{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:29:22Z","timestamp":1790418562023,"version":"4.1.0"},"reference-count":43,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T00:00:00Z","timestamp":1599091200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/S004505\/1"],"award-info":[{"award-number":["EP\/S004505\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The adsorption of biomolecules on biomaterial surfaces can promote their integration with surrounding tissue without changing their bulk properties. For biomaterials in bone reconstruction, the promotion of osteogenic differentiation and reduction of inflammation are desirable. Fibrillar coatings are interesting because of fibrils\u2019 high surface area-volume ratio, aiding adsorption and adhesion. Fibrils also serve as a matrix for the immobilization of biomolecules with biological activity, such as the phenolic compound phloroglucinol (PG), the subunit of marine polyphenols. The aim of this work was to investigate the influence of PG coatings on fibroblast- and osteoblast-like cells to increase the osseointegration of titanium implants. Collagen fibril coatings, containing PG at low and high concentrations, were produced on titanium alloy (Ti6Al4V) scaffolds generated by additive manufacturing (AM). These coatings, especially PG-enriched coatings, reduced hydrophobicity and modulated the behavior of human osteosarcoma SaOS-2 and mouse embryonic fibroblast 3T3 cell lines. Both osteoblastic and fibroblastic cells spread and adhered well on PG-enriched coatings. Coatings significantly reduced the inflammatory response. Moreover, osteogenic differentiation was promoted by collagen coatings with a high PG concentration. Thus, the enrichment of collagen fibril coatings with PG is a promising strategy to improve Ti6Al4V implants for bone contact in orthopedics and dentistry and is worthy of further investigation.<\/jats:p>","DOI":"10.3390\/ijms21176406","type":"journal-article","created":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T08:40:26Z","timestamp":1599122426000},"page":"6406","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Phenolic-Enriched Collagen Fibrillar Coatings on Titanium Alloy to Promote Osteogenic Differentiation and Reduce Inflammation"],"prefix":"10.3390","volume":"21","author":[{"given":"Anna","family":"Mieszkowska","sequence":"first","affiliation":[{"name":"Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 31-007 Krakow, Poland"},{"name":"Oral Surgery Department, University of Birmingham, Birmingham B15 2TT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harrison","family":"Beaumont","sequence":"additional","affiliation":[{"name":"Engineering Department, Lancaster University, Lancaster LA1 4YW, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7579-965X","authenticated-orcid":false,"given":"Laurine","family":"Martocq","sequence":"additional","affiliation":[{"name":"Engineering Department, Lancaster University, Lancaster LA1 4YW, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey","family":"Koptyug","sequence":"additional","affiliation":[{"name":"Department of Quality Technology, Mechanical Engineering &amp; Mathematics, Mid Sweden University, 851 70 \u00d6stersund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Surmeneva","sequence":"additional","affiliation":[{"name":"Physical Materials Science and Composite Materials Centre, Research School of Chemistry &amp; Applied Biomedical Sciences, National Research Tomsk Polytechnic University, 634050 Tomsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8061-3047","authenticated-orcid":false,"given":"Roman A.","family":"Surmenev","sequence":"additional","affiliation":[{"name":"Physical Materials Science and Composite Materials Centre, Research School of Chemistry &amp; Applied Biomedical Sciences, National Research Tomsk Polytechnic University, 634050 Tomsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3398-6422","authenticated-orcid":false,"given":"Javad","family":"Naderi","sequence":"additional","affiliation":[{"name":"Chemistry Department, Lancaster University, Lancaster LA1 4YW, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy E.L.","family":"Douglas","sequence":"additional","affiliation":[{"name":"Engineering Department, Lancaster University, Lancaster LA1 4YW, UK"},{"name":"Materials Science Institute (MSI), Lancaster University, Lancaster LA1 4YW, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna A.","family":"Gurzawska-Comis","sequence":"additional","affiliation":[{"name":"Oral Surgery Department, University of Birmingham, Birmingham B15 2TT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1159\/000047833","article-title":"Synergistic effect of titanium alloy and collagen type I on cell adhesion, proliferation and differentiation of osteoblast-like cells","volume":"168","author":"Roehlecke","year":"2001","journal-title":"Cells Tissues Organs"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1002\/1097-4636(20000915)51:4<752::AID-JBM25>3.0.CO;2-7","article-title":"Collagen type I-coating of Ti6A14V promotes adhesion of osteoblasts","volume":"51","author":"Hempel","year":"2000","journal-title":"J. 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