{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:45:09Z","timestamp":1780638309475,"version":"3.54.1"},"reference-count":64,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T00:00:00Z","timestamp":1593129600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Swedish Government","award":["ALFGBG-74390"],"award-info":[{"award-number":["ALFGBG-74390"]}]},{"name":"Swedish Government","award":["ALFGBG-719761"],"award-info":[{"award-number":["ALFGBG-719761"]}]},{"name":"Swedish Government","award":["ALFGBG-751111"],"award-info":[{"award-number":["ALFGBG-751111"]}]},{"DOI":"10.13039\/501100001081","name":"Hunter Medical Research Institute","doi-asserted-by":"publisher","award":["HMRI18-17"],"award-info":[{"award-number":["HMRI18-17"]}],"id":[{"id":"10.13039\/501100001081","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Cognitive impairment is common after stroke, and disturbances in hippocampal function are often involved, even in remote non-hippocampal injuries. In terms of hippocampal function, growth hormone (GH) is known to affects plasticity and cognition. We aimed to investigate whether GH treatment after an experimental cortical stroke could enhance remote hippocampal plasticity and the hippocampal-dependent visual discrimination task. C57BL6 male mice were subjected to cortical photothrombotic stroke. Stroke mice were then treated with either saline or GH at 48 h after occlusion for 28 days. We assessed learning and memory using mouse touchscreen platform for the visual discrimination task. We also evaluated markers of neural progenitor cells, synaptic plasticity and cerebrovascular remodelling in the hippocampal formation. GH treatment significantly improved the performance on visual discrimination task after stroke. We observed a concomitant increased number of bromodeoxyuridine-positive cells in the dentate gyrus of the hippocampus. We also detected increased protein levels and density of doublecortin, a neuronal precursor cells marker, as well as glutamate receptor 1 (GLuR1), a synaptic marker. These findings provide further neurobiological evidence for how GH treatment could be used to promote hippocampal plasticity in a remote region from the initial cortical injury, and thus enhance cognitive recovery after stroke.<\/jats:p>","DOI":"10.3390\/ijms21124563","type":"journal-article","created":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T05:28:56Z","timestamp":1593408536000},"page":"4563","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Growth Hormone Treatment Promotes Remote Hippocampal Plasticity after Experimental Cortical Stroke"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2753-2691","authenticated-orcid":false,"given":"Sonia","family":"Sanchez-Bezanilla","sequence":"first","affiliation":[{"name":"School of Biomedical Sciences and Pharmacy and the Priority Research Centre for Stroke and Brain Injury, The University of Newcastle, University Dr, Callaghan, NSW 2308, Australia"},{"name":"Hunter Medical Research Institute, Lot 1, Kookaburra Cct, New Lambton Heights, NSW 2305, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1474-5666","authenticated-orcid":false,"given":"N. David","family":"\u00c5berg","sequence":"additional","affiliation":[{"name":"Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, 40530 Gothenburg, Sweden"},{"name":"Department of Internal Medicine, Region V\u00e4stra G\u00f6taland, Sahlgrenska University Hospital, Bl\u00e5 str\u00e5ket 5, 41345 Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Crock","sequence":"additional","affiliation":[{"name":"Hunter Medical Research Institute, Lot 1, Kookaburra Cct, New Lambton Heights, NSW 2305, Australia"},{"name":"Department of Paediatric Endocrinology and Diabetes, John Hunter Children\u2019s Hospital, Kookaburra Cct, New Lambton Heights, NSW 2305, Australia"},{"name":"Priority Research Centre GrowUpWell, The University of Newcastle, University Dr, Callaghan, NSW 2308, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick R.","family":"Walker","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences and Pharmacy and the Priority Research Centre for Stroke and Brain Injury, The University of Newcastle, University Dr, Callaghan, NSW 2308, Australia"},{"name":"Hunter Medical Research Institute, Lot 1, Kookaburra Cct, New Lambton Heights, NSW 2305, Australia"},{"name":"NHMRC Centre of Research Excellence Stroke Rehabilitation and Brain Recovery, Heidelberg, VIC 3084, Australia"},{"name":"Centre for Rehab Innovations, The University of Newcastle, NSW 2305, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Nilsson","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences and Pharmacy and the Priority Research Centre for Stroke and Brain Injury, The University of Newcastle, University Dr, Callaghan, NSW 2308, Australia"},{"name":"Hunter Medical Research Institute, Lot 1, Kookaburra Cct, New Lambton Heights, NSW 2305, Australia"},{"name":"NHMRC Centre of Research Excellence Stroke Rehabilitation and Brain Recovery, Heidelberg, VIC 3084, Australia"},{"name":"Centre for Rehab Innovations, The University of Newcastle, NSW 2305, Australia"},{"name":"LKC School of Medicine, Nanyang Technological University, 50 Nanyang Ave, Singapore 639798, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rgen","family":"Isgaard","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences and Pharmacy and the Priority Research Centre for Stroke and Brain Injury, The University of Newcastle, University Dr, Callaghan, NSW 2308, Australia"},{"name":"Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, 40530 Gothenburg, Sweden"},{"name":"Department of Internal Medicine, Region V\u00e4stra G\u00f6taland, Sahlgrenska University Hospital, Bl\u00e5 str\u00e5ket 5, 41345 Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8664-0540","authenticated-orcid":false,"given":"Lin Kooi","family":"Ong","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences and Pharmacy and the Priority Research Centre for Stroke and Brain Injury, The University of Newcastle, University Dr, Callaghan, NSW 2308, Australia"},{"name":"Hunter Medical Research Institute, Lot 1, Kookaburra Cct, New Lambton Heights, NSW 2305, Australia"},{"name":"NHMRC Centre of Research Excellence Stroke Rehabilitation and Brain Recovery, Heidelberg, VIC 3084, Australia"},{"name":"School of Pharmacy, Monash University Malaysia, Bandar Sunway, Subang Jaya 47500, Selangor, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1093\/brain\/awh553","article-title":"Cerebral small-vessel disease and decline in information processing speed, executive function and memory","volume":"128","author":"Prins","year":"2005","journal-title":"Brain"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1212\/WNL.0b013e31823ed0cc","article-title":"Memory after silent stroke: Hippocampus and infarcts both matter","volume":"78","author":"Blum","year":"2012","journal-title":"Neurology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1161\/STROKEAHA.111.636498","article-title":"Hippocampal neuronal atrophy and cognitive function in delayed poststroke and aging-related dementias","volume":"43","author":"Gemmell","year":"2012","journal-title":"Stroke"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1038\/jcbfm.2015.110","article-title":"Hippocampal complex atrophy in poststroke and mild cognitive impairment","volume":"35","author":"Selnes","year":"2015","journal-title":"J. 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