{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T11:39:21Z","timestamp":1793014761902,"version":"4.5.0"},"reference-count":78,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2020,9,19]],"date-time":"2020-09-19T00:00:00Z","timestamp":1600473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Chronic rhinosinusitis is a common inflammatory disease of paranasal sinuses, which causes rhinorrhea, nasal congestion, and hyposmia. The genetic predisposition or the exposure to irritants can sustain the inflammatory response and the development of nasal polyposis. Nasal polyps are benign and teardrop-shaped growths that project in the nasal cavities, and originate from the ethmoid sinuses. This inflammatory process is associated with high expression of IL-4, IL-5 and IL-13 and IgE. Antibodies targeting these cytokines or receptors represent a therapeutic strategy in the treatment of nasal polyposis in combination with corticosteroids. The molecular pathogenesis of nasal polyps in chronic rhinosinusitis (CRS) patients is associated with remodeling transition, a process in which epithelial cells lose their typical phenotype, acquiring a mesenchymal-like aspect. TGF\u03b2\/SMAD, ERK, and Wnt\/\u03b2-catenin pathways are altered during the nasal tissue remodeling. miRNA and inhibitor molecules targeting these signaling pathways are able to interfere with the process; which could lead to alternative therapies. Nasal polyps are an alternative source of mesenchymal stem cells, which can be isolated from surgical biopsies. A molecular understanding of the biology of PO-MSCs will contribute to the delineating inflammatory process underlying the development of nasal polyps.<\/jats:p>","DOI":"10.3390\/ijms21186878","type":"journal-article","created":{"date-parts":[[2020,9,19]],"date-time":"2020-09-19T07:06:09Z","timestamp":1600499169000},"page":"6878","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Nasal Polyposis: Insights in Epithelial-Mesenchymal Transition and Differentiation of Polyp Mesenchymal Stem Cells"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8314-715X","authenticated-orcid":false,"given":"Emanuela","family":"Chiarella","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Haematopoiesis and Stem Cell Biology, Department of Experimental and Clinical Medicine, University \u201cMagna Gr\u00e6cia\u201d, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4479-399X","authenticated-orcid":false,"given":"Nicola","family":"Lombardo","sequence":"additional","affiliation":[{"name":"Otolaryngology Head and Neck Surgery, Department Medical and Surgical Sciences, University \u201cMagna Gr\u00e6cia\u201d, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Lobello","sequence":"additional","affiliation":[{"name":"Otolaryngology Head and Neck Surgery, Department Medical and Surgical Sciences, University \u201cMagna Gr\u00e6cia\u201d, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Aloisio","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Haematopoiesis and Stem Cell Biology, Department of Experimental and Clinical Medicine, University \u201cMagna Gr\u00e6cia\u201d, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teodoro","family":"Aragona","sequence":"additional","affiliation":[{"name":"Otolaryngology, A.O.U. 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(2020). Phenotypes in Chronic Rhinosinusitis. Curr. Allergy Asthma Rep., 20.","DOI":"10.1007\/s11882-020-00916-6"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.jaip.2016.05.004","article-title":"Phenotypes and emerging endotypes of chronic rhinosinusitis","volume":"4","author":"Bachert","year":"2016","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4193\/Rhin20.401","article-title":"European position paper on rhinosinusitis and nasal polyps","volume":"58","author":"Fokkens","year":"2020","journal-title":"Rhinology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s40629-017-0048-5","article-title":"Subtyping of polyposis nasi: Phenotypes, endotypes and comorbidities","volume":"27","author":"Koennecke","year":"2018","journal-title":"Allergo J. Int."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.amjoto.2018.03.020","article-title":"Nasal polyposis pathophysiology: Endotype and phenotype open issues","volume":"39","author":"Brescia","year":"2018","journal-title":"Am. J. Otolaryngol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.jaip.2016.04.012","article-title":"Chronic Rhinosinusitis with Nasal Polyps","volume":"4","author":"Stevens","year":"2016","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_7","first-page":"pii: S2239253X19029608","article-title":"Nasal and systemic eosinophilia associated with solid intestinal tumors, a case report and review of the literature","volume":"8","author":"Caruso","year":"2019","journal-title":"Ann. Ital. Chir."