{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T18:18:14Z","timestamp":1783275494331,"version":"3.54.6"},"reference-count":65,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2020,7,18]],"date-time":"2020-07-18T00:00:00Z","timestamp":1595030400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Uncontrolled type-1 diabetes (T1DM) can lead to dyslipidaemia and albuminuria, which may promote cardiovascular injuries. However, some lipidemic factors could be useful in predicting cardiac dysfunction. Seventy-eight adolescents under insulin treatment due to a 6-year history of T1DM and were retrospectively examined. Glycemia, lipidemia, and albuminuria were measured in addition to development of cardiovascular abnormalities Both girls and boys showed higher HbA1c and fasting blood glucose and 27.1% females and 33.3% males exhibited microalbuminuria though their plasma levels of total cholesterol (TC), triglycerides (TG), and low-density lipoproteins (LDL) and high-density lipoproteins (HDL lipoproteins were in the normal range. They exhibited a preserved systolic function, but 50% of females and 66.6% of males had developed diastolic failures. Interestingly, girls with diastolic dysfunction showed significantly lower concentrations of HDL and higher TC\/HDL and TG\/HDL ratios. In fact, low HDL levels (OR 0.93; 95% CI 0.88\u20130.99; p = 0.029) and high TC\/HDL (OR 2.55; 95% CI 1.9\u20135.45; p = 0.016) and TG\/HDL (OR 2.74; 95% CI 1.12\u20136.71; p = 0.028) ratios associated with the development of diastolic complications. The cut-off values for HDL, TC\/HDL, and TG\/HDL were 49 mg\/dL, 3.0 and 1.85, respectively. HDL and TC\/HDL and TG\/HDL ratios may be useful for predicting diastolic dysfunction in girls with uncontrolled T1DM.<\/jats:p>","DOI":"10.3390\/ijms21145079","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T06:08:17Z","timestamp":1595225297000},"page":"5079","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Lipid Biomarkers as Predictors of Diastolic Dysfunction in Diabetes with Poor Glycemic Control"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2112-8930","authenticated-orcid":false,"given":"Dina","family":"Khedr","sequence":"first","affiliation":[{"name":"Pediatric Diabetes, Endocrine and Metabolism Unit, Children Hospital, Cairo University, Cairo 12664, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Hafez","sequence":"additional","affiliation":[{"name":"Pediatric Diabetes, Endocrine and Metabolism Unit, Children Hospital, Cairo University, Cairo 12664, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3458-0328","authenticated-orcid":false,"given":"Jairo","family":"Lumpuy-Castillo","sequence":"additional","affiliation":[{"name":"Laboratory of Diabetes Research, Instituto de Investigaciones Sanitarias-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Universidad Aut\u00f3noma, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soha","family":"Emam","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology Unit, Children\u2019s Hospital, Cairo University, Cairo 12664, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Abdel-Massih","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology Unit, Children\u2019s Hospital, Cairo University, Cairo 12664, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Elmougy","sequence":"additional","affiliation":[{"name":"Department of Clinical and Chemical Pathology, Cairo University, Cairo 12664, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasha","family":"Elkaffas","sequence":"additional","affiliation":[{"name":"Department of Clinical and Chemical Pathology, Cairo University, Cairo 12664, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0558-6541","authenticated-orcid":false,"given":"Ignacio","family":"Mahillo-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Statistics Department, Instituto de Investigaciones Sanitarias-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Universidad Aut\u00f3noma, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5515-6078","authenticated-orcid":false,"given":"Oscar","family":"Lorenzo","sequence":"additional","affiliation":[{"name":"Laboratory of Diabetes Research, Instituto de Investigaciones Sanitarias-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Universidad Aut\u00f3noma, 28040 Madrid, Spain"},{"name":"Spanish Biomedical Research Centre on Diabetes and Associated Metabolic Disorders (CIBERDEM) network, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1036-9755","authenticated-orcid":false,"given":"Noha","family":"Musa","sequence":"additional","affiliation":[{"name":"Pediatric Diabetes, Endocrine and Metabolism Unit, Children Hospital, Cairo University, Cairo 12664, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,7,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1097\/MED.0b013e32834872ce","article-title":"The epidemic of type 1 diabetes: What is it telling us?","volume":"18","author":"Forlenza","year":"2011","journal-title":"Curr. 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