{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:53:42Z","timestamp":1790686422707,"version":"4.1.0"},"reference-count":336,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T00:00:00Z","timestamp":1597708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 and its associated pathology, COVID-19, have been of particular concerns these last months due to the worldwide burden they represent. The number of cases requiring intensive care being the critical point in this epidemic, a better understanding of the pathophysiology leading to these severe cases is urgently needed. Tissue lesions can be caused by the pathogen or can be driven by an overwhelmed immune response. Focusing on SARS-CoV-2, we and others have observed that this virus can trigger indeed an immune response that can be dysregulated in severe patients and leading to further injury to multiple organs. The purpose of the review is to bring to light the current knowledge about SARS-CoV-2 virologic and immunologic features. Thus, we address virus biology, life cycle, tropism for many organs and how ultimately it will affect several host biological and physiological functions, notably the immune response. Given that therapeutic avenues are now highly warranted, we also discuss the immunotherapies available to manage the infection and the clinical outcomes.<\/jats:p>","DOI":"10.3390\/ijms21165932","type":"journal-article","created":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T11:15:27Z","timestamp":1597749327000},"page":"5932","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Deciphering SARS-CoV-2 Virologic and Immunologic Features"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9664-3486","authenticated-orcid":false,"given":"Gr\u00e9gorie","family":"Lebeau","sequence":"first","affiliation":[{"name":"Unit\u00e9 de Recherche \u00c9tudes Pharmaco-Immunologiques, Centre Hospitalier Universitaire La R\u00e9union Site F\u00e9lix Guyon, CS11021, 97400 Saint Denis de La R\u00e9union, France"},{"name":"Laboratoire de Biologie, Secteur Laboratoire d\u2019immunologie Clinique et Exp\u00e9rimentale de la Zone de l\u2019oc\u00e9an Indien (LICE-OI), Centre Hospitalier Universitaire La R\u00e9union Site F\u00e9lix Guyon, CS11021, 97400 Saint Denis de La R\u00e9union, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Vagner","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherche \u00c9tudes Pharmaco-Immunologiques, Centre Hospitalier Universitaire La R\u00e9union Site F\u00e9lix Guyon, CS11021, 97400 Saint Denis de La R\u00e9union, France"},{"name":"Unit\u00e9 Mixte de Recherche Processus Infectieux en Milieu Insulaire Tropical (PIMIT), Universit\u00e9 de La R\u00e9union, INSERM UMR 1187, CNRS 9192, IRD 249, Platform CYROI, 2 rue Maxime Rivi\u00e8re, 97491 Sainte Clotilde, La R\u00e9union, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9tienne","family":"Frumence","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherche \u00c9tudes Pharmaco-Immunologiques, Centre Hospitalier Universitaire La R\u00e9union Site F\u00e9lix Guyon, CS11021, 97400 Saint Denis de La R\u00e9union, France"},{"name":"Laboratoire de Biologie, Secteur Laboratoire d\u2019immunologie Clinique et Exp\u00e9rimentale de la Zone de l\u2019oc\u00e9an Indien (LICE-OI), Centre Hospitalier Universitaire La R\u00e9union Site F\u00e9lix Guyon, CS11021, 97400 Saint Denis de La R\u00e9union, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6270-0665","authenticated-orcid":false,"given":"Franck","family":"Ah-Pine","sequence":"additional","affiliation":[{"name":"Service d\u2019anatomo-Pathologie, Centre Hospitalier Universitaire Sud R\u00e9union, 97410 Saint Pierre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1217-7351","authenticated-orcid":false,"given":"Xavier","family":"Guillot","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherche \u00c9tudes 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dashboard to track COVID-19 in real time","volume":"20","author":"Dong","year":"2020","journal-title":"Lancet Infect. Dis."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Chen, G., Wu, D., Guo, W., Cao, Y., Huang, D., Wang, H., Wang, T., Zhang, X., Chen, H., and Yu, H. (2020). Clinical and immunological features of severe and moderate coronavirus disease 2019. J. Clin. Investig.","DOI":"10.1172\/JCI137244"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ijid.2020.03.017","article-title":"Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: A systematic review and meta-analysis","volume":"94","author":"Yang","year":"2020","journal-title":"Int. J. Infect. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"102433","DOI":"10.1016\/j.jaut.2020.102433","article-title":"The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak","volume":"109","author":"Rothan","year":"2020","journal-title":"J. Autoimmun."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Mousavizadeh, L., and Ghasemi, S. (2020). Genotype and phenotype of COVID-19: Their roles in pathogenesis. J. Microbiol. Immunol. Infect.","DOI":"10.1016\/j.jmii.2020.03.022"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0140-6736(20)30251-8","article-title":"Genomic characterisation and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding","volume":"395","author":"Lu","year":"2020","journal-title":"Lancet"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Tang, X., Wu, C., Li, X., Song, Y., Yao, X., Wu, X., Duan, Y., Zhang, H., Wang, Y., and Qian, Z. (2020). On the origin and continuing evolution of SARS-CoV-2. Nat. Sci. Rev.","DOI":"10.1093\/nsr\/nwaa036"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/s41586-020-2008-3","article-title":"A new coronavirus associated with human respiratory disease in China","volume":"579","author":"Wu","year":"2020","journal-title":"Nature"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-020-2012-7","article-title":"A pneumonia outbreak associated with a new coronavirus of probable bat origin","volume":"579","author":"Zhou","year":"2020","journal-title":"Nature"},{"key":"ref_10","unstructured":"Knipe, D.M., and Howley, P.M. (2013). Fields Virology, Lippincott Williams & Wilkins Health."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1006\/viro.1996.0165","article-title":"The Production of Recombinant Infectious DI-Particles of a Murine Coronavirus in the Absence of Helper Virus","volume":"218","author":"Bos","year":"1996","journal-title":"Virology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1002\/j.1460-2075.1996.tb00553.x","article-title":"Nucleocapsid-independent assembly of coronavirus-like particles by co-expression of viral envelope protein genes","volume":"15","author":"Vennema","year":"1996","journal-title":"EMBO J."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Nieto-Torres, J.L., DeDiego, M.L., Verdi\u00e1-B\u00e1guena, C., Jimenez-Guarde\u00f1o, J.M., Regla-Nava, J.A., Fernandez-Delgado, R., Casta\u00f1o-Rodriguez, C., Alcaraz, A., Torres, J., and Aguilella, V.M. (2014). Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Ion Channel Activity Promotes Virus Fitness and Pathogenesis. PLoS Pathog., 10.","DOI":"10.1371\/journal.ppat.1004077"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.cell.2020.02.058","article-title":"Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein","volume":"181","author":"Walls","year":"2020","journal-title":"Cell"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cell.2020.02.052","article-title":"SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor","volume":"181","author":"Hoffmann","year":"2020","journal-title":"Cell"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/s41564-020-0688-y","article-title":"Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses","volume":"5","author":"Letko","year":"2020","journal-title":"Nat. Microbiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1038\/s41467-020-15562-9","article-title":"Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV","volume":"11","author":"Ou","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Tai, W., He, L., Zhang, X., Pu, J., Voronin, D., Jiang, S., Zhou, Y., and Du, L. (2020). Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: Implication for development of RBD protein as a viral attachment inhibitor and vaccine. Cell Mol. Immunol.","DOI":"10.1038\/s41423-020-0400-4"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1126\/science.abb2507","article-title":"Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation","volume":"367","author":"Wrapp","year":"2020","journal-title":"Science"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1126\/science.abb7269","article-title":"A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV","volume":"368","author":"Yuan","year":"2020","journal-title":"Science"},{"key":"ref_21","first-page":"107774","article-title":"Structural and biochemical characterization of nsp12-nsp7-nsp8 core polymerase complex from COVID-19 virus","volume":"31","author":"Peng","year":"2020","journal-title":"Microbiology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e86","DOI":"10.3346\/jkms.2020.35.e86","article-title":"Viral Load Kinetics of SARS-CoV-2 Infection in First Two Patients in Korea","volume":"35","author":"Kim","year":"2020","journal-title":"J. Korean Med. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1126\/science.abb3405","article-title":"Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved \u03b1-ketoamide inhibitors","volume":"368","author":"Zhang","year":"2020","journal-title":"Science"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.apsb.2020.02.008","article-title":"Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods","volume":"10","author":"Wu","year":"2020","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Wang, K., Chen, W., Zhou, Y.-S., Lian, J.-Q., Zhang, Z., Du, P., Gong, L., Zhang, Y., Cui, H.-Y., and Geng, J.-J. (2020). SARS-CoV-2 invades host cells via a novel route: CD147-spike protein. Microbiology.","DOI":"10.1101\/2020.03.14.988345"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.virol.2004.11.038","article-title":"Programmed ribosomal frameshifting in decoding the SARS-CoV genome","volume":"332","author":"Baranov","year":"2005","journal-title":"Virology"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Knoops, K., Kikkert, M., van den Worm, S.H.E., Zevenhoven-Dobbe, J.C., van der Meer, Y., Koster, A.J., Mommaas, A.M., and Snijder, E.J. (2008). SARS-Coronavirus Replication Is Supported by a Reticulovesicular Network of Modified Endoplasmic Reticulum. PLOS Biol., 6.","DOI":"10.1371\/journal.pbio.0060226"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Ogando, N.S., Dalebout, T.J., Zevenhoven-Dobbe, J.C., Limpens, R.W., van der Meer, Y., Caly, L., Druce, J., de Vries, J.J.C., Kikkert, M., and B\u00e1rcena, M. (2020). SARS-coronavirus-2 replication in Vero E6 cells: Replication kinetics, rapid adaptation and cytopathology. Microbiology.","DOI":"10.1101\/2020.04.20.049924"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"5626","DOI":"10.1073\/pnas.86.14.5626","article-title":"Coronavirus subgenomic minus-strand RNAs and the potential for mRNA replicons","volume":"86","author":"Sethna","year":"1989","journal-title":"Nat. Acad. Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0065-3527(06)66005-3","article-title":"The Molecular Biology of Coronaviruses","volume":"Volume 66","author":"Masters","year":"2006","journal-title":"Advances in Virus Research"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"7885","DOI":"10.1128\/JVI.72.10.7885-7894.1998","article-title":"Analysis of Constructed E Gene Mutants of Mouse Hepatitis Virus Confirms a Pivotal Role for E Protein in Coronavirus Assembly","volume":"72","author":"Fischer","year":"1998","journal-title":"J. Virol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e14","DOI":"10.1016\/S2666-5247(20)30004-5","article-title":"Comparative tropism, replication kinetics, and cell damage profiling of SARS-CoV-2 and SARS-CoV with implications for clinical manifestations, transmissibility, and laboratory studies of COVID-19: An observational study","volume":"1","author":"Chu","year":"2020","journal-title":"Lancet Microbe"},{"key":"ref_33","unstructured":"Schifanella, L., Anderson, J.L., Galli, M., Corbellino, M., Lai, A., Wieking, G., Grzywacz, B., Klatt, N.R., Haase, A.T., and Schacker, T.W. (2020). Massive viral replication and cytopathic effects in early COVID-19 pneumonia. arXiv."