"Department of Dermatology and Allergic Diseases; Ulm University, 89081 Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6520-9794","authenticated-orcid":false,"given":"Martina Vanessa","family":"Gatzka","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Ulm, 89081 Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,5,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2007.02.005","article-title":"Chromatin modifications and their function","volume":"128","author":"Kouzarides","year":"2007","journal-title":"Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.molcel.2012.06.002","article-title":"Prime, repair, restore: The active role of chromatin in the DNA damage response","volume":"46","author":"Soria","year":"2012","journal-title":"Mol. Cell"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/j.cell.2013.02.011","article-title":"Chromatin remodeling at DNA double-strand breaks","volume":"152","author":"Price","year":"2013","journal-title":"Cell"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1101\/gad.307702.117","article-title":"Chromatin and nucleosome dynamics in DNA damage and repair","volume":"31","author":"Hauer","year":"2017","journal-title":"Genes Dev."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Stadler, J., and Richly, H. (2017). Regulation of DNA repair mechanisms: How the chromatin environment regulates the DNA damage response. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18081715"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"296","DOI":"10.3389\/fgene.2014.00296","article-title":"Chromatin modifications and DNA repair: Beyond double-strand breaks","volume":"5","author":"House","year":"2014","journal-title":"Front. Genet."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"a016428","DOI":"10.1101\/cshperspect.a016428","article-title":"Sources of DNA Double-Strand Breaks and Models of Recombinational DNA Repair","volume":"6","author":"Mehta","year":"2014","journal-title":"Cold Spring Harb. Perspect. Boil."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/nature08467","article-title":"The DNA-damage response in human biology and disease","volume":"461","author":"Jackson","year":"2009","journal-title":"Nature"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.molcel.2016.08.004","article-title":"Do DNA double-strand breaks drive aging?","volume":"63","author":"White","year":"2016","journal-title":"Mol. Cell."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.dnarep.2015.03.007","article-title":"Cell cycle regulation of human DNA repair and chromatin remodeling genes","volume":"30","author":"Mjelle","year":"2015","journal-title":"DNA Repair"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/sj.onc.1210700","article-title":"High expression of DNA repair pathways is associated with metastasis in melanoma patients","volume":"27","author":"Kauffmann","year":"2008","journal-title":"Oncogene"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Gatzka, M. (2018). Targeted Tumor Therapy Remixed\u2014An Update on the Use of Small-Molecule Drugs in Combination Therapies. Cancers, 10.","DOI":"10.3390\/cancers10060155"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Toulany, M. (2019). Targeting DNA DSB repair pathways to improve radiotherapy response. Genes, 10.","DOI":"10.3390\/genes10010025"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.cell.2007.09.040","article-title":"RNF8 ubiquitlyates histones at DNA double-strand breaks and promotes assembly of repair proteins","volume":"131","author":"Mailand","year":"2007","journal-title":"Cell"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/j.cell.2012.08.005","article-title":"RNF168 ubiquitinates K13-15 on H2A\/H2AX to drive DNA damage signaling","volume":"150","author":"Mattiroli","year":"2012","journal-title":"Cell"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.tcb.2015.07.009","article-title":"Repair Pathway Choices and Consequences at the Double-Strand Break","volume":"26","author":"Ceccaldi","year":"2016","journal-title":"Trends Cell Biol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/s41580-019-0152-0","article-title":"DNA double-strand break repair pathway choice in somatic mammalian cells","volume":"20","author":"Scully","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/jcp.25053","article-title":"Error-Prone Repair of DNA Double-Strand Breaks","volume":"231","author":"Rodgers","year":"2016","journal-title":"J. Cell. Physiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1101\/gad.280545.116","article-title":"Noncanonical view of homology-directed DNA repair","volume":"30","author":"Verma","year":"2016","journal-title":"Genes. Dev."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3389\/fgene.2016.00122","article-title":"Writers, readers, and erasers of histone ubiquitylation in DNA double-strand break repair","volume":"7","author":"Smeenk","year":"2016","journal-title":"Front. Genet."