{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:26:34Z","timestamp":1790177194241,"version":"4.1.0"},"reference-count":54,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T00:00:00Z","timestamp":1593475200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["internal funding"],"award-info":[{"award-number":["internal funding"]}],"id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006451","name":"Hospices Civils de Lyon","doi-asserted-by":"publisher","award":["Internal funding"],"award-info":[{"award-number":["Internal funding"]}],"id":[{"id":"10.13039\/501100006451","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006687","name":"Universit\u00e9 Claude Bernard Lyon 1","doi-asserted-by":"publisher","award":["Internal funding"],"award-info":[{"award-number":["Internal funding"]}],"id":[{"id":"10.13039\/501100006687","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Association Fran\u00e7aise pour la Recherche Thermale","award":["NeuroImmuno Peau 1"],"award-info":[{"award-number":["NeuroImmuno Peau 1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Although sulfur-rich thermal waters have ancestrally been used in the context of dermatological conditions, a global mapping of the molecular effects exerted by H2S on human keratinocytes is still lacking. To fill this knowledge gap, we subjected cultured human keratinocytes to distinct amounts of the non-gaseous hydrogen sulfur donor NaHS. We first checked that H2S accumulated in the cytoplasm of keratinocytes under our experimental conditions andused a combination of proteomics, genomics and biochemical approaches to unravel functionally relevant H2S targets in human keratinocytes. We found that the identified targets fall into two main categories: (i) the oxidative stress response molecules superoxide dismutase 2 (SOD2), NAD(P)H quinone dehydrogenase 1 (NQO1) and culin 3 (CUL3) and (ii) the chemokines interleukin-8 (IL-8) and CXCL2. Interestingly, NaHS also stimulated the caspase-1 inflammasome pathway, leading to increased secretion of the pro-inflammatory molecule interleukin-18 (IL-18). Interestingly, the secretion of interleukin-1 beta (IL-1\u03b2) was only modestly impacted by NaHS exposure despite a significant accumulation of IL-1\u03b2 pro-form. Finally, we observed that NaHS significantly hampered the growth of human keratinocyte progenitors and stem cells cultured under clonogenic conditions or as epidermal cell sheets. We conclude that H2S exerts specific molecular effects on normal human keratinocytes.<\/jats:p>","DOI":"10.3390\/ijms21134648","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T09:36:04Z","timestamp":1593509764000},"page":"4648","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Molecular Mapping of Hydrogen Sulfide Targets in Normal Human Keratinocytes"],"prefix":"10.3390","volume":"21","author":[{"given":"Olivia","family":"Gross-Amat","sequence":"first","affiliation":[{"name":"Lyon-Est School of Medicine, University Claude Bernard Lyon-1, 69100 Villeurbanne, France"},{"name":"Bank of Tissues and Cells, Lyon University Hospital (Hospices Civils de Lyon), 69003 Lyon, France"},{"name":"CarMeN Laboratory, INSERM U1060, INRA U1397, INSA de Lyon, 69600 Oullins, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine","family":"Guillen","sequence":"additional","affiliation":[{"name":"Lyon-Est School of Medicine, University Claude Bernard Lyon-1, 69100 Villeurbanne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pascal","family":"Gimeno","sequence":"additional","affiliation":[{"name":"Inserm, CHRU Lille, U-1192-Laboratoire Prot\u00e9omique, R\u00e9ponse Inflammatoire et Spectrom\u00e9trie de Masse-PRISM, University of Lille, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Salzet","sequence":"additional","affiliation":[{"name":"Inserm, CHRU Lille, U-1192-Laboratoire Prot\u00e9omique, R\u00e9ponse Inflammatoire et Spectrom\u00e9trie de Masse-PRISM, University of Lille, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Lebonvallet","sequence":"additional","affiliation":[{"name":"Laboratory of Epithelial-Neural Interactions, University of Brest, LIEN, 29200 Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Misery","sequence":"additional","affiliation":[{"name":"Laboratory of Epithelial-Neural Interactions, University of Brest, LIEN, 29200 Brest, France"},{"name":"Department of dermatology, Brest University Hospital (CHU de Brest), 29200 Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Auxenfans","sequence":"additional","affiliation":[{"name":"Bank of Tissues and Cells, Lyon University Hospital (Hospices Civils de Lyon), 69003 Lyon, France"},{"name":"Tissue Biology and Therapeutic Engineering Laboratory, UMR 5305, 69007 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Nataf","sequence":"additional","affiliation":[{"name":"Lyon-Est School of Medicine, University Claude Bernard Lyon-1, 69100 Villeurbanne, France"},{"name":"Bank of