{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:01:53Z","timestamp":1760238113072,"version":"build-2065373602"},"reference-count":49,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2020,7,12]],"date-time":"2020-07-12T00:00:00Z","timestamp":1594512000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Studies conducted on Zebrafish embryos in our laboratory have allowed for the identification of precise moments of organogenesis in which a lot of genes are switched on and off, a sign that the genome is undergoing substantial changes in gene expression. Stem cell growth and differentiation stage-factors present in different moments of organogenesis have proven to have different specific functions in gene regulation. The substances present in the first stages of cell differentiation in Zebrafish embryos have demonstrated an ability to counteract the senescence of stem cells, reducing the expression of the beta-galactosidase marker, enhancing the genes Oct-4, Sox-2, c-Myc, TERT, and the transcription of Bmi-1, which act as key telomerase-independent repressors of cell aging. The molecules present in the intermediate to late stages of cell differentiation have proven to be able to reprogram pathological human cells, such as cancer cells and those of the basal layer of the epidermis in psoriasis, which present a higher multiplication rate than normal cells. The factors present in all the stages of cell differentiation are able to counteract neurodegeneration, and to regenerate tissues: It has been possible to regenerate hair follicles in many patients with androgenetic alopecia through transdermal administration of stem cell differentiation stage factors (SCDSFs) by means of cryopass-laser.<\/jats:p>","DOI":"10.3390\/ijms21144914","type":"journal-article","created":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T09:30:49Z","timestamp":1594719049000},"page":"4914","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Use of Stem Cell Differentiation Stage Factors (SCDSFs) Taken from Zebrafish Embryos during Organogenesis and Their Role in Regulating the Gene Expression of Normal and Pathological (Stem) Cells"],"prefix":"10.3390","volume":"21","author":[{"given":"Pier Mario","family":"Biava","sequence":"first","affiliation":[{"name":"Scientific Institute of Research and Care Multimedica, Via Milanese 300, 20099 Sesto S. Giovanni (Milano), Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,7,12]]},"reference":[{"key":"ref_1","first-page":"219","article-title":"Are there factors preventing cancer development during embryonic life?","volume":"4","author":"Einhorn","year":"1983","journal-title":"Oncodev. Biol. Med."},{"key":"ref_2","unstructured":"Sherbet, G.V. (1974). Embryonic and Tumor Cell Interactions, Karger Basel."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/tera.1420210304","article-title":"Radiation Teratogenesis","volume":"21","author":"Brent","year":"1980","journal-title":"Teratology"},{"key":"ref_4","first-page":"117","article-title":"The cancer cell and its control by the embryo. Rous-Whipple Award lecture","volume":"113","author":"Pierce","year":"1983","journal-title":"Am. J. 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