{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:50:08Z","timestamp":1792842608411,"version":"4.5.0"},"reference-count":296,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T00:00:00Z","timestamp":1595980800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["RO2511\/11-1"],"award-info":[{"award-number":["RO2511\/11-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Freiburg University Medical Faculty (Forschungskommission)","award":["ROL1193\/18"],"award-info":[{"award-number":["ROL1193\/18"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Since material stiffness controls many cell functions, we reviewed the currently available knowledge on stiffness sensing and elucidated what is known in the context of clinical and experimental articular cartilage (AC) repair. Remarkably, no stiffness information on the various biomaterials for clinical AC repair was accessible. Using mRNA expression profiles and morphology as surrogate markers of stiffness-related effects, we deduced that the various clinically available biomaterials control chondrocyte (CH) phenotype well, but not to equal extents, and only in non-degenerative settings. Ample evidence demonstrates that multiple molecular aspects of CH and mesenchymal stromal cell (MSC) phenotype are susceptible to material stiffness, because proliferation, migration, lineage determination, shape, cytoskeletal properties, expression profiles, cell surface receptor composition, integrin subunit expression, and nuclear shape and composition of CHs and\/or MSCs are stiffness-regulated. Moreover, material stiffness modulates MSC immuno-modulatory and angiogenic properties, transforming growth factor beta 1 (TGF-\u03b21)-induced lineage determination, and CH re-differentiation\/de-differentiation, collagen type II fragment production, and TGF-\u03b21- and interleukin 1 beta (IL-1\u03b2)-induced changes in cell stiffness and traction force. We then integrated the available molecular signaling data into a stiffness-regulated CH phenotype model. Overall, we recommend using material stiffness for controlling cell phenotype, as this would be a promising design cornerstone for novel future-oriented, cell-instructive biomaterials for clinical high-quality AC repair tissue.<\/jats:p>","DOI":"10.3390\/ijms21155399","type":"journal-article","created":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T03:36:38Z","timestamp":1596080198000},"page":"5399","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Mechanotransduction and Stiffness-Sensing: Mechanisms and Opportunities to Control Multiple Molecular Aspects of Cell Phenotype as a Design Cornerstone of Cell-Instructive Biomaterials for Articular Cartilage Repair"],"prefix":"10.3390","volume":"21","author":[{"given":"Mischa","family":"Selig","sequence":"first","affiliation":[{"name":"G.E.R.N. Research Center for Tissue Replacement, Regeneration &amp; Neogenesis, Department of Orthopedics and Trauma Surgery, Faculty of Medicine, Medical Center\u2014Albert-Ludwigs-University of Freiburg, 79085 Freiburg im Breisgau, Germany"},{"name":"Faculty of Biology, University of Freiburg, Schaenzlestrasse 1, D-79104 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmin C.","family":"Lauer","sequence":"additional","affiliation":[{"name":"G.E.R.N. Research Center for Tissue Replacement, Regeneration &amp; Neogenesis, Department of Orthopedics and Trauma Surgery, Faculty of Medicine, Medical Center\u2014Albert-Ludwigs-University of Freiburg, 79085 Freiburg im Breisgau, Germany"},{"name":"Faculty of Biology, University of Freiburg, Schaenzlestrasse 1, D-79104 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1876-2201","authenticated-orcid":false,"given":"Melanie L.","family":"Hart","sequence":"additional","affiliation":[{"name":"G.E.R.N. Research Center for Tissue Replacement, Regeneration &amp; Neogenesis, Department of Orthopedics and Trauma Surgery, Faculty of Medicine, Medical Center\u2014Albert-Ludwigs-University of Freiburg, 79085 Freiburg im Breisgau, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3275-8196","authenticated-orcid":false,"given":"Bernd","family":"Rolauffs","sequence":"additional","affiliation":[{"name":"G.E.R.N. Research Center for Tissue Replacement, Regeneration &amp; Neogenesis, Department of Orthopedics and Trauma Surgery, Faculty of Medicine, Medical Center\u2014Albert-Ludwigs-University of Freiburg, 79085 Freiburg im Breisgau, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,7,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1039\/c2ib20080e","article-title":"Control of stem cell fate and function by engineering physical microenvironments","volume":"4","author":"Park","year":"2012","journal-title":"Integr. Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1126\/science.1116995","article-title":"Tissue cells feel and respond to the stiffness of their substrate","volume":"310","author":"Discher","year":"2005","journal-title":"Science"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/j.jbiomech.2004.09.010","article-title":"Nanomechanics of opposing glycosaminoglycan macromolecules","volume":"38","author":"Seog","year":"2005","journal-title":"J. Biomech."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/nrm1890","article-title":"Local force and geometry sensing regulate cell functions","volume":"7","author":"Vogel","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/ncb3524","article-title":"Multiscale force sensing in development","volume":"19","author":"Petridou","year":"2017","journal-title":"Nat. Cell Biol."},{"key":"ref_6","first-page":"46","article-title":"Articular cartilage matrix and structure: A minireview","volume":"27","author":"Kuettner","year":"1991","journal-title":"J. Rheumatol. Suppl."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1002\/jor.1100060615","article-title":"Injury and repair of the musculoskeletal soft tissues. Savannah, Georgia, June 18\u201320, 1987","volume":"6","author":"Woo","year":"1988","journal-title":"J. Orthop. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"192","DOI":"10.2519\/jospt.1998.28.4.192","article-title":"Articular cartilage: Injuries and potential for healing","volume":"28","author":"Buckwalter","year":"1998","journal-title":"J. Orthop. Sports Phys. Ther."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1136\/annrheumdis-2013-204308","article-title":"The spatial organisation of joint surface chondrocytes: Review of its potential roles in tissue functioning, disease and early, preclinical diagnosis of osteoarthritis","volume":"73","author":"Aicher","year":"2014","journal-title":"Ann. Rheum. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/j.joca.2016.02.001","article-title":"Loss of spatial organization and destruction of the pericellular matrix in early osteoarthritis in vivo and in a novel in vitro methodology","volume":"24","author":"Felka","year":"2016","journal-title":"Osteoarthr. Cartil."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.jsb.2008.01.010","article-title":"Distinct horizontal patterns in the spatial organization of superficial zone chondrocytes of human joints","volume":"162","author":"Rolauffs","year":"2008","journal-title":"J. Struct. Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1002\/art.30217","article-title":"Onset of preclinical osteoarthritis: The angular spatial organization permits early diagnosis","volume":"63","author":"Rolauffs","year":"2011","journal-title":"Arthritis Rheum."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/art.27217","article-title":"Proliferative remodeling of the spatial organization of human superficial chondrocytes distant from focal early osteoarthritis","volume":"62","author":"Rolauffs","year":"2010","journal-title":"Arthritis Rheum."},{"key":"ref_14","first-page":"916530","article-title":"The age-related changes in cartilage and osteoarthritis","volume":"2013","author":"Li","year":"2013","journal-title":"BioMed Res. Int."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/nnano.2008.410","article-title":"Early detection of aging cartilage and osteoarthritis in mice and patient samples using atomic force microscopy","volume":"4","author":"Stolz","year":"2009","journal-title":"Nat. Nanotechnol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.joca.2007.08.004","article-title":"Surface ultrastructure and mechanical property of human chondrocyte revealed by atomic force microscopy","volume":"16","author":"Hsieh","year":"2008","journal-title":"Osteoarthr. Cartil."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/s00402-009-0981-y","article-title":"Changes in content and synthesis of collagen types and proteoglycans in osteoarthritis of the knee joint and comparison of quantitative analysis with Photoshop-based image analysis","volume":"130","author":"Lahm","year":"2010","journal-title":"Arch. Orthop. Trauma Surg."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Gottardi, R., Hansen, U., Raiteri, R., Loparic, M., D\u00fcggelin, M., Mathys, D., Friederich, N.F., Bruckner, P., and Stolz, M. (2016). Supramolecular organization of collagen fibrils in healthy and osteoarthritic human knee and hip joint cartilage. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0163552"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1002\/art.20101","article-title":"Mechanisms and kinetics of glycosaminoglycan release following in vitro cartilage injury","volume":"50","author":"DiMicco","year":"2004","journal-title":"Arthritis Rheum."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/S0736-0266(01)00052-3","article-title":"Compressive properties and function-composition relationships of developing bovine articular cartilage","volume":"19","author":"Williamson","year":"2001","journal-title":"J. Orthop. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/S0736-0266(03)00030-5","article-title":"Tensile mechanical properties of bovine articular cartilage: Variations with growth and relationships to collagen network components","volume":"21","author":"Williamson","year":"2003","journal-title":"J. Orthop. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1089\/107632703768247322","article-title":"Growth of immature articular cartilage in vitro: Correlated variation in tensile biomechanical and collagen network properties","volume":"9","author":"Williamson","year":"2003","journal-title":"Tissue Eng."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1002\/jor.1100170119","article-title":"Bioreactor cultivation conditions modulate the composition and mechanical properties of tissue-engineered cartilage","volume":"17","author":"Martin","year":"1999","journal-title":"J. Orthop. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/0304-4165(73)90093-7","article-title":"The tensile properties of the cartilage of human femoral condyles related to the content of collagen and glycosaminoglycans","volume":"297","author":"Kempson","year":"1973","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s10856-006-0689-2","article-title":"Biochemical markers of the mechanical quality of engineered hyaline cartilage","volume":"18","author":"Kelly","year":"2007","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.jsb.2013.06.011","article-title":"Stress-vs-time signals allow the prediction of structurally catastrophic events during fracturing of immature cartilage and predetermine the biomechanical, biochemical, and structural impairment","volume":"183","author":"Rolauffs","year":"2013","journal-title":"J. Struct. Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.1002\/art.27610","article-title":"Vulnerability of the superficial zone of immature articular cartilage to compressive injury","volume":"62","author":"Rolauffs","year":"2010","journal-title":"Arthritis Rheum."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-24258-6","article-title":"The effect of ageing and osteoarthritis on the mechanical properties of cartilage and bone in the human knee joint","volume":"8","author":"Peters","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.joca.2005.06.008","article-title":"Altered cartilage mechanics and histology in knee osteoarthritis: Relation to clinical assessment (ICRS Grade)","volume":"13","author":"Kleemann","year":"2005","journal-title":"Osteoarthr. Cartil."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.joca.2014.12.011","article-title":"An educational review of cartilage repair: Precepts & practice\u2013myths & misconceptions\u2013progress & prospects","volume":"23","author":"Hunziker","year":"2015","journal-title":"Osteoarthr. Cartil."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.knee.2016.02.001","article-title":"Autologous chondrocyte implantation (ACI) for cartilage defects of the knee: A guideline by the working group \u201cClinical Tissue Regeneration\u201d of the German Society of Orthopaedics and Trauma (DGOU)","volume":"23","author":"Niemeyer","year":"2016","journal-title":"Knee"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1177\/0363546510381575","article-title":"Arthroscopic treatment of osteochondral lesions of the ankle with matrix-associated chondrocyte implantation: Early clinical and magnetic resonance imaging results","volume":"39","author":"Aurich","year":"2011","journal-title":"Am. J. Sports Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1177\/0363546510388896","article-title":"Remodeling of articular cartilage and subchondral bone after bone grafting and matrix-associated autologous chondrocyte implantation for osteochondritis dissecans of the knee","volume":"39","author":"Ochs","year":"2011","journal-title":"Am. J. Sports Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1055\/s-2007-965167","article-title":"Treatment of osteochondritis dissecans of the knee: One-step procedure with bone grafting and matrix-supported autologous chondrocyte transplantation","volume":"145","author":"Ochs","year":"2007","journal-title":"Z. Orthop. Unfall."},{"key":"ref_35","first-page":"170","article-title":"Microfracture to treat full-thickness chondral defects: Surgical technique, rehabilitation, and outcomes","volume":"15","author":"Steadman","year":"2002","journal-title":"J. Knee Surg."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1177\/0363546517740575","article-title":"Autologous Matrix-Induced Chondrogenesis: A Systematic Review of the Clinical Evidence","volume":"47","author":"Gao","year":"2019","journal-title":"Am. J. Sports Med."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Steinwachs, M.R., Gille, J., Volz, M., Anders, S., Jakob, R., De Girolamo, L., Volpi, P., Schiavone-Panni, A., Scheffler, S., and Reiss, E. (2019). Systematic Review and Meta-Analysis of the Clinical Evidence on the Use of Autologous Matrix-Induced Chondrogenesis in the Knee. Cartilage, 1947603519870846.","DOI":"10.1177\/1947603519870846"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1039\/C4IB00019F","article-title":"Selective regulation of cytoskeletal tension and cell\u2013matrix adhesion by RhoA and Src","volume":"6","author":"Sreenivasappa","year":"2014","journal-title":"Integr. Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"ra57","DOI":"10.1126\/scisignal.2004838","article-title":"A FAK-Cas-Rac-lamellipodin signaling module transduces extracellular matrix stiffness into mechanosensitive cell cycling","volume":"7","author":"Bae","year":"2014","journal-title":"Sci. Signal."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"4261","DOI":"10.1242\/dev.158469","article-title":"Understanding the extracellular forces that determine cell fate and maintenance","volume":"144","author":"Kumar","year":"2017","journal-title":"Development"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41556-017-0012-0","article-title":"Mechanoreciprocity in cell migration","volume":"20","author":"Storm","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/j.jbiomech.2003.12.032","article-title":"Are in vivo and in situ brain tissues mechanically similar?","volume":"37","author":"Gefen","year":"2004","journal-title":"J. Biomech."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1083\/jcb.200405004","article-title":"Myotubes differentiate optimally on substrates with tissue-like stiffness: Pathological implications for soft or stiff microenvironments","volume":"166","author":"Engler","year":"2004","journal-title":"J. Cell Biol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.cell.2006.06.044","article-title":"Matrix elasticity directs stem cell lineage specification","volume":"126","author":"Engler","year":"2006","journal-title":"Cell"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1146\/annurev-biophys-042910-155306","article-title":"Forcing stem cells to behave: A biophysical perspective of the cellular microenvironment","volume":"41","author":"Sun","year":"2012","journal-title":"Annu. Rev. Biophys."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1080\/19336918.2016.1173800","article-title":"Single cell rigidity sensing: A complex relationship between focal adhesion dynamics and large-scale actin cytoskeleton remodeling","volume":"10","author":"Gupta","year":"2016","journal-title":"Cell Adh. Migr."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1083\/jcb.201510012","article-title":"Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity","volume":"213","author":"Kumar","year":"2016","journal-title":"J. Cell Biol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/0092-8674(78)90272-6","article-title":"Relationships between fibronectin (LETS protein) and actin","volume":"15","author":"Hynes","year":"1978","journal-title":"Cell"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1083\/jcb.92.2.398","article-title":"Association of fibronectin and vinculin with focal contacts and stress fibers in stationary hamster fibroblasts","volume":"92","author":"Singer","year":"1982","journal-title":"J. Cell Biol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0092-8674(86)90744-0","article-title":"Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actin","volume":"46","author":"Tamkun","year":"1986","journal-title":"Cell"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1038\/ncb0807-858","article-title":"Functional atlas of the integrin adhesome","volume":"9","author":"Itzkovitz","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/ncb2216","article-title":"Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for \u03b2-Pix in negative regulation of focal adhesion maturation","volume":"13","author":"Kuo","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1146\/annurev.cellbio.12.1.463","article-title":"Focal adhesions, contractility, and signaling","volume":"12","author":"Burridge","year":"1996","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Zaidel-Bar, R., Cohen, M., Addadi, L., and Geiger, B. (2004). Hierarchical Assembly of Cell\u2013Matrix Adhesion Complexes, Portland Press Ltd.","DOI":"10.1042\/bst0320416"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"13661","DOI":"10.1073\/pnas.94.25.13661","article-title":"Cell locomotion and focal adhesions are regulated by substrate flexibility","volume":"94","author":"Pelham","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"348","DOI":"10.2307\/1543109","article-title":"Cell locomotion and focal adhesions are regulated by the mechanical properties of the substrate","volume":"194","author":"Pelham","year":"1998","journal-title":"Biol. Bull."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/nature09621","article-title":"Nanoscale architecture of integrin-based cell adhesions","volume":"468","author":"Kanchanawong","year":"2010","journal-title":"Nature"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/ncb3180","article-title":"Molecular mechanism of vinculin activation and nanoscale spatial organization in focal adhesions","volume":"17","author":"Case","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"E231","DOI":"10.1038\/35046659","article-title":"Paxillin and focal adhesion signalling","volume":"2","author":"Turner","year":"2000","journal-title":"Nat. Cell Biol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"6459","DOI":"10.1038\/sj.onc.1204786","article-title":"Paxillin: A focal adhesion-associated adaptor protein","volume":"20","author":"Schaller","year":"2001","journal-title":"Oncogene"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"6766","DOI":"10.1073\/pnas.1820567116","article-title":"Structural and mechanistic insights into mechanoactivation of focal adhesion kinase","volume":"116","author":"Bauer","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"jcs239186","DOI":"10.1242\/jcs.239186","article-title":"FAK regulates actin polymerization during capacitation via the ERK2\/GEF- H1\/RhoA signaling pathway","volume":"133","year":"2020","journal-title":"J. Cell Sci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1038\/ncb1626","article-title":"Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2\/3 complex","volume":"9","author":"Serrels","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1038\/ncb3191","article-title":"Integration of actin dynamics and cell adhesion by a three-dimensional, mechanosensitive molecular clutch","volume":"17","author":"Case","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/nature10316","article-title":"Dynamic molecular processes mediate cellular mechanotransduction","volume":"475","author":"Hoffman","year":"2011","journal-title":"Nature"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1242\/jcs.190991","article-title":"Talin\u2014The master of integrin adhesions","volume":"130","author":"Klapholz","year":"2017","journal-title":"J. Cell Sci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"16006","DOI":"10.1074\/jbc.M600738200","article-title":"A conformational switch in vinculin drives formation and dynamics of a talin-vinculin complex at focal adhesions","volume":"281","author":"Cohen","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Golji, J., and Mofrad, M.R. (2013). The interaction of vinculin with actin. PLoS Comput. Biol., 9.","DOI":"10.1371\/journal.pcbi.1002995"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/j.bpj.2018.08.045","article-title":"Local Tension on Talin in Focal Adhesions Correlates with F-Actin Alignment at the Nanometer Scale","volume":"115","author":"Kumar","year":"2018","journal-title":"Biophys. J."