{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:07:04Z","timestamp":1790734024112,"version":"4.1.0"},"reference-count":178,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T00:00:00Z","timestamp":1600992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2018\/25813-8"],"award-info":[{"award-number":["2018\/25813-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Magnesium (Mg2+) is an essential mineral for the functioning and maintenance of the body. Disturbances in Mg2+ intracellular homeostasis result in cell-membrane modification, an increase in oxidative stress, alteration in the proliferation mechanism, differentiation, and apoptosis. Mg2+ deficiency often results in inflammation, with activation of inflammatory pathways and increased production of proinflammatory cytokines by immune cells. Immune cells and others that make up the blood system are from hematopoietic tissue in the bone marrow. The hematopoietic tissue is a tissue with high indices of renovation, and Mg2+ has a pivotal role in the cell replication process, as well as DNA and RNA synthesis. However, the impact of the intra- and extracellular disturbance of Mg2+ homeostasis on the hematopoietic tissue is little explored. This review deals specifically with the physiological requirements of Mg2+ on hematopoiesis, showing various studies related to the physiological requirements and the effects of deficiency or excess of this mineral on the hematopoiesis regulation, as well as on the specific process of erythropoiesis, granulopoiesis, lymphopoiesis, and thrombopoiesis. The literature selected includes studies in vitro, in animal models, and in humans, giving details about the impact that alterations of Mg2+ homeostasis can have on hematopoietic cells and hematopoietic tissue.<\/jats:p>","DOI":"10.3390\/ijms21197084","type":"journal-article","created":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T22:24:42Z","timestamp":1601245482000},"page":"7084","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["A Review of the Action of Magnesium on Several Processes Involved in the Modulation of Hematopoiesis"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3695-4458","authenticated-orcid":false,"given":"Fabiana da Silva","family":"Lima","sequence":"first","affiliation":[{"name":"Department of Food and Experimental Nutrition, School of Pharmaceutical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Ambr\u00f3sio","family":"Fock","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Hematology, Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of S\u00e3o Paulo, Avenida Lineu Prestes, 580-Bloco 17, S\u00e3o Paulo 05508-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1053\/j.ackd.2017.11.005","article-title":"Dietary Magnesium and Chronic Disease","volume":"25","author":"Nielsen","year":"2018","journal-title":"Adv. Chronic Kidney Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"620","DOI":"10.3181\/00379727-148-38596","article-title":"The Effect of Magnesium Deficiency in Mice on Serum Immunoglobulin Concentrations and Antibody Plaque-Forming Cells","volume":"148","author":"Elin","year":"1975","journal-title":"Exp. Boil. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"D607","DOI":"10.2741\/Wolf","article-title":"Magnesium in cell proliferation and differentiation","volume":"4","author":"Wolf","year":"1999","journal-title":"Front. Biosci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0925-4439(00)00018-1","article-title":"Inflammatory response following acute magnesium deficiency in the rat","volume":"1501","author":"Nowacki","year":"2000","journal-title":"Biochim. Biophys. Acta (BBA)-Mol. Basis Dis."},{"key":"ref_5","first-page":"93","article-title":"Influence of graded magnesium deficiencies on white blood cell counts and lymphocyte subpopulations in rats","volume":"19","author":"Eggett","year":"2006","journal-title":"Magnes. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2147\/JIR.S136742","article-title":"Magnesium deficiency and increased inflammation: Current perspectives","volume":"11","author":"Nielsen","year":"2018","journal-title":"J. Inflamm. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1126\/science.1163493","article-title":"Deletion of Trpm7 Disrupts Embryonic Development and Thymopoiesis Without Altering Mg2+ Homeostasis","volume":"322","author":"Jin","year":"2008","journal-title":"Science"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.3389\/fimmu.2019.02000","article-title":"Magnesium Restores Activity to Peripheral Blood Cells in a Patient With Functionally Impaired Interleukin-2-Inducible T Cell Kinase","volume":"10","author":"Howe","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.actbio.2015.08.037","article-title":"An in vivo model to assess magnesium alloys and their biological effect on human bone marrow stromal cells","volume":"28","author":"Yoshizawa","year":"2015","journal-title":"Acta Biomater."