Tissues and Cells, Lyon University Hospital (Hospices Civils de Lyon), 69003 Lyon, France"},{"name":"CarMeN Laboratory, INSERM U1060, INRA U1397, INSA de Lyon, 69600 Oullins, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/8034084","article-title":"Sulphurous Mineral Waters: New Applications for Health","volume":"2017","author":"Carbajo","year":"2017","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"566","DOI":"10.3889\/oamjms.2017.126","article-title":"History of the Baths and Thermal Medicine","volume":"5","author":"Gianfaldoni","year":"2017","journal-title":"Open Access Maced. J. Med. Sci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.clindermatol.2018.03.010","article-title":"The use of balneotherapy in dermatology","volume":"36","author":"Huang","year":"2018","journal-title":"Clin. Dermatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1046\/j.1529-8019.2003.01622.x","article-title":"Balneotherapy in dermatology","volume":"16","author":"Matz","year":"2003","journal-title":"Dermatol. Ther."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Davinelli, S., Bassetto, F., Vitale, M., and Scapagnini, G. (2019). Chapter 10\u2014Thermal Waters and the Hormetic Effects of Hydrogen Sulfide on Inflammatory Arthritis and Wound Healing. The Science of Hormesis in Health and Longevity, Academic Press.","DOI":"10.1016\/B978-0-12-814253-0.00010-3"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.bbrc.2016.01.047","article-title":"Exogenous hydrogen sulfide promotes cell proliferation and differentiation by modulating autophagy in human keratinocytes","volume":"472","author":"Xie","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1038\/labinvest.2011.76","article-title":"Hydrogen sulfide inhibits IL-8 expression in human keratinocytes via MAP kinase signaling","volume":"91","author":"Mirandola","year":"2011","journal-title":"Lab. Investig."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1038\/labinvest.2009.61","article-title":"Hydrogen sulfide impairs keratinocyte cell growth and adhesion inhibiting mitogen-activated protein kinase signaling","volume":"89","author":"Gobbi","year":"2009","journal-title":"Lab. Investig."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Yang, C., Yang, Z., Zhang, M., Dong, Q., Wang, X., Lan, A., Zeng, F., Chen, P., Wang, C., and Feng, J. (2011). Hydrogen sulfide protects against chemical hypoxia-induced cytotoxicity and inflammation in HaCaT cells through inhibition of ROS\/NF-\u03baB\/COX-2 pathway. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0021971"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.phrs.2012.07.002","article-title":"Hydrogen sulfide modulates the release of nitric oxide and VEGF in human keratinocytes","volume":"66","author":"Merighi","year":"2012","journal-title":"Pharmacol. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3902","DOI":"10.1073\/pnas.95.7.3902","article-title":"Identification and isolation of candidate human keratinocyte stem cells based on cell surface phenotype","volume":"95","author":"Li","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1089\/scd.2016.0319","article-title":"The Role of Integrin \u03b16 (CD49f) in Stem Cells: More than a Conserved Biomarker","volume":"26","author":"Krebsbach","year":"2017","journal-title":"Stem Cells Dev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"D948","DOI":"10.1093\/nar\/gky868","article-title":"The Comparative Toxicogenomics Database: Update 2019","volume":"47","author":"Davis","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"W90","DOI":"10.1093\/nar\/gkw377","article-title":"Enrichr: A comprehensive gene set enrichment analysis web server 2016 update","volume":"44","author":"Kuleshov","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.cotox.2017.10.005","article-title":"NQO1 in protection against oxidative stress","volume":"7","author":"Ross","year":"2018","journal-title":"Curr. Opin. Toxicol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1128\/MCB.24.16.7130-7139.2004","article-title":"Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase to Regulate Proteasomal Degradation of Nrf2","volume":"24","author":"Kobayashi","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.4049\/jimmunol.1700129","article-title":"CXCL1 and CXCL2 Regulate NLRP3 Inflammasome Activation via G-Protein\u2013Coupled Receptor CXCR2","volume":"199","author":"Boro","year":"2017","journal-title":"J. Immunol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"4930","DOI":"10.1182\/blood-2013-02-486217","article-title":"Mast cell and macrophage chemokines CXCL1\/CXCL2 control the early stage of neutrophil recruitment during tissue inflammation","volume":"121","author":"Dudeck","year":"2013","journal-title":"Blood"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cellsig.2018.11.004","article-title":"How do chemokines navigate neutrophils to the target site: Dissecting the structural mechanisms and signaling pathways","volume":"54","author":"Rajarathnam","year":"2019","journal-title":"Cell. Signal."