{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:57:25Z","timestamp":1790517445625,"version":"4.1.0"},"reference-count":68,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T00:00:00Z","timestamp":1596585600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Higher Education Institutional Excellence Program of the Ministry of Human Capacities in Hungary","award":["20765-3\/2018\/FEKUTSRTAT"],"award-info":[{"award-number":["20765-3\/2018\/FEKUTSRTAT"]}]},{"name":"LIVE LONGER, Human Resource Development Operational Program","award":["EFOP-3.6.2-16-2017-00006"],"award-info":[{"award-number":["EFOP-3.6.2-16-2017-00006"]}]},{"name":"The role of neuro-inflammation in neurodegeneration: from molecules to clinics","award":["EFOP-3.6.2-16-2017-00008"],"award-info":[{"award-number":["EFOP-3.6.2-16-2017-00008"]}]},{"name":"Economic Development and Innovation Operational Program","award":["GINOP-2.3.2-15-2016-00048 STAY ALIVE"],"award-info":[{"award-number":["GINOP-2.3.2-15-2016-00048 STAY ALIVE"]}]},{"name":"New National Excellence Program of the Ministry of Human Capacities","award":["\u00daNKP-19-3-III-PTE-211"],"award-info":[{"award-number":["\u00daNKP-19-3-III-PTE-211"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Acute gastritis is often untreatable by acid secretion-inhibiting drugs. Understanding the protective mechanisms including the role of Transient Receptor Potential Ankyrin1 (TRPA1) and Vanilloid1 (TRPV1) channels localized on capsaicin-sensitive afferents and non-neuronal structures might identify novel therapeutic approaches. Therefore, we characterized a translational gastritis model using iodoacetamide (IAA) and investigated TRPA1\/V1 expressions. Wistar rats and CD1, C57Bl\/6J mice were exposed to IAA-containing (0.05, 0.1, 0.2, 0.3, 0.5%) drinking water for 7 or 14 days. Body weight and water consumption were recorded daily. Macroscopic lesions were scored, qualitative histopathologic investigation was performed, TRPA1\/V1 immunopositivity and mRNA expressions were measured. IAA induced a concentration-dependent weight loss and reduced water intake in both species. Hyperemia, submucosal edema, inflammatory infiltration and hemorrhagic erosions developed after 7 days, while ulcers after 14 days in rats. Trpa1 mRNA\/protein expressions were upregulated at both timepoints. Meanwhile, TRPV1 immunopositivity was upregulated in the gastric corpus after 0.05% IAA ingestion, but downregulated after 0.2%, whereas Trpv1 mRNA did not change. Interestingly, no macroscopic\/microscopic changes were observed in mice. These are the first data for the concentration- and duration-dependent changes in the IAA-induced gastritis in rats accompanied by TRPA1 upregulation, therefore, its therapeutic potential in gastritis should further be investigated.<\/jats:p>","DOI":"10.3390\/ijms21165591","type":"journal-article","created":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T06:02:21Z","timestamp":1596607341000},"page":"5591","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Upregulation of the TRPA1 Ion Channel in the Gastric Mucosa after Iodoacetamide-Induced Gastritis in Rats: A Potential New Therapeutic Target"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2567-9836","authenticated-orcid":false,"given":"Kata","family":"Csek\u0151","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy, Medical School, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"},{"name":"Szentagothai Research Centre, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e1niel","family":"P\u00e9csi","sequence":"additional","affiliation":[{"name":"Institute for Translational Medicine, Medical School, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"},{"name":"1st Department of Medicine, Medical School, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9la","family":"Kajt\u00e1r","sequence":"additional","affiliation":[{"name":"Department of Pathology, Medical School, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivett","family":"Heged\u0171s","sequence":"additional","affiliation":[{"name":"Department of Pathology, Medical School, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Bollenbach","sequence":"additional","affiliation":[{"name":"Hannover Medical School, Institute of Toxicology, Core Unit Proteomics, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6320-0956","authenticated-orcid":false,"given":"Dimitrios","family":"Tsikas","sequence":"additional","affiliation":[{"name":"Hannover Medical School, Institute of Toxicology, Core Unit Proteomics, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imre L\u00e1szl\u00f3","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"1st Department of Medicine, Medical School, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e1ndor","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"School of Medicine, University of California, Irvine, CA 92697, USA"},{"name":"Department of Pharmaceutical Science, American University of Health Sciences, Signal Hill, CA 90755, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsuzsanna","family":"Helyes","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy, Medical School, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"},{"name":"Szentagothai Research Centre, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"},{"name":"PharmInVivo Ltd., H-7629 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,5]]},"reference":[{"key":"ref_1","unstructured":"Mozsik, G. 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