{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T06:27:00Z","timestamp":1778135220275,"version":"3.51.4"},"reference-count":74,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T00:00:00Z","timestamp":1590537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2017\/27\/B\/NZ3\/00582"],"award-info":[{"award-number":["2017\/27\/B\/NZ3\/00582"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2012\/05\/B\/NZ3\/00436"],"award-info":[{"award-number":["2012\/05\/B\/NZ3\/00436"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Hypoxia-ischemia (HI) in the neonatal brain frequently results in neurologic impairments, including cognitive disability. Unfortunately, there are currently no known treatment options to minimize ischemia-induced neural damage. We previously showed the neuroprotective\/neurogenic potential of a histone deacetylase inhibitor (HDACi), sodium butyrate (SB), in a neonatal HI rat pup model. The aim of the present study was to examine the capacity of another HDACi\u2014Trichostatin A (TSA)\u2014to stimulate neurogenesis in the subgranular zone of the hippocampus. We also assessed some of the cellular\/molecular processes that could be involved in the action of TSA, including the expression of neurotrophic factors (glial cell line-derived neurotrophic factor (GDNF), nerve growth factor (NGF), and brain-derived neurotrophic factor (BDNF)) as well as the TrkB receptor and its downstream signalling substrate\u2014 cAMP response element-binding protein (CREB). Seven-day-old rat pups were subjected to unilateral carotid artery ligation followed by hypoxia for 1 h. TSA was administered directly after the insult (0.2 mg\/kg body weight). The study demonstrated that treatment with TSA restored the reduced by hypoxia-ischemia number of immature neurons (neuroblasts, BrdU\/DCX-positive) as well as the number of oligodendrocyte progenitors (BrdU\/NG2+) in the dentate gyrus of the ipsilateral damaged hemisphere. However, new generated cells did not develop the more mature phenotypes. Moreover, the administration of TSA stimulated the expression of BDNF and increased the activation of the TrkB receptor. These results suggest that BDNF-TrkB signalling pathways may contribute to the effects of TSA after neonatal hypoxic-ischemic injury.<\/jats:p>","DOI":"10.3390\/ijms21113808","type":"journal-article","created":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T10:02:45Z","timestamp":1590660165000},"page":"3808","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Impact of a Histone Deacetylase Inhibitor\u2014Trichostatin A on Neurogenesis after Hypoxia-Ischemia in Immature Rats"],"prefix":"10.3390","volume":"21","author":[{"given":"Teresa","family":"Zalewska","sequence":"first","affiliation":[{"name":"NeuroRepair Department, Mossakowski Medical Research Centre, Polish Academy of Sciences, 02-106 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Jaworska","sequence":"additional","affiliation":[{"name":"NeuroRepair Department, Mossakowski Medical Research Centre, Polish Academy of Sciences, 02-106 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Sypecka","sequence":"additional","affiliation":[{"name":"NeuroRepair Department, Mossakowski Medical Research Centre, Polish Academy of Sciences, 02-106 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malgorzata","family":"Ziemka-Nalecz","sequence":"additional","affiliation":[{"name":"NeuroRepair Department, Mossakowski Medical Research Centre, Polish Academy of Sciences, 02-106 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,5,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1053\/j.nainr.2011.07.004","article-title":"Hypoxic Ischemic Encephalopathy: Pathophysiology and Experimental Treatments","volume":"11","author":"Allen","year":"2011","journal-title":"Newborn Infant Nurs. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.clp.2018.01.010","article-title":"Therapeutic Hypothermia","volume":"45","author":"Natarajan","year":"2018","journal-title":"Clin. Perinatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/pr.2016.198","article-title":"Therapeutic hypothermia translates from ancient history in to practice","volume":"81","author":"Gunn","year":"2016","journal-title":"Pediatr. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.brainres.2008.02.037","article-title":"Neurogenesis and neuronal commitment following ischemia in a new mouse model for neonatal stroke","volume":"1208","author":"Kadam","year":"2008","journal-title":"Brain Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1203\/01.PDR.0000179381.86809.02","article-title":"Hypoxic-Ischemic Injury Stimulates Subventricular Zone Proliferation and Neurogenesis in the Neonatal Rat","volume":"58","author":"Ong","year":"2005","journal-title":"Pediatr. