{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:19:16Z","timestamp":1790997556865,"version":"4.1.0"},"reference-count":71,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T00:00:00Z","timestamp":1599004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Spanish Ministry of Economy and Competitiveness","award":["SAF2014-59340-R"],"award-info":[{"award-number":["SAF2014-59340-R"]}]},{"name":"Spanish Ministry of Science Innovation and Universities","award":["PID2019-110356RB-I00"],"award-info":[{"award-number":["PID2019-110356RB-I00"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Olfactory dysfunction is one of the prodromal symptoms in dementia with Lewy bodies (DLB). However, the molecular pathogenesis associated with decreased smell function remains largely undeciphered. We generated quantitative proteome maps to detect molecular alterations in olfactory bulbs (OB) derived from DLB subjects compared to neurologically intact controls. A total of 3214 olfactory proteins were quantified, and 99 proteins showed significant alterations in DLB cases. Protein interaction networks disrupted in DLB indicated an imbalance in translation and the synaptic vesicle cycle. These alterations were accompanied by alterations in AKT\/MAPK\/SEK1\/p38 MAPK signaling pathways that showed a distinct expression profile across the OB\u2013olfactory tract (OT) axis. Taken together, our data partially reflect the missing links in the biochemical understanding of olfactory dysfunction in DLB.<\/jats:p>","DOI":"10.3390\/ijms21176371","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T09:29:28Z","timestamp":1599038968000},"page":"6371","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Proteomic Characterization of the Olfactory Molecular Imbalance in Dementia with Lewy Bodies"],"prefix":"10.3390","volume":"21","author":[{"given":"Mercedes","family":"Lach\u00e9n-Montes","sequence":"first","affiliation":[{"name":"Clinical Neuroproteomics Unit, Navarrabiomed, Complejo Hospitalario de Navarra (CHN), Universidad P\u00fablica de Navarra (UPNA), Irunlarrea 3, 31008 Pamplona, Spain"},{"name":"Proteored-ISCIII. Proteomics Platform, Navarrabiomed, Complejo Hospitalario de Navarra (CHN), Universidad P\u00fablica de Navarra (UPNA), Irunlarrea 3, 31008 Pamplona, Spain"},{"name":"IdiSNA, Navarra Institute for Health Research, Spain Irunlarrea 3, 31008 Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naroa","family":"Mendizuri","sequence":"additional","affiliation":[{"name":"Clinical Neuroproteomics Unit, Navarrabiomed, Complejo Hospitalario de Navarra (CHN), Universidad P\u00fablica de Navarra (UPNA), Irunlarrea 3, 31008 Pamplona, Spain"},{"name":"IdiSNA, Navarra Institute for Health Research, Spain Irunlarrea 3, 31008 Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1133-0462","authenticated-orcid":false,"given":"Domitille","family":"Schvartz","sequence":"additional","affiliation":[{"name":"Translational Biomarker Group, Department of Medicine, University of Geneva, Rue Michel Servet 1, 1211 Geneve, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5072-4099","authenticated-orcid":false,"given":"Joaqu\u00edn","family":"Fern\u00e1ndez-Irigoyen","sequence":"additional","affiliation":[{"name":"Clinical Neuroproteomics Unit, Navarrabiomed, Complejo Hospitalario de Navarra (CHN), Universidad P\u00fablica de Navarra (UPNA), Irunlarrea 3, 31008 Pamplona, Spain"},{"name":"Proteored-ISCIII. Proteomics Platform, Navarrabiomed, Complejo Hospitalario de Navarra (CHN), Universidad P\u00fablica de Navarra (UPNA), Irunlarrea 3, 31008 Pamplona, Spain"},{"name":"IdiSNA, Navarra Institute for Health Research, Spain Irunlarrea 3, 31008 Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Charles","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Translational Biomarker Group, Department of Medicine, University of Geneva, Rue Michel Servet 1, 1211 Geneve, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8046-8102","authenticated-orcid":false,"given":"Enrique","family":"Santamar\u00eda","sequence":"additional","affiliation":[{"name":"Clinical Neuroproteomics Unit, Navarrabiomed, Complejo Hospitalario de Navarra (CHN), Universidad P\u00fablica de Navarra (UPNA), Irunlarrea 3, 31008 Pamplona, Spain"},{"name":"Proteored-ISCIII. Proteomics Platform, Navarrabiomed, Complejo Hospitalario de Navarra (CHN), Universidad P\u00fablica de Navarra (UPNA), Irunlarrea 3, 31008 Pamplona, Spain"},{"name":"IdiSNA, Navarra Institute for Health Research, Spain Irunlarrea 3, 31008 Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0967-5868(99)90082-6","article-title":"Neuropathology of three clinical cases prospectively diagnosed as dementia with Lewy bodies","volume":"6","author":"McRitchie","year":"1999","journal-title":"J. Clin. 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