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In this review, we have summarized the papers present in the literature, to our acknowledge, that reported the EV effects on liver diseases. EVs purified from serum, stem cells, and hepatocytes were investigated in different experimental in vivo models of liver injury and in particular of liver fibrosis. Despite the different EV origin and the different types of injury (toxic, ischemic, diet induced, and so on), EVs showed an anti-fibrotic effect. In particular, EVs had the capacities to inhibit activation of hepatic stellate cells, one of the major players of liver fibrosis development; to reduce inflammation and apoptosis; to counteract the oxidative stress; and to increase hepatocyte proliferation, contributing to reducing fibrosis and ameliorating liver function and morphology.<\/jats:p>","DOI":"10.3390\/ijms21124255","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T12:16:57Z","timestamp":1592223417000},"page":"4255","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Extracellular Vesicles: A Therapeutic Option for Liver Fibrosis"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8879-9536","authenticated-orcid":false,"given":"Stefania","family":"Bruno","sequence":"first","affiliation":[{"name":"Department of Medical Sciences and Molecular Biotechnology Center, University of Torino, 10126 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1420-3517","authenticated-orcid":false,"given":"Giulia","family":"Chiabotto","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences and Molecular Biotechnology Center, University of Torino, 10126 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2795-232X","authenticated-orcid":false,"given":"Giovanni","family":"Camussi","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences and Molecular Biotechnology Center, University of Torino, 10126 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1007\/s00018-011-0689-3","article-title":"Membrane Vesicles, Current State-of-the-Art: Emerging Role of Extracellular Vesicles","volume":"68","author":"Aradi","year":"2011","journal-title":"Cell. 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