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/nature02985","article-title":"Role of histone H2A ubiquitination in Polycomb silencing","volume":"421","author":"Wang","year":"2004","journal-title":"Nature"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1101\/gad.373706","article-title":"DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A","volume":"20","author":"Bergink","year":"2006","journal-title":"Genes Dev."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s12013-013-9635-3","article-title":"Deubiquitylating enzymes and DNA damage response pathways","volume":"67","author":"Jacq","year":"2013","journal-title":"Cell Biochem. Biophys."},{"key":"ref_24","first-page":"133","article-title":"DUBbing cancer: Deubiquitylating enzymes involved in epigenetics, DNA damage and the cell cycle as therapeutic targets","volume":"7","author":"Kessler","year":"2016","journal-title":"Front. Genet."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"12872","DOI":"10.18632\/oncotarget.3671","article-title":"Deubiquitinases in Cancer","volume":"6","author":"Wei","year":"2015","journal-title":"Oncotarget"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3389\/fgene.2015.00282","article-title":"Fine-tuning the ubiquitin code at DNA double-strand breaks","volume":"6","author":"Citterio","year":"2015","journal-title":"Front. Genet."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.dnarep.2017.06.011","article-title":"Histone ubiquitination in the DNA damage response","volume":"56","author":"Uckelmann","year":"2017","journal-title":"DNA Repair"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1073\/pnas.1309085110","article-title":"Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair","volume":"111","author":"Yu","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"32883","DOI":"10.1074\/jbc.M114.599605","article-title":"The histone H2A deubiquitinase USP16 interacts with HERC2 and fine-tunes cellular response to DNA damage","volume":"289","author":"Zhang","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Jeusset, L.M.-P., and McManus, K.J. (2017). Ubiquitin specific peptidase 22 regulates histone H2B mono- ubiquitination and exhibits both oncogenic and tumor suppressor roles in cancer. Cancers, 9.","DOI":"10.3390\/cancers9120167"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.molcel.2007.07.024","article-title":"A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation","volume":"27","author":"Zhu","year":"2007","journal-title":"Mol. Cell"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Li, Y., Li, J., Liu, H., Liu, Y., and Cui, B. (2017). Expression of MYSM1 is associated with tumor progression in colorectal cancer. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0186530"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"67287","DOI":"10.18632\/oncotarget.18617","article-title":"MYSM1\/2A-DUB is an epigenetic regulator in human melanoma and contributes to tumor cell growth","volume":"8","author":"Wilms","year":"2017","journal-title":"Oncotarget"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1182\/blood-2011-05-352666","article-title":"The critical role of histone H2A-deubiquitinase Mysm1 in hematopoiesis and lymphocyte differentiation","volume":"119","author":"Nijnik","year":"2012","journal-title":"Blood"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1182\/blood-2013-03-489641","article-title":"The control of hematopoietic stem cell maintenance, self-renewal, and differentiation by Mysm1-mediated epigenetic regulation","volume":"122","author":"Wang","year":"2013","journal-title":"Blood"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"E3927","DOI":"10.1073\/pnas.1308888110","article-title":"Epigenetic control of natural killer cell maturation by histone H2A deubiquitinase, MYSM1","volume":"110","author":"Nandakumar","year":"2013","journal-title":"Proc. Nat. Acad. Sci. USA"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1182\/blood-2013-10-534313","article-title":"Epigenetic control of dendritic cell development and fate determination of common myeloid progenitor by Mysm1","volume":"124","author":"Won","year":"2014","journal-title":"Blood"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1038\/cdd.2014.231","article-title":"Interplay of H2A deubiquitinase 2A-DUB\/Mysm1 and the p19(ARF)\/p53 axis in hematopoiesis, early T-cell development and tissue differentiation","volume":"22","author":"Gatzka","year":"2015","journal-title":"Cell Death Differ."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3844","DOI":"10.1182\/blood-2013-09-527127","article-title":"MYSM1 is mutated in a family with transient transfusion-dependent anemia, mild thrombocytopenia, and low NK and B-cell counts","volume":"122","author":"Alsultan","year":"2013","journal-title":"Blood"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/j.jaci.2015.06.008","article-title":"An in vivo genetic reversion highlights the crucial role of Myb-Like, SWIRM, and MPN domains 1 (MYSM1) in human hematopoiesis and lymphocyte differentiation","volume":"136","author":"Touzot","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.jaci.2016.10.053","article-title":"Myb-like, SWIRM, and MPN domains 1 (MYSM1) deficiency: Genotoxic stress-associated bone marrow failure and developmental aberrations","volume":"140","author":"Bahrami","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1182\/blood-2014-05-574111","article-title":"p53 mediates loss of hematopoietic stem cell function and lymphopenia in Mysm1 deficiency","volume":"125","author":"Belle","year":"2015","journal-title":"Blood"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1096\/fj.201700871R","article-title":"p53 loss compensates osteopenia in murine Mysm1 deficiency","volume":"32","author":"Kovtun","year":"2018","journal-title":"FASEB J."