{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:33:48Z","timestamp":1791426828218,"version":"4.3.3"},"reference-count":75,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2018\/29\/B\/NZ4\/01384"],"award-info":[{"award-number":["2018\/29\/B\/NZ4\/01384"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014418","name":"Nencki Institute of Experimental Biology","doi-asserted-by":"publisher","award":["Statutory funds"],"award-info":[{"award-number":["Statutory funds"]}],"id":[{"id":"10.13039\/501100014418","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The S100A6 protein is present in different mammalian cells and tissues including the brain. It binds Ca2+ and Zn2+ and interacts with many target proteins\/ligands. The best characterized ligands of S100A6, expressed at high level in the brain, include CacyBP\/SIP and Sgt1. Research concerning the functional role of S100A6 and these two ligands indicates that they are involved in various signaling pathways that regulate cell proliferation, differentiation, cytoskeletal organization, and others. In this review, we focused on the expression\/localization of these proteins in the brain and on their possible role in neurodegenerative diseases. Published results demonstrate that S100A6, CacyBP\/SIP, and Sgt1 are expressed in various brain structures and in the spinal cord and can be found in different cell types including neurons and astrocytes. When it comes to their possible involvement in nervous system pathology, it is evident that their expression\/level and\/or subcellular localization is changed when compared to normal conditions. Among diseases in which such changes have been observed are Alzheimer\u2019s disease (AD), amyotrophic lateral sclerosis (ALS), epileptogenesis, Parkinson\u2019s disease (PD), Huntington\u2019s disease (HD), and others.<\/jats:p>","DOI":"10.3390\/ijms21113979","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T04:09:03Z","timestamp":1591070943000},"page":"3979","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["S100A6 and Its Brain Ligands in Neurodegenerative Disorders"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9484-9555","authenticated-orcid":false,"given":"Anna","family":"Filipek","sequence":"first","affiliation":[{"name":"Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur Street, 02-093 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wies\u0142awa","family":"Le\u015bniak","sequence":"additional","affiliation":[{"name":"Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur Street, 02-093 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"242","DOI":"10.18388\/pb.2018_136","article-title":"Current view on cellular function of S100A6 and its ligands, CacyBP\/SIP and Sgt1","volume":"64","author":"Filipek","year":"2018","journal-title":"Post. 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