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1146\/annurev-pathol-052016-100401","article-title":"Immunopathogenesis of Chronic Rhinosinusitis and Nasal Polyposis","volume":"12","author":"Schleimer","year":"2017","journal-title":"Annu. Rev. Pathol."},{"key":"ref_9","first-page":"47","article-title":"Olfactory mucosa in nasal polyposis: Implications for FESS outcome","volume":"48","author":"Konstantinidis","year":"2010","journal-title":"Rhinology"},{"key":"ref_10","first-page":"E1","article-title":"The role of MMP-2, MMP-9, and TIMP-1 in the pathogenesis of nasal polyps: Immunohistochemical assessment at eight different levels in the epithelial, subepithelial, and deep layers of the mucosa","volume":"94","author":"Muluk","year":"2015","journal-title":"Ear Nose Throat J."},{"key":"ref_11","first-page":"86","article-title":"Recurrent sinonasal polyposis after the endoscopic sinus surgery","volume":"1","author":"Fereshteh","year":"2014","journal-title":"Rev. Clin. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/j.jaci.2016.05.041","article-title":"Diversity of TH cytokine profiles in patients with chronic rhinosinusitis: A multicenter study in Europe, Asia, and Oceania","volume":"138","author":"Wang","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.4049\/jimmunol.1101283","article-title":"Hierarchical IL-5 expression defines a subpopulation of highly differentiated human Th2 cells","volume":"187","author":"Upadhyaya","year":"2011","journal-title":"J. Immunol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/nature12526","article-title":"Type 2 innate lymphoid cells control eosinophil homeostasis","volume":"502","author":"Nussbaum","year":"2013","journal-title":"Nature"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12950-016-0121-8","article-title":"Pathogenesis of eosinophilic chronic rhinosinusitis","volume":"13","author":"Shah","year":"2016","journal-title":"J. Inflamm."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.2147\/DDDT.S243053","article-title":"Dupilumab: Clinical Efficacy of Blocking IL-4\/IL-13 Signalling in Chronic Rhinosinusitis with Nasal Polyps","volume":"14","author":"Kariyawasam","year":"2020","journal-title":"Drug Des. Deve.l Ther."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s11882-018-0776-8","article-title":"Precision Medicine in Chronic Rhinosinusitis with Nasal Polyps","volume":"18","author":"Avdeeva","year":"2018","journal-title":"Curr. Allergy Asthma Rep."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2058738420950851","DOI":"10.1177\/2058738420950851","article-title":"Real-life effects of benralizumab on allergic chronic rhinosinusitis and nasal polyposis associated with severe asthma","volume":"34","author":"Lombardo","year":"2020","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1939-4551-7-32","article-title":"Anti-IL5 therapy for asthma and beyond","volume":"7","author":"Mukherjee","year":"2014","journal-title":"World Allergy Organ. J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.jaci.2020.05.032","article-title":"Efficacy and safety of omalizumab in nasal polyposis: 2 randomized phase 3 trials","volume":"146","author":"Gevaert","year":"2020","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1165\/rcmb.2003-0071OC","article-title":"Characterization of interleukin-4-stimulated nasal polyp fibroblasts","volume":"30","author":"Steinke","year":"2004","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s11882-013-0373-9","article-title":"Role of interleukin-13 in asthma","volume":"13","author":"Corren","year":"2013","journal-title":"Curr. Allergy Asthma Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"100050","DOI":"10.1016\/j.waojou.2019.100050","article-title":"Biologics for the treatment of chronic rhinosinusitis with nasal polyps - state of the art","volume":"12","author":"Ren","year":"2019","journal-title":"World Allergy Organ. J."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1016\/S0140-6736(19)31881-1","article-title":"Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): Results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials","volume":"394","author":"Bachert","year":"2019","journal-title":"Lancet"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1365-2559.2005.02310.x","article-title":"Wound healing after paranasal sinus surgery: Neutrophilic inflammation influences the outcome","volume":"48","author":"Watelet","year":"2006","journal-title":"Histopathology"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"4619","DOI":"10.1038\/srep04619","article-title":"Reduced growth and proliferation dynamics of nasal epithelial stem\/progenitor cells in nasal polyps in vitro","volume":"4","author":"Yu","year":"2014","journal-title":"Sci. Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1002\/lary.23320","article-title":"Airway stem cells: Review of potential impact on understanding of upper airway diseases","volume":"122","author":"Yu","year":"2012","journal-title":"Laryngoscope"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/j.jaci.2014.07.038","article-title":"Impairment of cilia architecture and ciliogenesis in hyperplastic nasal epithelium from nasal polyps","volume":"134","author":"Li","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1111\/all.13221","article-title":"A possible role of stem cells in nasal polyposis","volume":"72","author":"Klimek","year":"2017","journal-title":"Allergy"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1172\/JCI39104","article-title":"The basics of epithelial-mesenchymal transition","volume":"119","author":"Kalluri","year":"2009","journal-title":"J. Clin. Investig."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1164\/rccm.200811-1730OC","article-title":"Induction of epithelial\u2013mesenchymal transition in primary airway epithelial cells from patients with asthma by transforming growth factor-beta 1","volume":"180","author":"Hackett","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.cell.2009.11.007","article-title":"Epithelial-mesenchymal transitions in development and disease","volume":"139","author":"Thiery","year":"2009","journal-title":"Cell"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1177\/194589240401800502","article-title":"Transforming growth factor beta1 in nasal remodeling: Differences between chronic rhinosinusitis and nasal polyposis","volume":"18","author":"Watelet","year":"2004","journal-title":"Am. J. Rhinol."},{"key":"ref_34","first-page":"253.e1","article-title":"TGF-beta signaling and collagen deposition in chronic rhinosinusitis","volume":"124","author":"Derycke","year":"2009","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Park, I.H., Kang, J.H., Shin, J.M., and Lee, H.M. (2016). Trichostatin a Inhibits Epithelial Mesenchymal Transition Induced by TGF-\u03b21 in Airway Epithelium. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0162058"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"8123281","DOI":"10.1155\/2017\/8123281","article-title":"Chemical Chaperone of Endoplasmic Reticulum Stress Inhibits Epithelial-Mesenchymal Transition Induced by TGF-\u03b21 in Airway Epithelium via the c-Src Pathway","volume":"2017","author":"Lee","year":"2017","journal-title":"Mediat. Inflamm."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1165\/rcmb.2010-0347OC","article-title":"Role of endoplasmic reticulum stress in epithelial-mesenchymal transition of alveolar epithelial cells: Effects of misfolded surfactant protein","volume":"45","author":"Zhong","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1159\/000497829","article-title":"TGF-\u03b21 Induces Epithelial-Mesenchymal Transition of Chronic Sinusitis with Nasal Polyps through MicroRNA-21","volume":"179","author":"Li","year":"2019","journal-title":"Int. Arch. Allergy Immunol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3486","DOI":"10.1038\/s41598-017-02358-z","article-title":"Glucocorticoids ameliorate TGF-\u03b21-mediated epithelial-to-mesenchymal transition of airway epithelium through MAPK and Snail\/Slug signaling pathways","volume":"7","author":"Yang","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1164\/rccm.201109-1706OC","article-title":"Hypoxia-inducible factor 1 mediates nasal polypogenesis by inducing epithelial-to-mesenchymal transition","volume":"185","author":"Shin","year":"2012","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s00005-014-0281-2","article-title":"The MEK1\/2-ERK1\/2 pathway is activated in chronic rhinosinusitis with nasal polyps","volume":"62","author":"Linke","year":"2014","journal-title":"Arch. Immunol. Ther. Exp."},{"key":"ref_42","first-page":"3079","article-title":"Can the AGE\/RAGE\/ERK signalling pathway and the epithelial-to-mesenchymal transition interact in the pathogenesis of chronic rhinosinusitis with nasal polyps?","volume":"64","author":"Vetuschi","year":"2020","journal-title":"Eur. J. Histochem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"987","DOI":"10.3892\/ijmm.2017.3097","article-title":"Advanced glycation end products decrease collagen I levels in fibroblasts from the vaginal wall of patients with POP via the RAGE, MAPK and NF-\u03baB pathways","volume":"40","author":"Chen","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/s41385-019-0149-1","article-title":"The IFN-\u03b3-p38, ERK kinase axis exacerbates neutrophilic chronic rhinosinusitis by inducing the epithelial-to-mesenchymal transition","volume":"12","author":"Lee","year":"2019","journal-title":"Mucosal Immunol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1002\/alr.22199","article-title":"Nasal polyp fibroblasts modulate epithelial characteristics via Wnt