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1083\/jcb.200302001","article-title":"Talin1 is critical for force-dependent reinforcement of initial integrin\u2013cytoskeleton bonds but not tyrosine kinase activation","volume":"163","author":"Giannone","year":"2003","journal-title":"J. Cell Biol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1038\/ncb1765","article-title":"Talin depletion reveals independence of initial cell spreading from integrin activation and traction","volume":"10","author":"Zhang","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1098\/rsif.2011.0567","article-title":"Contributions of talin-1 to glioma cell-matrix tensional homeostasis","volume":"9","author":"Sen","year":"2012","journal-title":"J. R. Soc. Interface"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/j.cell.2012.11.034","article-title":"Force fluctuations within focal adhesions mediate ECM-rigidity sensing to guide directed cell migration","volume":"151","author":"Plotnikov","year":"2012","journal-title":"Cell"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1242\/jcs.030320","article-title":"Mechanical forces facilitate actin polymerization at focal adhesions in a zyxin-dependent manner","volume":"121 Pt 17","author":"Hirata","year":"2008","journal-title":"J. Cell Sci."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"jcs236604","DOI":"10.1242\/jcs.236604","article-title":"Spatial integration of mechanical forces by alpha-actinin establishes actin network symmetry","volume":"132","author":"Senger","year":"2019","journal-title":"J. Cell Sci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0092-8674(92)90163-7","article-title":"The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors","volume":"70","author":"Ridley","year":"1992","journal-title":"Cell"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1083\/jcb.153.6.1175","article-title":"Focal contacts as mechanosensors: Externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanism","volume":"153","author":"Riveline","year":"2001","journal-title":"J. Cell Biol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.cell.2006.12.039","article-title":"Lamellipodial actin mechanically links myosin activity with adhesion-site formation","volume":"128","author":"Giannone","year":"2007","journal-title":"Cell"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"d126","DOI":"10.2741\/A178","article-title":"Fibronectin-integrin interactions","volume":"2","author":"Johansson","year":"1997","journal-title":"Front. Biosci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"48206","DOI":"10.1074\/jbc.M104058200","article-title":"Selective binding of collagen subtypes by integrin \u03b11I, \u03b12I, and \u03b110I domains","volume":"276","author":"Tulla","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.matbio.2005.12.001","article-title":"Ligand-binding specificities of laminin-binding integrins: A comprehensive survey of laminin\u2013integrin interactions using recombinant \u03b13\u03b21, \u03b16\u03b21, \u03b17\u03b21 and \u03b16\u03b24 integrins","volume":"25","author":"Nishiuchi","year":"2006","journal-title":"Matrix Biol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"28071","DOI":"10.1074\/jbc.274.40.28071","article-title":"The talin head domain binds to integrin \u03b2 subunit cytoplasmic tails and regulates integrin activation","volume":"274","author":"Calderwood","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_83","first-page":"E1361","article-title":"Integrin-dependent force transmission to the extracellular matrix by \u03b1-actinin triggers adhesion maturation","volume":"110","author":"Gauthier","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/nrm3624","article-title":"Talins and kindlins: Partners in integrin-mediated adhesion","volume":"14","author":"Calderwood","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1073\/pnas.262791999","article-title":"Integrin \u03b2 cytoplasmic domain interactions with phosphotyrosine-binding domains: A structural prototype for diversity in integrin signaling","volume":"100","author":"Calderwood","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1242\/jcs.041624","article-title":"Mechanisms that regulate adaptor binding to \u03b2-integrin cytoplasmic tails","volume":"122","author":"Legate","year":"2009","journal-title":"J. Cell Sci."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1038\/embor.2008.202","article-title":"Kindlins: Essential regulators of integrin signalling and cell\u2013matrix adhesion","volume":"9","author":"Larjava","year":"2008","journal-title":"EMBO Rep."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1006\/bbrc.2001.5775","article-title":"Uniaxial cyclic stretch induces focal adhesion kinase (FAK) tyrosine phosphorylation followed by mitogen-activated protein kinase (MAPK) activation","volume":"288","author":"Wang","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1359\/jbmr.2000.15.8.1501","article-title":"Integrin and mechanosensitive ion channel-dependent tyrosine phosphorylation of focal adhesion proteins and \u03b2-catenin in human articular chondrocytes after mechanical stimulation","volume":"15","author":"Lee","year":"2000","journal-title":"J. Bone Miner. Res."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"C152","DOI":"10.1152\/ajpcell.1999.277.1.C152","article-title":"Focal adhesion proteins FAK and paxillin increase in hypertrophied skeletal muscle","volume":"277","author":"Carson","year":"1999","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"4326","DOI":"10.1038\/onc.2009.299","article-title":"Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK\u2013ERK linkage","volume":"28","author":"Provenzano","year":"2009","journal-title":"Oncogene"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"18476","DOI":"10.1038\/srep18476","article-title":"Focal adhesion kinase-dependent focal adhesion recruitment of SH2 domains directs SRC into focal adhesions to regulate cell adhesion and migration","volume":"5","author":"Wu","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.addr.2010.11.001","article-title":"Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis","volume":"63","author":"Zhao","year":"2011","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/jbmr.278","article-title":"Matrix stiffness regulation of integrin-mediated mechanotransduction during osteogenic differentiation of human mesenchymal stem cells","volume":"26","author":"Shih","year":"2011","journal-title":"J. Bone Miner. Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"211","DOI":"10.4161\/chan.24328","article-title":"A TRP to cardiac fibroblast differentiation","volume":"7","author":"Thodeti","year":"2013","journal-title":"Channels"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.4161\/cc.8.8.8147","article-title":"How ERK1\/2 activation controls cell proliferation and cell death: Is subcellular localization the answer?","volume":"8","author":"Mebratu","year":"2009","journal-title":"Cell Cycle"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"4703","DOI":"10.3892\/mmr.2015.3899","article-title":"Adiponectin affects vascular smooth muscle cell proliferation and apoptosis through modulation of the mitofusin-2-mediated Ras-Raf-Erk1\/2 signaling pathway","volume":"12","author":"Zhang","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.1002\/jcp.23016","article-title":"RhoA\/ROCK, cytoskeletal dynamics, and focal adhesion kinase are required for mechanical stretch-induced tenogenic differentiation of human mesenchymal stem cells","volume":"227","author":"Xu","year":"2012","journal-title":"J. Cell. Physiol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.yexcr.2006.09.013","article-title":"Focal adhesion kinase signaling pathways regulate the osteogenic differentiation of human mesenchymal stem cells","volume":"313","author":"Salasznyk","year":"2007","journal-title":"Exp. Cell Res."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"361906","DOI":"10.1155\/2013\/361906","article-title":"Activation of the ERK1\/2 signaling pathway during the osteogenic differentiation of mesenchymal stem cells cultured on substrates modified with various chemical groups","volume":"2013","author":"Bai","year":"2013","journal-title":"BioMed Res. Int."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"3673","DOI":"10.1242\/jcs.113.20.3673","article-title":"Focal adhesion kinase suppresses Rho activity to promote focal adhesion turnover","volume":"113","author":"Ren","year":"2000","journal-title":"J. Cell Sci."