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Ubiquitylation is mediated by ubiquitin ligases, which are predicted to be encoded by more than 600 genes in humans. RING finger (RNF) proteins form the majority of these ubiquitin ligases. It has also been predicted that there are 49 RNF proteins containing transmembrane regions in humans, several of which are specifically localized to membrane compartments in the secretory and endocytic pathways. Of these, RNF183, RNF186, RNF182, and RNF152 are closely related genes with high homology. These genes share a unique common feature of exhibiting tissue-specific expression patterns, such as in the kidney, nervous system, and colon. The products of these genes are also reported to be involved in various diseases such as cancers, inflammatory bowel disease, Alzheimer\u2019s disease, and chronic kidney disease, and in various biological functions such as apoptosis, endoplasmic reticulum stress, osmotic stress, nuclear factor-kappa B (NF-\u03baB), mammalian target of rapamycin (mTOR), and Notch signaling. This review summarizes the current knowledge of these tissue-specific ubiquitin ligases, focusing on their physiological roles and significance in diseases.<\/jats:p>","DOI":"10.3390\/ijms21113921","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T04:09:03Z","timestamp":1591070943000},"page":"3921","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["The Role of Tissue-Specific Ubiquitin Ligases, RNF183, RNF186, RNF182 and RNF152, in Disease and Biological Function"],"prefix":"10.3390","volume":"21","author":[{"given":"Takumi","family":"Okamoto","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunori","family":"Imaizumi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0477-0171","authenticated-orcid":false,"given":"Masayuki","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,5,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.sbi.2020.02.003","article-title":"Modes of allosteric regulation of the ubiquitination machinery","volume":"62","author":"Rennie","year":"2020","journal-title":"Curr. Opin. Struct. Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"15475","DOI":"10.1073\/pnas.1905488116","article-title":"Structural basis for adenylation and thioester bond formation in the ubiquitin E1","volume":"116","author":"Hann","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/nrm.2016.91","article-title":"Structural insights into the catalysis and regulation of E3 ubiquitin ligases","volume":"17","author":"Buetow","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/s41594-018-0063-3","article-title":"RBR ligase-mediated ubiquitin transfer: A tale with many twists and turns","volume":"25","author":"Walden","year":"2018","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.tibs.2019.08.004","article-title":"HECT-Type E3 Ubiquitin Ligases in Cancer","volume":"44","author":"Bernassola","year":"2019","journal-title":"Trends Biochem. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s12974-020-01783-8","article-title":"Deubiquitinating enzymes (DUBs): DoUBle-edged swords in CNS autoimmunity","volume":"17","author":"Ruan","year":"2020","journal-title":"J. Neuroinflamm."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.tibs.2017.09.002","article-title":"The Ubiquitin Code in the Ubiquitin-Proteasome System and Autophagy","volume":"42","author":"Kwon","year":"2017","journal-title":"Trends Biochem. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.virol.2015.02.033","article-title":"Ubiquitination in the antiviral immune response","volume":"479","author":"Davis","year":"2015","journal-title":"Virology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3497","DOI":"10.1007\/s00018-016-2255-5","article-title":"The recognition of ubiquitinated proteins by the proteasome","volume":"73","author":"Grice","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"30955","DOI":"10.1038\/srep30955","article-title":"Genome-wide identification and gene expression profiling of ubiquitin ligases for endoplasmic reticulum protein degradation","volume":"6","author":"Kaneko","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"E2762","DOI":"10.1073\/pnas.1716439115","article-title":"Transmembrane E3 ligase RNF183 mediates ER stress-induced apoptosis by degrading Bcl-xL","volume":"115","author":"Wu","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Wu, Y., Guo, X.P., Kanemoto, S., Maeoka, Y., Saito, A., Asada, R., Matsuhisa, K., Ohtake, Y., Imaizumi, K., and Kaneko, M. (2018). Sec16A, a key protein in COPII vesicle formation, regulates the stability and localization of the novel ubiquitin ligase RNF183. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0190407"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.bbrc.2019.04.168","article-title":"Renal medullary tonicity regulates RNF183 expression in the collecting ducts via NFAT5","volume":"514","author":"Maeoka","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1074\/jbc.RA118.002896","article-title":"NFAT5 up-regulates expression of the kidney-specific ubiquitin ligase gene Rnf183 under hypertonic conditions in inner-medullary collecting duct cells","volume":"294","author":"Maeoka","year":"2019","journal-title":"J. Biol. Chem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"8840","DOI":"10.1038\/ncomms9840","article-title":"Comprehensive functional characterization of cancer-testis antigens defines obligate participation in multiple hallmarks of cancer","volume":"6","author":"Maxfield","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Gallegos, Z.R., Taus, P., Gibbs, Z.A., McGlynn, K., Gomez, N.C., Davis, I., and Whitehurst, A.W. (2019). EWSR1-FLI1 Activation of the Cancer\/Testis Antigen FATE1 Promotes Ewing Sarcoma Survival. Mol. Cell Biol., 39.","DOI":"10.1128\/MCB.00138-19"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1093\/ecco-jcc\/jjw023","article-title":"E3 Ubiquitin ligase RNF183 Is a Novel Regulator in Inflammatory Bowel Disease","volume":"10","author":"Yu","year":"2016","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"20301","DOI":"10.1038\/s41598-019-56748-6","article-title":"Inflammatory bowel disease-associated ubiquitin ligase RNF183 promotes lysosomal degradation of DR5 and TRAIL-induced caspase activation","volume":"9","author":"Wu","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.bbrc.2019.11.001","article-title":"Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its \u03b21 subunit","volume":"521","author":"Okamoto","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s40880-017-0228-1","article-title":"Synthetic lethal short hairpin RNA screening reveals that ring finger protein 183 confers resistance to trametinib in colorectal cancer cells","volume":"36","author":"Geng","year":"2017","journal-title":"Chin. J. Cancer"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e2994","DOI":"10.1038\/cddis.2017.400","article-title":"RNF183 promotes proliferation and metastasis of colorectal cancer cells via activation of NF-\u03baB-IL-8 axis","volume":"8","author":"Geng","year":"2017","journal-title":"Cell Death Dis."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1002\/ijc.25901","article-title":"Molecular markers of endometrial carcinoma detected in uterine aspirates","volume":"129","author":"Colas","year":"2011","journal-title":"Int. J. Cancer"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1016\/j.cellsig.2013.07.016","article-title":"A novel RING finger E3 ligase RNF186 regulate ER stress-mediated apoptosis through interaction with BNip1","volume":"25","author":"Wang","year":"2013","journal-title":"Cell Signal."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"16527","DOI":"10.1074\/jbc.AC119.010671","article-title":"The RING-type E3 ligase RNF186 ubiquitinates Sestrin-2 and thereby controls nutrient sensing","volume":"294","author":"Lear","year":"2019","journal-title":"J. Biol. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/mi.2016.58","article-title":"Regulation of intestinal homeostasis by the ulcerative colitis-associated gene RNF186","volume":"10","author":"Fujimoto","year":"2017","journal-title":"Mucosal. Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.cellsig.2018.09.008","article-title":"RNF186 impairs insulin sensitivity by inducing ER stress in mouse primary hepatocytes","volume":"52","author":"Tong","year":"2018","journal-title":"Cell Signal."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/ng.764","article-title":"Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47","volume":"43","author":"Anderson","year":"2011","journal-title":"Nat. Genet."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Juyal, G., Prasad, P., Senapati, S., Midha, V., Sood, A., Amre, D., Juyal, R.C., and Bk, T. (2011). An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0016565"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/path.4817","article-title":"The genetic background of inflammatory bowel disease: From correlation to causality","volume":"241","author":"Voskuil","year":"2017","journal-title":"J. Pathol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"R162","DOI":"10.1093\/hmg\/ddz189","article-title":"Rare and common variant discovery in complex disease: The IBD case study","volume":"28","author":"Venkataraman","year":"2019","journal-title":"Hum. Mol. Genet."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Beaudoin, M., Goyette, P., Boucher, G., Lo, K.S., Rivas, M.A., Stevens, C., Alikashani, A., Ladouceur, M., Ellinghaus, D., and Torkvist, L. (2013). Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis. PLoS Genet., 9.","DOI":"10.1371\/journal.pgen.1003723"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"12342","DOI":"10.1038\/ncomms12342","article-title":"A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis","volume":"7","author":"Rivas","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1097\/MIB.0b013e3182802ab6","article-title":"Genome-wide association study of ulcerative colitis in Koreans suggests extensive overlapping of genetic susceptibility with Caucasians","volume":"19","author":"Yang","year":"2013","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"6935","DOI":"10.1093\/hmg\/ddu399","article-title":"Rare mutations associating with serum creatinine and chronic kidney disease","volume":"23","author":"Sveinbjornsson","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1750-1326-3-4","article-title":"A novel brain-enriched E3 ubiquitin ligase RNF182 is up regulated in the brains of Alzheimer\u2019s patients and targets ATP6V0C for degradation","volume":"3","author":"Liu","year":"2008","journal-title":"Mol. Neurodegener."