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1097\/ALN.0b013e31820a4d78","article-title":"Toll-like receptor signaling during myocardial ischemia","volume":"114","author":"Eckle","year":"2011","journal-title":"Anesthesiology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.yexcr.2012.01.025","article-title":"HDAC modulation and cell death in the clinic","volume":"318","author":"Lepore","year":"2012","journal-title":"Exp. Cell Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"7332","DOI":"10.1523\/JNEUROSCI.2174-14.2015","article-title":"Sp3\/REST\/HDAC1\/HDAC2 Complex Represses and Sp1\/HIF-1\/p300 Complex Activates ncx1 Gene Transcription, in Brain Ischemia and in Ischemic Brain Preconditioning, by Epigenetic Mechanism","volume":"35","author":"Formisano","year":"2015","journal-title":"J. Neurosci."},{"key":"ref_9","first-page":"1335","article-title":"Epigenetic mechanisms in cerebral ischemia","volume":"33","author":"Schweizer","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"383","DOI":"10.55782\/ane-2014-2001","article-title":"Neuroprotective effects of histone deacetylase inhibitors in brain ischemia","volume":"74","author":"Zalewska","year":"2014","journal-title":"Acta Neurobiol. Exp."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/hdy.2010.27","article-title":"Epigenetic regulation of neurogenesis in the adult hippocampus","volume":"105","author":"Covic","year":"2010","journal-title":"Heredity"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1124\/mol.106.027912","article-title":"Pharmacological Inhibition of Histone Deacetylases by Suberoylanilide Hydroxamic Acid Specifically Alters Gene Expression and Reduces Ischemic Injury in the Mouse Brain","volume":"70","author":"Faraco","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1124\/jpet.107.120188","article-title":"Histone Deacetylase Inhibitors Exhibit Anti-Inflammatory and Neuroprotective Effects in a Rat Permanent Ischemic Model of Stroke: Multiple Mechanisms of Action","volume":"321","author":"Kim","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1111\/j.1471-4159.2004.02406.x","article-title":"Valproic acid reduces brain damage induced by transient focal cerebral ischemia in rats: Potential roles of histone deacetylase inhibition and heat shock protein induction","volume":"89","author":"Ren","year":"2004","journal-title":"J. Neurochem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1161\/STROKEAHA.108.540229","article-title":"Targeting Histone Deacetylases as a Multifaceted Approach to Treat the Diverse Outcomes of Stroke","volume":"40","author":"Langley","year":"2009","journal-title":"Stroke"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.neuroscience.2012.06.012","article-title":"Valproic acid increases white matter repair and neurogenesis after stroke","volume":"220","author":"Liu","year":"2012","journal-title":"Neuroscience"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.gene.2005.09.010","article-title":"Acetylation and deacetylation of non-histone proteins","volume":"363","author":"Glozak","year":"2005","journal-title":"Gene"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1177\/08830738050200070801","article-title":"Protective effects of valproic acid against hypoxic-ischemic brain injury in neonatal rats","volume":"20","author":"Kabakus","year":"2005","journal-title":"J. Child Neurol."},{"key":"ref_19","first-page":"153","article-title":"The HDAC Inhibitor Phenylbutyrate Reverses Effects of Neonatal Ventral Hippocampal Lesion in Rats","volume":"1","author":"Sandner","year":"2011","journal-title":"Front. Psychol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/1742-2094-9-70","article-title":"Neuroprotection by the histone deacetylase inhibitor trichostatin A in a model of lipopolysaccharide-sensitised neonatal hypoxic-ischaemic brain injury","volume":"9","author":"Fleiss","year":"2012","journal-title":"J. Neuroinflamm."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3389\/fncel.2013.00123","article-title":"Impact of trichostatin A and sodium valproate treatment on post-stroke neurogenesis and behavioral outcomes in immature mice","volume":"7","author":"George","year":"2013","journal-title":"Front. Cell. Neurosci."