{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:44:16Z","timestamp":1791110656707,"version":"4.1.0"},"reference-count":34,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,6,7]],"date-time":"2020-06-07T00:00:00Z","timestamp":1591488000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009954","name":"Taiho Pharmaceutical","doi-asserted-by":"publisher","award":["AS2019A000431642"],"award-info":[{"award-number":["AS2019A000431642"]}],"id":[{"id":"10.13039\/100009954","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014422","name":"Eli Lilly Japan","doi-asserted-by":"publisher","award":["LGO-1600362"],"award-info":[{"award-number":["LGO-1600362"]}],"id":[{"id":"10.13039\/100014422","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Merck Biopharma Co., Ltd.","award":["MSJS20190430002"],"award-info":[{"award-number":["MSJS20190430002"]}]},{"DOI":"10.13039\/100010795","name":"Chugai Pharmaceutical","doi-asserted-by":"publisher","award":["AC-1-20190429180533-244801"],"award-info":[{"award-number":["AC-1-20190429180533-244801"]}],"id":[{"id":"10.13039\/100010795","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Yakult Honsha Co., Ltd","award":["2019-1127"],"award-info":[{"award-number":["2019-1127"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>To explore the underlying mechanism of rapid liver hypertrophy by liver partition in associating liver partition and portal vein ligation for staged hepatectomy (ALPPS), liver partition at different sites was investigated. Increased inflammatory cytokines owing to the liver partition have been reportedly responsible. If this were true, rapid liver hypertrophy should be achieved regardless of where the liver was split. A male Sprague-Dawley rat model was created, in which a liver split was placed inside the portal vein ligated lobe (PiLL), in addition to the ALPPS and portal vein ligation (PVL) models. Liver regeneration rate, inflammatory cytokine levels, activation status of the Janus kinase 2\/signal transducer and activator of transcription 3 (JAK2\/STAT3) pathway and expressions of regenerating islet-derived (Reg)3\u03b1 and Reg3\u03b2 were investigated. The liver regeneration rate was significantly higher in the ALPPS group than in the PiLL group, whereas inflammatory cytokine levels were nearly equal. Additional volume increase in ALPPS group over PVL and PiLL groups was JAK2\/STAT3-dependent. Reg3\u03b1 and Reg3\u03b2 expressions were observed only in the ALPPS group. An increase in inflammatory cytokines was not enough to describe the mechanism of rapid liver hypertrophy in ALPPS. Expressions of Reg3\u03b1 and Reg3\u03b2 could play an important role in conjunction with an activation of the JAK2\/STAT3 pathway.<\/jats:p>","DOI":"10.3390\/ijms21114077","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T05:16:14Z","timestamp":1591679774000},"page":"4077","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Reg3\u03b1 and Reg3\u03b2 Expressions Followed by JAK2\/STAT3 Activation Play a Pivotal Role in the Acceleration of Liver Hypertrophy in a Rat ALPPS Model"],"prefix":"10.3390","volume":"21","author":[{"given":"Naohiko","family":"Otsuka","sequence":"first","affiliation":[{"name":"Department of Gastroenterological Surgery, Akita University Graduate School of Medicine, Akita 0108543, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Yoshioka","sequence":"additional","affiliation":[{"name":"Department of Nursing, Akita University Graduate School of Health Science, Akita 0108543, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Akita University Graduate School of Medicine, Akita 0108543, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiko","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Akita University Graduate School of Medicine, Akita 0108543, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Uchinami","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Akita University Graduate School of Medicine, Akita 0108543, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5178-9169","authenticated-orcid":false,"given":"Yuzo","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Akita University Graduate School of Medicine, Akita 0108543, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/hep.23713","article-title":"What is critical for liver surgery and partial liver transplantation: Size or quality?","volume":"52","author":"Clavien","year":"2010","journal-title":"Hepatology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1056\/NEJMra065156","article-title":"Strategies for safer liver surgery and partial liver transplantation","volume":"356","author":"Clavien","year":"2007","journal-title":"N. 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