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/S0140-6736(20)30607-3","article-title":"First known person-to-person transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the USA","volume":"395","author":"Ghinai","year":"2020","journal-title":"Lancet"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/jmv.25749","article-title":"The transmission and diagnosis of 2019 novel coronavirus infection disease (COVID-19): A Chinese perspective","volume":"92","author":"Han","year":"2020","journal-title":"J. Med. Virol."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Chan, J.F.-W., Zhang, A.J., Yuan, S., Poon, V.K.-M., Chan, C.C.-S., Lee, A.C.-Y., Chan, W.-M., Fan, Z., Tsoi, H.-W., and Wen, L. (2020). Simulation of the clinical and pathological manifestations of Coronavirus Disease 2019 (COVID-19) in golden Syrian hamster model: Implications for disease pathogenesis and transmissibility. Clin. Infect. Dis.","DOI":"10.1093\/cid\/ciaa325"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S2468-1253(20)30048-0","article-title":"Enteric involvement of coronaviruses: Is faecal\u2013oral transmission of SARS-CoV-2 possible?","volume":"5","author":"Yeo","year":"2020","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Gu, J., Han, B., and Wang, J. (2020). COVID-19: Gastrointestinal Manifestations and Potential Fecal\u2013Oral Transmission. Gastroenterology.","DOI":"10.1053\/j.gastro.2020.02.054"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Napoli, P.E., Nioi, M., d\u2019Aloja, E., and Fossarello, M. (2020). The Ocular Surface and the Coronavirus Disease 2019: Does a Dual \u2018Ocular Route\u2019 Exist?. J. Clin. Med., 9.","DOI":"10.3390\/jcm9051269"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Zou, X., Chen, K., Zou, J., Han, P., Hao, J., and Han, Z. (2020). Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection. Front. Med.","DOI":"10.1007\/s11684-020-0754-0"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Muus, C., Luecken, M.D., Eraslan, G., Waghray, A., Heimberg, G., Sikkema, L., Kobayashi, Y., Vaishnav, E.D., Subramanian, A., and Smilie, C. (2020). Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells. Bioinformatics.","DOI":"10.1101\/2020.04.19.049254"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/s41591-020-0868-6","article-title":"SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes","volume":"26","author":"Sungnak","year":"2020","journal-title":"Nat. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/nm1267","article-title":"A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus\u2013induced lung injury","volume":"11","author":"Kuba","year":"2005","journal-title":"Nat. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nature03712","article-title":"Angiotensin-converting enzyme 2 protects from severe acute lung failure","volume":"436","author":"Imai","year":"2005","journal-title":"Nature"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"30113","DOI":"10.1074\/jbc.M505111200","article-title":"Tumor Necrosis Factor-\u03b1 Convertase (ADAM17) Mediates Regulated Ectodomain Shedding of the Severe-acute Respiratory Syndrome-Coronavirus (SARS-CoV) Receptor, Angiotensin-converting Enzyme-2 (ACE2)","volume":"280","author":"Lambert","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"7809","DOI":"10.1073\/pnas.0711241105","article-title":"Modulation of TNF- -converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF- production and facilitates viral entry","volume":"105","author":"Haga","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1128\/JVI.01248-09","article-title":"Differential Downregulation of ACE2 by the Spike Proteins of Severe Acute Respiratory Syndrome Coronavirus and Human Coronavirus NL63","volume":"84","author":"Glowacka","year":"2010","journal-title":"J. Virol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"L84","DOI":"10.1152\/ajplung.00071.2009","article-title":"Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia","volume":"297","author":"Jia","year":"2009","journal-title":"Am. J. Physiol.-Lung Cell. Mol. Physiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1016\/S0002-9440(10)64130-2","article-title":"Systemic Infusion of Angiotensin II into Normal Rats Activates Nuclear Factor-\u03baB and AP-1 in the Kidney: Role of AT1 and AT2 Receptors","volume":"158","author":"Lorenzo","year":"2001","journal-title":"Am. J. Pathol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1046\/j.1523-1755.2002.00365.x","article-title":"Angiotensin II activates nuclear transcription factor-\u03baB through AT1 and AT2 receptors11See Editorial by Luft, p. 2272","volume":"61","author":"Wolf","year":"2002","journal-title":"Kidney Int."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s11906-003-0014-0","article-title":"Molecular mechanisms of angiotensin II-induced vascular injury","volume":"5","author":"Ruperez","year":"2003","journal-title":"Curr. Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1161\/CIRCRESAHA.116.310509","article-title":"Clinical Relevance and Role of Neuronal AT1 Receptors in ADAM17-Mediated ACE2 Shedding in Neurogenic Hypertension","volume":"121","author":"Xu","year":"2017","journal-title":"Circ. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1128\/JVI.02202-13","article-title":"TMPRSS2 and ADAM17 Cleave ACE2 Differentially and Only Proteolysis by TMPRSS2 Augments Entry Driven by the Severe Acute Respiratory Syndrome Coronavirus Spike Protein","volume":"88","author":"Heurich","year":"2014","journal-title":"J. Virol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.virusres.2008.03.004","article-title":"Endocytosis of the receptor-binding domain of SARS-CoV spike protein together with virus receptor ACE2","volume":"136","author":"Wang","year":"2008","journal-title":"Virus Res."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Ziegler, C.G.K., Allon, S.J., Nyquist, S.K., Mbano, I.M., Miao, V.N., Tzouanas, C.N., Cao, Y., Yousif, A.S., Bals, J., and Hauser, B.M. (2020). SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues. Cell.","DOI":"10.1016\/j.cell.2020.04.035"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"12029","DOI":"10.1128\/JVI.00315-07","article-title":"Specific Asparagine-Linked Glycosylation Sites Are Critical for DC-SIGN- and L-SIGN-Mediated Severe Acute Respiratory Syndrome Coronavirus Entry","volume":"81","author":"Han","year":"2007","journal-title":"J. Virol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"15748","DOI":"10.1073\/pnas.0403812101","article-title":"CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus","volume":"101","author":"Jeffers","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"5642","DOI":"10.1128\/JVI.78.11.5642-5650.2004","article-title":"pH-Dependent Entry of Severe Acute Respiratory Syndrome Coronavirus Is Mediated by the Spike Glycoprotein and Enhanced by Dendritic Cell Transfer through DC-SIGN","volume":"78","author":"Yang","year":"2004","journal-title":"J. Virol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1086\/427811","article-title":"Function of HAb18G\/CD147 in Invasion of Host Cells by Severe Acute Respiratory Syndrome Coronavirus","volume":"191","author":"Chen","year":"2005","journal-title":"J. Infect. Dis."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"6360","DOI":"10.1073\/pnas.111583198","article-title":"CD147 facilitates HIV-1 infection by interacting with virus-associated cyclophilin A","volume":"98","author":"Pushkarsky","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"4183","DOI":"10.1128\/JVI.02168-09","article-title":"CD147\/EMMPRIN Acts as a Functional Entry Receptor for Measles Virus on Epithelial Cells","volume":"84","author":"Watanabe","year":"2010","journal-title":"J. Virol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"17411","DOI":"10.3390\/ijms151017411","article-title":"The Biological Function and Clinical Utilization of CD147 in Human Diseases: A Review of the Current Scientific Literature","volume":"15","author":"Xiong","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/j.1365-2249.2010.04115.x","article-title":"Cyclophilin\u2013CD147 interactions: A new target for anti-inflammatory therapeutics","volume":"160","author":"Yurchenko","year":"2010","journal-title":"Clin. Exp. Immunol."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Shilts, J., and Wright, G.J. (2020). No evidence for basigin\/CD147 as a direct SARS-CoV-2 spike binding receptor. bioRxiv.","DOI":"10.1101\/2020.07.25.221036"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Softic, L., Brillet, R., Berry, F., Ahnou, N., Nevers, Q., Morin-Dewaele, M., Hamadat, S., Bruscella, P., Fourati, S., and Pawlotsky, J.-M. (2020). Inhibition of SARS-CoV-2 Infection by the Cyclophilin Inhibitor Alisporivir (Debio 025). Antimicrob. Agents Chemother., 64.","DOI":"10.1128\/AAC.00876-20"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12929-016-0234-7","article-title":"Surface vimentin is critical for the cell entry of SARS-CoV","volume":"23","author":"Yu","year":"2016","journal-title":"J. Biomed. Sci."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Daly, J.L., Simonetti, B., Ant\u00f3n-Pl\u00e1garo, C., Williamson, M.K., Shoemark, D.K., Sim\u00f3n-Gracia, L., Klein, K., Bauer, M., Hollandi, R., and Greber, U.F. (2020). Neuropilin-1 is a host factor for SARS-CoV-2 infection. bioRxiv.","DOI":"10.1101\/2020.06.05.134114"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Cantuti-Castelvetri, L., Ojha, R., Pedro, L.D., Djannatian, M., Franz, J., Kuivanen, S., Kallio, K., Kaya, T., Anastasina, M., and Smura, T. (2020). Neuropilin-1 facilitates SARS-CoV-2 cell entry and provides a possible pathway into the central nervous system. bioRxiv.","DOI":"10.1101\/2020.06.07.137802"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Garc\u00eda, S.R., Deprez, M., Lebrigand, K., Cavard, A., Paquet, A., Arguel, M.-J., Magnone, V., Truchi, M., Caballero, I., and Leroy, S. (2019). Novel dynamics of human mucociliary differentiation revealed by single-cell RNA sequencing of nasal epithelial cultures. Development, 146.","DOI":"10.1242\/dev.177428"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1056\/NEJMc2001737","article-title":"SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients","volume":"382","author":"Zou","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Lechien, J.R., Chiesa-Estomba, C.M., De Siati, D.R., Horoi, M., Le Bon, S.D., Rodriguez, A., Dequanter, D., Blecic, S., El Afia, F., and Distinguin, L. (2020). Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): A multicenter European study. Eur. Arch. Otorhinolaryngol.","DOI":"10.1007\/s00405-020-05965-1"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Di Carlo, D.T., Montemurro, N., Petrella, G., Siciliano, G., Ceravolo, R., and Perrini, P. (2020). Exploring the clinical association between neurological symptoms and COVID-19 pandemic outbreak: A systematic review of current literature. J. Neurol.","DOI":"10.21203\/rs.3.rs-27152\/v1"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Rocke, J., Hopkins, C., Philpott, C., and Kumar, N. (2020). Is loss of sense of smell a diagnostic marker in COVID-19: A Systematic Review and Meta-analysis. Clin. Otolaryngol.","DOI":"10.1111\/coa.13620"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Butowt, R., and Bilinska, K. (2020). SARS-CoV-2: Olfaction, Brain Infection, and the Urgent Need for Clinical Samples Allowing Earlier Virus Detection. ACS Chem. Neurosci.","DOI":"10.1021\/acschemneuro.0c00172"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Brann, D.H., Tsukahara, T., Weinreb, C., Lipovsek, M., den Berge, K.V., Gong, B., Chance, R., Macaulay, I.C., Chou, H.-J., and Fletcher, R.B. (2020). Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia. Sci. Adv., 6.","DOI":"10.1126\/sciadv.abc5801"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Guan, W., Ni, Z., Hu, Y., Liang, W., Ou, C., He, J., Liu, L., Shan, H., Lei, C., and Hui, D.S.C. (2020). Clinical Characteristics of Coronavirus Disease 2019 in China. N. Engl. J. Med.","DOI":"10.1056\/NEJMoa2002032"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Lai, C.