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1111\/j.1582-4934.2010.01107.x","article-title":"Cell cloning-based transcriptome analysis in Rett patients: Relevance to the pathogenesis of Rett syndrome of new human MeCP2 target genes","volume":"14","author":"Nectoux","year":"2010","journal-title":"J. Cell Mol. Med."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Wang, J.H., Wei, Z.F., Gao, Y.L., Liu, C.C., and Sun, J.H. (2018). Activation of the mammalian target of rapamycin signaling pathway underlies a novel inhibitory role of ring finger protein 182 in ventricular remodeling after myocardial ischemia-reperfusion injury. J. Cell Biochem.","DOI":"10.1002\/jcb.28038"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3210","DOI":"10.1002\/1873-3468.13583","article-title":"The E3 ubiquitin ligase RNF182 inhibits TLR-triggered cytokine production through promoting p65 ubiquitination and degradation","volume":"593","author":"Cao","year":"2019","journal-title":"FEBS Lett."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Brim, H., Abu-Asab, M.S., Nouraie, M., Salazar, J., Deleo, J., Razjouyan, H., Mokarram, P., Schaffer, A.A., Naghibhossaini, F., and Ashktorab, H. (2014). An integrative CGH, MSI and candidate genes methylation analysis of colorectal tumors. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0082185"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1007\/s13238-010-0083-1","article-title":"RNF152, a novel lysosome localized E3 ligase with pro-apoptotic activities","volume":"1","author":"Zhang","year":"2010","journal-title":"Protein Cell"},{"key":"ref_41","first-page":"945","article-title":"Rnf152 Is Essential for NeuroD Expression and Delta-Notch Signaling in the Zebrafish Embryos","volume":"40","author":"Kumar","year":"2017","journal-title":"Mol. Cells"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.3389\/fnins.2019.01022","article-title":"Negative Regulation of mTOR Signaling Restricts Cell Proliferation in the Floor Plate","volume":"13","author":"Kadoya","year":"2019","journal-title":"Front. Neurosci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.molcel.2015.03.033","article-title":"The ubiquitination of rag A GTPase by RNF152 negatively regulates mTORC1 activation","volume":"58","author":"Deng","year":"2015","journal-title":"Mol. Cell"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/s41422-018-0120-9","article-title":"Ubiquitination of Rheb governs growth factor-induced mTORC1 activation","volume":"29","author":"Deng","year":"2019","journal-title":"Cell Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1002\/elps.200700093","article-title":"Scanning copy number and gene expression on the 18q21-qter chromosomal region by the systematic multiplex PCR and reverse transcription-PCR methods","volume":"28","author":"Yamamoto","year":"2007","journal-title":"Electrophoresis"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Wang, J.L., Lin, Y.W., Chen, H.M., Kong, X., Xiong, H., Shen, N., Hong, J., and Fang, J.Y. (2011). Calcium prevents tumorigenesis in a mouse model of colorectal cancer. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0022566"},{"key":"ref_47","first-page":"3701","article-title":"Ring finger protein 152 inhibits colorectal cancer cell growth and is a novel prognostic biomarker","volume":"10","author":"Cui","year":"2018","journal-title":"Am. J. Trans. Res."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Fu, J., Tang, W., Du, P., Wang, G., Chen, W., Li, J., Zhu, Y., Gao, J., and Cui, L. (2012). Identifying microRNA-mRNA regulatory network in colorectal cancer by a combination of expression profile and bioinformatics analysis. BMC Syst. Biol., 6.","DOI":"10.1186\/1752-0509-6-68"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0303-7207(01)00666-9","article-title":"Human FATE is a novel X-linked gene expressed in fetal and adult testis","volume":"184","author":"Olesen","year":"2001","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/sj.bjc.6601062","article-title":"Identification of two novel CT antigens and their capacity to elicit antibody response in hepatocellular carcinoma patients","volume":"89","author":"Dong","year":"2003","journal-title":"Br. J. Cancer"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.ccr.2004.10.012","article-title":"Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth","volume":"6","author":"Fei","year":"2004","journal-title":"Cancer Cell"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S1470-2045(12)70270-X","article-title":"Safety, pharmacokinetic, pharmacodynamic, and efficacy data for the oral MEK inhibitor trametinib: A phase 1 