{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T22:56:11Z","timestamp":1783551371634,"version":"3.55.0"},"reference-count":33,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T00:00:00Z","timestamp":1594339200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["31003A_173171"],"award-info":[{"award-number":["31003A_173171"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>This Special Issue, \u201cEmbryo-Maternal Interactions Underlying Reproduction in Mammals\u201d, gathers a collection of 23 articles, 16 original research articles and 7 up-to-date reviews, providing new findings or summarizing current knowledge on embryo\u2013maternal interactions in seven different mammalian species including humans. Considering the different players involved in these embryo-maternal interactions, articles are mainly focused on one of these different players: the oviduct, the uterus, the embryo or the emergent extracellular vesicles. Additionally, a few articles bring up the impact of reproductive, but also non-reproductive, diseases, as well as stress factors, on the establishment of pregnancy. We hope the readers enjoy this collection of articles and that the knowledge assembled here will support and inspire current and future research investigations. We would like to thank all authors for their contributions to this Special Issue.<\/jats:p>","DOI":"10.3390\/ijms21144872","type":"journal-article","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T09:25:28Z","timestamp":1594373128000},"page":"4872","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Embryo\u2013Maternal Interactions Underlying Reproduction in Mammals"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2450-1216","authenticated-orcid":false,"given":"Stefan","family":"Bauersachs","sequence":"first","affiliation":[{"name":"Functional Genomics, Institute of Veterinary Anatomy, Vetsuisse Faculty, University of Zurich, 8315 Lindau (ZH), Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Almi\u00f1ana","sequence":"additional","affiliation":[{"name":"Functional Genomics, Institute of Veterinary Anatomy, Vetsuisse Faculty, University of Zurich, 8315 Lindau (ZH), Switzerland"},{"name":"UMR85 PRC, INRAE, CNRS 7247, Universit\u00e9 de Tours, IFCE, 37380 Nouzilly, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,7,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1146\/annurev-animal-022114-110639","article-title":"Uterine responses to the preattachment embryo in domestic ungulates: Recognition of pregnancy and preparation for implantation","volume":"3","author":"Bauersachs","year":"2015","journal-title":"Ann. Rev. Anim. Biosci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/978-3-319-62414-3_4","article-title":"The Consequences of Maternal-Embryonic Cross Talk During the Periconception Period on Subsequent Embryonic Development","volume":"1014","author":"Rizos","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/rda.13297","article-title":"Embryonic maternal interaction in cattle and its relationship with fertility","volume":"53","author":"Sanchez","year":"2018","journal-title":"Reprod. Domest. Anim."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-3-319-15856-3_7","article-title":"Implantation and Establishment of Pregnancy in Ruminants","volume":"216","author":"Spencer","year":"2015","journal-title":"Adv. Anat. Embryol. Cell Biol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Ochoa-Bernal, M.A., and Fazleabas, A.T. (2020). Physiologic Events of Embryo Implantation and Decidualization in Human and Non-Human Primates. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21061973"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Fujiwara, H., Ono, M., Sato, Y., Imakawa, K., Iizuka, T., Kagami, K., Fujiwara, T., Horie, A., Tani, H., and Hattori, A. (2020). Promoting Roles of Embryonic Signals in Embryo Implantation and Placentation in Cooperation with Endocrine and Immune Systems. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21051885"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Bridi, A., Perecin, F., and Silveira, J.C.d. (2020). Extracellular Vesicles Mediated Early Embryo\u2013Maternal Interactions. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21031163"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Alminana, C., and Bauersachs, S. (2020). Extracellular vesicles: Multi-signal messengers in the gametes\/embryo-oviduct cross-talk. Theriogenology.","DOI":"10.1016\/j.theriogenology.2020.01.077"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Alminana, C., and Bauersachs, S. (2019). Extracellular Vesicles in the Oviduct: Progress, Challenges and Implications for the Reproductive Success. Bioengineering (Basel), 6.","DOI":"10.3390\/bioengineering6020032"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Saint-Dizier, M., Schoen, J., Chen, S., Banliat, C., and Mermillod, P. (2020). Composing the Early Embryonic Microenvironment: Physiology and Regulation of Oviductal Secretions. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21010223"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Banliat, C., Tsikis, G., Labas, V., Teixeira-Gomes, A.-P., Com, E., Lavigne, R., Pineau, C., Guyonnet, B., Mermillod, P., and Saint-Dizier, M. (2020). Identification of 56 Proteins Involved in Embryo\u2013Maternal Interactions in the Bovine Oviduct. Int. J. Mol. 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Asynchronous Embryo Transfer Followed by Comparative Transcriptomic Analysis of Conceptus Membranes and Endometrium Identifies Processes Important to the Establishment of Equine Pregnancy. Int. J. Mol. Sci., 21.","DOI":"10.20944\/preprints202003.0124.v1"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Salilew-Wondim, D., Gebremedhn, S., Hoelker, M., Tholen, E., Hailay, T., and Tesfaye, D. (2020). The Role of MicroRNAs in Mammalian Fertility: From Gametogenesis to Embryo Implantation. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21020585"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Kaczmarek, M.M., Najmula, J., Guzewska, M.M., and Przygrodzka, E. (2020). MiRNAs in the Peri-Implantation Period: Contribution to Embryo\u2013Maternal Communication in Pigs. Int. J. Mol. 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