-C., Liu, Y.H., Wang, C.-Y., Wang, Y.-H., Hsueh, S.-C., Yen, M.-Y., Ko, W.-C., and Hsueh, P.-R. (2020). Asymptomatic carrier state, acute respiratory disease, and pneumonia due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): Facts and myths. J. Microbiol. Immunol. Infect.","DOI":"10.1016\/j.jmii.2020.02.012"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1001\/jama.2020.1585","article-title":"Clinical Characteristics of 138 Hospitalized Patients with 2019 Novel Coronavirus\u2013Infected Pneumonia in Wuhan, China","volume":"323","author":"Wang","year":"2020","journal-title":"JAMA"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1164\/rccm.202003-0817LE","article-title":"COVID-19 Does Not Lead to a \u201cTypical\u201d Acute Respiratory Distress Syndrome","volume":"201","author":"Gattinoni","year":"2020","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1056\/NEJMoa2015432","article-title":"Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19","volume":"383","author":"Ackermann","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Tian, S., Xiong, Y., Liu, H., Niu, L., Guo, J., Liao, M., and Xiao, S.-Y. (2020). Pathological study of the 2019 novel coronavirus disease (COVID-19) through postmortem core biopsies. Mod. Pathol., 1\u20138.","DOI":"10.20944\/preprints202003.0311.v1"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/S2213-2600(20)30076-X","article-title":"Pathological findings of COVID-19 associated with acute respiratory distress syndrome","volume":"8","author":"Xu","year":"2020","journal-title":"Lancet Respir. Med."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Copin, M.-C., Parmentier, E., Duburcq, T., Poissy, J., Mathieu, D., Caplan, M., Cousin, N., Durand, A., Goutay, J., and Kalioubie, A.E. (2020). Time to consider histologic pattern of lung injury to treat critically ill patients with COVID-19 infection. Intensive Care Med.","DOI":"10.1007\/s00134-020-06057-8"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Barton, L.M., Duval, E.J., Stroberg, E., Ghosh, S., and Mukhopadhyay, S. (2020). COVID-19 Autopsies, Oklahoma, USA. Am. J. Clin. Pathol.","DOI":"10.1093\/ajcp\/aqaa062"},{"key":"ref_85","first-page":"E009","article-title":"A pathological report of three COVID-19 cases by minimally invasive autopsies","volume":"49","author":"Yao","year":"2020","journal-title":"Chin. J. Pathol."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Ingraham, N.E., Barakat, A.G., Reilkoff, R., Bezdicek, T., Schacker, T., Chipman, J.G., Tignanelli, C.J., and Puskarich, M.A. (2020). Understanding the Renin-Angiotensin-Aldosterone-SARS-CoV-Axis: A Comprehensive Review. Eur. Respir. J.","DOI":"10.1183\/13993003.00912-2020"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Wong, S.H., Lui, R.N., and Sung, J.J. (2020). Covid-19 and the digestive system. J. Gastroenterol. Hepatol.","DOI":"10.1111\/jgh.15047"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Xiao, F., Tang, M., Zheng, X., Liu, Y., Li, X., and Shan, H. (2020). Evidence for Gastrointestinal Infection of SARS-CoV-2. Gastroenterology.","DOI":"10.1053\/j.gastro.2020.02.055"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.ijid.2020.04.063","article-title":"Persistence of intestinal SARS-CoV-2 infection in patients with COVID-19 leads to re-admission after pneumonia resolved","volume":"95","author":"Wang","year":"2020","journal-title":"Int. J. Infect. Dis."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1111\/his.13379","article-title":"Histopathology of Middle East respiratory syndrome coronovirus (MERS-CoV) infection\u2014Clinicopathological and ultrastructural study","volume":"72","author":"Alsaad","year":"2018","journal-title":"Histopathology"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Zhao, B., Ni, C., Gao, R., Wang, Y., Yang, L., Wei, J., Lv, T., Liang, J., Zhang, Q., and Xu, W. (2020). Recapitulation of SARS-CoV-2 Infection and Cholangiocyte Damage with Human Liver Organoids. Cell Biol.","DOI":"10.1101\/2020.03.16.990317"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Nishiga, M., Wang, D.W., Han, Y., Lewis, D.B., and Wu, J.C. (2020). COVID-19 and cardiovascular disease: From basic mechanisms to clinical perspectives. Nat. Rev. Cardiol., 1\u201316.","DOI":"10.1038\/s41569-020-0413-9"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1001\/jamacardio.2020.1096","article-title":"Cardiac Involvement in a Patient with Coronavirus Disease 2019 (COVID-19)","volume":"5","author":"Inciardi","year":"2020","journal-title":"JAMA Cardiol."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Puntmann, V.O., Carerj, M.L., Wieters, I., Fahim, M., Arendt, C., Hoffmann, J., Shchendrygina, A., Escher, F., Vasa-Nicotera, M., and Zeiher, A.M. (2020). Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19). JAMA Cardiol.","DOI":"10.1001\/jamacardio.2020.3557"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1111\/j.1365-2362.2009.02153.x","article-title":"SARS-coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS","volume":"39","author":"Oudit","year":"2009","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"78","DOI":"10.5144\/0256-4947.2016.78","article-title":"Acute myocarditis associated with novel Middle East respiratory syndrome coronavirus","volume":"36","author":"Alhogbani","year":"2016","journal-title":"Annal. Saudi Med."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Lindner, D., Fitzek, A., Br\u00e4uninger, H., Aleshcheva, G., Edler, C., Meissner, K., Scherschel, K., Kirchhof, P., Escher, F., and Schultheiss, H.-P. (2020). Association of Cardiac Infection with SARS-CoV-2 in Confirmed COVID-19 Autopsy Cases. JAMA Cardiol.","DOI":"10.1001\/jamacardio.2020.3551"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Bojkova, D., Wagner, J.U.G., Shumliakivska, M., Aslan, G.S., Saleem, U., Hansen, A., Lux\u00e1n, G., G\u00fcnther, S., Pham, M.D., and Krishnan, J. (2020). SARS-CoV-2 infects and induces cytotoxic effects in human cardiomyocytes. bioRxiv.","DOI":"10.1101\/2020.06.01.127605"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/S0140-6736(20)30937-5","article-title":"Endothelial cell infection and endotheliitis in COVID-19","volume":"395","author":"Varga","year":"2020","journal-title":"Lancet"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/s41577-020-0343-0","article-title":"COVID-19: The vasculature unleashed","volume":"20","author":"Teuwen","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"e575","DOI":"10.1016\/S2352-3026(20)30216-7","article-title":"Endotheliopathy in COVID-19-associated coagulopathy: Evidence from a single-centre, cross-sectional study","volume":"7","author":"Goshua","year":"2020","journal-title":"Lancet Haematol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"4030","DOI":"10.4049\/jimmunol.173.6.4030","article-title":"Mechanisms of Host Defense following Severe Acute Respiratory Syndrome-Coronavirus (SARS-CoV) Pulmonary Infection of Mice","volume":"173","author":"Glass","year":"2004","journal-title":"J. Immunol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1093\/infdis\/jiv499","article-title":"Middle East Respiratory Syndrome Coronavirus Causes Multiple Organ Damage and Lethal Disease in Mice Transgenic for Human Dipeptidyl Peptidase 4","volume":"213","author":"Li","year":"2016","journal-title":"J. Infect. Dis."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/path.1560","article-title":"Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: Implications for pathogenesis and virus transmission pathways","volume":"203","author":"Ding","year":"2004","journal-title":"J. Pathol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1086\/444461","article-title":"Detection of Severe Acute Respiratory Syndrome Coronavirus in the Brain: Potential Role of the Chemokine Mig in Pathogenesis","volume":"41","author":"Xu","year":"2005","journal-title":"Clin. Infect. Dis."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/jmv.25728","article-title":"The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients","volume":"92","author":"Li","year":"2020","journal-title":"J. Med. Virol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1001\/jamaneurol.2020.1127","article-title":"Neurologic Manifestations of Hospitalized Patients with Coronavirus Disease 2019 in Wuhan, China","volume":"77","author":"Mao","year":"2020","journal-title":"JAMA Neurol."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Yachou, Y., El Idrissi, A., Belapasov, V., and Ait Benali, S. (2020). Neuroinvasion, neurotropic, and neuroinflammatory events of SARS-CoV-2: Understanding the neurological manifestations in COVID-19 patients. J. Neurol. Sci.","DOI":"10.1007\/s10072-020-04575-3"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"116832","DOI":"10.1016\/j.jns.2020.116832","article-title":"Central nervous system manifestations of COVID-19: A systematic review","volume":"413","author":"Simani","year":"2020","journal-title":"J. Neurol. Sci."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.jocn.2020.04.062","article-title":"Guillain Barre syndrome associated with COVID-19 infection: A case report","volume":"76","author":"Sedaghat","year":"2020","journal-title":"J. Clin. Neurosci."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S1474-4422(20)30109-5","article-title":"Guillain-Barr\u00e9 syndrome associated with SARS-CoV-2 infection: Causality or coincidence?","volume":"19","author":"Zhao","year":"2020","journal-title":"Lancet Neurol."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Diao, B., Wang, C., Wang, R., Feng, Z., Tan, Y., Wang, H., Wang, C., Liu, L., Liu, Y., and Liu, Y. (2020). Human Kidney is a Target for Novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection. Infect. Dis.","DOI":"10.1101\/2020.03.04.20031120"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1186\/s13054-020-02872-z","article-title":"Acute kidney injury in SARS-CoV-2 infected patients","volume":"24","author":"Fanelli","year":"2020","journal-title":"Crit. Care"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.kint.2020.05.006","article-title":"Acute kidney injury in patients hospitalized with COVID-19","volume":"98","author":"Hirsch","year":"2020","journal-title":"Kidney Int."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Qian, J.-Y., Wang, B., and Liu, B.-C. (2020). Acute Kidney Injury in the 2019 Novel Coronavirus Disease. Kidney Dis., 1\u20136.","DOI":"10.1159\/000509086"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1016\/S0140-6736(20)31189-2","article-title":"Epidemiology, clinical course, and outcomes of critically ill adults with COVID-19 in New York City: A prospective cohort study","volume":"395","author":"Cummings","year":"2020","journal-title":"Lancet"},{"key":"ref_117","unstructured":"Chen, Y., Feng, Z., Diao, B., Wang, R., Wang, G., Wang, C., Tan, Y., Liu, L., Wang, C., and Liu, Y. (2020). The Novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Directly Decimates Human Spleens and Lymph Nodes. Infect. Dis."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Fathi, N., and Rezaei, N. (2020). Lymphopenia in COVID-19: Therapeutic opportunities. Cell Biol. Int.","DOI":"10.1002\/cbin.11403"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"e519","DOI":"10.1038\/bcj.2016.126","article-title":"IFN-\u03b2 induces greater antiproliferative and proapoptotic effects and increased p53 signaling compared with IFN-\u03b1 in PBMCs of Adult T-cell Leukemia\/Lymphoma patients","volume":"7","author":"Dierckx","year":"2017","journal-title":"Blood Cancer J."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Simonnet, A., Chetboun, M., Poissy, J., Raverdy, V., Noulette, J., Duhamel, A., Labreuche, J., Mathieu, D., Pattou, F., and Jourdain, M. (2020). High prevalence of obesity in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) requiring invasive mechanical ventilation. Obesity.","DOI":"10.1002\/oby.22831"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"798","DOI":"10.4065\/mcp.2010.0166","article-title":"Hospitalized Patients with 2009 H1N1 Influenza Infection: The Mayo Clinic Experience","volume":"85","author":"Venkata","year":"2010","journal-title":"Mayo Clin. Proc."