},{"key":"ref_22","first-page":"5300","article-title":"Sodium Butyrate, a Histone Deacetylase Inhibitor, Exhibits Neuroprotective\/Neurogenic Effects in a Rat Model of Neonatal Hypoxia-Ischemia","volume":"54","author":"Jaworska","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"6341","DOI":"10.1007\/s12035-019-1518-1","article-title":"Effect of the HDAC Inhibitor, Sodium Butyrate, on Neurogenesis in a Rat Model of Neonatal Hypoxia\u2013Ischemia: Potential Mechanism of Action","volume":"56","author":"Jaworska","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/ana.410390117","article-title":"Nerve growth factor protects the neonatal brain against hypoxic-ischemic injury","volume":"39","author":"Holtzman","year":"1996","journal-title":"Ann. Neurol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1161\/01.STR.31.9.2212","article-title":"Intravenous Brain-Derived Neurotrophic Factor Reduces Infarct Size and Counterregulates Bax and Bcl-2 Expression after Temporary Focal Cerebral Ischemia","volume":"31","author":"Sommer","year":"2000","journal-title":"Stroke"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1602\/neurorx.2.1.120","article-title":"Neuroprotection in experimental stroke with targeted neurotrophins","volume":"2","author":"Wu","year":"2005","journal-title":"NeuroRX"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s11010-016-2925-5","article-title":"Therapeutic value of nerve growth factor in promoting neural stem cell survival and differentiation and protecting against neuronal hearing loss","volume":"428","author":"Han","year":"2017","journal-title":"Mol. Cell. Biochem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3175","DOI":"10.1523\/JNEUROSCI.20-09-03175.2000","article-title":"DNA Methyltransferase Contributes to Delayed Ischemic Brain Injury","volume":"20","author":"Endres","year":"2000","journal-title":"J. Neurosci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/nm747","article-title":"Neuronal replacement from endogenous precursors in the adult brain after stroke","volume":"8","author":"Arvidsson","year":"2002","journal-title":"Nat. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1038\/nm0902-928","article-title":"Limitations in brain repair","volume":"8","author":"Snyder","year":"2002","journal-title":"Nat. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.nbd.2004.04.003","article-title":"Neonatal hypoxic\u2013ischemic injury increases forebrain subventricular zone neurogenesis in the mouse","volume":"16","author":"Plane","year":"2004","journal-title":"Neurobiol. Dis."},{"key":"ref_32","first-page":"95","article-title":"Modeling the neurovascular niche: Implications for recovery from CNS injury","volume":"60","author":"Madri","year":"2009","journal-title":"J. Physiol. Pharmacol. Off. J. Pol. Physiol. Soc."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.neuropharm.2010.01.010","article-title":"A symphony of signals conducts early and late stages of adult neurogenesis","volume":"58","author":"Pathania","year":"2010","journal-title":"Neuropharmacology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/j.bbi.2011.03.021","article-title":"Mesenchymal stem cell transplantation changes the gene expression profile of the neonatal ischemic brain","volume":"25","author":"Kavelaars","year":"2011","journal-title":"Brain, Behav. Immun."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1111\/j.1471-4159.2009.06212.x","article-title":"The HDAC inhibitor, sodium butyrate, stimulates neurogenesis in the ischemic brain","volume":"110","author":"Kim","year":"2009","journal-title":"J. Neurochem."},{"key":"ref_36","first-page":"785","article-title":"Less Neurogenesis and Inflammation in the Immature than in the Juvenile Brain after Cerebral Hypoxia-Ischemia","volume":"27","author":"Qiu","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0165-3806(03)00032-4","article-title":"A delayed increase in hippocampal proliferation following global asphyxia in the neonatal rat","volume":"142","author":"Scheepens","year":"2003","journal-title":"Dev. Brain Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1002\/glia.21156","article-title":"Progenitors in the adult cerebral cortex: Cell cycle properties and regulation by physiological stimuli and injury","volume":"59","author":"Simon","year":"2011","journal-title":"Glia"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"5846","DOI":"10.1523\/JNEUROSCI.23-13-05846.2003","article-title":"The Trophic Role of Oligodendrocytes in the Basal Forebrain","volume":"23","author":"Dai","year":"2003","journal-title":"J. Neurosci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"6236","DOI":"10.1523\/JNEUROSCI.0567-10.2010","article-title":"Neurodegeneration in a transgenic mouse model of multiple system atrophy is associated with altered expression of oligodendroglial-derived neurotrophic factors","volume":"30","author":"Ubhi","year":"2010","journal-title":"J. Neurosci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"103","DOI":"10.5114\/fn.2013.35952","article-title":"Heterogeneity of local tissue microenvironment influences differentiation of oligodendroglial progenitors","volume":"2","author":"Joanna","year":"2013","journal-title":"Folia Neuropathol."},{"key":"ref_42","first-page":"207","article-title":"Impact of neonatal hypoxia-ischaemia on oligodendrocyte survival, maturation and myelinating potential","volume":"22","author":"Janowska","year":"2017","journal-title":"J. Cell. Mol. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1083\/jcb.200412101","article-title":"Histone modifications affect timing of oligodendrocyte progenitor differentiation in the developing rat brain","volume":"169","author":"Shen","year":"2005","journal-title":"J. Cell Boil."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.stem.2007.09.002","article-title":"In Vivo Fate Analysis Reveals the Multipotent and Self-Renewal Capacities of Sox2+ Neural Stem Cells in the Adult Hippocampus","volume":"1","author":"Suh","year":"2007","journal-title":"Cell Stem Cell"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"jcs210989","DOI":"10.1242\/jcs.210989","article-title":"Maturation of neural stem cells and integration into hippocampal circuits\u2014A functional study in an in situ model of cerebral ischemia","volume":"131","author":"Kopach","year":"2018","journal-title":"J. Cell Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s12974-017-0807-8","article-title":"The potential neuroprotective role of a histone deacetylase inhibitor, sodium butyrate, after neonatal hypoxia-ischemia","volume":"14","author":"Jaworska","year":"2017","journal-title":"J. Neuroinflamm."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"41","DOI":"10.2174\/1568007053005091","article-title":"Remodeling chromatin and stress resistance in the central nervous system: Histone deacetylase inhibitors as novel and broadly effective neuroprotective agents","volume":"4","author":"Langley","year":"2005","journal-title":"Curr. Drug Target -CNS Neurol. Disord."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1002\/jcb.22185","article-title":"Histone deacetylase inhibitors: Potential in cancer therapy","volume":"107","author":"Marks","year":"2009","journal-title":"J. Cell. Biochem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1089\/neu.1998.15.441","article-title":"Axonal Injury Caused by Focal Cerebral Ischemia in the Rat","volume":"15","author":"Yam","year":"1998","journal-title":"J. Neurotrauma"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1159\/000046141","article-title":"Neurodegeneration in the thalamus following neonatal hypoxia-ischemia is programmed cell death","volume":"23","author":"Northington","year":"2001","journal-title":"Dev. Neurosci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/jnr.20623","article-title":"Minocycline reduces lipopolysaccharide-induced neurological dysfunction and brain injury in the neonatal rat","volume":"82","author":"Fan","year":"2005","journal-title":"J. Neurosci. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"5245","DOI":"10.1038\/ncomms6245","article-title":"Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations","volume":"5","author":"Godena","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1097\/00001756-200204160-00025","article-title":"Anterograde axonal transport of internalized GDNF in sensory and motor neurons","volume":"13","author":"Rind","year":"2002","journal-title":"NeuroReport"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"6706","DOI":"10.1523\/JNEUROSCI.21-17-06706.2001","article-title":"Infusion of Brain-Derived Neurotrophic Factor into the Lateral Ventricle of the Adult Rat Leads to New Neurons in the Parenchyma of the Striatum, Septum, Thalamus, and Hypothalamus","volume":"21","author":"Pencea","year":"2001","journal-title":"J. Neurosci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"6718","DOI":"10.1523\/JNEUROSCI.21-17-06718.2001","article-title":"Adenoviral Brain-Derived Neurotrophic Factor Induces Both Neostriatal and Olfactory Neuronal Recruitment from Endogenous Progenitor Cells in the Adult Forebrain","volume":"21","author":"Benraiss","year":"2001","journal-title":"J. Neurosci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0092-8674(02)00862-0","article-title":"Regeneration of Hippocampal Pyramidal Neurons after Ischemic Brain Injury by Recruitment of Endogenous Neural Progenitors","volume":"110","author":"Nakatomi","year":"2002","journal-title":"Cell"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1161\/STROKEAHA.106.477331","article-title":"Intravenous Brain-Derived Neurotrophic Factor Enhances Poststroke Sensorimotor Recovery and Stimulates Neurogenesis","volume":"38","author":"Steigleder","year":"2007","journal-title":"Stroke"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1523\/JNEUROSCI.5071-04.2005","article-title":"Endothelial nitric oxide synthase regulates brain-derived neurotrophic factor expression and neurogenesis after stroke in mice","volume":"25","author":"Chen","year":"2005","journal-title":"J. Neurosci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1172\/JCI23559","article-title":"The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis","volume":"115","author":"Schneider","year":"2005","journal-title":"J. Clin. Investig."