signaling","volume":"8","author":"Dobzanski","year":"2018","journal-title":"Int. Forum. Allergy Rhinol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1165\/rcmb.2016-0024OC","article-title":"Wnt Signaling in Chronic Rhinosinusitis with Nasal Polyps","volume":"56","author":"Vladar","year":"2017","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.anai.2012.11.016","article-title":"Glycogen synthase kinase 3 in chronic rhinosinusitis: Two faces of a single enzyme in one disease","volume":"110","author":"Linke","year":"2013","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.ejphar.2018.07.060","article-title":"1,8-cineol inhibits the Wnt\/\u03b2-catenin signaling pathway through GSK-3 dephosphorylation in nasal polyps of chronic rhinosinusitis patients","volume":"835","author":"Bruchhage","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.7150\/ijms.35936","article-title":"Agonist of PPAR-\u03b3 Reduced Epithelial-Mesenchymal Transition in Eosinophilic Chronic Rhinosinusitis with Nasal Polyps via Inhibition of High Mobility Group Box1","volume":"16","author":"Yang","year":"2019","journal-title":"Int. J. Med. Sci."},{"key":"ref_50","first-page":"39","article-title":"Nasal Polyp-Derived Mesenchymal Stromal Cells Exhibit Lack of Immune-Associated Molecules and High Levels of Stem\/Progenitor Cells Markers","volume":"8","author":"Pezato","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1002\/jnr.22094","article-title":"ABCB1 is predominantly expressed in human fetal neural stem\/progenitor cells at an early development stage","volume":"87","author":"Yamamoto","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"323","DOI":"10.2478\/raon-2019-0029","article-title":"Transcription factors gene expression in chronic rhinosinusitis with and without nasal polyps","volume":"53","author":"Soklic","year":"2019","journal-title":"Radiol. Oncol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.amjoto.2018.12.002","article-title":"Identification of key genes and pathways in chronic rhinosinusitis with nasal polyps using bioinformatics analysis","volume":"40","author":"Yao","year":"2019","journal-title":"Am. J. Otolaryngol."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Plager, D.A., Kahl, J.C., Asmann, Y.W., Nilson, A.E., Pallanch, J.F., Friedman, O., and Kita, H. (2010). Gene transcription changes in asthmatic chronic rhinosinusitis with nasal polyps and comparison to those in atopic dermatitis. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0011450"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1097\/MLG.0b013e31816b4b6f","article-title":"Gene expression profiling of nasal polyps associated with chronic sinusitis and aspirin-sensitive asthma","volume":"118","author":"Stankovic","year":"2008","journal-title":"Laryngoscope"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.jaci.2004.04.052","article-title":"Gene expression profiles in human nasal polyp tissues studied by means of DNA microarray","volume":"114","author":"Liu","year":"2004","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_57","first-page":"3855","article-title":"Genome wide profiling of lncRNA and mRNA expression in CRSwNP","volume":"19","author":"Liu","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"e264","DOI":"10.18295\/squmj.2018.18.03.002","article-title":"Sources and Clinical Applications of Mesenchymal Stem Cells: State-of-the-art review","volume":"18","year":"2018","journal-title":"Sultan Qaboos Univ. Med. J."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells: The International Society for Cellular Therapy position statement","volume":"8","author":"Dominici","year":"2006","journal-title":"Cytotherapy"},{"key":"ref_60","first-page":"2638305","article-title":"The holy grail of orthopedic surgery: Mesenchymal stem cells - Their current uses and potential applications","volume":"2017","author":"Granados","year":"2017","journal-title":"Stem Cells Int."},{"key":"ref_61","first-page":"3","article-title":"A.J. Friedenstein, founder of the mesenchymal stem cell concept","volume":"1","author":"Afanasyev","year":"2009","journal-title":"Cell. Ther. Transplant."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1177\/1535370214553898","article-title":"Isolation and characterization of multipotent mesenchymal stem cells in nasal polyps","volume":"240","author":"Cho","year":"2015","journal-title":"Exp. Biol. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1177\/0963689718807680","article-title":"In Vitro Long-Term Expansion and High Osteogenic Potential of Periodontal Ligament Stem Cells: More Than a Mirage","volume":"28","author":"Giudice","year":"2019","journal-title":"Cell Transplant."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s00005-017-0456-8","article-title":"Neuronal Differentiation Capability of Nasal Polyps of Chronic Rhinosinusitis","volume":"65","author":"Koennecke","year":"2017","journal-title":"Arch. Immunol. Ther. Exp."