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1093\/infdis\/jiy370","article-title":"Obesity Increases the Duration of Influenza A Virus Shedding in Adults","volume":"218","author":"Maier","year":"2018","journal-title":"Infect. Dis."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Kruglikov, I.L., and Scherer, P.E. (2020). The role of adipocytes and adipocyte-like cells in the severity of COVID-19 infections. Obesity.","DOI":"10.1002\/oby.22856"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1093\/cvr\/cvx108","article-title":"The role of infiltrating immune cells in dysfunctional adipose tissue","volume":"113","author":"Guzik","year":"2017","journal-title":"Cardiovasc. Res."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Ryan, P.M., and Caplice, N.M. (2020). Is Adipose Tissue a Reservoir for Viral Spread, Immune Activation and Cytokine Amplification in COVID-19. Obesity.","DOI":"10.1002\/oby.22843"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet"},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Lechien, J.R., Chiesa-Estomba, C.M., Place, S., Laethem, Y.V., Cabaraux, P., Mat, Q., Huet, K., Plzak, J., Horoi, M., and Hans, S. (2020). Clinical and Epidemiological Characteristics of 1,420 European Patients with mild-to-moderate Coronavirus Disease 2019. J. Intern. Med.","DOI":"10.1111\/joim.13089"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s40249-020-00662-x","article-title":"Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues","volume":"9","author":"Li","year":"2020","journal-title":"Infect. Dis. Poverty"},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Severin, R., Arena, R., Lavie, C.J., Bond, S., and Phillips, S.A. (2020). Respiratory Muscle Performance Screening for Infectious Disease Management Following COVID-19: A Highly Pressurized Situation. Am. J. Med.","DOI":"10.1016\/j.amjmed.2020.04.003"},{"key":"ref_130","unstructured":"Prompetchara, E., Chutitorn, K., and Tanapat, T. (2020). Immune responses in COVID-19 and potential vaccines: Lessons learned from SARS and MERS epidemic. Asian Pac. J. Allergy Immunol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s00281-017-0629-x","article-title":"Pathogenic human coronavirus infections: Causes and consequences of cytokine storm and immunopathology","volume":"39","author":"Channappanavar","year":"2017","journal-title":"Semin. Immunopathol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nri1732","article-title":"Immunopathogenesis of coronavirus infections: Implications for SARS","volume":"5","author":"Dandekar","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nrmicro.2016.81","article-title":"SARS and MERS: Recent insights into emerging coronaviruses","volume":"14","author":"Falzarano","year":"2016","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/jmv.25685","article-title":"Coronavirus infections and immune responses","volume":"92","author":"Li","year":"2020","journal-title":"J. Med. Virol."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Hadjadj, J., Yatim, N., Barnabei, L., Corneau, A., Boussier, J., Pere, H., Charbit, B., Bondet, V., Chenevier-Gobeaux, C., and Breillat, P. (2020). Impaired type I interferon activity and exacerbated inflammatory responses in severe Covid-19 patients. Infect. Dis.","DOI":"10.1101\/2020.04.19.20068015"},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Sa Ribero, M., Jouvenet, N., Dreux, M., and Nisole, S. (2020). Interplay between SARS-CoV-2 and the type I interferon response. PLoS Pathog., 16.","DOI":"10.1371\/journal.ppat.1008737"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.virol.2014.02.018","article-title":"Productive replication of Middle East respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response","volume":"454\u2013455","author":"Chu","year":"2014","journal-title":"Virology"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"108427","DOI":"10.1016\/j.clim.2020.108427","article-title":"COVID-19 pathophysiology: A review","volume":"215","author":"Yuki","year":"2020","journal-title":"Clin. Immunol."},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Wang, F., Hou, H., Luo, Y., Tang, G., Wu, S., Huang, M., Liu, W., Zhu, Y., Lin, Q., and Mao, L. (2020). The laboratory tests and host immunity of COVID-19 patients with different severity of illness. JCI Insight.","DOI":"10.1172\/jci.insight.137799"},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Sanchez-Cerrillo, I., Landete, P., Aldave, B., Sanchez-Alonso, S., Sanchez-Azofra, A., Marcos-Jimenez, A., Avalos, E., Alcaraz-Serna, A., de los Santos, I., and Mateu-Albero, T. (2020). Differential Redistribution of Activated Monocyte and Dendritic Cell Subsets to the Lung Associates with Severity of COVID-19. MedRxiv.","DOI":"10.1101\/2020.05.13.20100925"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"118102","DOI":"10.1016\/j.lfs.2020.118102","article-title":"Contribution of monocytes and macrophages to the local tissue inflammation and cytokine storm in COVID-19: Lessons from SARS and MERS, and potential therapeutic interventions","volume":"257","author":"Jafarzadeh","year":"2020","journal-title":"Life Sci."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Ye, Q., Wang, B., and Mao, J. (2020). The pathogenesis and treatment of the \u2018Cytokine Storm\u2019 in COVID-19. J. Infect.","DOI":"10.1016\/j.jinf.2020.03.037"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.chom.2016.01.007","article-title":"Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice","volume":"19","author":"Channappanavar","year":"2016","journal-title":"Cell Host Microbe"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1038\/s41591-020-0901-9","article-title":"Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19","volume":"26","author":"Liao","year":"2020","journal-title":"Nat. Med."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Fu, Y., Cheng, Y., and Wu, Y. (2020). Understanding SARS-CoV-2-Mediated Inflammatory Responses: From Mechanisms to Potential Therapeutic Tools. Virol. Sin.","DOI":"10.1007\/s12250-020-00207-4"},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Giamarellos-Bourboulis, E.J., Netea, M.G., Rovina, N., Akinosoglou, K., Antoniadou, A., Antonakos, N., Damoraki, G., Gkavogianni, T., Adami, M.-E., and Katsaounou, P. (2020). Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure. Cell Host Microbe.","DOI":"10.1016\/j.chom.2020.04.009"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/path.5221","article-title":"Neutrophils in the initiation and resolution of acute pulmonary inflammation: Understanding biological function and therapeutic potential","volume":"247","author":"Potey","year":"2019","journal-title":"J. Pathol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.chest.2019.06.012","article-title":"The Emerging Role of Neutrophil Extracellular Traps in Respiratory Disease","volume":"156","author":"Twaddell","year":"2019","journal-title":"CHEST"},{"key":"ref_149","first-page":"212","article-title":"Immunothrombosis in Acute Respiratory Distress Syndrome: Cross Talks between Inflammation and Coagulation","volume":"93","author":"Frantzeskaki","year":"2017","journal-title":"RES"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-019-09801-x","article-title":"Adenosine receptor agonism protects against NETosis and thrombosis in antiphospholipid syndrome","volume":"10","author":"Ali","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/JLB.4MIR1118-425R","article-title":"New strategies for treatment of infectious sepsis","volume":"106","author":"Ward","year":"2019","journal-title":"J. Leukoc. Biol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1099\/vir.0.061986-0","article-title":"Neutrophils are needed for an effective immune response against pulmonary rat coronavirus infection, but also contribute to pathology","volume":"95","author":"Haick","year":"2014","journal-title":"J. Gen. Virol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1038\/s41591-020-0944-y","article-title":"A single-cell atlas of the peripheral immune response in patients with severe COVID-19","volume":"26","author":"Wilk","year":"2020","journal-title":"Nat. Med."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41577-020-0308-3","article-title":"COVID-19: Immunopathology and its implications for therapy","volume":"20","author":"Cao","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Barnes, B.J., Adrover, J.M., Baxter-Stoltzfus, A., Borczuk, A., Cools-Lartigue, J., Crawford, J.M., Da\u00dfler-Plenker, J., Guerci, P., Huynh, C., and Knight, J.S. (2020). Targeting potential drivers of COVID-19: Neutrophil extracellular traps. J. Exp. Med., 217.","DOI":"10.1084\/jem.20200652"},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Zuo, Y., Yalavarthi, S., Shi, H., Gockman, K., Zuo, M., Madison, J.A., Blair, C., Weber, A., Barnes, B.J., and Egeblad, M. (2020). Neutrophil extracellular traps (NETs) as markers of disease severity in COVID-19. Infect. Dis.","DOI":"10.1101\/2020.04.09.20059626"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"e01753-18","DOI":"10.1128\/mBio.01753-18","article-title":"Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis","volume":"9","author":"Gralinski","year":"2018","journal-title":"mBio"},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Magro, C., Mulvey, J.J., Berlin, D., Nuovo, G., Salvatore, S., Harp, J., Baxter-Stoltzfus, A., and Laurence, J. (2020). Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases. Transl. Res.","DOI":"10.1016\/j.trsl.2020.04.007"},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Lal, S.K. (2010). Host Immune Responses to SARS Coronavirus in Humans. Molecular Biology of the SARS-Coronavirus, Springer.","DOI":"10.1007\/978-3-642-03683-5"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"104361","DOI":"10.1016\/j.jcv.2020.104361","article-title":"The clinical course and its correlated immune status in COVID-19 pneumonia","volume":"127","author":"He","year":"2020","journal-title":"J. Clin. Virol."},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Zheng, M., Gao, Y., Wang, G., Song, G., Liu, S., Sun, D., Xu, Y., and Tian, Z. (2020). Functional exhaustion of antiviral lymphocytes in COVID-19 patients. Cell. Mol. Immunol.","DOI":"10.1038\/s41423-020-0402-2"},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Wang, F., Nie, J., Wang, H., Zhao, Q., Xiong, Y., Deng, L., Song, S., Ma, Z., Mo, P., and Zhang, Y. (2020). Characteristics of Peripheral Lymphocyte Subset Alteration in COVID-19 Pneumonia. J. Infect. Dis.","DOI":"10.1093\/infdis\/jiaa150"},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Rokni, M., Ghasemi, V., and Tavakoli, Z. (2020). Immune responses and pathogenesis of SARS-CoV-2 during an outbreak in Iran: Comparison with SARS and MERS. Rev. Med. Virol.","DOI":"10.1002\/rmv.2107"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"10464","DOI":"10.1128\/JVI.05039-11","article-title":"Engineering T Cells Specific for a Dominant Severe Acute Respiratory Syndrome Coronavirus CD8 T Cell Epitope","volume":"85","author":"Oh","year":"2011","journal-title":"J. Virol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/s12026-014-8534-z","article-title":"T cell-mediated immune response to respiratory coronaviruses","volume":"59","author":"Channappanavar","year":"2014","journal-title":"Immunol. Res."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1007\/s00705-009-0409-6","article-title":"Characterization of SARS-CoV-specific memory T cells from recovered individuals 4 years after infection","volume":"154","author":"Fan","year":"2009","journal-title":"Arch. Virol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.virol.2006.03.036","article-title":"Long-lived memory T lymphocyte responses against SARS coronavirus nucleocapsid protein in SARS-recovered patients","volume":"351","author":"Peng","year":"2006","journal-title":"Virology"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.clim.2006.05.002","article-title":"Long-lived effector\/central memory T-cell responses to severe acute respiratory syndrome coronavirus (SARS-CoV) S antigen in recovered SARS patients","volume":"120","author":"Yang","year":"2006","journal-title":"Clin. Immunol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.1099\/vir.0.82839-0","article-title":"Persistent memory CD4+ and CD8+ T-cell responses in recovered severe acute respiratory syndrome (SARS) patients to SARS coronavirus M antigen","volume":"88","author":"Yang","year":"2007","journal-title":"J. Gen. Virol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1038\/gt.2009.92","article-title":"Immune responses to T-cell epitopes of SARS CoV-N protein are enhanced by N immunization with a chimera of lysosome-associated membrane protein","volume":"16","author":"Yang","year":"2009","journal-title":"Gene Ther."