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.gene.2015.08.028","article-title":"Effects of magnesium degradation products on mesenchymal stem cell fate and osteoblastogenesis","volume":"575","year":"2016","journal-title":"Gene"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jnutbio.2018.02.006","article-title":"An insight into the role of magnesium in the immunomodulatory properties of mesenchymal stem cells","volume":"55","author":"Lima","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s12011-015-0459-4","article-title":"Role of Magnesium Transporter Subtype 1 (MagT1) in the Osteogenic Differentiation of Rat Bone Marrow Stem Cells","volume":"171","author":"Zheng","year":"2015","journal-title":"Boil. Trace Element Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1084\/jem.179.5.1677","article-title":"Human osteoblasts support hematopoiesis through the production of granulocyte colony-stimulating factor","volume":"179","author":"Taichman","year":"1994","journal-title":"J. Exp. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1182\/blood.V87.2.518.bloodjournal872518","article-title":"Human osteoblasts support human hematopoietic progenitor cells in vitro bone marrow cultures","volume":"87","author":"Taichman","year":"1996","journal-title":"Blood"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1182\/blood.V29.4.683.683","article-title":"Leukocytosis, Bone Marrow Hyperplasia and Leukemia in Chronic Magnesium Deficiency in the Rat","volume":"29","author":"McCreary","year":"1967","journal-title":"Blood"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"11097","DOI":"10.1038\/ncomms11097","article-title":"Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg2+ homeostasis and cytoskeletal architecture","volume":"7","author":"Stritt","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"eaah6692","DOI":"10.1126\/scisignal.aah6692","article-title":"The channel-kinase TRPM7 regulates antigen gathering and internalization in B cells","volume":"11","author":"Krishnamoorthy","year":"2018","journal-title":"Sci. Signal."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"751","DOI":"10.3390\/cells3030751","article-title":"Cellular and Developmental Biology of TRPM7 Channel-Kinase: Implicated Roles in Cancer","volume":"3","author":"Yee","year":"2014","journal-title":"Cells"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1113\/JP271564","article-title":"\u00d3; Ryazanova, L.V.; Penner, R.; Ryazanov, A.G.; Fleig, A. TRPM7 kinase activity regulates murine mast cell degranulation","volume":"594","author":"Zierler","year":"2016","journal-title":"J. Physiol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Nadolni, W., and Zierler, S. (2018). The Channel-Kinase TRPM7 as Novel Regulator of Immune System Homeostasis. Cells, 7.","DOI":"10.20944\/preprints201807.0237.v1"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1007\/s12035-019-01713-7","article-title":"Magnesium-Induced Cell Survival Is Dependent on TRPM7 Expression and Function","volume":"57","author":"Sun","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"72941","DOI":"10.18632\/oncotarget.12146","article-title":"Decreased TRPM7 inhibits activities and induces apoptosis of bladder cancer cells via ERK1\/2 pathway","volume":"7","author":"Cao","year":"2016","journal-title":"Oncotarget"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Zou, Z.G., Rios, F.J., Montezano, A.C., and Touyz, R.M. (2019). TRPM7, Magnesium, and Signaling. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20081877"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3563","DOI":"10.1002\/jcb.23284","article-title":"Magnesium deficiency suppresses cell cycle progression mediated by increase in transcriptional activity of p21Cip1 and p27Kip1 in renal epithelial NRK-52E cells","volume":"112","author":"Ikari","year":"2011","journal-title":"J. Cell. Biochem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0027-5107(01)00074-4","article-title":"Role of magnesium in genomic stability","volume":"475","author":"Hartwig","year":"2001","journal-title":"Mutat. Res. Mol. Mech. Mutagen."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/(SICI)1097-4644(19980901)70:3<313::AID-JCB4>3.0.CO;2-Q","article-title":"Magnesium restriction induces granulocytic differentiation and expression of p27Kip1 in human leukemic HL-60 cells","volume":"70","author":"Covacci","year":"1998","journal-title":"J. Cell. Biochem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.actbio.2015.08.042","article-title":"Effects of extracellular magnesium extract on the proliferation and differentiation of human osteoblasts and osteoclasts in coculture","volume":"27","author":"Wu","year":"2015","journal-title":"Acta Biomater."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Mammoli, F., Castiglioni, S., Parenti, S., Cappadone, C., Farruggia, G., Iotti, S., Davalli, P., Maier, J.A., Grande, A., and Frassineti, C. (2019). Magnesium Is a Key Regulator of the Balance between Osteoclast and Osteoblast Differentiation in the Presence of Vitamin D3. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20020385"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1093\/jn\/133.8.2505","article-title":"Magnesium deficiency induces apoptosis in primary cultures of rat hepatocytes","volume":"133","author":"Martin","year":"2003","journal-title":"J. Nutr."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Ohyama, T. (2019). New Aspects of Magnesium Function: A Key Regulator in Nucleosome Self-Assembly, Chromatin Folding and Phase Separation. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20174232"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"7839","DOI":"10.1038\/s41598-017-08379-y","article-title":"Magnesium Chloride promotes Osteogenesis through Notch signaling activation and expansion of Mesenchymal Stem Cells","volume":"7","author":"Herencia","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/s12011-017-0948-8","article-title":"Magnesium Ions Promote the Biological Behaviour of Rat Calvarial Osteoblasts by Activating the PI3K\/Akt Signalling Pathway","volume":"179","author":"Wang","year":"2017","journal-title":"Boil. Trace Element Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.actbio.2017.08.051","article-title":"Ion channel functional protein kinase TRPM7 regulates Mg ions to promote the osteoinduction of human osteoblast via PI3K pathway: In vitro simulation of the bone-repairing effect of Mg-based alloy implant","volume":"63","author":"Zhang","year":"2017","journal-title":"Acta Biomater."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1684\/mrh.2011.0271","article-title":"High magnesium inhibits human osteoblast differentiation in vitro","volume":"24","author":"Leidi","year":"2011","journal-title":"Magnes Res"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s00223-001-1091-1","article-title":"Magnesium Deficiency: Effect on Bone and Mineral Metabolism in the Mouse","volume":"72","author":"Rude","year":"2003","journal-title":"Calcif. Tissue Int."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.2741\/1610","article-title":"Magnesium and microvascular endothelial cells: A role in inflammation and angiogenesis","volume":"10","author":"Bernardini","year":"2005","journal-title":"Front. Biosci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.bbadis.2010.06.016","article-title":"Magnesium deficiency promotes a pro-atherogenic phenotype in cultured human endothelial cells via activation of NFkB","volume":"1802","author":"Baldoli","year":"2010","journal-title":"Biochim. Et Biophys. Acta (BBA)-Mol. Basis Dis."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s10456-011-9242-0","article-title":"Silencing TRPM7 mimics the effects of magnesium deficiency in human microvascular endothelial cells","volume":"15","author":"Baldoli","year":"2011","journal-title":"Angiogenesis"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1901166","DOI":"10.1002\/advs.201901166","article-title":"Magnesium Regulates Endothelial Barrier Functions through TRPM7, MagT1, and S1P1","volume":"6","author":"Zhu","year":"2019","journal-title":"Adv. Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1097\/HJH.0000000000001129","article-title":"Oral magnesium supplementation improves endothelial function and attenuates subclinical atherosclerosis in thiazide-treated hypertensive women","volume":"35","author":"Cunha","year":"2017","journal-title":"J. Hypertens."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/s41598-017-00205-9","article-title":"Effects of long-term magnesium supplementation on endothelial function and cardiometabolic risk markers: A randomized controlled trial in overweight\/obese adults","volume":"7","author":"Joris","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_42","first-page":"147","article-title":"Effects of a low extracellular magnesium concentration and endotoxin on IL-1beta and TNF-alpha release from, and mRNA levels in, isolated rat alveolar macrophages","volume":"15","author":"Shogi","year":"2002","journal-title":"Magnes. Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.jss.2012.04.045","article-title":"Magnesium deficiency promotes secretion of high-mobility group box 1 protein from lipopolysaccharide-activated macrophages in vitro","volume":"180","author":"Liu","year":"2013","journal-title":"J. Surg. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"6338","DOI":"10.4049\/jimmunol.1101765","article-title":"Magnesium decreases inflammatory cytokine production: A novel innate immunomodulatory mechanism","volume":"188","author":"Sugimoto","year":"2012","journal-title":"J. Immunol."