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Wilms, C., Krikki, I., Hainzl, A., Kilo, S., Alupei, M., and Wagner, M. (2018). Mysm1 regulates epidermal development by suppression of p53 mediated apoptotic programs. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19030687"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/cdd.2015.140","article-title":"Repression of p53-target gene Bbc3\/PUMA by MYSM1 is essential for the survival of hematopoietic multipotent progenitors and contributes to stem cell maintenance","volume":"23","author":"Belle","year":"2016","journal-title":"Cell Death Differ."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"5.28.1","DOI":"10.1002\/0471142301.ns0528s46","article-title":"Identifying novel protein-protein interactions using co-immunoprecipitation and mass spectroscopy","volume":"46","author":"Free","year":"2009","journal-title":"Curr. Protoc. Neurosci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1534\/g3.119.400197","article-title":"An interaction network of the human SEPT9 established by quantitative mass spectrometry","volume":"9","author":"Hecht","year":"2019","journal-title":"G3"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.4161\/15384101.2014.956551","article-title":"ISWI chromatin remodeling complexes in the DNA damage response","volume":"13","author":"Aydin","year":"2014","journal-title":"Cell Cycle"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/nmeth.2557","article-title":"The CRAPome: A contaminant repository for affinity purification-mass spectrometry data","volume":"10","author":"Mellacheruvu","year":"2013","journal-title":"Nat. Methods"},{"key":"ref_50","first-page":"D433","article-title":"STRING: Known and predicted protein-protein associations, integrated and transferred across organisms","volume":"31","author":"Jensen","year":"2004","journal-title":"Nucleic Acid Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.immuni.2015.09.010","article-title":"Deubiquitinase MYSM1 regulates innate immunity through inactivation of TRAF3 and TRAF6 complexes","volume":"43","author":"Panda","year":"2015","journal-title":"Immunity"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/bs.enz.2016.03.003","article-title":"The many roles of PCNA in eukaryotic DNA replication","volume":"39","author":"Boehm","year":"2016","journal-title":"Enzymes"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Shiomi, Y., and Nishitani, H. (2017). Control of genome integrity by RFC complexes: Conductors of PCNA loading onto and unloading from chromatin during DNA replication. Genes, 8.","DOI":"10.3390\/genes8020052"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1083\/jcb.200503129","article-title":"Unzipped and loaded: The role of DNA helicases and RFC clamp loading complexes in sister chromatid cohesion","volume":"169","author":"Skibbens","year":"2005","journal-title":"J. Cell Biol."},{"key":"ref_55","first-page":"5524","article-title":"The SFN2 family ATPase LSH promotes phosphorylation of H2AX and efficient repair of DNA double-strand breaks in mammalian cells","volume":"125","author":"Burrage","year":"2012","journal-title":"J. Cell Sci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.4161\/cc.20626","article-title":"The importance of being modified: PCNA modification and DNA damage response","volume":"11","author":"Gazy","year":"2012","journal-title":"Cell Cycle"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"19855","DOI":"10.1073\/pnas.0707579104","article-title":"Profiling of UV-induced ATM\/ATR signaling pathways","volume":"104","author":"Stokes","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"250","DOI":"10.2174\/138920209788488544","article-title":"Involvement of nucleotide excision and mismatch repair mechanisms in double strand break repair","volume":"10","author":"Zhang","year":"2009","journal-title":"Curr. Genomics"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.arr.2014.12.009","article-title":"Quality control mechanisms in cellular and systemic DNA damage responses","volume":"23","author":"Ermolaeva","year":"2015","journal-title":"Ageing Res. Rev."