},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Mateus, J., Grifoni, A., Tarke, A., Sidney, J., Ramirez, S.I., Dan, J.M., Burger, Z.C., Rawlings, S.A., Smith, D.M., and Phillips, E. (2020). Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans. Science.","DOI":"10.1126\/science.abd3871"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41577-020-0389-z","article-title":"Pre-existing immunity to SARS-CoV-2: The knowns and unknowns","volume":"20","author":"Sette","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"110049","DOI":"10.1016\/j.mehy.2020.110049","article-title":"Cross-immunity between respiratory coronaviruses may limit COVID-19 fatalities","volume":"144","author":"Yaqinuddin","year":"2020","journal-title":"Med. Hypotheses"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/j.cell.2020.05.015","article-title":"Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals","volume":"181","author":"Grifoni","year":"2020","journal-title":"Cell"},{"key":"ref_175","doi-asserted-by":"crossref","unstructured":"Weiskopf, D., Schmitz, K.S., Raadsen, M.P., Grifoni, A., Okba, N.M.A., Endeman, H., van den Akker, J.P.C., Molenkamp, R., Koopmans, M.P.G., and van Gorp, E.C.M. (2020). Phenotype of SARS-CoV-2-specific T-cells in COVID-19 patients with acute respiratory distress syndrome. medRxiv.","DOI":"10.1101\/2020.04.11.20062349"},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"Braun, J., Loyal, L., Frentsch, M., Wendisch, D., Georg, P., Kurth, F., Hippenstiel, S., Dingeldey, M., Kruse, B., and Fauchere, F. (2020). Presence of SARS-CoV-2 reactive T cells in COVID-19 patients and healthy donors. medRxiv.","DOI":"10.1101\/2020.04.17.20061440"},{"key":"ref_177","doi-asserted-by":"crossref","unstructured":"Meckiff, B.J., Ram\u00edrez-Su\u00e1stegui, C., Fajardo, V., Chee, S.J., Kusnadi, A., Simon, H., Grifoni, A., Pelosi, E., Weiskopf, D., and Sette, A. (2020). Single-cell transcriptomic analysis of SARS-CoV-2 reactive CD4+ T cells. bioRxiv.","DOI":"10.1101\/2020.06.12.148916"},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Bert, N.L., Tan, A.T., Kunasegaran, K., Tham, C.Y.L., Hafezi, M., Chia, A., Chng, M., Lin, M., Tan, N., and Linster, M. (2020). Different pattern of pre-existing SARS-COV-2 specific T cell immunity in SARS-recovered and uninfected individuals. bioRxiv.","DOI":"10.1101\/2020.05.26.115832"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1111\/j.1469-0691.2004.01009.x","article-title":"Chronological evolution of IgM, IgA, IgG and neutralisation antibodies after infection with SARS-associated coronavirus","volume":"10","author":"Hsueh","year":"2004","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1002\/jmv.25715","article-title":"Antibodies to coronaviruses are higher in older compared with younger adults and binding antibodies are more sensitive than neutralizing antibodies in identifying coronavirus-associated illnesses","volume":"92","author":"Gorse","year":"2020","journal-title":"J. Med. Virol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.3201\/eid1310.070576","article-title":"Duration of Antibody Responses after Severe Acute Respiratory Syndrome","volume":"13","author":"Wu","year":"2007","journal-title":"Emerg. Infect. Dis."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"7264","DOI":"10.4049\/jimmunol.0903490","article-title":"Lack of Peripheral Memory B Cell Responses in Recovered Patients with Severe Acute Respiratory Syndrome: A Six-Year Follow-Up Study","volume":"186","author":"Tang","year":"2011","journal-title":"J. Immunol."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1056\/NEJMc070348","article-title":"Disappearance of Antibodies to SARS-Associated Coronavirus after Recovery","volume":"357","author":"Cao","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Wang, B., Wang, L., Kong, X., Geng, J., Xiao, D., Ma, C., Jiang, X.-M., and Wang, P.-H. (2020). Long-term coexistence of SARS-CoV-2 with antibody response in COVID-19 patients. J. Med. Virol.","DOI":"10.1002\/jmv.25946"},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Zhang, B., Zhou, X., Zhu, C., Song, Y., Feng, F., Qiu, Y., Feng, J., Jia, Q., Song, Q., and Zhu, B. (2020). Immune Phenotyping Based on the Neutrophil-to-Lymphocyte Ratio and IgG Level Predicts Disease Severity and Outcome for Patients with COVID-19. Front. Mol. Biosci., 7.","DOI":"10.3389\/fmolb.2020.00157"},{"key":"ref_186","unstructured":"Dobi, A., Frumence, E., Rakoto, M.L., Lebeau, G., Vagner, D., Seteyen, A.-L.S., Giry, C., Septembre-Malaterre, A., Jaffar-Bandjee, M.-C., and Raffray, L. (2020). Serological surveys in Reunion Island of the first hospitalized patients revealed that long-lived immunoglobulin G antibodies specific against SARS-CoV2 virus are rapidly vanishing in severe cases. medRxiv."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S1473-3099(20)30196-1","article-title":"Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: An observational cohort study","volume":"20","author":"To","year":"2020","journal-title":"Lancet Infect. Dis."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41591-020-0965-6","article-title":"Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections","volume":"26","author":"Long","year":"2020","journal-title":"Nat. Med."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1080\/22221751.2020.1762515","article-title":"Kinetics of SARS-CoV-2 specific IgM and IgG responses in COVID-19 patients","volume":"9","author":"Sun","year":"2020","journal-title":"Emerg. Microbes Infect."},{"key":"ref_190","doi-asserted-by":"crossref","unstructured":"Huang, W., Berube, J., McNamara, M., Saksena, S., Hartman, M., Arshad, T., Bornheimer, S.J., and O\u2019Gorman, M. (2020). Lymphocyte Subset Counts in COVID-19 Patients: A Meta-Analysis. Cytom. Part A.","DOI":"10.1002\/cyto.a.24172"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.smim.2004.02.008","article-title":"Immunological memory in humans","volume":"16","author":"Crotty","year":"2004","journal-title":"Semin. Immunol."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S1074-7613(00)80541-5","article-title":"Humoral Immunity Due to Long-Lived Plasma Cells","volume":"8","author":"Slifka","year":"1998","journal-title":"Immunity"},{"key":"ref_193","doi-asserted-by":"crossref","unstructured":"Elsner, R.A., Hastey, C.J., Olsen, K.J., and Baumgarth, N. (2015). Suppression of Long-Lived Humoral Immunity Following Borrelia burgdorferi Infection. PLoS Pathog., 11.","DOI":"10.1371\/journal.ppat.1004976"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1038\/nri891","article-title":"Antibodies, viruses and vaccines","volume":"2","author":"Burton","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"ref_195","doi-asserted-by":"crossref","unstructured":"Kucharski, A.J., Lessler, J., Cummings, D.A.T., and Riley, S. (2018). Timescales of influenza A\/H3N2 antibody dynamics. PLoS Biol., 16.","DOI":"10.1371\/journal.pbio.2004974"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"7280","DOI":"10.1016\/j.vaccine.2019.09.066","article-title":"Long-term HPV-specific immune response after one versus two and three doses of bivalent HPV vaccination in Dutch girls","volume":"37","author":"Pasmans","year":"2019","journal-title":"Vaccine"},{"key":"ref_197","doi-asserted-by":"crossref","unstructured":"Ng, D.H.L., Skehel, J.J., Kassiotis, G., and Langhorne, J. (2014). Recovery of an Antiviral Antibody Response following Attrition Caused by Unrelated Infection. PLoS Pathog., 10.","DOI":"10.1371\/journal.ppat.1003843"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/cyto.a.22355","article-title":"Tracking plasma cell differentiation and survival","volume":"85","author":"Roth","year":"2014","journal-title":"Cytom. Part A"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.bbrc.2014.07.090","article-title":"Antibody-dependent SARS coronavirus infection is mediated by antibodies against spike proteins","volume":"451","author":"Wang","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/1743-422X-11-82","article-title":"Antibody-dependent infection of human macrophages by severe acute respiratory syndrome coronavirus","volume":"11","author":"Yip","year":"2014","journal-title":"Virology"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.micinf.2020.02.006","article-title":"Is COVID-19 receiving ADE from other coronaviruses?","volume":"22","author":"Tetro","year":"2020","journal-title":"Microbes Infect."},{"key":"ref_202","doi-asserted-by":"crossref","unstructured":"Sharma, A. (2020). It is too soon to attribute ADE to COVID-19. Microbes Infect.","DOI":"10.1016\/j.micinf.2020.03.005"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"102597","DOI":"10.1016\/j.autrev.2020.102597","article-title":"Covid-19 and autoimmunity","volume":"19","author":"Ehrenfeld","year":"2020","journal-title":"Autoimmun. Rev."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/s41584-020-0448-7","article-title":"Autoimmune and inflammatory diseases following COVID-19","volume":"16","author":"Galeotti","year":"2020","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_205","doi-asserted-by":"crossref","unstructured":"Xiao, M., Zhang, Y., Zhang, S., Qin, X., Xia, P., Cao, W., Jiang, W., Chen, H., Ding, X., and Zhao, H. (2020). Brief Report: Anti-phospholipid antibodies in critically ill patients with Coronavirus Disease 2019 (COVID-19). Arthritis Rheumatol.","DOI":"10.1002\/art.41425"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"e61","DOI":"10.1111\/bjh.16850","article-title":"COVID-19-associated immune thrombocytopenia","volume":"190","author":"Bomhof","year":"2020","journal-title":"Br. J. Haematol."},{"key":"ref_207","doi-asserted-by":"crossref","unstructured":"Zulfiqar, A.-A., Lorenzo-Villalba, N., Hassler, P., and Andr\u00e8s, E. (2020). Immune Thrombocytopenic Purpura in a Patient with Covid-19. N. Eng. J. Med.","DOI":"10.1056\/NEJMc2010472"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/bjh.16794","article-title":"Autoimmune haemolytic anaemia associated with COVID-19 infection","volume":"190","author":"Lazarian","year":"2020","journal-title":"Br. J. Haematol."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/bjh.16786","article-title":"Simultaneous onset of COVID-19 and autoimmune haemolytic anaemia","volume":"190","author":"Lopez","year":"2020","journal-title":"Br. Haematol."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s13365-020-00840-5","article-title":"COVID-19 and the nervous system","volume":"26","author":"Berger","year":"2020","journal-title":"J. Neurovirol."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"e781","DOI":"10.1212\/NXI.0000000000000781","article-title":"Guillain-Barr\u00e9 syndrome: The first documented COVID-19\u2013triggered autoimmune neurologic disease: More to come with myositis in the offing","volume":"7","author":"Dalakas","year":"2020","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1136\/annrheumdis-2020-217960","article-title":"Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 mimicking Kawasaki disease (Kawa-COVID-19): A multicentre cohort","volume":"79","author":"Pouletty","year":"2020","journal-title":"Annal. Rheum. Dis."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.ajem.2007.10.031","article-title":"The cytokine storm and factors determining the sequence and severity of organ dysfunction in multiple organ dysfunction syndrome","volume":"26","author":"Wang","year":"2008","journal-title":"Am. J. Emerg. Med."