},{"key":"ref_45","first-page":"765","article-title":"Effect of magnesium deficiency on erythrocyte aging in rats","volume":"100","author":"Elin","year":"1980","journal-title":"Am. J. Pathol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0955-2863(99)00076-5","article-title":"Influence of magnesium deficiency on the bioavailability and tissue distribution of iron in the rat","volume":"11","author":"Planells","year":"2000","journal-title":"J. Nutr. Biochem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.nut.2008.05.002","article-title":"Joint association of magnesium and iron intake with anemia among Chinese adults","volume":"24","author":"Shi","year":"2008","journal-title":"Nutrition"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s12011-014-9967-x","article-title":"Association between serum magnesium and anemia: China health and nutrition survey","volume":"159","author":"Zhan","year":"2014","journal-title":"Biol. Trace Element Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/trstmh\/try109","article-title":"The prevalence of serum magnesium and iron deficiency anaemia among Sudanese women in early pregnancy: A cross-sectional study","volume":"113","author":"Eltayeb","year":"2019","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/BF02685995","article-title":"Effects of magnesium supplementation on blood parameters of athletes at rest and after exercise","volume":"115","author":"Cinar","year":"2007","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"182","DOI":"10.3181\/00379727-115-28864","article-title":"Role of histamine in producing the eosinophilia of magnesium deficiency","volume":"115","author":"Hungerford","year":"1964","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1093\/jn\/110.5.851","article-title":"Blood and mast cell histamine levels in magnesium-deficient rats","volume":"110","author":"Kraeuter","year":"1980","journal-title":"J. Nutr."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1093\/jn\/107.12.2164","article-title":"Variations in the mast cell population of skin and bone marrow in magnesium-deprived rats. The influence of sex hormones","volume":"107","year":"1977","journal-title":"J. Nutr."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1079\/BJN2001498","article-title":"Increased phagocytosis and production of reactive oxygen species by neutrophils during magnesium deficiency in rats and inhibition by high magnesium concentration","volume":"87","author":"Gueux","year":"2002","journal-title":"Br. J. Nutr."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s12011-015-0406-4","article-title":"Prevalence of Thrombocytopenia and Its Association with Serum Magnesium","volume":"169","author":"Lu","year":"2016","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_56","first-page":"717","article-title":"Effects of reduced dietary magnesium on platelet production and function in hamsters","volume":"63","author":"Rishi","year":"1990","journal-title":"Lab. Investig."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1152\/physrev.1924.4.4.533","article-title":"Relation of Blood cells to connective tissues and endothelium","volume":"4","author":"Maximow","year":"1924","journal-title":"Physiol. Rev."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1126\/science.102.2651.400","article-title":"Immunogenetic consequences of vascular anastomoses between bovine twins","volume":"102","author":"Owen","year":"1945","journal-title":"Science"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"213","DOI":"10.2307\/3570892","article-title":"A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells","volume":"14","author":"McCulloch","year":"1961","journal-title":"Radiat. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"3923","DOI":"10.1182\/blood-2007-08-078147","article-title":"Stem-cell ecology and stem cells in motion","volume":"111","author":"Papayannopoulou","year":"2008","journal-title":"Blood"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"3543","DOI":"10.1182\/blood-2008-08-078220","article-title":"The origins of the identification and isolation of hematopoietic stem cells, and their capability to induce donor-specific transplantation tolerance and treat autoimmune diseases","volume":"112","author":"Weissman","year":"2008","journal-title":"Blood"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1097\/MOH.0b013e3283007db5","article-title":"Cytokines regulating hematopoietic stem cell function","volume":"15","author":"Zhang","year":"2008","journal-title":"Curr. Opin. Hematol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.tcb.2018.06.001","article-title":"Hematopoietic Hierarchy \u2013 An Updated Roadmap","volume":"28","author":"Zhang","year":"2018","journal-title":"Trends Cell Boil."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.cell.2008.01.025","article-title":"Hematopoiesis: An Evolving Paradigm for Stem Cell Biology","volume":"132","author":"Orkin","year":"2008","journal-title":"Cell"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"a008250","DOI":"10.1101\/cshperspect.a008250","article-title":"Hematopoiesis","volume":"4","author":"Rieger","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_66","first-page":"7","article-title":"The relationship between the spleen colony-forming cell and the haemopoietic stem cell","volume":"4","author":"Schofield","year":"1978","journal-title":"Blood Cells"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.cytogfr.2014.12.004","article-title":"The unbearable lightness of bone marrow homeostasis","volume":"26","author":"Agas","year":"2015","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cell.2014.02.013","article-title":"Nice neighborhood: Emerging concepts of the stem cell niche","volume":"157","author":"Scadden","year":"2014","journal-title":"Cell"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1152\/physiol.00025.2005","article-title":"The Bone Marrow Vascular Niche: Home of HSC Differentiation and Mobilization","volume":"20","author":"Kopp","year":"2005","journal-title":"Physiology"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nature12984","article-title":"The bone marrow niche for haematopoietic stem cells","volume":"505","author":"Morrison","year":"2014","journal-title":"Nature"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"jcs201707","DOI":"10.1242\/jcs.201707","article-title":"The bone marrow microenvironment in health and disease at a glance","volume":"131","author":"Kumar","year":"2018","journal-title":"J. Cell Sci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nature08099","article-title":"Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment","volume":"460","author":"Naveiras","year":"2009","journal-title":"Nature"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/jmcb\/mjp030","article-title":"Shifting in Balance between Osteogenesis and Adipogenesis Substantially Influences Hematopoiesis","volume":"2","author":"Sugimura","year":"2009","journal-title":"J. Mol. Cell Boil."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.jnutbio.2004.08.001","article-title":"Magnesium deficiency and osteoporosis: Animal and human observations","volume":"15","author":"Rude","year":"2004","journal-title":"J. Nutr. Biochem."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.3390\/nu5083022","article-title":"Magnesium and Osteoporosis: Current State of Knowledge and Future Research Directions","volume":"5","author":"Castiglioni","year":"2013","journal-title":"Nutrients"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"16195","DOI":"10.1038\/s41598-018-34324-8","article-title":"TRPM7 and MagT1 in the osteogenic differentiation of human mesenchymal stem cells in vitro","volume":"8","author":"Castiglioni","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.bbrc.2019.03.178","article-title":"The simultaneous downregulation of TRPM7 and MagT1 in human mesenchymal stem cells in vitro: Effects on growth and osteogenic differentiation","volume":"513","author":"Castiglioni","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Gruber, H., Rude, R.K., Wei, L., Frausto, A., Mills, B.G., and Norton, H.J. (2003). Magnesium deficiency: Effect on bone mineral density in the mouse appendicular skeleton. BMC Musculoskelet. Disord., 4.","DOI":"10.1186\/1471-2474-4-7"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1743-7075-2-24","article-title":"Immunolocalization of RANKL is Increased and OPG Decreased during Dietary Magnesium Deficiency in the Rat","volume":"2","author":"Rude","year":"2005","journal-title":"Nutr. Metab."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1136\/jcp.55.9.693","article-title":"Adipocytic proportion of bone marrow is inversely related to bone formation in osteoporosis","volume":"55","author":"Verma","year":"2002","journal-title":"J. Clin. Pathol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1023\/A:1011513223894","article-title":"Adipocyte tissue volume in bone marrow is increased with aging and in patients with osteoporosis","volume":"2","author":"Justesen","year":"2001","journal-title":"Biogerontology"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.bone.2017.10.011","article-title":"\u2018T; Lips, P.; Bisschop, P.H.; et al. The effect of raloxifene on bone marrow adipose tissue and bone turnover in postmenopausal women with osteoporosis","volume":"118","author":"Beekman","year":"2019","journal-title":"Bone"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1210\/jc.2012-3949","article-title":"Vertebral Bone Marrow Fat Associated With Lower Trabecular BMD and Prevalent Vertebral Fracture in Older Adults","volume":"98","author":"Schwartz","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1111\/jcmm.13356","article-title":"Oxidative stress induces imbalance of adipogenic\/osteoblastic lineage commitment in mesenchymal stem cells through decreasing SIRT1 functions","volume":"22","author":"Lin","year":"2017","journal-title":"J. Cell. Mol. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S0925-4439(01)00089-8","article-title":"Changes in gene expression in rat thymocytes identified by cDNA array support the occurrence of oxidative stress in early magnesium deficiency","volume":"1586","author":"Petrault","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1017\/S0007114599000690","article-title":"Accelerated thymus involution in magnesium-deficient rats is related to enhanced apoptosis and sensitivity to oxidative stress","volume":"81","author":"Nowacki","year":"1999","journal-title":"Br. J. Nutr."