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0960-9822(99)00263-8","article-title":"A novel Rad24 checkpoint protein complex closely related to replication factor C","volume":"10","author":"Green","year":"2000","journal-title":"Curr. Biol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"7672","DOI":"10.1073\/pnas.1222241110","article-title":"PCNA is efficiently loaded on the DNA recombination intermediate to modulate polymerase \u03b4, \u03b7, and \u03b6 activities","volume":"110","author":"Li","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1093\/nar\/gkz1146","article-title":"The human HELLS chromatin remodeling protein promotes end resection to facilitate homologous recombination and contributes to DSB repair within heterochromatin","volume":"48","author":"Kollarovic","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"E876","DOI":"10.1073\/pnas.1717509115","article-title":"HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome","volume":"115","author":"Jenness","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1101\/gad.1176104","article-title":"Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG","volume":"18","author":"Sun","year":"2004","journal-title":"Genes Dev."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1101\/gad.2053211","article-title":"Analysis of protein dynamics at active, stalled, and collapsed replication forks","volume":"25","author":"Sirbu","year":"2011","journal-title":"Genes Dev."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1101\/gad.614411","article-title":"MCM-BP regulates unloading of the MCM2-7 helicase in late S phase","volume":"25","author":"Nishiyama","year":"2011","journal-title":"Genes Dev."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.celrep.2013.03.009","article-title":"A proteomic characterization of factors enriched at nascent DNA molecules","volume":"3","author":"Ruppen","year":"2013","journal-title":"Cell Rep."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"13722","DOI":"10.7554\/eLife.13722","article-title":"The cell proliferation antigen Ki-67 organises heterochromatin","volume":"5","author":"Sobecki","year":"2016","journal-title":"eLife"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"E6875","DOI":"10.1073\/pnas.1706508114","article-title":"DNA damage tolerance in hematopoietic stem and progenitor cells in mice","volume":"114","author":"Pilzecker","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/nature13619","article-title":"Replication stress is a potent driver of functional decline in ageing hematopoietic stem cells","volume":"512","author":"Flach","year":"2014","journal-title":"Nature"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.stem.2010.06.014","article-title":"Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis","volume":"7","author":"Mohrin","year":"2010","journal-title":"Cell Stem Cell"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.stem.2014.04.016","article-title":"Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle","volume":"15","author":"Beerman","year":"2014","journal-title":"Cell Stem Cell"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"160225","DOI":"10.1098\/rsob.160225","article-title":"A role for the p53 tumour suppressor in regulating the balance between homologous recombination and non-homologous end joining","volume":"6","author":"Moureau","year":"2016","journal-title":"Open Biol."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Ryu, B., Kim, D.S., DeLuca, A.M., and Alani, R. (2007). Comprehensive Expression Profiling of Tumor Cell Lines Identifies Molecular Signatures of Melanoma Progression. PLoS ONE, 2.","DOI":"10.1371\/journal.pone.0000594"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1111\/j.1755-148X.2010.00753.x","article-title":"Quantitative measurement of circulating lymphoid-specific helicase (HELLS) gene transcript: A potential serum biomarker for melanoma metastasis","volume":"23","author":"Kim","year":"2010","journal-title":"Pigment. Cell Melanoma Res."},{"key":"ref_76","first-page":"553","article-title":"Identification of genes associated with melanoma metastasis","volume":"31","author":"Qiu","year":"2015","journal-title":"J. Med. Sci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s10565-017-9381-1","article-title":"FoxM1-mediated RFC5 expression promotes temozolomide resistance","volume":"33","author":"Peng","year":"2017","journal-title":"Cell Biol. Toxicol."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Faraoni, I., and Graziani, G. (2018). Role of BRCA mutations in cancer treatment with poly(ADP-ribose)polymerase (PARP) inhibitors. Cancers, 10.","DOI":"10.3390\/cancers10120487"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1038\/s41467-019-09232-8","article-title":"The deubiquitylating enzyme USP15 regulates homologous recombination repair and cancer cell response to PARP inhibitors","volume":"10","author":"Peng","year":"2019","journal-title":"Nat. Commun."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/21\/11\/3762\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:32:52Z","timestamp":1760175172000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/21\/11\/3762"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,26]]},"references-count":79,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,6]]}},"alternative-id":["ijms21113762"],"URL":"https:\/\/doi.org\/10.3390\/ijms21113762","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,26]]}}}