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"33857","DOI":"10.1074\/jbc.M204429200","article-title":"Roles of Rho-associated kinase and myosin light chain kinase in morphological and migratory defects of focal adhesion kinase-null cells","volume":"277","author":"Chen","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1083\/jcb.200212114","article-title":"Differential regulation of cell motility and invasion by FAK","volume":"160","author":"Hsia","year":"2003","journal-title":"J. Cell Biol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1165\/rcmb.2012-0050OC","article-title":"Matrix stiffness\u2013induced myofibroblast differentiation is mediated by intrinsic mechanotransduction","volume":"47","author":"Huang","year":"2012","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/ncb2254","article-title":"The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins","volume":"13","author":"Guilluy","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nrm1128","article-title":"Rocks: Multifunctional kinases in cell behaviour","volume":"4","author":"Riento","year":"2003","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ccr.2005.08.009","article-title":"Cell tension, matrix mechanics, and cancer development","volume":"8","author":"Huang","year":"2005","journal-title":"Cancer Cell"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"3731","DOI":"10.1091\/mbc.e12-03-0172","article-title":"ECM stiffness primes the TGF\u03b2 pathway to promote chondrocyte differentiation","volume":"23","author":"Allen","year":"2012","journal-title":"Mol. Biol. Cell"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1242\/jcs.039446","article-title":"Adhesion signaling\u2013crosstalk between integrins, Src and Rho","volume":"122","author":"Huveneers","year":"2009","journal-title":"J. Cell Sci."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1111\/j.1365-2818.2008.02057.x","article-title":"Mechanisms of actin stress fibre assembly","volume":"231","author":"Naumanen","year":"2008","journal-title":"J. Microsc."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.devcel.2006.05.001","article-title":"Staying in shape with formins","volume":"10","author":"Faix","year":"2006","journal-title":"Dev. Cell"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"16913","DOI":"10.1074\/jbc.273.27.16913","article-title":"Identification of a potential effector pathway for the trimeric Go protein associated with secretory granules Go stimulates a granule-bound phosphatidylinositol 4-kinase by activating RhoA in chromaffin cells","volume":"273","author":"Gasman","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1146\/annurev.biochem.75.103004.142647","article-title":"Mechanism and function of formins in the control of actin assembly","volume":"76","author":"Goode","year":"2007","journal-title":"Annu. Rev. Biochem."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1038\/35010008","article-title":"Direct observation of dendritic actin filament networks nucleated by Arp2\/3 complex and WASP\/Scar proteins","volume":"404","author":"Blanchoin","year":"2000","journal-title":"Nature"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"6181","DOI":"10.1073\/pnas.95.11.6181","article-title":"The interaction of Arp2\/3 complex with actin: Nucleation, high affinity pointed end capping, and formation of branching networks of filaments","volume":"95","author":"Mullins","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Tilghman, R.W., Cowan, C.R., Mih, J.D., Koryakina, Y., Gioeli, D., Slack-Davis, J.K., Blackman, B.R., Tschumperlin, D.J., and Parsons, J.T. (2010). Matrix rigidity regulates cancer cell growth and cellular phenotype. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0012905"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.ccr.2005.08.010","article-title":"Tensional homeostasis and the malignant phenotype","volume":"8","author":"Paszek","year":"2005","journal-title":"Cancer Cell"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"5974","DOI":"10.1242\/jcs.108886","article-title":"Matrix stiffness reverses the effect of actomyosin tension on cell proliferation","volume":"125","author":"Mih","year":"2012","journal-title":"J. Cell Sci."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/j.cub.2009.07.069","article-title":"Cell-cycle control by physiological matrix elasticity and in vivo tissue stiffening","volume":"19","author":"Klein","year":"2009","journal-title":"Curr. Biol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"4167","DOI":"10.1158\/0008-5472.CAN-08-4859","article-title":"The mechanical rigidity of the extracellular matrix regulates the structure, motility, and proliferation of glioma cells","volume":"69","author":"Ulrich","year":"2009","journal-title":"Cancer Res."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"3921","DOI":"10.1016\/j.biomaterials.2011.02.019","article-title":"The effect of matrix stiffness on the differentiation of mesenchymal stem cells in response to TGF-\u03b2","volume":"32","author":"Park","year":"2011","journal-title":"Biomaterials"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s10735-013-9502-y","article-title":"YAP-mediated regulation of the chondrogenic phenotype in response to matrix elasticity","volume":"44","author":"Zhong","year":"2013","journal-title":"J. Mol. Histol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1083\/jcb.145.7.1461","article-title":"Integrin-mediated activation of focal adhesion kinase is required for signaling to Jun NH2-terminal kinase and progression through the G1 phase of the cell cycle","volume":"145","author":"Oktay","year":"1999","journal-title":"J. Cell Biol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.ccr.2007.03.009","article-title":"Rewired ERK-JNK signaling pathways in melanoma","volume":"11","author":"Huang","year":"2007","journal-title":"Cancer Cell"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1242\/jcs.017012","article-title":"Rac-dependent cyclin D1 gene expression regulated by cadherin-and integrin-mediated adhesion","volume":"121","author":"Fournier","year":"2008","journal-title":"J. Cell Sci."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature10137","article-title":"Role of YAP\/TAZ in mechanotransduction","volume":"474","author":"Dupont","year":"2011","journal-title":"Nature"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40169-018-0202-9","article-title":"Mechanoregulation and pathology of YAP\/TAZ via Hippo and non-Hippo mechanisms","volume":"7","author":"Dobrokhotov","year":"2018","journal-title":"Clin. Transl. Med."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"3907","DOI":"10.1242\/dev.070987","article-title":"Hippo pathway regulation by cell morphology and stress fibers","volume":"138","author":"Wada","year":"2011","journal-title":"Development"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"5002","DOI":"10.1158\/1078-0432.CCR-15-0411","article-title":"Molecular Pathways: Hippo Signaling, a Critical Tumor Suppressor","volume":"21","author":"Sebio","year":"2015","journal-title":"Clin. Cancer Res."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.cell.2017.10.008","article-title":"Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores","volume":"171","author":"Andreu","year":"2017","journal-title":"Cell"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41413-018-0018-7","article-title":"YAP promotes osteogenesis and suppresses adipogenic differentiation by regulating beta-catenin signaling","volume":"6","author":"Pan","year":"2018","journal-title":"Bone Res."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1016\/j.celrep.2016.02.021","article-title":"Yap1 Regulates Multiple Steps of Chondrocyte Differentiation during Skeletal Development and Bone Repair","volume":"14","author":"Deng","year":"2016","journal-title":"Cell Rep."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/273345a0","article-title":"Role of cell shape in growth control","volume":"273","author":"Folkman","year":"1978","journal-title":"Nature"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1126\/science.276.5317.1425","article-title":"Geometric control of cell life and death","volume":"276","author":"Chen","year":"1997","journal-title":"Science"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1091\/mbc.9.11.3179","article-title":"Control of cyclin D1, p27Kip1, and cell cycle progression in human capillary endothelial cells by cell shape and cytoskeletal tension","volume":"9","author":"Huang","year":"1998","journal-title":"Mol. Biol. Cell"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S1534-5807(04)00075-9","article-title":"Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment","volume":"6","author":"McBeath","year":"2004","journal-title":"Dev. Cell"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S0006-3495(00)76279-5","article-title":"Cell movement is guided by the rigidity of the substrate","volume":"79","author":"Lo","year":"2000","journal-title":"Biophys. J."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/j.bpj.2009.06.021","article-title":"Vascular smooth muscle cell durotaxis depends on substrate stiffness gradient strength","volume":"97","author":"Isenberg","year":"2009","journal-title":"Biophys. J."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"jcs211391","DOI":"10.1242\/jcs.211391","article-title":"Matrix elasticity regulates mesenchymal stem cell chemotaxis","volume":"131","author":"Saxena","year":"2018","journal-title":"J. Cell Sci."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/biot.201200205","article-title":"Mesenchymal stem cell durotaxis depends on substrate stiffness gradient strength","volume":"8","author":"Vincent","year":"2013","journal-title":"Biotechnol. J."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1039\/C6BM00100A","article-title":"Dynamic control of cell adhesion on a stiffness-tunable substrate for analyzing the mechanobiology of collective cell migration","volume":"4","author":"Kamimura","year":"2016","journal-title":"Biomater. Sci."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1002\/bit.23079","article-title":"Stiffness of photocrosslinked RGD-alginate gels regulates adipose progenitor cell behavior","volume":"108","author":"Chandler","year":"2011","journal-title":"Biotechnol. Bioeng."