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s10534-005-6898-1","article-title":"Magnesium Deficiency Enhances Hydrogen Peroxide Production and Oxidative Damage in Chick Embryo Hepatocyte In Vitro","volume":"19","author":"Yang","year":"2006","journal-title":"BioMetals"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1016\/j.jnutbio.2011.06.016","article-title":"Nitric oxide mediates low magnesium inhibition of osteoblast-like cell proliferation","volume":"23","author":"Leidi","year":"2012","journal-title":"J. Nutr. Biochem."},{"key":"ref_89","first-page":"237","article-title":"Magnesium deficiency in rats induces a rise in plasma nitric oxide","volume":"8","author":"Rock","year":"1995","journal-title":"Magnes. Res."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Cunha, M.C.R., Lima, F.D.S., Vinolo, M.A.R., Hastreiter, A., Curi, R., Borelli, P., and Fock, R.A. (2013). Protein Malnutrition Induces Bone Marrow Mesenchymal Stem Cells Commitment to Adipogenic Differentiation Leading to Hematopoietic Failure. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0058872"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.3389\/fimmu.2018.02573","article-title":"Lack of Adipocytes Alters Hematopoiesis in Lipodystrophic Mice","volume":"9","author":"Wilson","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_92","first-page":"891","article-title":"Bone marrow adipocytes promote the regeneration of stem cells and haematopoiesis by secreting SCF","volume":"19","author":"Zhou","year":"2017","journal-title":"Nature"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/j.exphem.2009.09.005","article-title":"Downregulation of GATA-2 and overexpression of adipogenic gene-PPAR\u03b3 in mesenchymal stem cells from patients with aplastic anemia","volume":"37","author":"Xu","year":"2009","journal-title":"Exp. Hematol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"eaau9087","DOI":"10.1126\/scitranslmed.aau9087","article-title":"Reprogrammed marrow adipocytes contribute to myeloma-induced bone disease","volume":"11","author":"Liu","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/ncb2730","article-title":"Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment","volume":"15","author":"Pivarnik","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s10456-017-9541-1","article-title":"The role of vasculature in bone development, regeneration and proper systemic functioning","volume":"20","author":"Filipowska","year":"2017","journal-title":"Angiogenesis"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.cell.2005.05.026","article-title":"SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells","volume":"121","author":"Kiel","year":"2005","journal-title":"Cell"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nature10783","article-title":"Endothelial and perivascular cells maintain haematopoietic stem cells","volume":"481","author":"Ding","year":"2012","journal-title":"Nature"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.stem.2010.02.001","article-title":"Endothelial Cells Are Essential for the Self-Renewal and Repopulation of Notch-Dependent Hematopoietic Stem Cells","volume":"6","author":"Butler","year":"2010","journal-title":"Cell Stem Cell"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.celrep.2013.07.048","article-title":"Endothelial Jagged-1 Is Necessary for Homeostatic and Regenerative Hematopoiesis","volume":"4","author":"Poulos","year":"2013","journal-title":"Cell Rep."},{"key":"ref_101","first-page":"306","article-title":"Bone marrow blood vessels: Normal and neoplastic niche","volume":"10","author":"Shahrabi","year":"2016","journal-title":"Oncol. Rev."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nature17624","article-title":"Distinct bone marrow blood vessels differentially regulate haematopoiesis","volume":"532","author":"Itkin","year":"2016","journal-title":"Nature"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1042\/CS20110506","article-title":"Endothelial cells and magnesium: Implications in atherosclerosis","volume":"122","author":"Maier","year":"2011","journal-title":"Clin. Sci."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.bbadis.2004.01.002","article-title":"Low magnesium promotes endothelial cell dysfunction: Implications for atherosclerosis, inflammation and thrombosis","volume":"1689","author":"Maier","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Baldoli, E., Castiglioni, S., and Maier, J.A. (2013). Regulation and Function of TRPM7 in Human Endothelial Cells: TRPM7 as a Potential Novel Regulator of Endothelial Function. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0059891"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.atherosclerosis.2018.04.020","article-title":"Effect of magnesium supplementation on endothelial function: A systematic review and meta-analysis of randomized controlled trials","volume":"273","author":"Mofrad","year":"2018","journal-title":"Atherosclerosis"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"4815","DOI":"10.1182\/blood-2009-11-253534","article-title":"Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs","volume":"116","author":"Winkler","year":"2010","journal-title":"Blood"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.exphem.2016.01.003","article-title":"Macrophages: Key regulators of steady-state and demand-adapted hematopoiesis","volume":"44","author":"McCabe","year":"2016","journal-title":"Exp. Hematol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1084\/jem.20101688","article-title":"Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche","volume":"208","author":"Chow","year":"2011","journal-title":"J. Exp. Med."