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1089\/scd.2009.0267","article-title":"The human nose harbors a niche of olfactory ectomesenchymal stem cells displaying neurogenic and osteogenic properties","volume":"19","author":"Delorme","year":"2010","journal-title":"Stem Cells Dev."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Chiarella, E., Aloisio, A., Scicchitano, S., Lucchino, V., Montalcini, Y., Galasso, O., Greco, M., Gasparini, G., Mesuraca, M., and Bond, H.M. (2018). ZNF521 Represses Osteoblastic Differentiation in Human Adipose-Derived Stem Cells. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19124095"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Di Vito, A., Chiarella, E., Baudi, F., Scardamaglia, P., Antonelli, A., Giudice, D., Barni, T., Fortunato, L., and Giudice, A. (2020). Dose-dependent effects of zoledronic acid on human periodontal ligament stem cells: An in vitro pilot study. Cell Transplant., in press.","DOI":"10.1177\/0963689720948497"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Hwang, S.H., Park, S.H., Choi, J., Lee, D.C., Oh, J.H., Kim, S.W., and Kim, J.B. (2014). Characteristics of mesenchymal stem cells originating from the bilateral inferior turbinate in humans with nasal septal deviation. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0100219"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1007\/s12015-018-9830-0","article-title":"ZNF521 Has an Inhibitory Effect on the Adipogenic Differentiation of Human Adipose-Derived Mesenchymal Stem Cells","volume":"14","author":"Chiarella","year":"2018","journal-title":"Stem Cell Rev. Rep."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3389\/fendo.2018.00255","article-title":"ZNF423: A New Player in Estrogen Receptor-Positive Breast Cancer","volume":"9","author":"Bond","year":"2018","journal-title":"Front. Endocrinol."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Kang, S., Akerblad, P., Kiviranta, R., Gupta, R.K., Kajimura, S., Griffin, M.J., Min, J., Baron, R., and Rosen, E.D. (2012). Regulation of early adipose commitment by Zfp521. PLoS Biol, 10.","DOI":"10.1371\/journal.pbio.1001433"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1021\/pr501288h","article-title":"Validation of a novel shotgun proteomic workflow for the discovery of protein-protein interactions: Focus on ZNF521","volume":"14","author":"Bernaudo","year":"2015","journal-title":"J. Proteome Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"318793","DOI":"10.1155\/2014\/318793","article-title":"Expression profiling and functional implications of a set of zinc finger proteins, ZNF423, ZNF470, ZNF521, and ZNF780B, in primary osteoarthritic articular chondrocytes","volume":"2014","author":"Mesuraca","year":"2014","journal-title":"Mediat. Inflamm."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1089\/104454903321515922","article-title":"OX9 exerts a bifunctional effect on type II collagen gene (COL2A1) expression in chondrocytes depending on the differentiation state","volume":"22","author":"Kypriotou","year":"2003","journal-title":"DNA Cell Biol."},{"key":"ref_75","first-page":"e2762","article-title":"Isolating nasal olfactory stem cells from rodents or humans","volume":"54","author":"Girard","year":"2011","journal-title":"J. Vis. Exp."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"583409","DOI":"10.1155\/2014\/583409","article-title":"Immunoregulatory effects of bone marrow-derived mesenchymal stem cells in the nasal polyp microenvironment","volume":"2014","author":"Pezato","year":"2014","journal-title":"Mediat. Inflamm."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"436476","DOI":"10.1155\/2014\/436476","article-title":"Adipose-derived stem cells ameliorate allergic airway inflammation by inducing regulatory T cells in a mouse model of asthma","volume":"2014","author":"Cho","year":"2014","journal-title":"Mediat. Inflamm."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.3727\/096368911X623925","article-title":"Adipose Tissue-Derived Stem Cell Treatment Prevents Renal Disease Progression","volume":"21","author":"Semedo","year":"2012","journal-title":"Cell Transplant."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/21\/18\/6878\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:11:38Z","timestamp":1760177498000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/21\/18\/6878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,19]]},"references-count":78,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2020,9]]}},"alternative-id":["ijms21186878"],"URL":"https:\/\/doi.org\/10.3390\/ijms21186878","relation":{"has-preprint":[{"id-type":"doi","id":"10.20944\/preprints202008.0087.v1","asserted-by":"object"}]},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,19]]}}}