{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:09:49Z","timestamp":1790165389891,"version":"4.1.0"},"reference-count":145,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T00:00:00Z","timestamp":1592265600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["OC170228"],"award-info":[{"award-number":["OC170228"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R00CA194318-03"],"award-info":[{"award-number":["R00CA194318-03"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Gynecologic malignancies, including ovarian cancer, endometrial cancer, and cervical cancer, affect hundreds of thousands of women worldwide every year. Wnt signaling, specifically Wnt\/\u03b2-catenin signaling, has been found to play an essential role in many oncogenic processes in gynecologic malignancies, including tumorigenesis, metastasis, recurrence, and chemotherapy resistance. As such, the Wnt\/\u03b2-catenin signaling pathway has the potential to be a target for effective treatment, improving patient outcomes. In this review, we discuss the evidence supporting the importance of the Wnt signaling pathways in the development, progression, and treatment of gynecologic malignancies.<\/jats:p>","DOI":"10.3390\/ijms21124272","type":"journal-article","created":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T13:20:43Z","timestamp":1592313643000},"page":"4272","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Wnt Signaling in Gynecologic Malignancies"],"prefix":"10.3390","volume":"21","author":[{"given":"Alexandra","family":"McMellen","sequence":"first","affiliation":[{"name":"Department of OB\/GYN, Division of Reproductive Sciences, The University of Colorado, Aurora, CO 80045, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth R.","family":"Woodruff","sequence":"additional","affiliation":[{"name":"Department of OB\/GYN, Division of Reproductive Sciences, The University of Colorado, Aurora, CO 80045, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley R.","family":"Corr","sequence":"additional","affiliation":[{"name":"Department of OB\/GYN, Division of Gynecologic Oncology, The University of Colorado, Aurora, CO 80045, USA"},{"name":"University of Colorado Comprehensive Cancer Center, Aurora, CO 80045, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin G.","family":"Bitler","sequence":"additional","affiliation":[{"name":"Department of OB\/GYN, Division of Reproductive Sciences, The University of Colorado, Aurora, CO 80045, USA"},{"name":"University of Colorado Comprehensive Cancer Center, Aurora, CO 80045, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2385-1903","authenticated-orcid":false,"given":"Marisa R.","family":"Moroney","sequence":"additional","affiliation":[{"name":"Department of OB\/GYN, Division of Gynecologic Oncology, The University of Colorado, Aurora, CO 80045, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrc3419","article-title":"Wnt signalling pathways as therapeutic targets in cancer","volume":"13","author":"Anastas","year":"2013","journal-title":"Nat. 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