{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:23:09Z","timestamp":1792603389836,"version":"4.5.0"},"reference-count":125,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,5,31]],"date-time":"2020-05-31T00:00:00Z","timestamp":1590883200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["19-74-10059"],"award-info":[{"award-number":["19-74-10059"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["19-29-08007"],"award-info":[{"award-number":["19-29-08007"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003443","name":"Ministry of Education and Science of the Russian Federation","doi-asserted-by":"publisher","award":["Increase Competitiveness Program of NUST \u2018\u2018MISIS\u201d implemented by a governmental decree dated 16 March 2013, No. 211"],"award-info":[{"award-number":["Increase Competitiveness Program of NUST \u2018\u2018MISIS\u201d implemented by a governmental decree dated 16 March 2013, No. 211"]}],"id":[{"id":"10.13039\/501100003443","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Copper-containing coordination compounds attract wide attention due to the redox activity and biogenicity of copper ions, providing multiple pathways of biological activity. The pharmacological properties of metal complexes can be fine-tuned by varying the nature of the ligand and donor atoms. Copper-containing coordination compounds are effective antitumor agents, constituting a less expensive and safer alternative to classical platinum-containing chemotherapy, and are also effective as antimicrobial, antituberculosis, antimalarial, antifugal, and anti-inflammatory drugs. 64Cu-labeled coordination compounds are promising PET imaging agents for diagnosing malignant pathologies, including head and neck cancer, as well as the hallmark of Alzheimer\u2019s disease amyloid-\u03b2 (A\u03b2). In this review article, we summarize different strategies for possible use of coordination compounds in the treatment and diagnosis of various diseases, and also various studies of the mechanisms of antitumor and antimicrobial action.<\/jats:p>","DOI":"10.3390\/ijms21113965","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T04:09:03Z","timestamp":1591070943000},"page":"3965","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":188,"title":["Copper Coordination Compounds as Biologically Active Agents"],"prefix":"10.3390","volume":"21","author":[{"given":"Olga","family":"Krasnovskaya","sequence":"first","affiliation":[{"name":"Chemistry Department, Lomonosov Moscow State University, Leninskie gory 1,3, 119991 Moscow, Russia"},{"name":"Department of Materials Science of Semiconductors and Dielectrics, National University of Science and Technology (MISIS), Leninskiy prospect 4, 101000 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexey","family":"Naumov","sequence":"additional","affiliation":[{"name":"Chemistry Department, Lomonosov Moscow State University, Leninskie gory 1,3, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5674-8654","authenticated-orcid":false,"given":"Dmitry","family":"Guk","sequence":"additional","affiliation":[{"name":"Chemistry Department, Lomonosov Moscow State University, Leninskie gory 1,3, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4860-9013","authenticated-orcid":false,"given":"Peter","family":"Gorelkin","sequence":"additional","affiliation":[{"name":"Department of Materials Science of Semiconductors and Dielectrics, National University of Science and Technology (MISIS), Leninskiy prospect 4, 101000 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Erofeev","sequence":"additional","affiliation":[{"name":"Chemistry Department, Lomonosov Moscow State University, Leninskie gory 1,3, 119991 Moscow, Russia"},{"name":"Department of Materials Science of Semiconductors and Dielectrics, National University of Science and Technology (MISIS), Leninskiy prospect 4, 101000 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Beloglazkina","sequence":"additional","affiliation":[{"name":"Chemistry Department, Lomonosov Moscow State University, Leninskie gory 1,3, 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Majouga","sequence":"additional","affiliation":[{"name":"Chemistry Department, Lomonosov Moscow State University, Leninskie gory 1,3, 119991 Moscow, Russia"},{"name":"Department of Materials Science of Semiconductors and Dielectrics, National University of Science and Technology (MISIS), Leninskiy prospect 4, 101000 Moscow, Russia"},{"name":"Mendeleev University of Chemical Technology of Russia, Miusskaya Ploshchad\u2019 9, 125047 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,5,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jinorgbio.2016.12.008","article-title":"Studies on the mechanism of action of antitumor bis(aminophenolate) ruthenium (III) complexes","volume":"168","author":"Matos","year":"2017","journal-title":"J. Inorg. Biochem."