{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T05:18:36Z","timestamp":1770355116123,"version":"3.49.0"},"reference-count":87,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T00:00:00Z","timestamp":1597276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI15\/00120"],"award-info":[{"award-number":["PI15\/00120"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI18\/00882"],"award-info":[{"award-number":["PI18\/00882"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI17\/00119"],"award-info":[{"award-number":["PI17\/00119"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["RD16\/0009"],"award-info":[{"award-number":["RD16\/0009"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010198","name":"Ministerio de Econom\u00eda, Industria y Competitividad, Gobierno de Espa\u00f1a","doi-asserted-by":"publisher","award":["EIN2019-103294"],"award-info":[{"award-number":["EIN2019-103294"]}],"id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010198","name":"Ministerio de Econom\u00eda, Industria y Competitividad, Gobierno de Espa\u00f1a","doi-asserted-by":"publisher","award":["SAF2016-80648-R"],"award-info":[{"award-number":["SAF2016-80648-R"]}],"id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["812699"],"award-info":[{"award-number":["812699"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Peritoneal hyalinizing vasculopathy (PHV) represents the cornerstone of long-term peritoneal dialysis (PD), and especially characterizes patients associated with encapsulating peritoneal sclerosis. However, the mechanisms of PHV development remain unknown. A cross sectional study was performed in 100 non-selected peritoneal biopsies of PD patients. Clinical data were collected and lesions were evaluated by immunohistochemistry. In selected biopsies a microRNA (miRNA)-sequencing analysis was performed. Only fifteen patients (15%) showed PHV at different degrees. PHV prevalence was significantly lower among patients using PD fluids containing low glucose degradation products (GDP) (5.9% vs. 24.5%), angiotensin converting enzyme inhibitors (ACEIs) (7.5% vs. 23.4%), statins (6.5% vs. 22.6%) or presenting residual renal function, suggesting the existence of several PHV protective factors. Peritoneal biopsies from PHV samples showed loss of endothelial markers and induction of mesenchymal proteins, associated with collagen IV accumulation and wide reduplication of the basement membrane. Moreover, co-expression of endothelial and mesenchymal markers, as well as TGF-\u03b21\/Smad3 signaling activation were found in PHV biopsies. These findings suggest that an endothelial-to-mesenchymal transition (EndMT) process was taking place. Additionally, significantly higher levels of miR-7641 were observed in severe PHV compared to non-PHV peritoneal biopsies. Peritoneal damage by GDPs induce miRNA deregulation and an EndMT process in submesothelial vessels, which could contribute to collagen IV accumulation and PHV.<\/jats:p>","DOI":"10.3390\/ijms21165824","type":"journal-article","created":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T09:23:44Z","timestamp":1597310624000},"page":"5824","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Increased miR-7641 Levels in Peritoneal Hyalinizing Vasculopathy in Long-Term Peritoneal Dialysis Patients"],"prefix":"10.3390","volume":"21","author":[{"given":"Raquel","family":"D\u00edaz","sequence":"first","affiliation":[{"name":"Research Institute of La Paz (IdiPAZ), University Hospital La Paz, 28046 Madrid, Spain"},{"name":"Red de Investigaci\u00f3n Renal (REDINREN), Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5893-7037","authenticated-orcid":false,"given":"Pilar","family":"Sandoval","sequence":"additional","affiliation":[{"name":"Centro de Biolog\u00eda Molecular \u201cSevero Ochoa\u201d (CBM), Spanish Council for Scientific Research (CSIC), Universidad Aut\u00f3noma de Madrid (UAM), 28049 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2456-6709","authenticated-orcid":false,"given":"Raul R.","family":"Rodrigues-Diez","sequence":"additional","affiliation":[{"name":"Red de Investigaci\u00f3n Renal (REDINREN), Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"Cellular and Molecular Biology in Renal and Vascular Pathology Laboratory, Fundaci\u00f3n Instituto de Investigaci\u00f3n Sanitaria-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Universidad Aut\u00f3noma Madrid, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria","family":"del Peso","sequence":"additional","affiliation":[{"name":"Research Institute of La Paz (IdiPAZ), University Hospital La Paz, 28046 Madrid, Spain"},{"name":"Red de Investigaci\u00f3n Renal (REDINREN), Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"ISRIN (Instituto Reina Sofia de Investigaci\u00f3n Nefrol\u00f3gica), 28003 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 A","family":"Jim\u00e9nez-Heffernan","sequence":"additional","affiliation":[{"name":"Departamento de Anatom\u00eda Patol\u00f3gica, Instituto de Investigaci\u00f3n Sanitaria La Princesa (IP), Hospital Universitario La Princesa, 28006 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Ramos-Ru\u00edz","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Parque Cient\u00edfico de Madrid, Genomics Unit, 28049 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1402-4743","authenticated-orcid":false,"given":"Carlos","family":"Llorens","sequence":"additional","affiliation":[{"name":"BiotechVana S.L. Parc Cientific, 46980 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo","family":"Laham","sequence":"additional","affiliation":[{"name":"Secci\u00f3n Nefrolog\u00eda del Centro de Educaci\u00f3n M\u00e9dica e Investigaciones Cl\u00ednicas (CEMIC), C1431FWO Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mabel","family":"Alvarez-Quiroga","sequence":"additional","affiliation":[{"name":"Secci\u00f3n Nefrolog\u00eda del Centro de Educaci\u00f3n M\u00e9dica e Investigaciones Cl\u00ednicas (CEMIC), C1431FWO Buenos Aires, Argentina"},{"name":"Programa de Di\u00e1lisis Peritoneal, Fresenius Medical Care Argentina, C1061AAA Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0976-9719","authenticated-orcid":false,"given":"Manuel","family":"L\u00f3pez-Cabrera","sequence":"additional","affiliation":[{"name":"Centro de Biolog\u00eda Molecular \u201cSevero Ochoa\u201d (CBM), Spanish Council for Scientific Research (CSIC), Universidad Aut\u00f3noma de Madrid (UAM), 28049 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Ruiz-Ortega","sequence":"additional","affiliation":[{"name":"Red de Investigaci\u00f3n Renal (REDINREN), Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"Cellular and Molecular Biology in Renal and Vascular Pathology Laboratory, Fundaci\u00f3n Instituto de Investigaci\u00f3n Sanitaria-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Universidad Aut\u00f3noma Madrid, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda A.","family":"Bajo","sequence":"additional","affiliation":[{"name":"Research Institute of La Paz (IdiPAZ), University Hospital La Paz, 28046 Madrid, Spain"},{"name":"Red de Investigaci\u00f3n Renal (REDINREN), Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"ISRIN (Instituto Reina Sofia de Investigaci\u00f3n Nefrol\u00f3gica), 28003 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Selgas","sequence":"additional","affiliation":[{"name":"Research Institute of La Paz (IdiPAZ), University Hospital La Paz, 28046 Madrid, Spain"},{"name":"Red de Investigaci\u00f3n Renal (REDINREN), Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"ISRIN (Instituto Reina Sofia de Investigaci\u00f3n Nefrol\u00f3gica), 28003 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.cub.2014.06.043","article-title":"Aberrant regulation and function of microRNAs in cancer","volume":"24","author":"Adams","year":"2014","journal-title":"Curr. 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