},{"key":"ref_214","doi-asserted-by":"crossref","unstructured":"McGonagle, D., Sharif, K., O\u2019Regan, A., and Bridgewood, C. (2020). The Role of Cytokines including Interleukin-6 in COVID-19 induced Pneumonia and Macrophage Activation Syndrome-Like Disease. Autoimmun. Rev., 102537.","DOI":"10.1016\/j.autrev.2020.102537"},{"key":"ref_215","doi-asserted-by":"crossref","unstructured":"Camp, J.V., and Jonsson, C.B. (2017). A Role for Neutrophils in Viral Respiratory Disease. Front. Immunol., 8.","DOI":"10.3389\/fimmu.2017.00550"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.smim.2016.04.003","article-title":"Neutrophil-derived chemokines on the road to immunity","volume":"28","author":"Tecchio","year":"2016","journal-title":"Semin. Immunol."},{"key":"ref_217","doi-asserted-by":"crossref","unstructured":"Chen, I.-Y., Moriyama, M., Chang, M.-F., and Ichinohe, T. (2019). Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome. Front. Microbiol., 10.","DOI":"10.3389\/fmicb.2019.00050"},{"key":"ref_218","doi-asserted-by":"crossref","unstructured":"Lagunas-Rangel, F.A., and Ch\u00e1vez-Valencia, V. (2020). High IL-6\/IFN-\u03b3 ratio could be associated with severe disease in COVID-19 patients. J. Med. Virol.","DOI":"10.1002\/jmv.25900"},{"key":"ref_219","doi-asserted-by":"crossref","unstructured":"Yang, Y., Shen, C., Li, J., Yuan, J., Yang, M., Wang, F., Li, G., Li, Y., Xing, L., and Peng, L. (2020). Exuberant elevation of IP-10, MCP-3 and IL-1ra during SARS-CoV-2 infection is associated with disease severity and fatal outcome. Infect. Dis.","DOI":"10.1101\/2020.03.02.20029975"},{"key":"ref_220","doi-asserted-by":"crossref","unstructured":"Qin, C., Zhou, L., Hu, Z., Zhang, S., Yang, S., Tao, Y., Xie, C., Ma, K., Shang, K., and Wang, W. (2020). Dysregulation of immune response in patients with COVID-19 in Wuhan, China. Clin. Infect. Dis.","DOI":"10.2139\/ssrn.3541136"},{"key":"ref_221","doi-asserted-by":"crossref","unstructured":"Kumar, Y., Liang, C., Bo, Z., Rajapakse, J.C., Ooi, E.E., and Tannenbaum, S.R. (2012). Serum Proteome and Cytokine Analysis in a Longitudinal Cohort of Adults with Primary Dengue Infection Reveals Predictive Markers of DHF. PLoS Negl. Trop. Dis., 6.","DOI":"10.1371\/journal.pntd.0001887"},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"312","DOI":"10.3892\/etm.2016.3323","article-title":"Inflammatory molecules expression pattern for identifying pathogen species in febrile patient serum","volume":"12","author":"Liu","year":"2016","journal-title":"Exp. Ther. Med."},{"key":"ref_223","doi-asserted-by":"crossref","unstructured":"Reis, E.A.G., Hagan, J.E., Ribeiro, G.S., Teixeira-Carvalho, A., Martins-Filho, O.A., Montgomery, R.R., Shaw, A.C., Ko, A.I., and Reis, M.G. (2013). Cytokine Response Signatures in Disease Progression and Development of Severe Clinical Outcomes for Leptospirosis. PLoS Negl. Trop. Dis., 7.","DOI":"10.1371\/journal.pntd.0002457"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1002\/jmv.23875","article-title":"Correlation of plasma viral loads and presence of Chikungunya IgM antibodies with cytokine\/chemokine levels during acute Chikungunya virus infection","volume":"86","author":"Reddy","year":"2014","journal-title":"J. Med. Virol."},{"key":"ref_225","doi-asserted-by":"crossref","unstructured":"Brenner, E.J., Ungaro, R.C., Gearry, R.B., Kaplan, G.G., Kissous-Hunt, M., Lewis, J.D., Ng, S.C., Rahier, J.-F., Reinisch, W., and Ruemmele, F.M. (2020). Corticosteroids, But Not TNF Antagonists, Are Associated with Adverse COVID-19 Outcomes in Patients with Inflammatory Bowel Diseases: Results From an International Registry. Gastroenterology.","DOI":"10.1053\/j.gastro.2020.05.032"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/MPG.0000000000002809","article-title":"Pediatric Crohn Disease and Multisystem Inflammatory Syndrome in Children (MIS-C) and COVID-19 Treated with Infliximab","volume":"71","author":"Dolinger","year":"2020","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_227","doi-asserted-by":"crossref","unstructured":"Henderson, L.A., Canna, S.W., Schulert, G.S., Volpi, S., Lee, P.Y., Kernan, K.F., Caricchio, R., Mahmud, S., Hazen, M.M., and Halyabar, O. (2020). On the alert for cytokine storm: Immunopathology in COVID-19. Arthritis Rheumatol.","DOI":"10.1002\/art.41285"},{"key":"ref_228","doi-asserted-by":"crossref","unstructured":"Cron, R.Q., and Behrens, E.M. (2019). Cytokine Storm Syndrome, Springer International Publishing.","DOI":"10.1007\/978-3-030-22094-5"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1164\/rccm.201203-0508OC","article-title":"CXCL10-CXCR3 Enhances the Development of Neutrophil-mediated Fulminant Lung Injury of Viral and Nonviral Origin","volume":"187","author":"Ichikawa","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1002\/ppul.21496","article-title":"Cytokine response in pediatric patients with pandemic influenza H1N1 2009 virus infection and pneumonia: Comparison with pediatric pneumonia without H1N1 2009 infection","volume":"46","author":"Kim","year":"2011","journal-title":"Pediatr. Pulmonol."},{"key":"ref_231","doi-asserted-by":"crossref","unstructured":"Tang, X., Du, R., Wang, R., Cao, T., Guan, L., Yang, C., Zhu, Q., Hu, M., Li, X., and Li, Y. (2020). Comparison of Hospitalized Patients with ARDS Caused by COVID-19 and H1N1. Chest.","DOI":"10.1016\/j.chest.2020.03.032"},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/bs.aivir.2016.08.006","article-title":"Chapter Seven\u2014Interaction of SARS and MERS Coronaviruses with the Antiviral Interferon Response","volume":"Volume 96","author":"Ziebuhr","year":"2016","journal-title":"Advances in Virus Research"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.dsx.2020.04.020","article-title":"Ysrafil Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): An overview of viral structure and host response","volume":"14","author":"Astuti","year":"2020","journal-title":"Diabetes Metab. Syndr. Clin. Res. Rev."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s12250-015-3683-3","article-title":"A molecular arms race between host innate antiviral response and emerging human coronaviruses","volume":"31","author":"Wong","year":"2016","journal-title":"Virol. Sin."},{"key":"ref_235","doi-asserted-by":"crossref","unstructured":"Hu, Y., Li, W., Gao, T., Cui, Y., Jin, Y., Li, P., Ma, Q., Liu, X., and Cao, C. (2017). The Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Inhibits Type I Interferon Production by Interfering with TRIM25-Mediated RIG-I Ubiquitination. J. Virol., 91.","DOI":"10.1128\/JVI.02143-16"},{"key":"ref_236","doi-asserted-by":"crossref","unstructured":"Chen, J., and Ly, H. (2017). Immunosuppression by viral N proteins. Oncotarget, 8.","DOI":"10.18632\/oncotarget.18597"},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1002\/jcp.27155","article-title":"Modulation of the immune response by Middle East respiratory syndrome coronavirus","volume":"234","author":"Shokri","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_238","doi-asserted-by":"crossref","unstructured":"Comar, C.E., Goldstein, S.A., Li, Y., Yount, B., Baric, R.S., and Weiss, S.R. (2019). Antagonism of dsRNA-Induced Innate Immune Pathways by NS4a and NS4b Accessory Proteins during MERS Coronavirus Infection. mBio, 10.","DOI":"10.1128\/mBio.00319-19"},{"key":"ref_239","doi-asserted-by":"crossref","unstructured":"Rabouw, H.H., Langereis, M.A., Knaap, R.C.M., Dalebout, T.J., Canton, J., Sola, I., Enjuanes, L., Bredenbeek, P.J., Kikkert, M., and de Groot, R.J. (2016). Middle East Respiratory Coronavirus Accessory Protein 4a Inhibits PKR-Mediated Antiviral Stress Responses. PLoS Pathog., 12.","DOI":"10.1371\/journal.ppat.1005982"},{"key":"ref_240","doi-asserted-by":"crossref","unstructured":"Thornbrough, J.M., Jha, B.K., Yount, B., Goldstein, S.A., Li, Y., Elliott, R., Sims, A.C., Baric, R.S., Silverman, R.H., and Weiss, S.R. (2016). Middle East Respiratory Syndrome Coronavirus NS4b Protein Inhibits Host RNase L Activation. mBio, 7.","DOI":"10.1128\/mBio.00258-16"},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"13606","DOI":"10.1074\/jbc.RA119.009713","article-title":"A conserved region of nonstructural protein 1 from alphacoronaviruses inhibits host gene expression and is critical for viral virulence","volume":"294","author":"Shen","year":"2019","journal-title":"J. Biol. Chem."},{"key":"ref_242","doi-asserted-by":"crossref","unstructured":"Jauregui, A.R., Savalia, D., Lowry, V.K., Farrell, C.M., and Wathelet, M.G. (2013). Identification of Residues of SARS-CoV nsp1 That Differentially Affect Inhibition of Gene Expression and Antiviral Signaling. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0062416"},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.virusres.2014.09.009","article-title":"Coronavirus non-structural protein 16: Evasion, attenuation, and possible treatments","volume":"194","author":"Menachery","year":"2014","journal-title":"Virus Res."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"3080","DOI":"10.4049\/jimmunol.1303196","article-title":"SARS-Coronavirus Open Reading Frame-9b Suppresses Innate Immunity by Targeting Mitochondria and the MAVS\/TRAF3\/TRAF6 Signalosome","volume":"193","author":"Shi","year":"2014","journal-title":"J. Immunol."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.antiviral.2014.12.015","article-title":"The SARS-coronavirus papain-like protease: Structure, function and inhibition by designed antiviral compounds","volume":"115","author":"Mesecar","year":"2015","journal-title":"Antivir. Res."},{"key":"ref_246","doi-asserted-by":"crossref","unstructured":"Yang, J.-R., Deng, D.-T., Wu, N., Yang, B., Li, H.-J., and Pan, X.-B. (2020). Persistent viral RNA positivity during recovery period of a patient with SARS-CoV-2 infection. J. Med. Virol.","DOI":"10.1002\/jmv.25940"},{"key":"ref_247","doi-asserted-by":"crossref","unstructured":"Wang, L., He, W., Yu, X., Hu, D., Bao, M., Liu, H., Zhou, J., and Jiang, H. (2020). Coronavirus disease 2019 in elderly patients: Characteristics and prognostic factors based on 4-week follow-up. J. Infect.","DOI":"10.1016\/j.jinf.2020.03.019"},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1385\/IR:36:1:221","article-title":"Age-dependent alterations of the T cell repertoire and functional diversity of T cells of the aged","volume":"36","author":"Vallejo","year":"2006","journal-title":"Immunol. Res."},{"key":"ref_249","doi-asserted-by":"crossref","unstructured":"Lega, S., Naviglio, S., Volpi, S., and Tommasini, A. (2020). Recent Insight into SARS-CoV2 Immunopathology and Rationale for Potential Treatment and Preventive Strategies in COVID-19. Vaccines, 8.","DOI":"10.3390\/vaccines8020224"},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/INF.0000000000002660","article-title":"Coronavirus Infections in Children Including COVID-19: An Overview of the Epidemiology, Clinical Features, Diagnosis, Treatment and Prevention Options in Children","volume":"39","author":"Zimmermann","year":"2020","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/jpc.14876","article-title":"Children may be less affected than adults by novel coronavirus (COVID-19)","volume":"56","author":"Kevat","year":"2020","journal-title":"Paediatr. Child Health"},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1038\/nri3277","article-title":"The impact of differential antiviral immunity in children and adults","volume":"12","author":"Prendergast","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"2001010","DOI":"10.2807\/1560-7917.ES.2020.25.22.2001010","article-title":"SARS-CoV-2-related paediatric inflammatory multisystem syndrome, an epidemiological study, France, 1 March to 17 May 2020","volume":"25","author":"Belot","year":"2020","journal-title":"Eurosurveillance"},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1016\/S0140-6736(20)31103-X","article-title":"An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: An observational cohort study","volume":"395","author":"Verdoni","year":"2020","journal-title":"Lancet"},{"key":"ref_255","doi-asserted-by":"crossref","unstructured":"Dashraath, P., Wong, J.L.J., Lim, M.X.K., Lim, L.M., Li, S., Biswas, A., Choolani, M., Mattar, C., and Su, L.L. (2020). Coronavirus disease 2019 (COVID-19) pandemic and pregnancy. Am. J. Obstet. Gynecol.","DOI":"10.1016\/j.ajog.2020.03.021"},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"103122","DOI":"10.1016\/j.jri.2020.103122","article-title":"Why are pregnant women susceptible to COVID-19? An immunological viewpoint","volume":"139","author":"Liu","year":"2020","journal-title":"J. Reprod. Immunol."