dose-escalation trial","volume":"13","author":"Infante","year":"2012","journal-title":"Lancet Oncol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"6735","DOI":"10.1158\/1078-0432.CCR-07-4843","article-title":"The interleukin-8 pathway in cancer","volume":"14","author":"Waugh","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.1242\/dev.120.10.3033","article-title":"bcl-XL is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria","volume":"120","author":"Ding","year":"1994","journal-title":"Development"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1091\/mbc.e12-02-0090","article-title":"Distinct roles of mitochondria- and ER-localized Bcl-xL in apoptosis resistance and Ca2+ homeostasis","volume":"23","author":"Eno","year":"2012","journal-title":"Mol. Biol. Cell"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.cmet.2012.07.007","article-title":"IRE1\u03b1 induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress","volume":"16","author":"Lerner","year":"2012","journal-title":"Cell Metab."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1126\/science.1226191","article-title":"IRE1\u03b1 cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2","volume":"338","author":"Upton","year":"2012","journal-title":"Science"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"C1","DOI":"10.1152\/ajpcell.00327.2011","article-title":"Tonicity-independent regulation of the osmosensitive transcription factor TonEBP (NFAT5)","volume":"302","author":"Halterman","year":"2012","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1146\/annurev.biochem.71.102201.141218","article-title":"Biochemistry of Na,K-ATPase","volume":"71","author":"Kaplan","year":"2002","journal-title":"Annu. Rev. Biochem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1038\/ki.1993.132","article-title":"Na,K-ATPase expression and cell volume during hypertonic stress in human renal cells","volume":"43","author":"Yordy","year":"1993","journal-title":"Kidney Int."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1038\/sj.onc.1203565","article-title":"Functional identification of the apoptosis effector BH3 domain in cellular protein BNIP1","volume":"19","author":"Yasuda","year":"2000","journal-title":"Oncogene"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.cell.2017.02.004","article-title":"mTOR Signaling in Growth, Metabolism, and Disease","volume":"168","author":"Saxton","year":"2017","journal-title":"Cell"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/13810","article-title":"Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2","volume":"23","author":"Amir","year":"1999","journal-title":"Nat. Genet."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"4507","DOI":"10.1042\/BCJ20160826","article-title":"Deubiquitylating enzymes in receptor endocytosis and trafficking","volume":"473","author":"McCann","year":"2016","journal-title":"Biochem. J."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Thomas, J.L., Ochocinska, M.J., Hitchcock, P.F., and Thummel, R. (2012). Using the Tg(nrd:egfp)\/albino zebrafish line to characterize in vivo expression of neurod. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0029128"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.21150","article-title":"Dynamic expression of the basic helix-loop-helix transcription factor neuroD in the rod and cone photoreceptor lineages in the retina of the embryonic and larval zebrafish","volume":"501","author":"Ochocinska","year":"2007","journal-title":"J. Comp. Neurol."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Raymond, P.A., Barthel, L.K., Bernardos, R.L., and Perkowski, J.J. (2006). Molecular characterization of retinal stem cells and their niches in adult zebrafish. BMC Dev. Biol., 6.","DOI":"10.1186\/1471-213X-6-36"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"7496","DOI":"10.1167\/iovs.15-17616","article-title":"The bHLH Transcription Factor NeuroD Governs Photoreceptor Genesis and Regeneration Through Delta-Notch Signaling","volume":"56","author":"Taylor","year":"2015","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1002\/dneu.22015","article-title":"Dorsal-ventral patterning of the neural tube: A tale of three signals","volume":"72","author":"Marti","year":"2012","journal-title":"Dev. Neurobiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.devcel.2016.02.013","article-title":"Neural Progenitors Adopt Specific Identities by Directly Repressing All Alternative Progenitor Transcriptional Programs","volume":"36","author":"Kutejova","year":"2016","journal-title":"Dev. Cell"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.cell.2017.07.022","article-title":"Renal Sodium Gradient Orchestrates a Dynamic Antibacterial Defense Zone","volume":"170","author":"Berry","year":"2017","journal-title":"Cell"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"584","DOI":"10.2174\/138920210793360961","article-title":"Role of NFAT5 in inflammatory disorders associated with osmotic stress","volume":"11","author":"Neuhofer","year":"2010","journal-title":"Curr. 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