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1210\/en.2012-1415","article-title":"Roles of chemokine ligand-2 (CXCL2) and neutrophils in influencing endothelial cell function and inflammation of human adipose tissue","volume":"154","author":"Rouault","year":"2013","journal-title":"Endocrinology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nm.3893","article-title":"Inflammasomes: Mechanism of action, role in disease, and therapeutics","volume":"21","author":"Guo","year":"2015","journal-title":"Nat. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1038\/jid.2015.119","article-title":"Regulation and function of the caspase-1 in an inflammatory microenvironment","volume":"135","author":"Lee","year":"2015","journal-title":"J. Investig. Dermatol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"75","DOI":"10.4110\/in.2010.10.2.75","article-title":"The Production IL-21 and VEGF in UVB-irradiated Human Keratinocyte Cell Line, HaCaT","volume":"10","author":"Kim","year":"2010","journal-title":"Immune Netw."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/s004030050172","article-title":"Expression of vascular endothelial growth factor in normal epidermis, epithelial tumors and cultured keratinocytes","volume":"289","author":"Viac","year":"1997","journal-title":"Arch. Dermatol. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1006\/jsre.2000.5892","article-title":"Bioactive Interleukin-8 Is Expressed in Wounds and Enhances Wound Healing","volume":"93","author":"Rennekampff","year":"2000","journal-title":"J. Surg. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/1523-1747.ep12514689","article-title":"Localization of neutrophil-activating peptide-1\/interleukin-8-immunoreactivity in normal and psoriatic skin","volume":"96","author":"Sticherling","year":"1991","journal-title":"J. Investig. Dermatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"39511","DOI":"10.1074\/jbc.M110.159681","article-title":"Tumor Necrosis Factor \u03b1-induced Inflammation Is Increased but Apoptosis Is Inhibited by Common Food Additive Carrageenan","volume":"285","author":"Bhattacharyya","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"464","DOI":"10.3389\/fphar.2017.00464","article-title":"Attenuation of TNF-\u03b1-Induced Inflammatory Injury in Endothelial Cells by Ginsenoside Rb1 via Inhibiting NF-\u03baB, JNK and p38 Signaling Pathways","volume":"8","author":"Zhou","year":"2017","journal-title":"Front. Pharmacol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1177\/1721727X1301100303","article-title":"Skin, Inflammation and Sulfurous Waters: What is Known, What is Believed, Skin, Inflammation and Sulfurous Waters: What is Known, What is Believed","volume":"11","author":"Carubbi","year":"2013","journal-title":"Eur. J. Inflamm."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1159\/000492504","article-title":"Protective Effects of Hydrogen Sulfide Against Cigarette Smoke Exposure-Induced Placental Oxidative Damage by Alleviating Redox Imbalance via Nrf2 Pathway in Rats","volume":"48","author":"Zhao","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.scienta.2017.10.044","article-title":"Nitrate reductase-dependent NO production is involved in H2S-induced nitrate stress tolerance in tomato via activation of antioxidant enzymes","volume":"229","author":"Liang","year":"2018","journal-title":"Sci. Hortic."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Wen, Y.-D., Wang, H., Kho, S., Rinkiko, S., Sheng, X., Shen, H.-M., and Zhu, Y.-Z. (2013). Hydrogen Sulfide Protects HUVECs against Hydrogen Peroxide Induced Mitochondrial Dysfunction and Oxidative Stress. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0053147"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.freeradbiomed.2016.08.032","article-title":"The antioxidant transcription factor Nrf2 contributes to the protective effect of mild thermotolerance (40 \u00b0C) against heat shock-induced apoptosis","volume":"99","author":"Glory","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"9091879","DOI":"10.1155\/2017\/9091879","article-title":"Expression of the NRF2 Target Gene NQO1 Is Enhanced in Mononuclear Cells in Human Chronic Kidney Disease","volume":"2017","author":"Shen","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"6043038","DOI":"10.1155\/2016\/6043038","article-title":"Hydrogen Sulfide and Cellular Redox Homeostasis","volume":"2016","author":"Xie","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-09648-6","article-title":"Neglected role of hydrogen sulfide in sulfur mustard poisoning: Keap1 S-sulfhydration and subsequent Nrf2 pathway activation","volume":"7","author":"Meng","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Corsello, T., Komaravelli, N., and Casola, A. (2018). Role of Hydrogen Sulfide in NRF2- and Sirtuin-Dependent Maintenance