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Dabrowiak, J.C. (2009). Metals in Medicine, Wiley.","DOI":"10.1002\/9780470684986"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12929-019-0518-9","article-title":"Molecular mechanisms of cisplatin-induced nephrotoxicity: A balance on the knife edge between renoprotection and tumor toxicity","volume":"26","author":"Volarevic","year":"2019","journal-title":"J. Biomed. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1158\/1535-7163.MCT-08-0840","article-title":"Platinum Neurotoxicity Pharmacogenetics","volume":"8","author":"McWhinney","year":"2009","journal-title":"Mol. Cancer Ther."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"8113","DOI":"10.1039\/c0dt00292e","article-title":"The Status of Platinum Anticancer Drugs in the Clinic and in Clinical Trials","volume":"39","author":"Wheate","year":"2010","journal-title":"Dalton Trans."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jtemb.2018.01.011","article-title":"Metal Transport Capabilities of Anticancer Copper Chelators","volume":"47","author":"Mihucz","year":"2018","journal-title":"Trace Elem. Med. Biol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ejphar.2017.09.003","article-title":"Hinokitiol copper complex inhibits proteasomal deubiquitination and induces paraptosis-like cell death in human cancer cells","volume":"815","author":"Xin","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbpc.2016.02.008","article-title":"ROS dependent copper toxicity in Hydra-biochemical and molecular study","volume":"185","author":"Zeeshan","year":"2016","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1016\/j.ejmech.2017.10.058","article-title":"Synthesis, crystal structure and biological evaluation of a new dasatinib copper(II) complex as telomerase inhibitor","volume":"143","author":"Qin","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"321","DOI":"10.2174\/157015912804499483","article-title":"NADPH oxidase and neurodegeneration","volume":"10","author":"Hernandes","year":"2012","journal-title":"Curr. Neuropharmacol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Fatfat, M., Merhi, R.A., Rahal, O., Stoyanovsky, D.A., Zaki, A., Haidar, H., Kagan, V.E., Gali-Muhtasib, H., and Machaca, K. (2014). Copper Chelation Selectively Kills Colon Cancer Cells through Redox Cycling and Generation of Reactive Oxygen Species. BMC Cancer., 14.","DOI":"10.1186\/1471-2407-14-527"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3595","DOI":"10.1039\/a903915e","article-title":"Mechanism of the Fenton reaction. Evidence for a new intermediate","volume":"1","author":"Kremer","year":"1999","journal-title":"Phys. Chem. Chem. Phys."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1016\/j.ijbiomac.2017.10.131","article-title":"Non-covalent DNA binding, protein interaction, DNA cleavage and cytotoxicity of [Cu(quamol)Cl]\u00b7H2O","volume":"107","author":"Sangeetha","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jinorgbio.2014.09.007","article-title":"2,6-Bis(2,6-diethylphenyliminomethyl)pyridine coordination compounds with cobalt(II), nickel(II), copper(II), and zinc(II): Synthesis, spectroscopic characterization, X-ray study and in vitro cytotoxicity","volume":"142","author":"Mijangos","year":"2015","journal-title":"J. Inorg. Biochem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.ejmech.2018.01.041","article-title":"High anticancer potency on tumor cells of dehydroabietylamine Schiff-base derivatives and a copper(II) complex","volume":"146","author":"Fengyi","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1021\/acsabm.0c00098","article-title":"Copper-Cysteamine Nanoparticles as a Heterogeneous Fenton-Like Catalyst for Highly Selective Cancer Treatment","volume":"3","author":"Chudal","year":"2020","journal-title":"ACS Appl. Bio Mater."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1016\/S0006-2952(02)00918-8","article-title":"Metal-Organic Compounds: A New Approach for Drug Discovery: N1-(4-Methyl-2-Pyridyl)-2,3,6-Trimethoxybenzamide Copper(II) Complex as an Inhibitor of Human Immunodeficiency Virus 1 Protease","volume":"63","author":"Lebon","year":"2002","journal-title":"Biochem. Pharmacol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/0006-2952(90)90065-S","article-title":"Non-Steroidal Anti-Inflammatory Drug-Copper Complex Modulation of Polymorphonuclear Leukocyte Migration","volume":"39","author":"Huy","year":"1990","journal-title":"Biochem. Pharmacol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"124","DOI":"10.15835\/nbha3926847","article-title":"Antibacterial Activity of Copper and Cobalt Amino Acids Complexes","volume":"39","author":"Stanila","year":"2011","journal-title":"Not. Bot. Horti Agrobot. Cluj-Na."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1021\/ic981100x","article-title":"Anti-Inflammatory Dinuclear Copper(II) Complexes with Indomethacin. Synthesis, Magnetism and EPR Spectroscopy. Crystal Structure of the N,N-Dimethylformamide Adduct","volume":"38","author":"Weder","year":"1999","journal-title":"Inorg. Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/s41467-020-14698-y","article-title":"Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis","volume":"11","author":"Liao","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/s13346-019-00674-7","article-title":"Characterization of a liposom al copper(II)-quercetin formulation suitable for parenteral use","volume":"10","author":"Chen","year":"2020","journal-title":"Drug Delivery Transl. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.jddst.2019.03.037","article-title":"In vitro and in vivo evaluation of biotin-mediated PEGylated nanostructured lipid as carrier of disulfiram coupled with copper ion","volume":"51","author":"Liu","year":"2019","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Pellei, M., Bagnarelli, L., Luciani, L., Del Bello, F., Giorgioni, G., Piergentili, A., Quaglia, W., De Franco, M., Gandin, V., and Marzano, C. (2020). Synthesis and Cytotoxic Activity Evaluation of New Cu(I) Complexes of Bis(pyrazol-1-yl) Acetate Ligands Functionalized with an NMDA Receptor Antagonist. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21072616"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.ica.2017.11.043","article-title":"Mixed ligand complexes of cadmium(II) and copper(II) dithiocarbazate: Synthesis, spectral characterization, X-ray crystal structure","volume":"471","author":"Takjoo","year":"2018","journal-title":"Inorg. Chim. Acta."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Khan, M.H., Cai, M., Deng, J., Yu, P., Liang, H., and Yang, F. (2019). Anticancer Function and ROS-Mediated Multi-Targeting Anticancer Mechanisms of Copper (II) 2-hydroxy-1-naphthaldehyde Complexes. Molecules, 24.","DOI":"10.3390\/molecules24142544"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"4550","DOI":"10.1002\/aoc.4550","article-title":"DNA Binding and in vitro anticancer activity of 2-((1H-benzimidazol-2-yl)methylamino)acetic acid and its copper(II) mixed-polypyridyl complexes: Synthesis and crystal structure","volume":"32","author":"Sabithakala","year":"2018","journal-title":"Appl. Organomet. Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1515\/9783110470734-016","article-title":"Copper Complexes in Cancer Therapy","volume":"16","author":"Denoyer","year":"2018","journal-title":"Metallo-Drugs Dev. Action Anticancer Agents"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.nano.2016.08.001","article-title":"Poly lactic-co-glycolic acid controlled delivery of disulfiram to target liver cancer stem-like cells","volume":"13","author":"Wang","year":"2017","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.ijpharm.2018.12.051","article-title":"Integrating the drug, disulfiram into the vitamin E-TPGS-modified PEGylated nanostructured lipid carriers to synergize its repurposing for anti-cancer therapy of solid tumors","volume":"557","author":"Banerjee","year":"2019","journal-title":"Int J. Pharm."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4172\/2161-0444.1000445","article-title":"Progress in Copper Complexes as Anticancer Agents","volume":"7","author":"Tabti","year":"2017","journal-title":"Med. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"10758","DOI":"10.1039\/C7DT01955F","article-title":"A Perspective \u2013 can copper complexes be developed as a novel class of therapeutics?","volume":"46","author":"Wehbe","year":"2017","journal-title":"Dalton Trans."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1021\/cr400135x","article-title":"Advances in Copper Complexes as Anticancer Agents","volume":"114","author":"Santini","year":"2014","journal-title":"Chem. Rev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1021\/acs.chemrev.8b00338","article-title":"Metal Compounds against Neglected Tropical Diseases","volume":"119","author":"Roy","year":"2019","journal-title":"Chem. Rev."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Ruiz-Azuara, L., Bastian, G., Bravo-G\u00f3mez, M.E., Ca\u00f1as, R.C., Flores-Alamo, M., Fuentes, I., Mejia, C., Garc\u00eda-Ramos, J., and Serrano, A. (2014). Abstract CT408: Phase I study of one mixed chelates copper(II) compound, Casiope\u00edna CasIIIia with antitumor activity and its mechanism of action. AACR. Cancer Res., 74.","DOI":"10.1158\/1538-7445.AM2014-CT408"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"5364","DOI":"10.1093\/nar\/gkv467","article-title":"Intercalation processes of copper complexes in DNA","volume":"43","author":"Cheatham","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jinorgbio.2019.03.012","article-title":"Antigiardiasic activity of Cu(II) coordination compounds: Redox imbalance and membrane damage after a short exposure time","volume":"195","year":"2019","journal-title":"J. Inorg. Biochem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.compbiolchem.2018.11.021","article-title":"Identification of Casiopeina II-gly secondary targets through a systems pharmacology approach","volume":"78","author":"Hur","year":"2019","journal-title":"Comput. Biol. Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.molliq.2018.08.075","article-title":"Synthesis, characterization, DNA binding and antitumor activities of Cu(II) complexes","volume":"269","author":"Shoair","year":"2018","journal-title":"J. Mol. Liq."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.ejmech.2018.07.022","article-title":"Mixed-ligand Cu(II) hydrazone complexes designed to enhance anticancer activity","volume":"156","author":"Mo","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.poly.2019.04.021","article-title":"An unexpected mixed valence tetranuclear Copper (I\/II) Complex: Synthesis, Structural Characterization, DNA\/Protein Binding, Antioxidant and Anticancer Properties","volume":"167","author":"Anu","year":"2019","journal-title":"Polyhedron."},{"key":"ref_42","unstructured":"Synta and GlaxoSmithKline Announce Elesclomol Granted Orphan Drug Designation by the FDA. Available online: https:\/\/ir.madrigalpharma.com\/news-releases\/news-release-details\/synta-and-glaxosmithkline-announce-elesclomol-granted-orphan."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.3109\/10428194.2016.1138293","article-title":"A phase I study of elesclomol sodium in patients with acute myeloid leukemia. Leuk","volume":"57","author":"Hedley","year":"2016","journal-title":"Leuk. Lymphoma."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Vincent, G., Fayewicz, S.L., Bateman, N.W., Hood, B.L., Sun, M., Suhan, J., Duensing, S., Yin, Y., Sander, C., and Kirkwood, J.M. (2012). Mitochondrial respiration-an important therapeutic target in melanoma. PLoS ONE., 7.","DOI":"10.1371\/journal.pone.0040690"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.tranon.2018.11.016","article-title":"Quantitative Chemotherapeutic Profiling of Gynecologic Cancer Cell Lines Using Approved Drugs and Bioactive Compounds","volume":"12","author":"Gorshkov","year":"2019","journal-title":"Transl. Oncol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1002\/cmdc.201200383","article-title":"Interactions between Artemisinins and other Antimalarial Drugs in Relation to the Cofactor Model\u2014A Unifying Proposal for Drug Action","volume":"7","author":"Haynes","year":"2012","journal-title":"Chem. Med. Chem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1038\/cddis.2015.142","article-title":"Disruption of cellular homeostasis induces organelle stress and triggers apoptosis like cell-death pathways in malaria parasite","volume":"6","author":"Rathore","year":"2015","journal-title":"Cell Death Dis."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1002\/iub.2002","article-title":"The evaluation of the anti-cancer drug elesclomol that forms a redox-active copper chelate as a potential anti-tubercular drug","volume":"71","author":"Ngwane","year":"2019","journal-title":"IUBMB Life."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jinorgbio.2009.10.009","article-title":"Nitroimidazole conjugates of bis (thiosemicarbazonato) 64Cu (II) \u2013 Potential combination agents for the PET imaging of hypoxia","volume":"104","author":"Paul","year":"2010","journal-title":"J. Inorg. Biochem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1021\/jm0104217","article-title":"Studies on the Mechanism of Hypoxic Selectivity in Copper Bis(Thiosemicarbazone) Radiopharmaceuticals","volume":"45","author":"Maurer","year":"2002","journal-title":"J. Med. Chem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1053\/j.semnuclmed.2008.10.006","article-title":"Functional imaging of inflammatory diseases using nuclear medicine techniques","volume":"39","author":"Basu","year":"2009","journal-title":"Semin. Nucl. Med."},{"key":"ref_52","first-page":"58","article-title":"Focus on the Controversial Aspects of (64) Cu-ATSM in Tumoral Hypoxia Mapping by PET Imaging","volume":"2","author":"Gouard","year":"2015","journal-title":"Front. Med."},{"key":"ref_53","unstructured":"Clinicaltrials.gov. Phase 1 Dose Escalation and PK Study of Cu(II)ATSM in ALS\/MND. NCT02870634."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"13709","DOI":"10.1021\/acs.inorgchem.9b01281","article-title":"Synthesis, Characterization, and in Vitro Anticancer Activity of Copper and Zinc Bis(Thiosemicarbazone) complexes","volume":"58","author":"Anjum","year":"2019","journal-title":"Inorg. Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1126\/science.1566067","article-title":"Alzheimer\u2019s disease: The amyloid cascade hypothesis","volume":"256","author":"Hardy","year":"1992","journal-title":"Science."