{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:41:53Z","timestamp":1761745313866,"version":"build-2065373602"},"reference-count":388,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T00:00:00Z","timestamp":1600819200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Commission ERA-NET on Cardiovascular Diseases JTC 2018 \u201cTransnational Cardiovascular Research Projects driven by Early Career Scientists\u201d, JTC2018-046 DENIM","award":["JTC2018-046"],"award-info":[{"award-number":["JTC2018-046"]}]},{"DOI":"10.13039\/501100002426","name":"Fondazione Telethon","doi-asserted-by":"publisher","award":["GUP19012"],"award-info":[{"award-number":["GUP19012"]}],"id":[{"id":"10.13039\/501100002426","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004710","name":"Fondazione Umberto Veronesi","doi-asserted-by":"publisher","award":["FUV2015-2017"],"award-info":[{"award-number":["FUV2015-2017"]}],"id":[{"id":"10.13039\/501100004710","id-type":"DOI","asserted-by":"publisher"}]},{"name":"La Fondazione Istituto Europeo di Oncologia e del Centro Cardiologico Monzino","award":["IEO-CCM 2017-2018"],"award-info":[{"award-number":["IEO-CCM 2017-2018"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The ultimate goal of precision disease modeling is to artificially recreate the disease of affected people in a highly controllable and adaptable external environment. This field has rapidly advanced which is evident from the application of patient-specific pluripotent stem-cell-derived precision therapies in numerous clinical trials aimed at a diverse set of diseases such as macular degeneration, heart disease, spinal cord injury, graft-versus-host disease, and muscular dystrophy. Despite the existence of semi-adequate treatments for tempering skeletal muscle degeneration in dystrophic patients, nonischemic cardiomyopathy remains one of the primary causes of death. Therefore, cardiovascular cells derived from muscular dystrophy patients\u2019 induced pluripotent stem cells are well suited to mimic dystrophin-associated cardiomyopathy and hold great promise for the development of future fully effective therapies. The purpose of this article is to convey the realities of employing precision disease models of dystrophin-associated cardiomyopathy. This is achieved by discussing, as suggested in the title echoing William Shakespeare\u2019s words, the settlements (or \u201cleagues\u201d) made by researchers to manage the constraints (\u201cbetwixt mine eye and heart\u201d) distancing them from achieving a perfect precision disease model.<\/jats:p>","DOI":"10.3390\/ijms21196997","type":"journal-article","created":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T09:28:08Z","timestamp":1600853288000},"page":"6997","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["\u201cBetwixt Mine Eye and Heart a League Is Took\u201d: The Progress of Induced Pluripotent Stem-Cell-Based Models of Dystrophin-Associated Cardiomyopathy"],"prefix":"10.3390","volume":"21","author":[{"given":"Davide","family":"Rovina","sequence":"first","affiliation":[{"name":"Centro Cardiologico Monzino-IRCCS, Unit of Vascular Biology and Regenerative Medicine, 20138 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Castiglioni","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino-IRCCS, Unit of Vascular Biology and Regenerative Medicine, 20138 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Niro","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino-IRCCS, Unit of Vascular Biology and Regenerative Medicine, 20138 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Mallia","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino-IRCCS, Unit of Vascular Biology and Regenerative Medicine, 20138 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulio","family":"Pompilio","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino-IRCCS, Unit of Vascular Biology and Regenerative Medicine, 20138 Milan, Italy"},{"name":"Centro Cardiologico Monzino-IRCCS, Department of Cardiac Surgery, Centro Cardiologico Monzino IRCCS, 20138 Milan, Italy"},{"name":"Department of Clinical Sciences and Community Health, Universit\u00e0 degli Studi di Milano, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aoife","family":"Gowran","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino-IRCCS, Unit of Vascular Biology and Regenerative Medicine, 20138 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1038\/nbt.3388","article-title":"A comparison of genetically matched cell lines reveals the equivalence of human iPSCs and ESCs","volume":"33","author":"Choi","year":"2015","journal-title":"Nat. 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