{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T19:33:32Z","timestamp":1781897612845,"version":"3.54.5"},"reference-count":46,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T00:00:00Z","timestamp":1600992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Tzu-Chi Medical Foundation","award":["TCMMP108-04"],"award-info":[{"award-number":["TCMMP108-04"]}]},{"name":"Tzu-Chi Medical Foundation","award":["TCMMP104-06"],"award-info":[{"award-number":["TCMMP104-06"]}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["107-2311-B-320-002-MY3"],"award-info":[{"award-number":["107-2311-B-320-002-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["105-2923-B-320-001-MY3"],"award-info":[{"award-number":["105-2923-B-320-001-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Ultraviolet (UV) radiation from sunlight has various adverse effects; thus, UV blockage is recommended for preventing sunburn. Common sunscreen ingredients, such as nanosized titanium dioxide and zinc oxide, offer effective protection and enhance cosmetic appearance; however, health concerns have been raised regarding their photocatalytic activity, which generates reactive oxygen species under UV illumination. Silver nanoparticles (AgNPs) are known as safe materials for use in a wide spectrum of biomedical applications. In vitro studies have revealed that AgNPs may have a protective effect against UV irradiation, but the effects in animal studies remain unclear. The present study demonstrated that AgNPs effectively protect against UVB-induced skin damage both in cell cultures and mouse models. These results suggested that AgNPs are feasible and safe as sunscreen ingredients for protection against UVB-induced skin damage.<\/jats:p>","DOI":"10.3390\/ijms21197082","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T09:15:23Z","timestamp":1601025323000},"page":"7082","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Silver Nanoparticles Protect Skin from Ultraviolet B-Induced Damage in Mice"],"prefix":"10.3390","volume":"21","author":[{"given":"Yu-Yi","family":"Ho","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Human Genetics, Tzu-Chi University, Hualien 97004, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Der-Shan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Human Genetics, Tzu-Chi University, Hualien 97004, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8731-3485","authenticated-orcid":false,"given":"Hsin-Hou","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Human Genetics, Tzu-Chi University, Hualien 97004, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/S0140-6736(07)60638-2","article-title":"Photoprotection","volume":"370","author":"Lautenschlager","year":"2007","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"164","DOI":"10.4103\/0973-7847.91114","article-title":"Potential of herbs in skin protection from ultraviolet radiation","volume":"5","author":"Korac","year":"2011","journal-title":"Pharmacogn. 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