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1002\/hep.24108","article-title":"Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells","volume":"53","author":"Schrader","year":"2011","journal-title":"Hepatology"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"8608","DOI":"10.1016\/j.biomaterials.2010.07.075","article-title":"The role of stiffness of gelatin\u2013hydroxyphenylpropionic acid hydrogels formed by enzyme-mediated crosslinking on the differentiation of human mesenchymal stem cell","volume":"31","author":"Wang","year":"2010","journal-title":"Biomaterials"},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Hart, M.L., Lauer, J.C., Selig, M., Hanak, M., Walters, B., and Rolauffs, B. (2017). Shaping the Cell and the Future: Recent Advancements in Biophysical Aspects Relevant to Regenerative Medicine. J. Funct. Morphol. Kinesiol., 3.","DOI":"10.3390\/jfmk3010002"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"3508","DOI":"10.1002\/term.2263","article-title":"The geometrical shape of mesenchymal stromal cells measured by quantitative shape descriptors is determined by the stiffness of the biomaterial and by cyclic tensile forces","volume":"11","author":"Rothdiener","year":"2017","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"6640","DOI":"10.1038\/s41598-017-06794-9","article-title":"Engineering the geometrical shape of mesenchymal stromal cells through defined cyclic stretch regimens","volume":"7","author":"Walters","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.msec.2019.04.030","article-title":"Engineering microenvironments towards harnessing pro-angiogenic potential of mesenchymal stem cells","volume":"102","author":"Nasser","year":"2019","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Harvey, J.W. (2012). Chapter 8-Bone Marrow Examination. Veterinary Hematology, W.B. Saunders.","DOI":"10.1016\/B978-1-4377-0173-9.00008-7"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1007\/s00114-002-0344-9","article-title":"Stem cells for regenerative medicine: Advances in the engineering of tissues and organs","volume":"89","author":"Ringe","year":"2002","journal-title":"Naturwissenschaften"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"C1037","DOI":"10.1152\/ajpcell.67.2008","article-title":"Directing osteogenic and myogenic differentiation of MSCs: Interplay of stiffness and adhesive ligand presentation","volume":"295","author":"Rowlands","year":"2008","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1002\/ppap.200900040","article-title":"Plasma Polymer Coatings to Support Mesenchymal Stem Cell Adhesion, Growth and Differentiation on Variable Stiffness Silicone Elastomers","volume":"6","author":"Colley","year":"2009","journal-title":"Plasma Process. Polym."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"6501","DOI":"10.1039\/c1sm05167a","article-title":"Substrate induced differentiation of human mesenchymal stem cells on hydrogels with modified surface chemistry and controlled modulus","volume":"7","author":"Lanniel","year":"2011","journal-title":"Soft Matter"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"35840","DOI":"10.1038\/srep35840","article-title":"Stretching human mesenchymal stromal cells on stiffness-customized collagen type I generates a smooth muscle marker profile without growth factor addition","volume":"6","author":"Rothdiener","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1186\/s13287-019-1494-4","article-title":"YAP as a key regulator of adipo-osteogenic differentiation in human MSCs","volume":"10","author":"Lorthongpanich","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.biomaterials.2019.03.009","article-title":"Substrate mechanics controls adipogenesis through YAP phosphorylation by dictating cell spreading","volume":"205","author":"Nardone","year":"2019","journal-title":"Biomaterials"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s13075-015-0639-9","article-title":"Yes-associated protein (YAP) is a negative regulator of chondrogenesis in mesenchymal stem cells","volume":"17","author":"Karystinou","year":"2015","journal-title":"Arthritis Res. Ther."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1016\/j.biomaterials.2011.12.004","article-title":"Mechanical derivation of functional myotubes from adipose-derived stem cells","volume":"33","author":"Choi","year":"2012","journal-title":"Biomaterials"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"4426","DOI":"10.1529\/biophysj.108.132217","article-title":"Substrate modulus directs neural stem cell behavior","volume":"95","author":"Saha","year":"2008","journal-title":"Biophys. J."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"6867","DOI":"10.1016\/j.biomaterials.2009.09.002","article-title":"The effect of substrate stiffness on adult neural stem cell behavior","volume":"30","author":"Leipzig","year":"2009","journal-title":"Biomaterials"},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Noguchi, S., Saito, A., and Nagase, T. (2018). YAP\/TAZ Signaling as a Molecular Link between Fibrosis and Cancer. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19113674"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"4564","DOI":"10.1038\/s41467-018-07022-2","article-title":"Reciprocal inhibition of YAP\/TAZ and NF-\u03baB regulates osteoarthritic cartilage degradation","volume":"9","author":"Deng","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"9424","DOI":"10.1073\/pnas.1505700112","article-title":"Matrix cross-linking\u2013mediated mechanotransduction promotes posttraumatic osteoarthritis","volume":"112","author":"Kim","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"e31","DOI":"10.1002\/term.501","article-title":"The influence of matrix elasticity on chondrocyte behavior in 3D","volume":"6","author":"Schuh","year":"2012","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1038\/nmat4993","article-title":"Mechanical confinement regulates cartilage matrix formation by chondrocytes","volume":"16","author":"Lee","year":"2017","journal-title":"Nat. Mater."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1089\/ten.tea.2009.0614","article-title":"Effect of matrix elasticity on the maintenance of the chondrogenic phenotype","volume":"16","author":"Schuh","year":"2010","journal-title":"Tissue Eng. Part A"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.yexcr.2004.07.027","article-title":"Adhesion-mediated signal transduction in human articular chondrocytes: The influence of biomaterial chemistry and tenascin-C","volume":"301","author":"Mahmood","year":"2004","journal-title":"Exp. Cell Res."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"4167","DOI":"10.1016\/j.actbio.2014.05.023","article-title":"The effects of varying poly (ethylene glycol) hydrogel crosslinking density and the crosslinking mechanism on protein accumulation in three-dimensional hydrogels","volume":"10","author":"Lee","year":"2014","journal-title":"Acta Biomater."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1093\/abbs\/gmw087","article-title":"The effect of matrix stiffness on biomechanical properties of chondrocytes","volume":"48","author":"Zhang","year":"2016","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/nrm3112","article-title":"Balancing forces: Architectural control of mechanotransduction","volume":"12","author":"DuFort","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"4262","DOI":"10.1128\/MCB.01779-08","article-title":"The transcriptional activity of Sox9 in chondrocytes is regulated by RhoA signaling and actin polymerization","volume":"29","author":"Kumar","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"3409","DOI":"10.1101\/gad.1735208","article-title":"The A- and B-type nuclear lamin networks: Microdomains involved in chromatin organization and transcription","volume":"22","author":"Shimi","year":"2008","journal-title":"Genes Dev."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1240104","DOI":"10.1126\/science.1240104","article-title":"Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiation","volume":"341","author":"Swift","year":"2013","journal-title":"Science"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1007\/s12195-013-0270-2","article-title":"Modulation of Nuclear Shape by Substrate Rigidity","volume":"6","author":"Lovett","year":"2013","journal-title":"Cell. Mol. Bioeng."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00412-016-0614-5","article-title":"Nuclear morphologies: Their diversity and functional relevance","volume":"126","author":"Skinner","year":"2017","journal-title":"Chromosoma"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.biomaterials.2015.01.023","article-title":"Cytoskeletal tension induces the polarized architecture of the nucleus","volume":"48","author":"Kim","year":"2015","journal-title":"Biomaterials"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.3892\/ijmm.2012.1107","article-title":"RhoA\/Rho kinase signaling regulates transforming growth factor-beta1-induced chondrogenesis and actin organization of synovium-derived mesenchymal stem cells through interaction with the Smad pathway","volume":"30","author":"Xu","year":"2012","journal-title":"Int. J. Mol. Med."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"16106","DOI":"10.1021\/am504135b","article-title":"Substrate stiffness together with soluble factors affects chondrocyte mechanoresponses","volume":"6","author":"Chen","year":"2014","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/j.joca.2006.05.013","article-title":"The effects of TGF-beta1 and IGF-I on the biomechanics and cytoskeleton of single chondrocytes","volume":"14","author":"Leipzig","year":"2006","journal-title":"Osteoarthr. Cartil."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"e12532","DOI":"10.1111\/cpr.12532","article-title":"Zyxin-involved actin regulation is essential in the maintenance of vinculin focal adhesion and chondrocyte differentiation status","volume":"52","author":"Li","year":"2019","journal-title":"Cell Prolif."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"4074","DOI":"10.1111\/j.1742-4658.2008.06549.x","article-title":"A novel mechanism of TGF\u03b2-induced actin reorganization mediated by Smad proteins and Rho GTPases","volume":"275","author":"Vardouli","year":"2008","journal-title":"FEBS J."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"26019","DOI":"10.3390\/ijms161125936","article-title":"Changes in Ultrastructure and Cytoskeletal Aspects of Human Normal and Osteoarthritic Chondrocytes Exposed to Interleukin-1beta and Cyclical Hydrostatic Pressure","volume":"16","author":"Pascarelli","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/jor.21198","article-title":"Vimentin contributes to changes in chondrocyte stiffness in osteoarthritis","volume":"29","author":"Haudenschild","year":"2011","journal-title":"J. Orthop. Res."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1093\/abbs\/gmu116","article-title":"Interleukin-1\u03b2 and tumor necrosis factor-\u03b1 increase stiffness and impair contractile function of articular chondrocytes","volume":"47","author":"Chen","year":"2015","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1006\/excr.2001.5395","article-title":"Regulation of articular chondrocyte phenotype by bone morphogenetic protein 7, interleukin 1, and cellular context is dependent on the cytoskeleton","volume":"272","author":"Vinall","year":"2002","journal-title":"Exp. Cell Res."