{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:01:25Z","timestamp":1760238085188,"version":"build-2065373602"},"reference-count":58,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T00:00:00Z","timestamp":1594339200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"DGICYT","award":["BFU2015-70616-R"],"award-info":[{"award-number":["BFU2015-70616-R"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The sleep apnea-hypopnea syndrome (SAHS) involves periods of intermittent hypoxia, experimentally reproduced by exposing animal models to oscillatory PO2 patterns. In both situations, chronic intermittent hypoxia (CIH) exposure produces carotid body (CB) hyperactivation generating an increased input to the brainstem which originates sympathetic hyperactivity, followed by hypertension that is abolished by CB denervation. CB has dopamine (DA) receptors in chemoreceptor cells acting as DA-2 autoreceptors. The aim was to check if blocking DA-2 receptors could decrease the CB hypersensitivity produced by CIH, minimizing CIH-related effects. Domperidone (DOM), a selective peripheral DA-2 receptor antagonist that does not cross the blood-brain barrier, was used to examine its effect on CIH (30 days) exposed rats. Arterial pressure, CB secretory activity and whole-body plethysmography were measured. DOM, acute or chronically administered during the last 15 days of CIH, reversed the hypertension produced by CIH, an analogous effect to that obtained with CB denervation. DOM marginally decreased blood pressure in control animals and did not affect hypoxic ventilatory response in control or CIH animals. No adverse effects were observed. DOM, used as gastrokinetic and antiemetic drug, could be a therapeutic opportunity for hypertension in SAHS patients\u2019 resistant to standard treatments.<\/jats:p>","DOI":"10.3390\/ijms21144893","type":"journal-article","created":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T09:30:49Z","timestamp":1594719049000},"page":"4893","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Peripheral Dopamine 2-Receptor Antagonist Reverses Hypertension in a Chronic Intermittent Hypoxia Rat Model"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5128-0036","authenticated-orcid":false,"given":"Elena","family":"Olea","sequence":"first","affiliation":[{"name":"Departamento de Enfermer\u00eda, Universidad de Valladolid, 47005 Valladolid, Spain"},{"name":"Instituto de Biolog\u00eda y Gen\u00e9tica Molecular, Consejo Superior de Investigaciones Cient\u00edficas-Universidad de Valladolid, 47005 Valladolid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inmaculada","family":"Docio","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Biolog\u00eda Molecular y Fisiolog\u00eda, Universidad de Valladolid, 47005 Valladolid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Quintero","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Biolog\u00eda Molecular y Fisiolog\u00eda, Universidad de Valladolid, 47005 Valladolid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9043-0474","authenticated-orcid":false,"given":"Asunci\u00f3n","family":"Rocher","sequence":"additional","affiliation":[{"name":"Instituto de Biolog\u00eda y Gen\u00e9tica Molecular, Consejo Superior de Investigaciones Cient\u00edficas-Universidad de Valladolid, 47005 Valladolid, Spain"},{"name":"Departamento de Bioqu\u00edmica, Biolog\u00eda Molecular y Fisiolog\u00eda, Universidad de Valladolid, 47005 Valladolid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3197-1697","authenticated-orcid":false,"given":"Ana","family":"Obeso","sequence":"additional","affiliation":[{"name":"Instituto de Biolog\u00eda y Gen\u00e9tica Molecular, Consejo Superior de Investigaciones Cient\u00edficas-Universidad de Valladolid, 47005 Valladolid, Spain"},{"name":"Departamento de Bioqu\u00edmica, Biolog\u00eda Molecular y Fisiolog\u00eda, Universidad de Valladolid, 47005 Valladolid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Rigual","sequence":"additional","affiliation":[{"name":"Instituto de Biolog\u00eda y Gen\u00e9tica Molecular, Consejo Superior de Investigaciones Cient\u00edficas-Universidad de Valladolid, 47005 Valladolid, Spain"},{"name":"Departamento de Bioqu\u00edmica, Biolog\u00eda Molecular y Fisiolog\u00eda, Universidad de Valladolid, 47005 Valladolid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5240-2410","authenticated-orcid":false,"given":"Angela","family":"Gomez-Ni\u00f1o","sequence":"additional","affiliation":[{"name":"Instituto de Biolog\u00eda y Gen\u00e9tica Molecular, Consejo Superior de Investigaciones Cient\u00edficas-Universidad de Valladolid, 47005 Valladolid, Spain"},{"name":"Departamento de Biolog\u00eda Celular, Histolog\u00eda y Farmacolog\u00eda, Universidad de Valladolid, 47005 Valladolid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,7,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1161\/HYPERTENSIONAHA.113.00613","article-title":"Obstructive sleep apnea and hypertension: an update","volume":"63","author":"Konecny","year":"2014","journal-title":"Hypertension"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1161\/01.HYP.19.6.555","article-title":"Repetitive, episodic hypoxia causes diurnal elevation of blood pressure in rats","volume":"19","author":"Fletcher","year":"1992","journal-title":"Hypertension"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1152\/japplphysiol.00301.2007","article-title":"Left ventricular dysfunction and associated cellular injury in rats exposed to chronic intermittent hypoxia","volume":"104","author":"Chen","year":"2008","journal-title":"J. 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