{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T22:46:30Z","timestamp":1776465990358,"version":"3.51.2"},"reference-count":47,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T00:00:00Z","timestamp":1594771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31760311"],"award-info":[{"award-number":["31760311"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21764005"],"award-info":[{"award-number":["21764005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21565029"],"award-info":[{"award-number":["21565029"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Projects of Yunnan Natural Science Foundation","award":["2018FA005"],"award-info":[{"award-number":["2018FA005"]}]},{"name":"Key Research and Development Projects of Yunnan","award":["2018BC005"],"award-info":[{"award-number":["2018BC005"]}]},{"name":"Program for Excellent Young Talents and Donglu Scholars of Yunnan University","award":["-"],"award-info":[{"award-number":["-"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>We reported for the first time that cationic pillar[6]arene (cPA6) could tightly bind to peptide polymer (MW~20\u201350 kDa), an artificial substrate for tyrosine (Tyr) phosphorylation, and efficiently inhibit Tyr protein phosphorylation through host\u2013guest recognition. We synthesized a nanocomposite of black phosphorus nanosheets loaded with cPA6 (BPNS@cPA6) to explore the effect of cPA6 on cells. BPNS@cPA6 was able to enter HepG2 cells, induced apoptosis, and inhibited cell proliferation by reducing the level of Tyr phosphorylation. Furthermore, BPNS@cPA6 showed a stronger ability of inhibiting cell proliferation in tumor cells than in normal cells. Our results revealed the supramolecular modulation of enzymatic Tyr phosphorylation by the host\u2013guest recognition of cPA6.<\/jats:p>","DOI":"10.3390\/ijms21144979","type":"journal-article","created":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T10:35:18Z","timestamp":1594809318000},"page":"4979","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cationic Pillar[6]arene Induces Cell Apoptosis by Inhibiting Protein Tyrosine Phosphorylation Via Host\u2013Guest Recognition"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1770-7796","authenticated-orcid":false,"given":"Can-Peng","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Xun","family":"Lu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Conservation and Utilization of Bio-resource, School of Life Science, Yunnan University, Kunming 650091, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Ting","family":"Zi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pu-er Tea Science, Ministry of Education in Yunnan, College of State Science, Yunnan Agricultural University, Kunming 650201, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Ting","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Conservation and Utilization of Bio-resource, School of Life Science, Yunnan University, Kunming 650091, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-Ping","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Conservation and Utilization of Bio-resource, School of Life Science, Yunnan University, Kunming 650091, China"},{"name":"Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,7,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1021\/cr9900026","article-title":"Peptide and protein recognition by designed molecules","volume":"100","author":"Peczuh","year":"2000","journal-title":"Chem. 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