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1021\/jm901039z","article-title":"18F Stilbenes and Styrylpyridines for PET Imaging of A\u03b2 Plaques in Alzheimer\u2019s Disease: A Miniperspective","volume":"53","author":"Kung","year":"2010","journal-title":"J. Med. Chem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S1474-4422(12)70142-4","article-title":"Cerebral PET with florbetapir compared with neuropathology at autopsy for detection of neuritic amyloid-\u03b2 plaques: A prospective cohort study","volume":"11","author":"Clark","year":"2012","journal-title":"Lancet Neurol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"446","DOI":"10.3389\/fnagi.2017.00446","article-title":"Role of Copper in the Onset of Alzheimer\u2019s Disease Compared to Other Metals","volume":"9","author":"Bagheri","year":"2018","journal-title":"Front. Aging. Neurosci."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Kim, A.C., Lim, S., and Kim, Y.K. (2018). Metal Ion Effects on A\u03b2 and Tau Aggregation. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19010128"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"5437","DOI":"10.1039\/c0cc01175d","article-title":"A copperradiopharmaceutical for diagnostic imaging of Alzheimer\u2019s disease: A bis(thiosemicarbazonato)copper(ii) complex that binds to amyloid-\u03b2 plaques","volume":"46","author":"Lim","year":"2010","journal-title":"Chem. Commun."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"16120","DOI":"10.1021\/ja4057807","article-title":"Diagnostic Imaging Agents for Alzheimer\u2019s Disease: Copper Radiopharmaceuticals that Target A\u03b2 Plaques","volume":"135","author":"Hickey","year":"2013","journal-title":"J. Am. Chem. Soc."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"3382","DOI":"10.1021\/acs.inorgchem.8b03466","article-title":"Potential Diagnostic Imaging of Alzheimer\u2019s Disease with Copper-64 Complexes That Bind to Amyloid-\u03b2 Plaques","volume":"5","author":"McInnes","year":"2019","journal-title":"Inorg. Chem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0020-1693(03)00047-1","article-title":"Synthesis and characterization of copper(II) complexes of pyridine-2-carboxamidrazones as potent antimalarial agents","volume":"349","author":"Gokhale","year":"2003","journal-title":"Inorg. Chim. Acta."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jinorgbio.2014.07.012","article-title":"The antimicrobial and antibiofilm activities of copper (II) complexes","volume":"140","author":"Beeton","year":"2014","journal-title":"J. Inorg. Biochem."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/nchembio.189","article-title":"Bacillithiol is an antioxidant thiol produced in Bacilli","volume":"5","author":"Newton","year":"2009","journal-title":"Nat. Chem. Biol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ica.2018.12.017","article-title":"Development of novel Cu(I) compounds with vitamin B1 derivative and their potential application as anticancer drugs","volume":"487","author":"Guieu","year":"2019","journal-title":"Inorg. Chim. Acta."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.arabjc.2016.04.013","article-title":"Novel 2-aminoimidazole-4-one complexes of copper(ii) and cobalt(ii): Synthesis, structural characterization and cytotoxicity","volume":"12","author":"Krasnovskaya","year":"2019","journal-title":"Arab. J. Chem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"5237","DOI":"10.1038\/s41598-019-41063-x","article-title":"Copper(II) complexes as potential anticancer and Nonsteroidal anti-inflammatory agents: In vitro and in vivo studies","volume":"9","author":"Hussain","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"741","DOI":"10.3390\/molecules25030741","article-title":"Synthesis, Structural, and Cytotoxic Properties of New Water-Soluble Copper(II) Complexes Based on 2,9-Dimethyl-1,10-Phenanthroline and Their One Derivative Containing 1,3,5-Triaza-7-Phosphaadamantane-7-Oxide","volume":"25","author":"Siczek","year":"2020","journal-title":"Molecules"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"5526","DOI":"10.1002\/aoc.5526","article-title":"A new class of copper(I) complexes with imine-containing chelators which show potent anticancer activity","volume":"34","author":"Milani","year":"2020","journal-title":"Appl. Organometal. Chem."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"4310","DOI":"10.1016\/j.arabjc.2019.08.002","article-title":"A mononuclear copper(II) complex containing benzimidazole and pyridyl ligands: Synthesis, characterization, and antiproliferative activity against human cancer cells","volume":"13","author":"Kacar","year":"2020","journal-title":"Arabian J. Chem."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"6252","DOI":"10.1021\/jm500154f","article-title":"Mixed Valence Copper(I,II) Binuclear Complexes with Unexpected Structure: Synthesis, Biological Properties and Anticancer Activity","volume":"14","author":"Majouga","year":"2014","journal-title":"J. Med. Chem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/S0140-6736(48)91514-1","article-title":"A Drug Sensitizing the Organism to Ethyl Alcohol","volume":"252","author":"Hald","year":"1948","journal-title":"Lancet."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1039\/c5tx00210a","article-title":"The Cytotoxic Mechanisms of Disulfiram and Copper(II) in Cancer Cells","volume":"4","author":"Tawari","year":"2015","journal-title":"Toxicol. Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12951-016-0183-z","article-title":"Delivery of Disulfiram into Breast Cancer Cells Using Folate-Receptor-Targeted Plga-Peg Nanoparticles: In Vitro and in Vivo Investigations","volume":"14","author":"Fasehee","year":"2016","journal-title":"J. Nanobiotechnol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jab.2014.04.002","article-title":"Diethyldithiocarbamate Complexes with Metals Used as Food Supplements Show Different Effects in Cancer Cells","volume":"12","author":"Sedlacek","year":"2014","journal-title":"J. Appl. Biomed."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2018.02.039","article-title":"Suppressing autophagy enhances disulfiram\/copper-induced apoptosis in non-small cell","volume":"827","author":"Wu","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"13334","DOI":"10.1039\/C4CC04767B","article-title":"On the Interaction of Copper(II) with Disulfiram","volume":"50","author":"Lewis","year":"2014","journal-title":"Chem. Commun."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.2174\/092986710791859315","article-title":"Turning Tumor-Promoting Copper into an Anti-Cancer Weapon Via High-Throughput Chemistry","volume":"17","author":"Wang","year":"2010","journal-title":"Curr. Med. Chem."},{"key":"ref_80","unstructured":"Phase II Trial of Disulfiram With Copper in Metastatic Breast Cancer (DISC). The Institute of Molecular and Translational Medicine, Czech Republic. Clinicaltrials.gov Identifier: NCT03323346."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1038\/bjc.2012.442","article-title":"Cytotoxic effect of disulfiram\/copper on human glioblastoma cell lines and ALDH-positive cancer-stem-like cells","volume":"107","author":"Liu","year":"2012","journal-title":"Br. J. Cancer"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1038\/bjc.2013.18","article-title":"Comment on \u2018Cytotoxic effect of disulfiram\/copper on human glioblastoma cell lines and ALDH-positive cancer-stem-like cells\u2019","volume":"108","author":"Cvek","year":"2013","journal-title":"Br. J. Cancer."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/BF01877380","article-title":"Sodium ditiocarb as adjuvant immunotherapy for high risk breast cancer: A randomized study","volume":"6","author":"Dufour","year":"1993","journal-title":"Biotherapy"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1039\/C8BM00271A","article-title":"Synergistic breast tumor cell killing achieved by intracellular co-delivery of doxorubicin and disulfiram via core-shell-corona nanoparticles","volume":"6","author":"Tao","year":"2018","journal-title":"Biomater. Sci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"11531","DOI":"10.1021\/jacs.9b03503","article-title":"Enhanced Tumor-Specific Disulfiram Chemotherapy by In Situ Cu2+ Chelation-Initiated Nontoxicity-to-Toxicity Transition","volume":"29","author":"Wu","year":"2019","journal-title":"J. Am. Chem. Soc."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"109529","DOI":"10.1016\/j.biopha.2019.109529","article-title":"Antitumor effects of disulfiram\/copper complex in the poorly-differentiated nasopharyngeal carcinoma cells via activating ClC-3 chloride channel","volume":"120","author":"Xu","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.biocel.2017.01.007","article-title":"The selective cytotoxicity of DSF-Cu attributes to the biomechanical properties and cytoskeleton rearrangements in the normal and cancerous nasopharyngeal epithelial cells","volume":"84","author":"Yaping","year":"2017","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Li, Y., Chen, F., Chen, J., Chan, S., He, Y., Liu, W., and Zhang, G. (2020). Disulfiram\/Copper Induces Antitumor Activity against Both Nasopharyngeal Cancer Cells and Cancer-Associated Fibroblasts through ROS\/MAPK and Ferroptosis Pathways. Cancers, 12.","DOI":"10.3390\/cancers12010138"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.jconrel.2020.01.001","article-title":"Old wine in new bottles: Advanced drug delivery systems for disulfiram-based cancer therapy","volume":"319","author":"McMahon","year":"2020","journal-title":"J. Control Release"},{"key":"ref_90","unstructured":"Phase II Study of Disulfiram and Cisplatin in Refractory TGCTs. National Cancer Institute, Slovakia. ClinicalTrials.gov Identifier: NCT03950830."},{"key":"ref_91","unstructured":"Phase II Study of Vinorelbine, Cisplatin, Disulfiram and Copper in CTC_EMT Positive Refractory Metastatic Breast Cancer. National Cancer Institute, Slovakia. ClinicalTrials.gov Identifier: NCT04265274."},{"key":"ref_92","first-page":"00194-16","article-title":"Zinc Pyrithione Improves the Antibacterial Activity of Silver Sulfadiazine Ointment","volume":"5","author":"Blanchard","year":"2016","journal-title":"mSphere"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"5240","DOI":"10.1038\/srep05240","article-title":"A Novel Proteasome Inhibitor Suppresses Tumor Growth Via Targeting Both 19s Proteasome Deubiquitinases and 20s Proteolytic Peptidases","volume":"4","author":"Liu","year":"2014","journal-title":"Sci. Rep."