{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T11:47:17Z","timestamp":1773402437568,"version":"3.50.1"},"reference-count":62,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T00:00:00Z","timestamp":1600128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Grant from the President of the Russian Federation for young scientists","award":["MD-757.2020.7"],"award-info":[{"award-number":["MD-757.2020.7"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Preeclampsia is a severe disease of late pregnancy. Etiological factors and a pathogenetic pattern of events still require significant clarification, but it is now recognized that a large role is played by placentation disorders and emerging endothelial dysfunction. The administration of short-chain peptides mimicking the spatial structure of the B erythropoietin chain may become one of the directions of searching for new drugs for preeclampsia prevention and therapy. Simulation of ADMA-like preeclampsia in Wistar rats was performed by the administration of a non-selective NOS blocker L-NAME from the 14th to 20th day of pregnancy. The administration of the pHBSP at the doses of 10 \u00b5g\/kg and 250 \u00b5g\/kg corrected the established morphofunctional disorders. The greatest effect was observed at a dose of 250 \u00b5g\/kg. There was a decrease in systolic and diastolic blood pressure by 31.2 and 32.8%, respectively (p &lt; 0.0001), a decrease in the coefficient of endothelial dysfunction by 48.6% (p = 0.0006), placental microcirculation increased by 82.8% (p &lt; 0.0001), the NOx concentration was increased by 42,6% (p = 0.0003), the greater omentum edema decreased by 11.7% (p = 0.0005) and proteinuria decreased by 76.1% (p &lt; 0.0002). In addition, there was an improvement in the morphological pattern of the fetoplacental complex and the ratio of BAX to Bcl-2 expression which characterizes the apoptotic orientation of the cells.<\/jats:p>","DOI":"10.3390\/ijms21186759","type":"journal-article","created":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T10:24:09Z","timestamp":1600165449000},"page":"6759","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Erythropoietin Mimetic Peptide (pHBSP) Corrects Endothelial Dysfunction in a Rat Model of Preeclampsia"],"prefix":"10.3390","volume":"21","author":[{"given":"Mikhail","family":"Korokin","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Clinical Pharmacology, Institute of medicine, Belgorod State National Research University, 308015 Belgorod, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1433-1225","authenticated-orcid":false,"given":"Vladimir","family":"Gureev","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Clinical Pharmacology, Institute of medicine, Belgorod State National Research University, 308015 Belgorod, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oleg","family":"Gudyrev","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Clinical Pharmacology, Institute of medicine, Belgorod State National Research University, 308015 Belgorod, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Golubev","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Clinical Pharmacology, Institute of medicine, Belgorod State National Research University, 308015 Belgorod, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliya","family":"Korokina","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Clinical Pharmacology, Institute of medicine, Belgorod State National Research University, 308015 Belgorod, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Peresypkina","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Clinical Pharmacology, Institute of medicine, Belgorod State National Research University, 308015 Belgorod, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana","family":"Pokrovskaia","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Clinical Pharmacology, Institute of medicine, Belgorod State National Research University, 308015 Belgorod, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Galina","family":"Lazareva","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology FPE, Kursk State Medical University, 305000 Kursk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladislav","family":"Soldatov","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Clinical Pharmacology, Institute of medicine, Belgorod State National Research University, 308015 Belgorod, Russia"},{"name":"Institute of Gene Biology of the Russian Academy of Sciences, Core Facility \u201cGenome editing\u201d, 119334 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariya","family":"Zatolokina","sequence":"additional","affiliation":[{"name":"Department of Histology, Embryology, Cytology, Kursk State Medical University, 305000 Kursk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0541-8946","authenticated-orcid":false,"given":"Anna","family":"Pobeda","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Clinical Pharmacology, Institute of medicine, Belgorod State National Research University, 308015 Belgorod, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Avdeeva","sequence":"additional","affiliation":[{"name":"Department of Normal Physiology, Kursk State Medical University, 305000 Kursk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6009-5740","authenticated-orcid":false,"given":"Evgeniya","family":"Beskhmelnitsyna","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Clinical Pharmacology, Institute of medicine, Belgorod State National Research University, 308015 Belgorod, 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State National Research University, 308015 Belgorod, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1111\/aogs.13774","article-title":"The maternal and perinatal implications of hypertensive disorders of pregnancy in a multiple pregnancy cohort Acta Obstet","volume":"99","author":"Meaney","year":"2020","journal-title":"Gynecol. 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