{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:40:40Z","timestamp":1791315640339,"version":"4.3.1"},"reference-count":177,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T00:00:00Z","timestamp":1598313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI17\/02197-General Subdirection of Assesment and Promotion of the Research \u2013 European Regional Development Fund (FEDER) \u201cA way of making Europe"],"award-info":[{"award-number":["PI17\/02197-General Subdirection of Assesment and Promotion of the Research \u2013 European Regional Development Fund (FEDER) \u201cA way of making Europe"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010801","name":"Xunta de Galicia","doi-asserted-by":"publisher","award":["R2016\/036, R2014\/050, CN2012\/142 and GPC2014\/048, postdoctoral and predoctoral fellowships"],"award-info":[{"award-number":["R2016\/036, R2014\/050, CN2012\/142 and GPC2014\/048, postdoctoral and predoctoral fellowships"]}],"id":[{"id":"10.13039\/501100010801","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Induced pluripotent stem cells (iPSCs) represent an unlimited source of pluripotent cells capable of differentiating into any cell type of the body. Several studies have demonstrated the valuable use of iPSCs as a tool for studying the molecular and cellular mechanisms underlying disorders affecting bone, cartilage and muscle, as well as their potential for tissue repair. Musculoskeletal diseases are one of the major causes of disability worldwide and impose an important socio-economic burden. To date there is neither cure nor proven approach for effectively treating most of these conditions and therefore new strategies involving the use of cells have been increasingly investigated in the recent years. Nevertheless, some limitations related to the safety and differentiation protocols among others remain, which humpers the translational application of these strategies. Nonetheless, the potential is indisputable and iPSCs are likely to be a source of different types of cells useful in the musculoskeletal field, for either disease modeling or regenerative medicine. In this review, we aim to illustrate the great potential of iPSCs by summarizing and discussing the in vitro tissue regeneration preclinical studies that have been carried out in the musculoskeletal field by using iPSCs.<\/jats:p>","DOI":"10.3390\/ijms21176124","type":"journal-article","created":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T09:24:56Z","timestamp":1598347496000},"page":"6124","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Versatility of Induced Pluripotent Stem Cells (iPSCs) for Improving the Knowledge on Musculoskeletal Diseases"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2702-7804","authenticated-orcid":false,"given":"Clara","family":"Sanjurjo-Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Cell Therapy and Regenerative Medicine Group, Department of Physiotherapy, Medicine and Biomedical Sciences, Faculty of Health Sciences, University of A Coru\u00f1a (UDC), 15006 A Coru\u00f1a, Galicia, Spain"},{"name":"Institute of Biomedical Research of A Coru\u00f1a (INIBIC), University Hospital Complex A Coru\u00f1a (CHUAC), Galician Health Service (SERGAS), 15006 A Coru\u00f1a, Galicia, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red (CIBER) de Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER-BBN), 28029 Madrid, Spain"},{"name":"Centro de Investigaciones Cient\u00edficas Avanzadas (CICA), Agrupaci\u00f3n estrat\u00e9gica CICA-INIBIC, University of A Coru\u00f1a, 15008 A Coru\u00f1a, Galicia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roc\u00edo","family":"Castro-Vi\u00f1uelas","sequence":"additional","affiliation":[{"name":"Cell Therapy and Regenerative Medicine Group, Department of Physiotherapy, Medicine and Biomedical Sciences, Faculty of Health Sciences, University of A Coru\u00f1a (UDC), 15006 A Coru\u00f1a, Galicia, Spain"},{"name":"Institute of Biomedical 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Medicine Group, Department of Physiotherapy, Medicine and Biomedical Sciences, Faculty of Health Sciences, University of A Coru\u00f1a (UDC), 15006 A Coru\u00f1a, Galicia, Spain"},{"name":"Institute of Biomedical Research of A Coru\u00f1a (INIBIC), University Hospital Complex A Coru\u00f1a (CHUAC), Galician Health Service (SERGAS), 15006 A Coru\u00f1a, Galicia, Spain"},{"name":"Centro de Investigaciones Cient\u00edficas Avanzadas (CICA), Agrupaci\u00f3n estrat\u00e9gica CICA-INIBIC, University of A Coru\u00f1a, 15008 A Coru\u00f1a, Galicia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9821-7635","authenticated-orcid":false,"given":"Francisco J.","family":"Blanco","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Research of A Coru\u00f1a (INIBIC), University Hospital Complex A Coru\u00f1a (CHUAC), Galician Health Service (SERGAS), 15006 A Coru\u00f1a, Galicia, Spain"},{"name":"Centro de Investigaci\u00f3n 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