{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T21:49:45Z","timestamp":1781214585518,"version":"3.54.1"},"reference-count":45,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T00:00:00Z","timestamp":1596758400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Cancer remains one of the world\u2019s most devastating diseases and is responsible for more than 20% of all deaths. It is defined as uncontrolled proliferation of cells and spreads rapidly to healthy tissue. Controlled drug delivery systems offers great opportunities for the development of new non-invasive strategies for the treatment of cancers. The main advantage of these systems is their capacity to accumulate in tumors via enhanced permeability and retention effects. In the present study, an innovative hybrid drug delivery system based on nanocapsules obtained from the interfacial condensation between chitosan and poly(N-vinyl pyrrolidone-alt-itaconic anhydride) and containing both magnetic nanoparticles and an antitumoral drug was developed in order to improve the efficiency of the antitumoral treatment. Using dynamic light scattering, it was observed that the mean diameter of these hybrid nanocapsules was in the range of 43 to 142 nm. SEM confirmed their nanometric size and their well-defined spherical shape. These nanocapsules allowed the encapsulation of an increased amount of 5-fluorouracil and provided controlled drug release. In vitro studies have revealed that these drug-loaded hybrid nanocapsules were able to induce a cytostatic effect on breast carcinoma MCF-7 cell lines (Human Caucasian breast adenocarcinoma - HTB-22) comparable to that of the free drug.<\/jats:p>","DOI":"10.3390\/ijms21165659","type":"journal-article","created":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T09:30:54Z","timestamp":1596792654000},"page":"5659","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Antitumoral Drug: Loaded Hybrid Nanocapsules Based on Chitosan with Potential Effects in Breast Cancer Therapy"],"prefix":"10.3390","volume":"21","author":[{"given":"Kheira Zanoune","family":"Dellali","sequence":"first","affiliation":[{"name":"Laboratory of Structure, Elaboration and Application of Molecular Materials, University Abdelhamid Ibn Badis of Mostaganem, Mostaganem 27000, Algeria"},{"name":"Faculty of Technology, University Hassiba Benbouali of Chlef, Chlef BP 151 02000, Algeria"},{"name":"Department of Natural and Synthetic Polymers, Gheorghe Asachi Technical University of Iasi, Mangeron Bld. no. 73, 700050 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4917-9406","authenticated-orcid":false,"given":"Delia Mihaela","family":"Rata","sequence":"additional","affiliation":[{"name":"Faculty of Medical Dentistry, \u201cApollonia\u201d University of Iasi, Pacurari Street, No. 11, 700511Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4929-0830","authenticated-orcid":false,"given":"Marcel","family":"Popa","sequence":"additional","affiliation":[{"name":"Department of Natural and Synthetic Polymers, Gheorghe Asachi Technical University of Iasi, Mangeron Bld. no. 73, 700050 Iasi, Romania"},{"name":"Faculty of Medical Dentistry, \u201cApollonia\u201d University of Iasi, Pacurari Street, No. 11, 700511Iasi, Romania"},{"name":"Academy of Romanian Scientists, Splaiul Independentei Street, No 54, 050094 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u2019hamed","family":"Djennad","sequence":"additional","affiliation":[{"name":"Laboratory of Structure, Elaboration and Application of Molecular Materials, University Abdelhamid Ibn Badis of Mostaganem, Mostaganem 27000, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1110-9493","authenticated-orcid":false,"given":"Abdallah","family":"Ouagued","sequence":"additional","affiliation":[{"name":"Faculty of Technology, University Hassiba Benbouali of Chlef, Chlef BP 151 02000, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Gherghel","sequence":"additional","affiliation":[{"name":"Department of Experimental and Applied Biology, NIRDBS-Institute of Biological Research Iasi, Lascar Catargi 47, 700107 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1007\/s11051-015-3115-1","article-title":"Chitosan: Poly(N-vinylpyrrolidone-alt-itaconic anhydride) nanocapsules\u2014A promising alternative for the lung cancer treatment","volume":"17","author":"Rata","year":"2015","journal-title":"J. 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