{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T22:21:34Z","timestamp":1773181294868,"version":"3.50.1"},"reference-count":171,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T00:00:00Z","timestamp":1593993600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Systemic sclerosis is a rare chronic heterogenous disease that involves inflammation and vasculopathy, and converges in end-stage development of multisystem tissue fibrosis. The loss of tight spatial distribution and temporal expression of proteins in the extracellular matrix (ECM) leads to progressive organ stiffening, which is a hallmark of fibrotic disease. A group of nonstructural matrix proteins, known as matricellular proteins (MCPs) are implicated in dysregulated processes that drive fibrosis such as ECM remodeling and various cellular behaviors. Accordingly, MCPs have been described in the context of fibrosis in sclerosis (SSc) as predictive disease biomarkers and regulators of ECM synthesis, with promising therapeutic potential. In this present review, an informative summary of major MCPs is presented highlighting their clear correlations to SSc- fibrosis.<\/jats:p>","DOI":"10.3390\/ijms21134776","type":"journal-article","created":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T09:49:11Z","timestamp":1594028951000},"page":"4776","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Emerging Roles of Matricellular Proteins in Systemic Sclerosis"],"prefix":"10.3390","volume":"21","author":[{"given":"Daniel","family":"Feng","sequence":"first","affiliation":[{"name":"D\u00e9partement de Pharmacologie et Physiologie, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC H3T 1J4, Canada"},{"name":"Centre de recherche de l\u2019H\u00f4pital Maisonneuve-Rosemont, Facult\u00e9 de M\u00e9decine, Centre affili\u00e9 \u00e0 l\u2019Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC H1T 2M4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Casimiro","family":"Gerarduzzi","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Pharmacologie et Physiologie, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC H3T 1J4, Canada"},{"name":"Centre de recherche de l\u2019H\u00f4pital Maisonneuve-Rosemont, Facult\u00e9 de M\u00e9decine, Centre affili\u00e9 \u00e0 l\u2019Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC H1T 2M4, Canada"},{"name":"D\u00e9partement de M\u00e9decine, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC H3T 1J4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,7,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"272","DOI":"10.3389\/fimmu.2015.00272","article-title":"Pathogenesis of Systemic Sclerosis","volume":"6","author":"Pattanaik","year":"2015","journal-title":"Front. 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