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"e09300","DOI":"10.7554\/eLife.09300","article-title":"Discrete spatial organization of TGFbeta receptors couples receptor multimerization and signaling to cellular tension","volume":"4","author":"Rys","year":"2015","journal-title":"Elife"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"9466","DOI":"10.1073\/pnas.1106467108","article-title":"Integrin activation and internalization on soft ECM as a mechanism of induction of stem cell differentiation by ECM elasticity","volume":"108","author":"Du","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/stem.308","article-title":"Stem cell shape regulates a chondrogenic versus myogenic fate through Rac1 and N-cadherin","volume":"28","author":"Gao","year":"2010","journal-title":"Stem Cells"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/art.25051","article-title":"Rho kinase\u2013dependent activation of SOX9 in chondrocytes","volume":"62","author":"Haudenschild","year":"2010","journal-title":"Arthritis Rheum. Off. J. Am. Coll. Rheumatol."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"11626","DOI":"10.1074\/jbc.M409158200","article-title":"RhoA\/ROCK signaling regulates Sox9 expression and actin organization during chondrogenesis","volume":"280","author":"Woods","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1016\/j.biocel.2007.05.019","article-title":"Control of cell fate and differentiation by Sry-related high-mobility-group box (Sox) transcription factors","volume":"39","author":"Lefebvre","year":"2007","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"5313","DOI":"10.1128\/MCB.16.10.5313","article-title":"The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton","volume":"16","author":"Leung","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1083\/jcb.150.4.797","article-title":"Distinct roles of ROCK (Rho-kinase) and MLCK in spatial regulation of MLC phosphorylation for assembly of stress fibers and focal adhesions in 3T3 fibroblasts","volume":"150","author":"Totsukawa","year":"2000","journal-title":"J. Cell Biol."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1083\/jcb.106.1.171","article-title":"Alterations in chondrocyte cytoskeletal architecture during phenotypic modulation by retinoic acid and dihydrocytochalasin B-induced reexpression","volume":"106","author":"Brown","year":"1988","journal-title":"J. Cell Biol."},{"key":"ref_195","doi-asserted-by":"crossref","unstructured":"Olivares-Navarrete, R., Lee, E.M., Smith, K., Hyzy, S.L., Doroudi, M., Williams, J.K., Gall, K., Boyan, B.D., and Schwartz, Z. (2017). Substrate Stiffness Controls Osteoblastic and Chondrocytic Differentiation of Mesenchymal Stem Cells without Exogenous Stimuli. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0170312"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.joca.2012.04.022","article-title":"Identification of signalling pathways triggered by changes in the mechanical environment in rat chondrocytes","volume":"20","author":"Mora","year":"2012","journal-title":"Osteoarthr. Cartil."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jmbbm.2011.11.009","article-title":"Mesenchymal stem cell fate is regulated by the composition and mechanical properties of collagen\u2013glycosaminoglycan scaffolds","volume":"11","author":"Murphy","year":"2012","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.biomaterials.2012.09.052","article-title":"The influence of hyaluronic acid hydrogel crosslinking density and macromolecular diffusivity on human MSC chondrogenesis and hypertrophy","volume":"34","author":"Bian","year":"2013","journal-title":"Biomaterials"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1089\/ten.tea.2019.0068","article-title":"The Effects of ROCK Inhibition on Mesenchymal Stem Cell Chondrogenesis Are Culture Model Dependent","volume":"26","author":"Gegg","year":"2020","journal-title":"Tissue Eng. Part A"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/adfm.201201212","article-title":"Microribbon-Like Elastomers for Fabricating Macroporous and Highly Flexible Scaffolds that Support Cell Proliferation in 3D","volume":"23","author":"Han","year":"2013","journal-title":"Adv. Funct. Mater."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1039\/c2sm06869a","article-title":"Biomimetic interpenetrating polymer network hydrogels based on methacrylated alginate and collagen for 3D pre-osteoblast spreading and osteogenic differentiation","volume":"8","author":"Sun","year":"2012","journal-title":"Soft Matter"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.stem.2011.06.008","article-title":"The MSC: An injury drugstore","volume":"9","author":"Caplan","year":"2011","journal-title":"Cell Stem Cell"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1089\/ten.teb.2016.0365","article-title":"Trophic Effects of Mesenchymal Stem Cells in Tissue Regeneration","volume":"23","author":"Fu","year":"2017","journal-title":"Tissue Eng. Part B Rev."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s13287-016-0394-0","article-title":"Secreted trophic factors of mesenchymal stem cells support neurovascular and musculoskeletal therapies","volume":"7","author":"Hofer","year":"2016","journal-title":"Stem Cell Res. Ther"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1089\/ten.tea.2013.0661","article-title":"Matrix composition and mechanics direct proangiogenic signaling from mesenchymal stem cells","volume":"20","author":"Abdeen","year":"2014","journal-title":"Tissue Eng. Part A"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.msec.2017.02.001","article-title":"Impact of matrix stiffness on fibroblast function","volume":"74","author":"Wu","year":"2017","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1089\/scd.2016.0349","article-title":"Effect of the Microenvironment on Mesenchymal Stem Cell Paracrine Signaling: Opportunities to Engineer the Therapeutic Effect","volume":"26","author":"Kusuma","year":"2017","journal-title":"Stem Cells Dev."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jmbbm.2016.01.021","article-title":"Breast cancer cells mechanosensing in engineered matrices: Correlation with aggressive phenotype","volume":"61","author":"Li","year":"2016","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"1900929","DOI":"10.1002\/adhm.201900929","article-title":"Materials Stiffness-Dependent Redox Metabolic Reprogramming of Mesenchymal Stem Cells for Secretome-Based Therapeutic Angiogenesis","volume":"8","author":"Yang","year":"2019","journal-title":"Adv. Healthc. Mater."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.bbrc.2009.09.051","article-title":"Matrix elasticity regulates the secretory profile of human bone marrow-derived multipotent mesenchymal stromal cells (MSCs)","volume":"389","author":"Seib","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.aanat.2009.05.003","article-title":"Activation and dedifferentiation of chondrocytes: Implications in cartilage injury and repair","volume":"191","year":"2009","journal-title":"Ann. Anat. Anat. Anz."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.joca.2012.06.016","article-title":"Redifferentiation of dedifferentiated human articular chondrocytes: Comparison of 2D and 3D cultures","volume":"20","author":"Caron","year":"2012","journal-title":"Osteoarthr. Cartil."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"R133","DOI":"10.1186\/ar2800","article-title":"Chondrogenic differentiation potential of osteoarthritic chondrocytes and their possible use in matrix-associated autologous chondrocyte transplantation","volume":"11","author":"Dehne","year":"2009","journal-title":"Arthritis Res. Ther."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1089\/ten.tea.2016.0505","article-title":"Induced Redifferentiation of Human Chondrocytes from Articular Cartilage Lesion in Alginate Bead Culture After Monolayer Dedifferentiation: An Alternative Cell Source for Cell-Based Therapies?","volume":"24","author":"Aurich","year":"2018","journal-title":"Tissue Eng. Part A"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/jbm.a.33226","article-title":"Chondrocyte redifferentiation in 3D: The effect of adhesion site density and substrate elasticity","volume":"100","author":"Schuh","year":"2012","journal-title":"J. Biomed. Mater. Res. A"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1002\/jbm.a.34924","article-title":"Chondrocyte redifferentiation and construct mechanical property development in single-component photocrosslinkable hydrogels","volume":"102","author":"Levett","year":"2014","journal-title":"J. Biomed. Mater. Res. A"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"16400","DOI":"10.1038\/srep16400","article-title":"Activin A\/BMP2 chimera AB235 drives efficient redifferentiation of long term cultured autologous chondrocytes","volume":"5","author":"Jimenez","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.1089\/ten.tea.2008.0628","article-title":"Expansion and redifferentiation of chondrocytes from osteoarthritic cartilage: Cells for human cartilage tissue engineering","volume":"15","author":"Wu","year":"2009","journal-title":"Tissue Eng. Part A"},{"key":"ref_219","doi-asserted-by":"crossref","unstructured":"Babur, B.K., Ghanavi, P., Levett, P., Lott, W.B., Klein, T., Cooper-White, J.J., Crawford, R., and Doran, M.R. (2013). The interplay between chondrocyte redifferentiation pellet size and oxygen concentration. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0058865"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1089\/ten.tec.2013.0532","article-title":"Articular chondrocyte redifferentiation in 3D co-cultures with mesenchymal stem cells","volume":"20","author":"Meretoja","year":"2014","journal-title":"Tissue Eng. Part C Methods"},{"key":"ref_221","first-page":"e200002","article-title":"Expansion of Chondrocytes for Cartilage Tissue Engineering: A Review of Chondrocyte Dedifferentiation and Redifferentiation as a Function of Growth in Expansion Culture","volume":"2","author":"Kisiday","year":"2020","journal-title":"Regen. Med. Front."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3109\/03008207.2012.762360","article-title":"Response of sheep chondrocytes to changes in substrate stiffness from 2 to 20 Pa: Effect of cell passaging","volume":"54","author":"Mora","year":"2013","journal-title":"Connect. Tissue Res."