},{"key":"ref_257","doi-asserted-by":"crossref","unstructured":"Nasiri, M.J., Haddadi, S., Tahvildari, A., Farsi, Y., Arbabi, M., Hasanzadeh, S., Jamshidi, P., Murthi, M., and Mirsaeidi, M. (2020). COVID-19 clinical characteristics, and sex-specific risk of mortality: Systematic Review and Meta-analysis. medRxiv.","DOI":"10.1101\/2020.03.24.20042903"},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"4046","DOI":"10.4049\/jimmunol.1601896","article-title":"Sex-Based Differences in Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection","volume":"198","author":"Channappanavar","year":"2017","journal-title":"J. Immunol."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/nri.2016.90","article-title":"Sex differences in immune responses","volume":"16","author":"Klein","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"ref_260","doi-asserted-by":"crossref","unstructured":"Kadel, S., and Kovats, S. (2018). Sex Hormones Regulate Innate Immune Cells and Promote Sex Differences in Respiratory Virus Infection. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.01653"},{"key":"ref_261","doi-asserted-by":"crossref","unstructured":"Kachuri, L., Francis, S.S., Morrison, M., Boss\u00e9, Y., Cavazos, T.B., Rashkin, S.R., Ziv, E., and Witte, J.S. (2020). The landscape of host genetic factors involved in infection to common viruses and SARS-CoV-2. medRxiv.","DOI":"10.1101\/2020.05.01.20088054"},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s13073-018-0568-8","article-title":"Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines","volume":"10","author":"Scepanovic","year":"2018","journal-title":"Genome Med."},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1146\/annurev-genet-120116-023425","article-title":"Human Genetic Determinants of Viral Diseases","volume":"51","author":"Kenney","year":"2017","journal-title":"Annu. Rev. Genet."},{"key":"ref_264","doi-asserted-by":"crossref","unstructured":"Lin, M., Tseng, H.-K., Trejaut, J.A., Lee, H.-L., Loo, J.-H., Chu, C.-C., Chen, P.-J., Su, Y.-W., Lim, K.H., and Tsai, Z.-U. (2003). Association of HLA class I with severe acute respiratory syndrome coronavirus infection. BMC Med. Genet., 4.","DOI":"10.1186\/1471-2350-4-9"},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1001\/jama.293.12.1450-c","article-title":"ABO Blood Group and Susceptibility to Severe Acute Respiratory Syndrome","volume":"293","author":"Cheng","year":"2005","journal-title":"JAMA"},{"key":"ref_266","unstructured":"Ellinghaus, D., Degenhardt, F., Bujanda, L., Buti, M., Albillos, A., Invernizzi, P., Fern\u00e1ndez, J., Prati, D., Baselli, G., and Asselta, R. (2020). Genomewide Association Study of Severe Covid-19 with Respiratory Failure. N. Eng. J. Med."},{"key":"ref_267","doi-asserted-by":"crossref","unstructured":"Zhao, J., Yang, Y., Huang, H., Li, D., Gu, D., Lu, X., Zhang, Z., Liu, L., Liu, T., and Liu, Y. (2020). Relationship between the ABO Blood Group and the COVID-19 Susceptibility. medRxiv.","DOI":"10.1101\/2020.03.11.20031096"},{"key":"ref_268","doi-asserted-by":"crossref","unstructured":"Zietz, M., and Tatonetti, N.P. (2020). Testing the association between blood type and COVID-19 infection, intubation, and death. medRxiv.","DOI":"10.1101\/2020.04.08.20058073"},{"key":"ref_269","doi-asserted-by":"crossref","unstructured":"Alzoughool, F., and Alanagreh, L. (2020). Coronavirus drugs: Using plasma from recovered patients as a treatment for COVID-19. JRS, 1\u20135.","DOI":"10.3233\/JRS-201017"},{"key":"ref_270","doi-asserted-by":"crossref","unstructured":"Jawhara, S. (2020). Could Intravenous Immunoglobulin Collected from Recovered Coronavirus Patients Protect against COVID-19 and Strengthen the Immune System of New Patients?. IJMS, 21.","DOI":"10.3390\/ijms21072272"},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/s13054-020-2836-4","article-title":"A novel treatment approach to the novel coronavirus: An argument for the use of therapeutic plasma exchange for fulminant COVID-19","volume":"24","author":"Keith","year":"2020","journal-title":"Crit. Care"},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1128\/AAC.38.8.1695","article-title":"Serum therapy revisited: Animal models of infection and development of passive antibody therapy","volume":"38","author":"Casadevall","year":"1994","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/S1471-4906(03)00228-X","article-title":"Antibody-mediated regulation of cellular immunity and the inflammatory response","volume":"24","author":"Casadevall","year":"2003","journal-title":"Trends Immunol."},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"102554","DOI":"10.1016\/j.autrev.2020.102554","article-title":"Convalescent plasma in Covid-19: Possible mechanisms of action","volume":"19","author":"Rojas","year":"2020","journal-title":"Autoimmun. Rev."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"106560","DOI":"10.1016\/j.intimp.2020.106560","article-title":"Towards treatment planning of COVID-19: Rationale and hypothesis for the use of multiple immunosuppressive agents: Anti-antibodies, immunoglobulins, and corticosteroids","volume":"84","author":"Saghazadeh","year":"2020","journal-title":"Int. Immunopharm."},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1111\/j.1469-0691.2004.00956.x","article-title":"Retrospective comparison of convalescent plasma with continuing high-dose methylprednisolone treatment in SARS patients","volume":"10","author":"Soo","year":"2004","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1093\/jac\/dki346","article-title":"Experience of using convalescent plasma for severe acute respiratory syndrome among healthcare workers in a Taiwan hospital","volume":"56","author":"Yeh","year":"2005","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_278","doi-asserted-by":"crossref","unstructured":"Bloch, E.M., Shoham, S., Casadevall, A., Sachais, B.S., Shaz, B., Winters, J.L., van Buskirk, C., Grossman, B.J., Joyner, M., and Henderson, J.P. (2020). Deployment of convalescent plasma for the prevention and treatment of COVID-19. J. Clin. Investig.","DOI":"10.1172\/JCI138745"},{"key":"ref_279","doi-asserted-by":"crossref","unstructured":"Perotti, C., Baldanti, F., Bruno, R., Fante, C.D., Seminari, E., Casari, S., Percivalle, E., Glingani, C., Musella, V., and Belliato, M. (2020). Mortality reduction in 46 severe Covid-19 patients treated with hyperimmune plasma. A proof of concept single arm multicenter trial. Haematologica.","DOI":"10.1101\/2020.05.26.20113373"},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"625","DOI":"10.21037\/atm-20-3305","article-title":"Effectiveness of intravenous immunoglobulin for children with severe COVID-19: A rapid review","volume":"8","author":"Zhang","year":"2020","journal-title":"Annal. Transl. Med."},{"key":"ref_281","doi-asserted-by":"crossref","unstructured":"Cao, W., Liu, X., Bai, T., Fan, H., Hong, K., Song, H., Han, Y., Lin, L., Ruan, L., and Li, T. (2020). High-Dose Intravenous Immunoglobulin as a Therapeutic Option for Deteriorating Patients with Coronavirus Disease 2019. Open Forum Infect. Dis., 7.","DOI":"10.1093\/ofid\/ofaa102"},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.virol.2020.05.006","article-title":"Recovery of severely ill COVID-19 patients by intravenous immunoglobulin (IVIG) treatment: A case series","volume":"548","author":"Mohtadi","year":"2020","journal-title":"Virology"},{"key":"ref_283","doi-asserted-by":"crossref","unstructured":"Feldstein, L.R., Rose, E.B., Horwitz, S.M., Collins, J.P., Newhams, M.M., Son, M.B.F., Newburger, J.W., Kleinman, L.C., Heidemann, S.M., and Martin, A.A. (2020). Multisystem Inflammatory Syndrome in U.S. Children and Adolescents. N. Eng. J. Med.","DOI":"10.1056\/NEJMoa2021680"},{"key":"ref_284","doi-asserted-by":"crossref","unstructured":"Sokolovsky, S., Soni, P., Hoffman, T., Kahn, P., and Scheers-Masters, J. (2020). COVID-19 associated Kawasaki-like multisystem inflammatory disease in an adult. Am. J. Emerg. Med.","DOI":"10.1016\/j.ajem.2020.06.053"},{"key":"ref_285","doi-asserted-by":"crossref","unstructured":"Yi\u011feno\u011flu, T.N., Ulas, T., Dal, M.S., Korkmaz, S., Erkurt, M.A., and Altunta\u015f, F. (2020). Extracorporeal blood purification treatment options for COVID-19: The role of immunoadsorption. Transfus. Apher. Sci., 102855.","DOI":"10.1016\/j.transci.2020.102855"},{"key":"ref_286","doi-asserted-by":"crossref","unstructured":"Daoud, A.M., Soliman, K.M., and Ali, H.K. (2020). Potential Limitations of Plasmapheresis in Treatment of COVID-19 Patients and How to Overcome Them?. Ther. Apher. Dial.","DOI":"10.1111\/1744-9987.13568"},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/s13054-020-02943-1","article-title":"Therapeutic plasma exchange as a routine therapy in septic shock and as an experimental treatment for COVID-19: We are not sure","volume":"24","author":"Honore","year":"2020","journal-title":"Critic. Care"},{"key":"ref_288","doi-asserted-by":"crossref","unstructured":"Khamis, F., Al-Zakwani, I., Al Hashmi, S., Al Dowaiki, S., Al Bahrani, M., Pandak, N., Al Khalili, H., and Memish, Z. (2020). Therapeutic Plasma Exchange in Adults with Severe COVID-19 Infection. Int. J. Infect. Dis.","DOI":"10.1016\/j.ijid.2020.06.064"},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"12526","DOI":"10.1073\/pnas.2006691117","article-title":"Get rid of the bad first: Therapeutic plasma exchange with convalescent plasma for severe COVID-19","volume":"117","author":"Kesici","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_290","doi-asserted-by":"crossref","unstructured":"Wang, C., Li, W., Drabek, D., Okba, N.M.A., van Haperen, R., Osterhaus, A.D.M.E., van Kuppeveld, F.J.M., Haagmans, B.L., Grosveld, F., and Bosch, B.-J. A human monoclonal antibody blocking SARS-CoV-2 infection. Microbiology, 2020.","DOI":"10.1101\/2020.03.11.987958"},{"key":"ref_291","doi-asserted-by":"crossref","unstructured":"Pan, X., Zhou, P., Fan, T., Wu, Y., Zhang, J., Shi, X., Shang, W., Fang, L., Jiang, X., and Shi, J. (2020). Immunoglobulin fragment F(ab\u2019)2 against RBD potently neutralizes SARS-CoV-2 in vitro. Pharmacol. Toxicol.","DOI":"10.1101\/2020.04.07.029884"},{"key":"ref_292","doi-asserted-by":"crossref","unstructured":"Alsoussi, W.B., Turner, J.S., Case, J.B., Zhao, H., Schmitz, A.J., Zhou, J.Q., Chen, R.E., Lei, T., Rizk, A.A., and McIntire, K.M. (2020). A Potently Neutralizing Antibody Protects Mice against SARS-CoV-2 Infection. J. Immunol.","DOI":"10.4049\/jimmunol.2000583"},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1038\/s41467-020-16048-4","article-title":"Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig","volume":"11","author":"Lei","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_294","doi-asserted-by":"crossref","unstructured":"D\u00edez, J.-M., Romero, C., and Gajardo, R. (2020). Currently available intravenous immunoglobulin (Gamunex\u00ae-C and Flebogamma\u00ae DIF) contains antibodies reacting against SARS-CoV-2 antigens. Immunology.","DOI":"10.1101\/2020.04.07.029017"},{"key":"ref_295","doi-asserted-by":"crossref","unstructured":"Baum, A., Fulton, B.O., Wloga, E., Copin, R., Pascal, K.E., Russo, V., Giordano, S., Lanza, K., Negron, N., and Ni, M. (2020). Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies. Science.","DOI":"10.1126\/science.abd0831"},{"key":"ref_296","doi-asserted-by":"crossref","unstructured":"Tu, Y.-F., Chien, C.-S., Yarmishyn, A.A., Lin, Y.-Y., Luo, Y.-H., Lin, Y.-T., Lai, W.-Y., Yang, D.-M., Chou, S.-J., and Yang, Y.-P. (2020). A Review of SARS-CoV-2 and the Ongoing Clinical Trials. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21072657"},{"key":"ref_297","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1080\/14740338.2017.1269168","article-title":"Hydroxychloroquine in systemic lupus erythematosus (SLE)","volume":"16","author":"Ponticelli","year":"2017","journal-title":"Expert Opin. Drug Saf."