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00775-007-0299-6","article-title":"Synthesis and characterization of new copper thiosemicarbazone complexes with an ONNS quadridentate system: Cell growth inhibition, S-phase cell cycle arrest and proapoptotic activities on cisplatin-resistant neuroblastoma cells","volume":"13","author":"Zhang","year":"2008","journal-title":"J. Biol. Inorg. Chem."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.freeradbiomed.2010.10.696","article-title":"A copper chelate of thiosemicarbazone NSC 689534 induces oxidative\/ER stress and inhibits tumor growth in vitro and in vivo","volume":"50","author":"Hancock","year":"2011","journal-title":"Free Radical Biol. Med."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"112266","DOI":"10.1016\/j.ejmech.2020.112266","article-title":"In vitro and in vivo anticancer activity of tridentate thiosemicarbazone copper complexes: Unravelling an unexplored pharmacological target","volume":"194","author":"Carcelli","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.saa.2019.01.020","article-title":"Potent drug candidature of an ONS donor tethered copper (II) complex: Anticancer activity, cytotoxicity and spectroscopically approached BSA binding studies","volume":"212","author":"Kongot","year":"2019","journal-title":"Spectrochim. Acta Part A"},{"key":"ref_98","unstructured":"Balakrishna, M.S. (2019). Copper(I) Chemistry of Phosph ines, Functionalized Phosphines and Phosphorus Heterocycles, Elsevier."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"19318","DOI":"10.1039\/C9NJ03005K","article-title":"Heteroleptic copper(I) halides with triphenylphosphine and acetylthiourea: Synthesis, characterization and biological studies (experimental and molecular docking)","volume":"43","author":"Khan","year":"2019","journal-title":"New J. Chem."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jinorgbio.2016.10.004","article-title":"Novel metalloantimalarials: Transmission blocking effects of water soluble Cu(I), Ag(I) and Au(I) phosphane complexes on the murine malaria parasite Plasmodium berghei","volume":"166","author":"Tapanelli","year":"2017","journal-title":"J. Inorg. Biochem."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"12688","DOI":"10.1039\/C5DT01146A","article-title":"Copper(I) complexes with phosphine derived from sparfloxacin. Part I \u2013 structures, spectroscopic properties and cytotoxicity","volume":"44","author":"Komarnicka","year":"2015","journal-title":"Dalton Trans."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.poly.2018.10.062","article-title":"Synthesis, structures, DNA-binding and anticancer activities of some copper(I)-phosphine complexes","volume":"158","author":"Mashat","year":"2019","journal-title":"Polyhedron"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0162-0134(95)00082-8","article-title":"Copper(II) Complexes of the Fluoroquinolone Antimicrobial Ciprofloxacin. Synthesis, X-Ray Structural Characterization, and Potentiometric Study","volume":"62","author":"Wallis","year":"1996","journal-title":"J. Inorg. Biochem."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1021\/jm00143a021","article-title":"Structure of a Copper-Isoniazid Complex","volume":"24","author":"Hanson","year":"1981","journal-title":"J. Med. Chem."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0960-894X(00)00058-5","article-title":"Isoniazid Related Copper(II) and Nickel(II) Complexes with Antimycobacterial in Vitro Activity","volume":"10","author":"Bottari","year":"2000","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"221","DOI":"10.2174\/1871523016666170217103402","article-title":"Synthesis, Characterization and Comparison of Local Analgesic, Anti-Inflammatory, Anti-Ulcerogenic Activity of Copper and Zinc Complexes of Indomethacin","volume":"15","author":"Sukul","year":"2017","journal-title":"Anti-Inflamm. Anti-Allergy Agents Med. Chem."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"3795","DOI":"10.1021\/ic0494051","article-title":"Clioquinol, a Drug for Alzheimer\u2019s Disease Specifically Interfering with Brain Metal Metabolism: Structural Characterization of Its Zinc(II) and Copper(II) Complexes","volume":"43","author":"Bazzicalupi","year":"2004","journal-title":"Inorg. Chem."},{"key":"ref_108","first-page":"1491","article-title":"Effect of a Topical Copper Indomethacin Gel on Inflammatory Parameters in a Rat Model of Osteoarthritis","volume":"9","author":"Yassin","year":"2015","journal-title":"Drug Des. Devel. Ther."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/BF01974933","article-title":"Copper Complexes of Non-Steroidal Antiinflammatory Agents: Analgesic Activity and Possible Opioid Receptor Activation","volume":"21","author":"Okuyama","year":"1987","journal-title":"Agents Actions."