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"4275","DOI":"10.1038\/s41598-019-40575-w","article-title":"Characterization of polydactyly chondrocytes and their use in cartilage engineering","volume":"9","author":"Cavalli","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.cell.2006.10.018","article-title":"Wnt\/\u03b2-catenin signaling in development and disease","volume":"127","author":"Clevers","year":"2006","journal-title":"Cell"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"20395","DOI":"10.1038\/srep20395","article-title":"Extracellular matrix stiffness dictates Wnt expression through integrin pathway","volume":"6","author":"Du","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"11751","DOI":"10.1074\/jbc.M111.281014","article-title":"alpha-Catenin inhibits beta-catenin-T-cell factor\/lymphoid enhancing factor transcriptional activity and collagen type II expression in articular chondrocytes through formation of Gli3R.alpha-catenin.beta-catenin ternary complex","volume":"287","author":"Rhee","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"12758","DOI":"10.1074\/jbc.M413367200","article-title":"Regulation of beta-catenin signaling and maintenance of chondrocyte differentiation by ubiquitin-independent proteasomal degradation of alpha-catenin","volume":"280","author":"Hwang","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.biomaterials.2010.08.100","article-title":"The influence of scaffold architecture on chondrocyte distribution and behavior in matrix-associated chondrocyte transplantation grafts","volume":"32","author":"Nuernberger","year":"2011","journal-title":"Biomaterials"},{"key":"ref_229","first-page":"1130","article-title":"Good clinical results with autologous matrix-induced chondrogenesis (Amic) technique in large knee chondral defects","volume":"26","author":"Panni","year":"2018","journal-title":"Knee Surg. Sports Traumatol. Arthrosc."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1177\/0363546514532337","article-title":"Results 2 years after matrix-associated autologous chondrocyte transplantation using the Novocart 3D scaffold: An analysis of clinical and radiological data","volume":"42","author":"Zak","year":"2014","journal-title":"Am. J. Sports Med."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1007\/s00167-019-05661-6","article-title":"Third-generation autologous chondrocyte implantation after failed bone marrow stimulation leads to inferior clinical results","volume":"28","author":"Gallik","year":"2020","journal-title":"Knee Surg. Sports Traumatol. Arthrosc."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s00264-015-2825-4","article-title":"Analysis of the autologous chondrocyte quality of matrix-based autologous chondrocyte implantation in the knee joint","volume":"40","author":"Niethammer","year":"2016","journal-title":"Int. Orthop."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"979","DOI":"10.2106\/JBJS.K.00533","article-title":"NeoCart, an autologous cartilage tissue implant, compared with microfracture for treatment of distal femoral cartilage lesions: An FDA phase-II prospective, randomized clinical trial after two years","volume":"94","author":"Crawford","year":"2012","journal-title":"JBJS"},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1177\/0363546516677255","article-title":"Magnetic resonance imaging characterization and clinical outcomes after NeoCart surgical therapy as a primary reparative treatment for knee cartilage injuries","volume":"45","author":"Anderson","year":"2017","journal-title":"Am. J. Sports Med."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s00776-012-0305-x","article-title":"CaReS\u00ae(MACT) versus microfracture in treating symptomatic patellofemoral cartilage defects: A retrospective matched-pair analysis","volume":"18","author":"Petri","year":"2013","journal-title":"J. Orthop. Sci."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1177\/0363546514528093","article-title":"Matrix-applied characterized autologous cultured chondrocytes versus microfracture: Two-year follow-up of a prospective randomized trial","volume":"42","author":"Saris","year":"2014","journal-title":"Am. J. Sports Med."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1177\/0363546518756976","article-title":"Matrix-applied characterized autologous cultured chondrocytes versus microfracture: Five-year follow-up of a prospective randomized trial","volume":"46","author":"Brittberg","year":"2018","journal-title":"Am. J. Sports Med."},{"key":"ref_238","first-page":"1260","article-title":"Use of innovative biomimetic scaffold in the treatment for large osteochondral lesions of the knee","volume":"22","author":"Delcogliano","year":"2014","journal-title":"Knee Surg. Sports Traumatol. Arthrosc."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1089\/ten.tea.2011.0416","article-title":"Effect of collagen type I or type II on chondrogenesis by cultured human articular chondrocytes","volume":"19","author":"Rutgers","year":"2013","journal-title":"Tissue Eng. Part A"},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"R82","DOI":"10.1186\/ar3009","article-title":"Biomechanical modulation of collagen fragment-induced anabolic and catabolic activities in chondrocyte\/agarose constructs","volume":"12","author":"Chowdhury","year":"2010","journal-title":"Arthritis Res. Ther."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3109\/03008200109014250","article-title":"The effects of collagen fragments on the extracellular matrix metabolism of bovine and human chondrocytes","volume":"42","author":"Jennings","year":"2001","journal-title":"Connect. Tissue Res."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1172\/JCI119316","article-title":"Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage","volume":"99","author":"Billinghurst","year":"1997","journal-title":"J. Clin. Investig."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"3693","DOI":"10.1002\/art.22968","article-title":"Transforming growth factor alpha suppression of articular chondrocyte phenotype and Sox9 expression in a rat model of osteoarthritis","volume":"56","author":"Appleton","year":"2007","journal-title":"Arthritis Rheum."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nmat4893","article-title":"EGFR and HER2 activate rigidity sensing only on rigid matrices","volume":"16","author":"Saxena","year":"2017","journal-title":"Nat. Mater."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.orthres.2004.09.002","article-title":"Type I and II collagen regulation of chondrogenic differentiation by mesenchymal progenitor cells","volume":"23","author":"Chen","year":"2005","journal-title":"J. Orthop. Res."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"43519","DOI":"10.1038\/srep43519","article-title":"Monomeric, porous type II collagen scaffolds promote chondrogenic differentiation of human bone marrow mesenchymal stem cells in vitro","volume":"7","author":"Tamaddon","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"22884","DOI":"10.1021\/acsami.6b07097","article-title":"Softening substrates promote chondrocytes phenotype via RhoA\/ROCK pathway","volume":"8","author":"Zhang","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jcyt.2015.10.015","article-title":"Collagen Type II enhances chondrogenic differentiation in agarose-based modular microtissues","volume":"18","author":"Annamalai","year":"2016","journal-title":"Cytotherapy"},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s10195-012-0219-6","article-title":"Arthroscopic treatment of early glenohumeral arthritis","volume":"14","author":"Porcellini","year":"2013","journal-title":"J. Orthop. Traumatol."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1177\/0363546514526695","article-title":"Treatment of full-thickness chondral defects with hyalograft C in the knee: Long-term results","volume":"42","author":"Brix","year":"2014","journal-title":"Am. J. Sports Med."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1051\/sicotj\/2017037","article-title":"Arthroscopic autologous chondrocyte implantation in the hip for the treatment of full-thickness cartilage defects: A case series of 29 patients and review of the literature","volume":"3","author":"Thier","year":"2017","journal-title":"SICOT J."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1053\/j.otsm.2013.03.007","article-title":"Treatment of focal cartilage defects with a juvenile allogeneic 3-dimensional articular cartilage graft","volume":"21","author":"McCormick","year":"2013","journal-title":"Oper. Tech. Sports Med."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1089\/ten.tea.2014.0673","article-title":"Direct Cell-Cell Contact with Chondrocytes Is a Key Mechanism in Multipotent Mesenchymal Stromal Cell-Mediated Chondrogenesis","volume":"21","author":"Saris","year":"2015","journal-title":"Tissue Eng. Part A"},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/267531a0","article-title":"Relationship between cell shape and type of collagen synthesised as chondrocytes lose their cartilage phenotype in culture","volume":"267","author":"Gauss","year":"1977","journal-title":"Nature"},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1083\/jcb.90.1.78","article-title":"Extracellular matrix formation by chondrocytes in monolayer culture","volume":"90","author":"Dessau","year":"1981","journal-title":"J. Cell Biol."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.joca.2011.07.004","article-title":"Gene expression and cell differentiation in matrix-associated chondrocyte transplantation grafts: A comparative study","volume":"19","author":"Albrecht","year":"2011","journal-title":"Osteoarthr. Cartil."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0092-8674(82)90027-7","article-title":"Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels","volume":"30","author":"Benya","year":"1982","journal-title":"Cell"},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1177\/0363546511423369","article-title":"A prospective multicenter study on the outcome of type I collagen hydrogel-based autologous chondrocyte implantation (CaReS) for the repair of articular cartilage defects in the knee","volume":"39","author":"Schneider","year":"2011","journal-title":"Am. J. Sports Med."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"5188","DOI":"10.1038\/srep05188","article-title":"Rewiring mesenchymal stem cell lineage specification by switching the biophysical microenvironment","volume":"4","author":"Lee","year":"2014","journal-title":"Sci. Rep."