},{"key":"ref_298","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41422-020-0282-0","article-title":"Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro","volume":"30","author":"Wang","year":"2020","journal-title":"Cell Res."},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/acem.14005","article-title":"A Rapid Systematic Review of Clinical Trials Utilizing Chloroquine and Hydroxychloroquine as a Treatment for COVID-19","volume":"27","author":"Chowdhury","year":"2020","journal-title":"Acad. Emerg. Med."},{"key":"ref_300","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1743-422X-2-69","article-title":"Chloroquine is a potent inhibitor of SARS coronavirus infection and spread","volume":"2","author":"Vincent","year":"2005","journal-title":"Virol. J."},{"key":"ref_301","doi-asserted-by":"crossref","first-page":"100131","DOI":"10.1016\/j.onehlt.2020.100131","article-title":"Coalition: Advocacy for prospective clinical trials to test the post-exposure potential of hydroxychloroquine against COVID-19","volume":"9","author":"Picot","year":"2020","journal-title":"One Health"},{"key":"ref_302","doi-asserted-by":"crossref","first-page":"101791","DOI":"10.1016\/j.tmaid.2020.101791","article-title":"Outcomes of 3737 COVID-19 patients treated with hydroxychloroquine\/azithromycin and other regimens in Marseille, France: A retrospective analysis","volume":"36","author":"Lagier","year":"2020","journal-title":"Travel Med. Infect. Dis."},{"key":"ref_303","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.medmal.2020.03.006","article-title":"No evidence of rapid antiviral clearance or clinical benefit with the combination of hydroxychloroquine and azithromycin in patients with severe COVID-19 infection","volume":"50","author":"Molina","year":"2020","journal-title":"M\u00e9d. Mal. Infect."},{"key":"ref_304","doi-asserted-by":"crossref","unstructured":"Putman, M., Chock, Y.P.E., Tam, H., Kim, A.H.J., Sattui, S.E., Berenbaum, F., Danila, M.I., Korsten, P., Sanchez-Alvarez, C., and Sparks, J.A. (2020). Antirheumatic Disease Therapies for the Treatment of COVID-19: A Systematic Review and Meta-analysis. Arthritis Rheumatol.","DOI":"10.1002\/art.41469"},{"key":"ref_305","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/phar.2387","article-title":"Chloroquine and Hydroxychloroquine in the Era of SARS\u2014CoV2: Caution on Their Cardiac Toxicity","volume":"40","author":"Bauman","year":"2020","journal-title":"Pharmacotherapy"},{"key":"ref_306","doi-asserted-by":"crossref","unstructured":"Lofgren, S.M.M., Nicol, M.R., Bangdiwala, A.S., Pastick, K.A., Okafor, E.C., Skipper, C.P., Pullen, M.F., Engen, N.W., Abassi, M., and Williams, D.A. (2020). Safety of Hydroxychloroquine among Outpatient Clinical Trial Participants for COVID-19. medRxiv.","DOI":"10.1093\/ofid\/ofaa500"},{"key":"ref_307","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1186\/s13063-020-04527-4","article-title":"PROTECT Trial: A cluster-randomized study with hydroxychloroquine versus observational support for prevention or early-phase treatment of Coronavirus disease (COVID-19): A structured summary of a study protocol for a randomized controlled trial","volume":"21","author":"Nanni","year":"2020","journal-title":"Trials"},{"key":"ref_308","doi-asserted-by":"crossref","unstructured":"Zou, L., Dai, L., Zhang, X., Zhang, Z., and Zhang, Z. (2020). Hydroxychloroquine and chloroquine: A potential and controversial treatment for COVID-19. Arch. Pharm. Res.","DOI":"10.1007\/s12272-020-01258-7"},{"key":"ref_309","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S0140-6736(20)30317-2","article-title":"Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury","volume":"395","author":"Russell","year":"2020","journal-title":"Lancet"},{"key":"ref_310","doi-asserted-by":"crossref","unstructured":"Yang, Z., Liu, J., Zhou, Y., Zhao, X., Zhao, Q., and Liu, J. (2020). The effect of corticosteroid treatment on patients with coronavirus infection: A systematic review and meta-analysis. J. Infect.","DOI":"10.1016\/j.jinf.2020.03.062"},{"key":"ref_311","doi-asserted-by":"crossref","unstructured":"Wang, D., Wang, J., Jiang, Q., Yang, J., Li, J., Gao, C., Jiang, H., Ge, L., and Liu, Y. (2020). No Clear Benefit to the Use of Corticosteroid as Treatment in Adult Patients with Coronavirus Disease 2019: A Retrospective Cohort Study. Infect. Dis.","DOI":"10.1101\/2020.04.21.20066258"},{"key":"ref_312","doi-asserted-by":"crossref","unstructured":"Hu, F., Yin, G., Chen, Y., Song, J., Ye, M., Liu, J., Chen, C., Song, Y., Tang, X., and Zhang, Y. (2020). Corticosteroid, oseltamivir, and delayed admission are independent risk factors for prolonged viral shedding in patients with Coronavirus Disease 2019. Clin. Respir. J.","DOI":"10.1111\/crj.13243"},{"key":"ref_313","doi-asserted-by":"crossref","unstructured":"Lee, K.H., Yoon, S., Jeong, G.H., Kim, J.Y., Han, Y.J., Hong, S.H., Ryu, S., Kim, J.S., Lee, J.Y., and Yang, J.W. (2020). Efficacy of Corticosteroids in Patients with SARS, MERS and COVID-19: A Systematic Review and Meta-Analysis. J. Clin. Med., 9.","DOI":"10.3390\/jcm9082392"},{"key":"ref_314","doi-asserted-by":"crossref","unstructured":"Hasan, S.S., Capstick, T., Ahmed, R., Kow, C.S., Mazhar, F., Merchant, H.A., and Zaidi, S.T.R. (2020). Mortality in COVID-19 patients with acute respiratory distress syndrome and corticosteroids use: A systematic review and meta-analysis. Expert Rev. Respir. Med.","DOI":"10.1080\/17476348.2020.1804365"},{"key":"ref_315","unstructured":"Group, T.R.C. (2020). Dexamethasone in Hospitalized Patients with Covid-19\u2014Preliminary Report. N. Eng. J. Med."},{"key":"ref_316","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41392-020-0127-9","article-title":"Potential benefits of precise corticosteroids therapy for severe 2019-nCoV pneumonia","volume":"5","author":"Zhou","year":"2020","journal-title":"Sig. Transduct. Target. Ther."},{"key":"ref_317","doi-asserted-by":"crossref","first-page":"373","DOI":"10.55563\/clinexprheumatol\/r3k9l6","article-title":"COVID-19: The new challenge for rheumatologists. First update","volume":"38","author":"Ferro","year":"2020","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_318","doi-asserted-by":"crossref","first-page":"337","DOI":"10.55563\/clinexprheumatol\/xcdary","article-title":"COVID-19, cytokines and immunosuppression: What can we learn from severe acute respiratory syndrome?","volume":"38","author":"Giorgi","year":"2020","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_319","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s12967-020-02333-9","article-title":"Anti-IL6R role in treatment of COVID-19-related ARDS","volume":"18","author":"Buonaguro","year":"2020","journal-title":"J. Transl. Med."},{"key":"ref_320","unstructured":"Guo, C., Li, B., Ma, H., Wang, X., Cai, P., Yu, Q., Zhu, L., Jin, L., Jiang, C., and Fang, J. (2020). Tocilizumab treatment in severe COVID-19 patients attenuates the inflammatory storm incited by monocyte centric immune interactions revealed by single-cell analysis. Genomics."},{"key":"ref_321","doi-asserted-by":"crossref","unstructured":"Bonaventura, A., Vecchi\u00e9, A., Wang, T.S., Lee, E., Cremer, P.C., Carey, B., Rajendram, P., Hudock, K.M., Korbee, L., and Van Tassell, B.W. (2020). Targeting GM-CSF in COVID-19 Pneumonia: Rationale and Strategies. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.01625"},{"key":"ref_322","doi-asserted-by":"crossref","first-page":"e465","DOI":"10.1016\/S2665-9913(20)30170-3","article-title":"GM-CSF blockade with mavrilimumab in severe COVID-19 pneumonia and systemic hyperinflammation: A single-centre, prospective cohort study","volume":"2","author":"Luca","year":"2020","journal-title":"Lancet Rheumatol."},{"key":"ref_323","unstructured":"Lokugamage, K.G., Hage, A., Schindewolf, C., Rajsbaum, R., and Menachery, V.D. (2020). SARS-CoV-2 is sensitive to type I interferon pretreatment. Microbiology."},{"key":"ref_324","doi-asserted-by":"crossref","first-page":"104791","DOI":"10.1016\/j.antiviral.2020.104791","article-title":"Type 1 interferons as a potential treatment against COVID-19","volume":"178","author":"Sallard","year":"2020","journal-title":"Antivir. Res."},{"key":"ref_325","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1007\/s10067-020-05190-5","article-title":"Cytokine storm in COVID-19: Pathogenesis and overview of anti-inflammatory agents used in treatment","volume":"39","author":"Soy","year":"2020","journal-title":"Clin. Rheumatol."},{"key":"ref_326","doi-asserted-by":"crossref","unstructured":"Cauchois, R., Koubi, M., Delarbre, D., Manet, C., Carvelli, J., Blasco, V.B., Jean, R., Fouche, L., Bornet, C., and Pauly, V. (2020). Early IL-1 receptor blockade in severe inflammatory respiratory failure complicating COVID-19. PNAS.","DOI":"10.1073\/pnas.2009017117"},{"key":"ref_327","unstructured":"Diurno, F., Numis, F.G., Porta, G., Cirillo, F., Maddaluno, S., Ragozzino, A., Negri, P.D., Gennaro, C.D., Pagano, A., and Allegorico, E. (2020). Eculizumab treatment in patients with COVID-19: Preliminary results from real life ASL Napoli 2 Nord experience. Eur. Rev. Med. Pharmacol. Sci., 8."},{"key":"ref_328","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/S1473-3099(20)30132-8","article-title":"COVID-19: Combining antiviral and anti-inflammatory treatments","volume":"20","author":"Stebbing","year":"2020","journal-title":"Lancet Infect. Dis."},{"key":"ref_329","doi-asserted-by":"crossref","unstructured":"Cantini, F., Niccoli, L., Nannini, C., Matarrese, D., Natale, M.E.D., Lotti, P., Aquilini, D., Landini, G., Cimolato, B., and Pietro, M.A.D. (2020). Beneficial impact of Baricitinib in COVID-19 moderate pneumonia; multicentre study. J. Infect.","DOI":"10.1016\/j.jinf.2020.06.052"},{"key":"ref_330","doi-asserted-by":"crossref","unstructured":"Cingolani, A., Tummolo, A.M., Montemurro, G., Gremese, E., Larosa, L., Cipriani, M.C., Pasciuto, G., Liperoti, R., Murri, R., and Pirronti, T. (2020). Baricitinib as rescue therapy in a patient with COVID-19 with no complete response to sarilumab. Infection.","DOI":"10.1007\/s15010-020-01476-7"},{"key":"ref_331","doi-asserted-by":"crossref","unstructured":"Titanji, B.K., Farley, M.M., Mehta, A., Connor-Schuler, R., Moanna, A., Cribbs, S.K., O\u2019Shea, J., DeSilva, K., Chan, B., and Edwards, A. (2020). Use of Baricitinib in Patients with Moderate and Severe COVID-19. Clin. Infect. Dis.","DOI":"10.1093\/cid\/ciaa879"},{"key":"ref_332","doi-asserted-by":"crossref","unstructured":"Bari, E., Ferrarotti, I., Saracino, L., Perteghella, S., Torre, M.L., and Corsico, A.G. (2020). Mesenchymal Stromal Cell Secretome for Severe COVID-19 Infections: Premises for the Therapeutic Use. Cells, 9.","DOI":"10.3390\/cells9040924"},{"key":"ref_333","doi-asserted-by":"crossref","first-page":"216","DOI":"10.14336\/AD.2020.0228","article-title":"Transplantation of ACE2-Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia","volume":"11","author":"Leng","year":"2020","journal-title":"Aging Dis."},{"key":"ref_334","doi-asserted-by":"crossref","first-page":"462","DOI":"10.14336\/AD.2020.0301","article-title":"Mesenchymal Stem Cell Infusion Shows Promise for Combating Coronavirus (COVID-19)-Induced Pneumonia","volume":"11","author":"Shetty","year":"2020","journal-title":"Aging Dis."},{"key":"ref_335","doi-asserted-by":"crossref","unstructured":"Zhao, R.C. (2020). Stem Cell\u2013Based Therapy for Coronavirus Disease 2019. Stem Cells Dev.","DOI":"10.1089\/scd.2020.0071"},{"key":"ref_336","first-page":"E71","article-title":"Expanded Umbilical Cord Mesenchymal Stem Cells (UC-MSCs) as a Therapeutic Strategy In Managing Critically Ill COVID-19 Patients: The Case for Compassionate Use","volume":"23","author":"Atluri","year":"2020","journal-title":"Pain Physician"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/21\/16\/5932\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:02:32Z","timestamp":1760176952000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/21\/16\/5932"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,18]]},"references-count":336,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2020,8]]}},"alternative-id":["ijms21165932"],"URL":"https:\/\/doi.org\/10.3390\/ijms21165932","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,18]]}}}