{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T12:05:02Z","timestamp":1774008302680,"version":"3.50.1"},"reference-count":109,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,6,6]],"date-time":"2020-06-06T00:00:00Z","timestamp":1591401600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["IG-23068"],"award-info":[{"award-number":["IG-23068"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Breast cancer (BC) is a heterogeneous disease characterized by different biopathological features, differential response to therapy and substantial variability in long-term-survival. BC heterogeneity recapitulates genetic and epigenetic alterations affecting transformed cell behavior. The estrogen receptor alpha positive (ER\u03b1+) is the most common BC subtype, generally associated with a better prognosis and improved long-term survival, when compared to ER\u03b1-tumors. This is mainly due to the efficacy of endocrine therapy, that interfering with estrogen biosynthesis and actions blocks ER-mediated cell proliferation and tumor spread. Acquired resistance to endocrine therapy, however, represents a great challenge in the clinical management of ER\u03b1+ BC, causing tumor growth and recurrence irrespective of estrogen blockade. Improving overall survival in such cases requires new and effective anticancer drugs, allowing adjuvant treatments able to overcome resistance to first-line endocrine therapy. To date, several studies focus on the application of loss-of-function genome-wide screenings to identify key (hub) \u201cfitness\u201d genes essential for BC progression and representing candidate drug targets to overcome lack of response, or acquired resistance, to current therapies. Here, we review the biological significance of essential genes and relative functional pathways affected in ER\u03b1+ BC, most of which are strictly interconnected with each other and represent potential effective targets for novel molecular therapies.<\/jats:p>","DOI":"10.3390\/ijms21114068","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T05:16:14Z","timestamp":1591679774000},"page":"4068","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Global View of Candidate Therapeutic Target Genes in Hormone-Responsive Breast Cancer"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9601-2975","authenticated-orcid":false,"given":"Annamaria","family":"Salvati","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry \u2018Scuola Medica Salernitana\u2019, University of Salerno, 84081 Baronissi (SA), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerio","family":"Gigantino","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry \u2018Scuola Medica Salernitana\u2019, University of Salerno, 84081 Baronissi (SA), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7453-1240","authenticated-orcid":false,"given":"Giovanni","family":"Nassa","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry \u2018Scuola Medica Salernitana\u2019, University of Salerno, 84081 Baronissi (SA), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Mirici Cappa","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry \u2018Scuola Medica Salernitana\u2019, University of Salerno, 84081 Baronissi (SA), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna Maria","family":"Ventola","sequence":"additional","affiliation":[{"name":"Genomix4Life, 84081 Baronissi (SA), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela Georgia Cristina","family":"Cracas","sequence":"additional","affiliation":[{"name":"Genomix4Life, 84081 Baronissi (SA), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaella","family":"Mastrocinque","sequence":"additional","affiliation":[{"name":"Genomix4Life, 84081 Baronissi (SA), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1783-5015","authenticated-orcid":false,"given":"Francesca","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry \u2018Scuola Medica Salernitana\u2019, University of Salerno, 84081 Baronissi (SA), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9668-3632","authenticated-orcid":false,"given":"Roberta","family":"Tarallo","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry \u2018Scuola Medica Salernitana\u2019, University of Salerno, 84081 Baronissi (SA), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0455-2083","authenticated-orcid":false,"given":"Alessandro","family":"Weisz","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry \u2018Scuola Medica Salernitana\u2019, University of Salerno, 84081 Baronissi (SA), Italy"},{"name":"CRGS\u2014Genome Research Center for Health, University of Salerno Campus of Medicine, 84081 Baronissi (SA), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0538-8978","authenticated-orcid":false,"given":"Giorgio","family":"Giurato","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry \u2018Scuola Medica Salernitana\u2019, University of Salerno, 84081 Baronissi (SA), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,6]]},"reference":[{"key":"ref_1","first-page":"2929","article-title":"Breast cancer intrinsic subtype classification, clinical use and future trends","volume":"5","author":"Dai","year":"2015","journal-title":"Am. 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