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1021\/acsbiomaterials.5b00377","article-title":"Influence of Surface Topographical Cues on the Differentiation of Mesenchymal Stem Cells in Vitro","volume":"2","author":"Metavarayuth","year":"2016","journal-title":"ACS Biomater. Sci. Eng."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3389\/fbioe.2016.00038","article-title":"Mesenchymal Stem Cell Fate: Applying Biomaterials for Control of Stem Cell Behavior","volume":"4","author":"Anderson","year":"2016","journal-title":"Front. Bioeng. Biotechnol."},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1159\/000325144","article-title":"Effect of fiber diameter on the spreading, proliferation and differentiation of chondrocytes on electrospun chitosan matrices","volume":"195","author":"Noriega","year":"2012","journal-title":"Cells Tissues Organs"},{"key":"ref_263","first-page":"38","article-title":"Autologous chondrocyte implantation (ACI) for cartilage defects of the knee: A guideline by the working group \u201cTissue Regeneration\u201d of the German Society of Orthopaedic Surgery and Traumatology (DGOU)","volume":"151","author":"Niemeyer","year":"2013","journal-title":"Z. Orthop. Unfall."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/S0020-1383(15)30012-7","article-title":"Defect type, localization and marker gene expression determines early adverse events of matrix-associated autologous chondrocyte implantation","volume":"46","author":"Angele","year":"2015","journal-title":"Injury"},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1007\/s00402-016-2453-5","article-title":"Cartilage repair surgery for full-thickness defects of the knee in Germany: Indications and epidemiological data from the German Cartilage Registry (KnorpelRegister DGOU)","volume":"136","author":"Niemeyer","year":"2016","journal-title":"Arch. Orthop. Trauma Surg."},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1007\/s00264-017-3615-y","article-title":"Tissue engineering-relevant characteristics of ex vivo and monolayer-expanded chondrocytes from the notch versus trochlea of human knee joints","volume":"41","author":"Aurich","year":"2017","journal-title":"Int. Orthop."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1007\/s00402-006-0125-6","article-title":"Histological and cell biological characterization of dissected cartilage fragments in human osteochondritis dissecans of the femoral condyle","volume":"126","author":"Aurich","year":"2006","journal-title":"Arch. Orthop. Trauma Surg."},{"key":"ref_268","doi-asserted-by":"crossref","unstructured":"Aurich, M., Hofmann, G.O., Gras, F., and Rolauffs, B. (2018). Human osteochondritis dissecans fragment-derived chondrocyte characteristics ex vivo, after monolayer expansion-induced de-differentiation, and after re-differentiation in alginate bead culture. BMC Musculoskelet. Disord., 19.","DOI":"10.1186\/s12891-018-2079-6"},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"e1206","DOI":"10.1002\/term.2516","article-title":"Human osteoarthritic chondrons outnumber patient- and joint-matched chondrocytes in hydrogel culture-Future application in autologous cell-based OA cartilage repair?","volume":"12","author":"Rothdiener","year":"2018","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00018-002-8401-2","article-title":"Molecular basis for differences between human joints","volume":"59","author":"Cole","year":"2002","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S1083-7515(03)00012-3","article-title":"Distinguishing ankle and knee articular cartilage","volume":"8","author":"Cole","year":"2003","journal-title":"Foot Ankle Clin."},{"key":"ref_272","first-page":"18","article-title":"Differences in metabolism of chondrocytes of the knee and ankle joint","volume":"141","author":"Eger","year":"2003","journal-title":"Z. Orthop. Ihre Grenzgeb."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/S0736-0266(01)00125-5","article-title":"Human knee and ankle cartilage explants: Catabolic differences","volume":"20","author":"Eger","year":"2002","journal-title":"J. Orthop. Res."},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"478","DOI":"10.3109\/s10165-012-0686-x","article-title":"Layilin, a talin-binding hyaluronan receptor, is expressed in human articular chondrocytes and synoviocytes and is down-regulated by interleukin-1beta","volume":"23","author":"Murata","year":"2013","journal-title":"Mod. Rheumatol."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s13287-015-0083-4","article-title":"Mechanism of regulation of stem cell differentiation by matrix stiffness","volume":"6","author":"Lv","year":"2015","journal-title":"Stem Cell Res. Ther."},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"e1806727","DOI":"10.1002\/adma.201806727","article-title":"Phytochrome-Based Extracellular Matrix with Reversibly Tunable Mechanical Properties","volume":"31","author":"Horner","year":"2019","journal-title":"Adv. Mater."},{"key":"ref_277","doi-asserted-by":"crossref","unstructured":"Boehme, K.A., and Rolauffs, B. (2018). Onset and Progression of Human Osteoarthritis-Can Growth Factors, Inflammatory Cytokines, or Differential miRNA Expression Concomitantly Induce Proliferation, ECM Degradation, and Inflammation in Articular Cartilage?. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19082282"},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"17693","DOI":"10.1074\/jbc.REV119.007963","article-title":"Control of cellular responses to mechanical cues through YAP\/TAZ regulation","volume":"294","author":"Dasgupta","year":"2019","journal-title":"J. Biol. Chem."},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/ncb3336","article-title":"Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity","volume":"18","author":"Oria","year":"2016","journal-title":"Nat. Cell Biol."},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1038\/s41556-018-0142-z","article-title":"YAP\/TAZ upstream signals and downstream responses","volume":"20","author":"Totaro","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"19179","DOI":"10.1074\/jbc.M117.808063","article-title":"beta1 integrin-dependent Rac\/group I PAK signaling mediates YAP activation of Yes-associated protein 1 (YAP1) via NF2\/merlin","volume":"292","author":"Sabra","year":"2017","journal-title":"J. Biol. Chem."},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.cels.2016.11.015","article-title":"Multiparametric Analysis of Cell Shape Demonstrates that beta-PIX Directly Couples YAP Activation to Extracellular Matrix Adhesion","volume":"4","author":"Sero","year":"2017","journal-title":"Cell Syst."},{"key":"ref_283","first-page":"3181","article-title":"Hypoxia promotes maintenance of the chondrogenic phenotype in rat growth plate chondrocytes through the HIF-1alpha\/YAP signaling pathway","volume":"42","author":"Li","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1038\/s41388-018-0476-9","article-title":"Unbalanced YAP-SOX9 circuit drives stemness and malignant progression in esophageal squamous cell carcinoma","volume":"38","author":"Wang","year":"2019","journal-title":"Oncogene"},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.joca.2011.05.003","article-title":"The relationship between fibrogenic TGFbeta1 signaling in the joint and cartilage degradation in post-injury osteoarthritis","volume":"19","author":"Plaas","year":"2011","journal-title":"Osteoarthr. Cartil."},{"key":"ref_286","doi-asserted-by":"crossref","unstructured":"Thielen, N.G.M., van der Kraan, P.M., and van Caam, A.P.M. (2019). TGF\u03b2\/BMP Signaling Pathway in Cartilage Homeostasis. Cells, 8.","DOI":"10.3390\/cells8090969"},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s00441-011-1194-6","article-title":"Age-dependent alteration of TGF-beta signalling in osteoarthritis","volume":"347","author":"Goumans","year":"2012","journal-title":"Cell Tissue Res."},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"dev149823","DOI":"10.1242\/dev.149823","article-title":"alpha-Catenin-dependent cytoskeletal tension controls Yap activity in the heart","volume":"145","author":"Vite","year":"2018","journal-title":"Development"},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1091\/mbc.E17-04-0231","article-title":"Force-dependent binding of vinculin to alpha-catenin regulates cell-cell contact stability and collective cell behavior","volume":"29","author":"Seddiki","year":"2018","journal-title":"Mol. Biol. Cell"},{"key":"ref_290","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/ncb2055","article-title":"alpha-Catenin as a tension transducer that induces adherens junction development","volume":"12","author":"Yonemura","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"30463","DOI":"10.1074\/jbc.M109.021295","article-title":"Vinculin nucleates actin polymerization and modifies actin filament structure","volume":"284","author":"Wen","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"ra41","DOI":"10.1126\/scisignal.2005781","article-title":"Actin cytoskeletal remodeling with protrusion formation is essential for heart regeneration in Hippo-deficient mice","volume":"8","author":"Morikawa","year":"2015","journal-title":"Sci. Signal."},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1080\/19336918.2016.1148864","article-title":"Modeling cell shape and dynamics on micropatterns","volume":"10","author":"Albert","year":"2016","journal-title":"Cell Adh. Migr."},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1038\/nrm3903","article-title":"Appreciating force and shape-the rise of mechanotransduction in cell biology","volume":"15","author":"Iskratsch","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_295","doi-asserted-by":"crossref","unstructured":"Paluch, E.K., Nelson, C.M., Biais, N., Fabry, B., Moeller, J., Pruitt, B.L., Wollnik, C., Kudryasheva, G., Rehfeldt, F., and Federle, W. (2015). Mechanotransduction: Use the force(s). BMC Biol., 13.","DOI":"10.1186\/s12915-015-0150-4"},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/nrm.2016.105","article-title":"Mechanotransduction: May the force be with you","volume":"17","author":"Strzyz","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/21\/15\/5399\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:52:45Z","timestamp":1760176365000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/21\/15\/5399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,29]]},"references-count":296,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2020,8]]}},"alternative-id":["ijms21155399"],"URL":"https:\/\/doi.org\/10.3390\/ijms21155399","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,29]]}}}