{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T07:04:02Z","timestamp":1776755042160,"version":"3.51.2"},"reference-count":29,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T00:00:00Z","timestamp":1597622400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["17-15-013418"],"award-info":[{"award-number":["17-15-013418"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003443","name":"Ministry of Education and Science of the Russian Federation","doi-asserted-by":"publisher","award":["17.7255.2017\/8.9"],"award-info":[{"award-number":["17.7255.2017\/8.9"]}],"id":[{"id":"10.13039\/501100003443","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003443","name":"Ministry of Education and Science of the Russian Federation","doi-asserted-by":"publisher","award":["AAAA\u2010A18\u2010118020690020\u20101"],"award-info":[{"award-number":["AAAA\u2010A18\u2010118020690020\u20101"]}],"id":[{"id":"10.13039\/501100003443","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Hexobarbital sleep test (HST) was performed in male Wistar rats (hexobarbital 60 mg\/kg, i.p.) 30 days prior to stress exposure. Based on the duration of hexobarbital-induced sleep, rats were divided into two groups, animals with high intensity (fast metabolizers (FM), sleep duration &lt;15 min) or low intensity of hexobarbital metabolism (slow metabolizers (SM), sleep duration \u226515 min). The SM and FM groups were then divided into two subgroups: unstressed and stressed groups. The stressed subgroups were exposed to predator scent stress for 10 days followed by 15 days of rest. SM and FM rats from the unstressed group exhibited different behavioral and endocrinological patterns. SM showed greater anxiety and higher corticosterone levels. In stressed animals, anxiety-like posttraumatic stress disorder (PTSD) behavior was aggravated only in SM. Corticosterone levels in the stressed FM, PTSD-resistant rats, were lower than in unstressed SM. Thus, HST was able to predict the susceptibility or resistance to experimental PTSD, which was consistent with the changes in glucocorticoid metabolism.<\/jats:p>","DOI":"10.3390\/ijms21165900","type":"journal-article","created":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T06:33:20Z","timestamp":1597646000000},"page":"5900","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Hexobarbital Sleep Test for Predicting the Susceptibility or Resistance to Experimental Posttraumatic Stress Disorder"],"prefix":"10.3390","volume":"21","author":[{"given":"Maria","family":"Komelkova","sequence":"first","affiliation":[{"name":"School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia"},{"name":"Institute of Immunology and Physiology, Ural Division of the Russian Academy of Sciences, 620049 Ekaterinburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8102-173X","authenticated-orcid":false,"given":"Eugenia","family":"Manukhina","sequence":"additional","affiliation":[{"name":"School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia"},{"name":"Laboratory for Regulatory Mechanisms of Stress and Adaptation, Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia"},{"name":"Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX 76107, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. Fred","family":"Downey","sequence":"additional","affiliation":[{"name":"School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia"},{"name":"Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX 76107, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3101-9655","authenticated-orcid":false,"given":"Alexey","family":"Sarapultsev","sequence":"additional","affiliation":[{"name":"Institute of Immunology and Physiology, Ural Division of the Russian Academy of Sciences, 620049 Ekaterinburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8035-2422","authenticated-orcid":false,"given":"Olga","family":"Cherkasova","sequence":"additional","affiliation":[{"name":"Biophysics Laboratory, Institute of Laser Physics, Siberian Branch of the Russian Academy of Science, 630090 Novosibirsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viacheslav","family":"Kotomtsev","sequence":"additional","affiliation":[{"name":"Institute of Immunology and Physiology, Ural Division of the Russian Academy of Sciences, 620049 Ekaterinburg, Russia"},{"name":"Laboratory of Biomedical Research, Ural Research Institute for Phthisiopulmonology of Ministry of Health of Russian Federation, 620039 Ekaterinburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel","family":"Platkovskiy","sequence":"additional","affiliation":[{"name":"Department of Fundamental Medicine, Chelyabinsk State University, 454001 Chelyabinsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanislav","family":"Fedorov","sequence":"additional","affiliation":[{"name":"Department of Fundamental Medicine, Chelyabinsk State University, 454001 Chelyabinsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petr","family":"Sarapultsev","sequence":"additional","affiliation":[{"name":"Institute of Immunology and Physiology, Ural Division of the Russian Academy of Sciences, 620049 Ekaterinburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Tseilikman","sequence":"additional","affiliation":[{"name":"School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia"},{"name":"Department of Fundamental Medicine, Chelyabinsk State University, 454001 Chelyabinsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Tseilikman","sequence":"additional","affiliation":[{"name":"Department of Fundamental Medicine, Chelyabinsk State University, 454001 Chelyabinsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vadim","family":"Tseilikman","sequence":"additional","affiliation":[{"name":"School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/nrn3339","article-title":"Biological studies of post-traumatic stress disorder","volume":"13","author":"Pitman","year":"2012","journal-title":"Nat. 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