of Cellular Redox Balance. Antioxidants (Basel), 7.","DOI":"10.3390\/antiox7100129"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"21349","DOI":"10.1074\/jbc.M110.121863","article-title":"An Autoregulatory Loop between Nrf2 and Cul3-Rbx1 Controls Their Cellular Abundance","volume":"285","author":"Kaspar","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_39","first-page":"312","article-title":"Regulation of Nrf2 Signaling","volume":"8","author":"Li","year":"2019","journal-title":"React. Oxyg. Species (Apex)"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.redox.2017.11.009","article-title":"Metabolism of hydrogen sulfide (H2S) and Production of Reactive Sulfur Species (RSS) by superoxide dismutase","volume":"15","author":"Olson","year":"2017","journal-title":"Redox Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2019.02.011","article-title":"Effects of inhibiting antioxidant pathways on cellular hydrogen sulfide and polysulfide metabolism","volume":"135","author":"Olson","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1038\/jid.2010.37","article-title":"Staphylococcus aureus stimulates neutrophil targeting chemokine expression in keratinocytes through an autocrine IL-1alpha signaling loop","volume":"130","author":"Olaru","year":"2010","journal-title":"J. Investig. Dermatol."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Ridiandries, A., Tan, J.T.M., and Bursill, C.A. (2018). The Role of Chemokines in Wound Healing. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19103217"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1189\/jlb.69.4.513","article-title":"Chemokines in cutaneous wound healing","volume":"69","author":"Gillitzer","year":"2001","journal-title":"J. Leukoc. Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1073\/pnas.84.8.2302","article-title":"Three clonal types of keratinocyte with different capacities for multiplication","volume":"84","author":"Barrandon","year":"1987","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1089\/ten.2005.11.723","article-title":"Optimization and characterization of an engineered human skin equivalent","volume":"11","author":"Black","year":"2005","journal-title":"Tissue Eng."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1152\/japplphysiol.00096.2006","article-title":"Hydrogen sulfide and its possible roles in myocardial ischemia in experimental rats","volume":"102","author":"Zhu","year":"2007","journal-title":"J. Appl. Physiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1096\/fj.04-3583fje","article-title":"Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse","volume":"19","author":"Li","year":"2005","journal-title":"FASEB J."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.18632\/aging.101322","article-title":"Selenium preserves keratinocyte stemness and delays senescence by maintaining epidermal adhesion","volume":"9","author":"Jobeili","year":"2017","journal-title":"Aging (Albany NY)"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1603048","DOI":"10.1080\/20013078.2019.1603048","article-title":"Proteomic characterisation of leech microglia extracellular vesicles (EVs): Comparison between differential ultracentrifugation and OptiprepTM density gradient isolation","volume":"8","author":"Arab","year":"2019","journal-title":"J. Extracell. Vesicles"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e02763-16","DOI":"10.1128\/AAC.02763-16","article-title":"Subinhibitory Concentrations of Ciprofloxacin Enhance Antimicrobial Resistance and Pathogenicity of Enterococcus faecium","volume":"61","author":"Sinel","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1021\/acs.analchem.9b04188","article-title":"Optimized Sample Preparation Workflow for Improved Identification of Ghost Proteins","volume":"92","author":"Cardon","year":"2020","journal-title":"Anal. Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.ccell.2017.09.006","article-title":"Microenvironment-Driven Shift of Cohesion\/Detachment Balance within Tumors Induces a Switch toward Metastasis in Neuroblastoma","volume":"32","author":"Bertin","year":"2017","journal-title":"Cancer Cell"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.mod.2015.02.001","article-title":"Involvement of orphan nuclear receptor COUP-TFII in cadherin-6 and cadherin-11 regulation: Implications in development and cancer","volume":"136","author":"Bringuier","year":"2015","journal-title":"Mech. Dev."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/21\/13\/4648\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:45:02Z","timestamp":1760175902000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/21\/13\/4648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,30]]},"references-count":54,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2020,7]]}},"alternative-id":["ijms21134648"],"URL":"https:\/\/doi.org\/10.3390\/ijms21134648","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,30]]}}}