{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:10:07Z","timestamp":1760238607490,"version":"build-2065373602"},"reference-count":19,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T00:00:00Z","timestamp":1598486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["180542"],"award-info":[{"award-number":["180542"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004885","name":"Umea University","doi-asserted-by":"publisher","award":["2019"],"award-info":[{"award-number":["2019"]}],"id":[{"id":"10.13039\/501100004885","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Lion's cancer research foundation","award":["2019"],"award-info":[{"award-number":["2019"]}]},{"name":"Region V\u00e4sterbotten","award":["2019"],"award-info":[{"award-number":["2019"]}]},{"name":"Ministry of health Czech Republic","award":["MMCI, 00209805"],"award-info":[{"award-number":["MMCI, 00209805"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Oral cancers are surrounded by epithelium that histologically might seem normal, but genetically has aberrations. In patients with squamous cell carcinoma of the oral tongue (SCCOT), it is therefore important to study not only the tumor but also the clinically tumor-free contralateral tongue tissue that remains in the patient after treatment to map changes of prognostic and\/or diagnostic value. The transporter associated with antigen processing (TAP) dimer is a key factor in the process of activating cytotoxic T cells. By downregulating the expression of TAP, tumor cells can escape cytotoxic T cell recognition. Biopsies from tumor and clinically tumor-free contralateral tongue tissue in 21 patients with SCCOT were analyzed together with tongue biopsies from 14 healthy individuals, which served as the control group. Dividing patients into TAP1-high and TAP1-low groups according to the median TAP1 level in tumor-free samples showed that patients with lower TAP1 mRNA levels in tumor-free samples had better overall (p = 0.003) and disease-free survival (p = 0.002). The results showing that TAP1 levels in tumor-free tongue tissue contralateral to the SCCOT correlate with survival is an important contribution to early diagnosis and follow up of SCCOT.<\/jats:p>","DOI":"10.3390\/ijms21176220","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T09:17:08Z","timestamp":1598606228000},"page":"6220","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Downregulation of TAP1 in Tumor-Free Tongue Contralateral to Squamous Cell Carcinoma of the Oral Tongue, an Indicator of Better Survival"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0074-0434","authenticated-orcid":false,"given":"Nima","family":"Attaran","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences\/ENT, Ume\u00e5 University, SE-901 85 Ume\u00e5, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6574-3628","authenticated-orcid":false,"given":"Xiaolian","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Medical Biosciences, Ume\u00e5 University, SE-901 85 Ume\u00e5, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip J.","family":"Coates","sequence":"additional","affiliation":[{"name":"RECAMO, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin","family":"F\u00e5hraeus","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique Mol\u00e9culaire, Universit\u00e9 Paris 7, Inserm UMR 1162, 750 13 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Boldrup","sequence":"additional","affiliation":[{"name":"Department of Medical Biosciences, Ume\u00e5 University, SE-901 85 Ume\u00e5, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torben","family":"Wilms","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences\/ENT, Ume\u00e5 University, SE-901 85 Ume\u00e5, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lixiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Biosciences, Ume\u00e5 University, SE-901 85 Ume\u00e5, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Sgaramella","sequence":"additional","affiliation":[{"name":"Department of Medical Biosciences, Ume\u00e5 University, SE-901 85 Ume\u00e5, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarina","family":"Zborayova","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences\/ENT, Ume\u00e5 University, SE-901 85 Ume\u00e5, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4831-4100","authenticated-orcid":false,"given":"Karin","family":"Nylander","sequence":"additional","affiliation":[{"name":"Department of Medical Biosciences, Ume\u00e5 University, SE-901 85 Ume\u00e5, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"214","DOI":"10.2174\/1568026618666180116121624","article-title":"Searching for New Targets and Treatments in the Battle Against Squamous Cell Carcinoma of the Head and Neck, with Specific Focus on Tumours of the Tongue","volume":"18","author":"Sgaramella","year":"2018","journal-title":"Curr. 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