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jinorgbio.2012.12.002","article-title":"A Novel Copper(II) Mononuclear Complex with the Non-Steroidal Anti-Inflammatory Drug Diclofenac: Structural Characterization and Biological Activity","volume":"120","author":"Sayen","year":"2013","journal-title":"J. Inorg. Biochem."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ejphar.2011.11.049","article-title":"Anti Nociceptive Activity and Toxicity Evaluation of Cu(II)-Fenoprofenate Complexes in Mice","volume":"675","author":"Gumilar","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1080\/14756360802361589","article-title":"Anti-oxidant, in vitro, in vivo anti-inflammatory activity and antiproliferative activity of mefenamic acid and its metal complexes with manganese(II), cobalt(II), nickel(II), copper(II) and zinc(II)","volume":"24","author":"Staninska","year":"2009","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jinorgbio.2018.10.003","article-title":"Anticancer copper complex with nucleus, mitochondrion and cyclooxygenase-2 as multiple targets","volume":"190","author":"Shi","year":"2019","journal-title":"J. Inorg. Biochem."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.ejmech.2008.05.016","article-title":"Synthesis of some N-substituted nitroimidazole derivatives as potential antioxidant and antifungal agents","volume":"44","author":"Olender","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.ejmech.2009.11.009","article-title":"Synthesis of nitroimidazole derived oxazolidinones as antibacterial agents","volume":"45","author":"Varshney","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.molstruc.2019.02.101","article-title":"Synthesis, structural and biological activity of N-substituted 2-methyl-4-\/5-nitroimidazole derivatives","volume":"1185","author":"Mushtaque","year":"2019","journal-title":"J. Mol. Struct."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1158\/0008-5472.CAN-04-3577","article-title":"Anticancer Activity of the Antibiotic Clioquinol","volume":"65","author":"Ding","year":"2005","journal-title":"Cancer Res."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jinorgbio.2018.07.008","article-title":"Syntheses and biological studies of nitroimidazole conjugated heteroscorpionate ligands and related Cu(I) and Cu(II) complexes","volume":"187","author":"Pellei","year":"2018","journal-title":"J. Inorg. Biochem."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"10448","DOI":"10.1021\/jm301053a","article-title":"Copper-Dependent Cytotoxicity of 8-Hydroxyquinoline Derivatives Correlates with Their Hydrophobicity and Does Not Require Caspase Activation","volume":"55","author":"Tardito","year":"2012","journal-title":"J. Med. Chem."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0968-0004(99)01492-9","article-title":"Intracellular Copper Routing: The Role of Copper Chaperones","volume":"25","author":"Harrison","year":"2000","journal-title":"Trends Biochem. Sci."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"5765","DOI":"10.1128\/AAC.00325-16","article-title":"8-Hydroxyquinolines Are Boosting Agents of Copper-Related Toxicity in Mycobacterium Tuberculosis","volume":"60","author":"Shah","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Silva, P.B., Souza, P.C., Calixto, G.M.F., Lopes, E.D.O., Frem, R.C.G., Netto, A.V.G., Mauro, A.E., Pavan, F.R., and Chorilli, M. (2016). In Vitro Activity of Copper(II) Complexes, Loaded or Unloaded into a Nanostructured Lipid System, against Mycobacterium tuberculosis. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17050745"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"104653","DOI":"10.1016\/j.yrtph.2020.104653","article-title":"Cyto-genotoxic evaluation of novel anti-tubercular copper (II) complexes containing isoniazid-based ligands","volume":"113","author":"Fregonezi","year":"2020","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"48","DOI":"10.2174\/1871520618666180420165821","article-title":"Metal Complexes of Natural Product Like-compounds with Antitumor Activity","volume":"19","author":"Heras","year":"2019","journal-title":"Anti-Cancer Agents Med. Chem."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"15646","DOI":"10.1039\/C9DT01942A","article-title":"Biological evaluation of optically pure chiral binuclear copper(II) complexes based on a rosin derivative as highly potential anticancer agents","volume":"48","author":"Fei","year":"2019","journal-title":"Dalton Trans."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/21\/11\/3965\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:34:24Z","timestamp":1760175264000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/21\/11\/3965"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,31]]},"references-count":125,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,6]]}},"alternative-id":["ijms21113965"],"URL":"https:\/\/doi.org\/10.3390\/ijms21113965","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,31]]}}}