{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:40:48Z","timestamp":1785307248214,"version":"3.55.0"},"reference-count":119,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T00:00:00Z","timestamp":1593648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007637","name":"Departamento Administrativo de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n (COLCIENCIAS)","doi-asserted-by":"publisher","award":["RC # 0309-2013"],"award-info":[{"award-number":["RC # 0309-2013"]}],"id":[{"id":"10.13039\/100007637","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Protein-protein interactions (IPP) play an essential role in practically all biological processes, including those related to microorganism invasion of their host cells. It has been found that a broad repertoire of receptor-ligand interactions takes place in the binding interphase with host cells in malaria, these being vital interactions for successful parasite invasion. Several trials have been conducted for elucidating the molecular interface of interactions between some Plasmodium falciparum and Plasmodium vivax antigens with receptors on erythrocytes and\/or reticulocytes. Structural information concerning these complexes is available; however, deeper analysis is required for correlating structural, functional (binding, invasion, and inhibition), and polymorphism data for elucidating new interaction hotspots to which malaria control methods can be directed. This review describes and discusses recent structural and functional details regarding three relevant interactions during erythrocyte invasion: Duffy-binding protein 1 (DBP1)\u2013Duffy antigen receptor for chemokines (DARC); reticulocyte-binding protein homolog 5 (PfRh5)-basigin, and erythrocyte binding antigen 175 (EBA175)-glycophorin A (GPA).<\/jats:p>","DOI":"10.3390\/ijms21134729","type":"journal-article","created":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T06:51:20Z","timestamp":1593759080000},"page":"4729","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Hotspots in Plasmodium and RBC Receptor-Ligand Interactions: Key Pieces for Inhibiting Malarial Parasite Invasion"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4751-2500","authenticated-orcid":false,"given":"Manuel Alfonso","family":"Patarroyo","sequence":"first","affiliation":[{"name":"Molecular Biology and Immunology Department, Fundaci\u00f3n Instituto de Inmunolog\u00eda de Colombia (FIDIC), Carrera 50#26-20, Bogot\u00e1 111321, Colombia"},{"name":"School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24#63C-69, Bogot\u00e1 112111, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6865-3153","authenticated-orcid":false,"given":"Jessica","family":"Molina-Franky","sequence":"additional","affiliation":[{"name":"Molecular Biology and Immunology Department, Fundaci\u00f3n Instituto de Inmunolog\u00eda de Colombia (FIDIC), Carrera 50#26-20, Bogot\u00e1 111321, Colombia"},{"name":"Ph.D. Programme in Biomedical and Biological Sciences, Universidad del Rosario, Carrera 24#63C-69, Bogot\u00e1 112111, Colombia"},{"name":"Medicine Programme, Health Sciences Faculty, Universidad de Boyac\u00e1, Carrera 2\u00aa Este#64-169, Tunja 150003, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Ph.D. Programme in Biomedical and Biological Sciences, Universidad del Rosario, Carrera 24#63C-69, Bogot\u00e1 112111, Colombia"},{"name":"Biology and Microbiology Department, Sciences and Engineering Faculty, Universidad de Boyac\u00e1, Carrera 2\u00aa Este#64-169, Tunja 150003, Colombia"},{"name":"Receptor-Ligand Department, Fundaci\u00f3n Instituto de Inmunolog\u00eda de Colombia (FIDIC), Carrera 50#26-20, Bogot\u00e1 111321, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5331-5693","authenticated-orcid":false,"given":"Gabriela","family":"Ar\u00e9valo-Pinz\u00f3n","sequence":"additional","affiliation":[{"name":"School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24#63C-69, Bogot\u00e1 112111, Colombia"},{"name":"Receptor-Ligand Department, Fundaci\u00f3n Instituto de Inmunolog\u00eda de Colombia (FIDIC), Carrera 50#26-20, Bogot\u00e1 111321, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel Elkin","family":"Patarroyo","sequence":"additional","affiliation":[{"name":"Molecular Biology and Immunology Department, Fundaci\u00f3n Instituto de Inmunolog\u00eda de Colombia (FIDIC), Carrera 50#26-20, Bogot\u00e1 111321, Colombia"},{"name":"Universidad Nacional de Colombia, Carrera 45 # 26-85, Bogot\u00e1 111321, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,7,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"17050","DOI":"10.1038\/nrdp.2017.50","article-title":"Malaria","volume":"3","author":"Phillips","year":"2017","journal-title":"Nat. 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