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1002\/stem.1569","article-title":"Loss of spastin function results in disease-specific axonal defects in human pluripotent stem cell-based models of hereditary spastic paraplegia","volume":"32","author":"Denton","year":"2014","journal-title":"Stem Cells"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/j.neuron.2014.11.006","article-title":"Pervasive Axonal Transport Deficits in Multiple Sclerosis Models","volume":"84","author":"Sorbara","year":"2014","journal-title":"Neuron"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1002\/stem.1744","article-title":"Neutralization of Nerve Growth Factor Impairs Proliferation and Differentiation of Adult Neural Progenitors in the Subventricular Zone","volume":"32","author":"Scardigli","year":"2014","journal-title":"Stem Cells"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.ajog.2005.01.014","article-title":"Implantation of encapsulated glial cell line-derived neurotrophic factor-secreting cells prevents long-lasting learning impairment following neonatal hypoxic-ischemic brain insult in rats","volume":"192","author":"Katsuragi","year":"2005","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/sj.mp.4002099","article-title":"The mood stabilizers lithium and valproate selectively activate the promoter IV of brain-derived neurotrophic factor in neurons","volume":"14","author":"Yasuda","year":"2007","journal-title":"Mol. Psychiatry"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1046\/j.1471-4159.2002.01085.x","article-title":"Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice","volume":"82","author":"Lee","year":"2002","journal-title":"J. Neurochem."},{"key":"ref_66","first-page":"206","article-title":"HDAC inhibitors mitigate ischemia-induced oligodendrocyte damage: Potential roles of oligodendrogenesis, VEGF, and anti-inflammation","volume":"6","author":"Kim","year":"2014","journal-title":"Am. J. Transl. Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nn2038","article-title":"Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF","volume":"11","author":"Matsumoto","year":"2008","journal-title":"Nat. Neurosci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"9453","DOI":"10.1073\/pnas.0401063101","article-title":"Activation of cAMP-response-element-binding protein (CREB) after focal cerebral ischemia stimulates neurogenesis in the adult dentate gyrus","volume":"101","author":"Zhu","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"5149","DOI":"10.1523\/JNEUROSCI.23-12-05149.2003","article-title":"Endogenously Produced Neurotrophins Regulate Survival and Differentiation of Cortical Progenitors via Distinct Signaling Pathways","volume":"23","author":"Miller","year":"2003","journal-title":"J. Neurosci."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1523\/JNEUROSCI.3741-04.2005","article-title":"Brain-Derived Neurotrophic Factor and Antidepressant Drugs Have Different But Coordinated Effects on Neuronal Turnover, Proliferation, and Survival in the Adult Dentate Gyrus","volume":"25","author":"Sairanen","year":"2005","journal-title":"J. Neurosci."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0306-4522(98)00352-2","article-title":"Persistent phosphorylation of cyclic amp responsive element-binding protein and activating transcription factor-2 transcription factors following transient cerebral ischemia in rat brain","volume":"89","author":"Hu","year":"1999","journal-title":"Neuroscience"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0006-8993(00)02512-9","article-title":"Effects of blockade of voltage-sensitive Ca(2+)\/Na(+) channels by a novel phenylpyrimidine derivative, NS-7, on CREB phosphorylation in focal cerebral ischemia in the rat","volume":"873","author":"Tanaka","year":"2000","journal-title":"Brain Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"9204","DOI":"10.1523\/JNEUROSCI.21-23-09204.2001","article-title":"Phosphorylation of cAMP Response Element-Binding Protein in Hippocampal Neurons as a Protective Response after Exposure to Glutamate In Vitro and Ischemia In Vivo","volume":"21","author":"Mabuchi","year":"2001","journal-title":"J. Neurosci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/ana.410090206","article-title":"The influence of immaturity on hypoxic-ischemic brain damage in the rat","volume":"9","author":"Rice","year":"1981","journal-title":"Ann. Neurol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/21\/11\/3808\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:33:14Z","timestamp":1760175194000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/21\/11\/3808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,27]]},"references-count":74,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,6]]}},"alternative-id":["ijms21113808"],"URL":"https:\/\/doi.org\/10.3390\/ijms21113808","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,27]]}}}