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1182\/blood-2008-03-077883","article-title":"Erythroblastic islands: Niches for erythropoiesis","volume":"112","author":"Chasis","year":"2008","journal-title":"Blood"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41586-018-0709-7","article-title":"VCAM-1+ macrophages guide the homing of HSPCs to a vascular niche","volume":"564","author":"Li","year":"2018","journal-title":"Nature"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/0753-3322(94)90005-1","article-title":"Cytokines and macrophages","volume":"48","author":"Cavaillon","year":"1994","journal-title":"Biomed. Pharmacother."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1182\/blood-2007-03-079681","article-title":"Hematopoietic cytokines","volume":"111","author":"Metcalf","year":"2008","journal-title":"Blood"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1684\/mrh.2016.0398","article-title":"Extracellular magnesium and calcium blockers modulate macrophage activity","volume":"29","author":"Libako","year":"2016","journal-title":"Magnes. Res."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1038\/sj.ejcn.1601689","article-title":"Possible roles of magnesium on the immune system","volume":"57","author":"Tam","year":"2003","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"R734","DOI":"10.1152\/ajpregu.1992.263.3.R734","article-title":"Pathobiology of magnesium deficiency: A cytokine\/neurogenic inflammation hypothesis","volume":"263","author":"Weglicki","year":"1992","journal-title":"Am. J. Physiol. Integr. Comp. Physiol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.abb.2006.03.031","article-title":"Magnesium and the inflammatory response: Potential physiopathological implications","volume":"458","author":"Mazur","year":"2007","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/S0024-3205(02)02371-8","article-title":"Magnesium-deficient medium enhances NO production in alveolar macrophages isolated from rats","volume":"72","author":"Yokoyama","year":"2003","journal-title":"Life Sci."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jnutbio.2018.01.008","article-title":"Regulatory responses of hepatocytes, macrophages and vascular endothelial cells to magnesium deficiency","volume":"56","author":"Shigematsu","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"3406","DOI":"10.1038\/s41598-018-21783-2","article-title":"Magnesium enhances the chondrogenic differentiation of mesenchymal stem cells by inhibiting activated macrophage-induced inflammation","volume":"8","author":"Hu","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.jss.2013.06.030","article-title":"Phosphoinositide 3-kinase\/Akt pathway is involved in mediating the anti-inflammation effects of magnesium sulfate","volume":"185","author":"Su","year":"2013","journal-title":"J. Surg. Res."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/rb\/rbaa010","article-title":"In vitro immunomodulation of magnesium on monocytic cell toward anti-inflammatory macrophages","volume":"7","author":"Sun","year":"2020","journal-title":"Regen. Biomater."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"42707","DOI":"10.1038\/srep42707","article-title":"In vitro and in vivo responses of macrophages to magnesium-doped titanium","volume":"7","author":"Li","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.stem.2019.05.019","article-title":"TNF-\u03b1 Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration","volume":"25","author":"Yamashita","year":"2019","journal-title":"Cell Stem Cell"},{"key":"ref_125","first-page":"607","article-title":"Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal","volume":"18","author":"Pietras","year":"2016","journal-title":"Nature"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.dci.2015.12.012","article-title":"Development and differentiation of the erythroid lineage in mammals","volume":"58","author":"Barminko","year":"2016","journal-title":"Dev. Comp. Immunol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.stem.2018.11.022","article-title":"Restricted Hematopoietic Progenitors and Erythropoiesis Require SCF from Leptin Receptor+ Niche Cells in the Bone Marrow","volume":"24","author":"Comazzetto","year":"2019","journal-title":"Cell Stem Cell"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41420-019-0151-0","article-title":"Maturation-associated gene expression profiles during normal human bone marrow erythropoiesis","volume":"5","author":"Mello","year":"2019","journal-title":"Cell Death Discov."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.bone.2018.03.014","article-title":"Erythropoiesis, EPO, macrophages, and bone","volume":"119","author":"Eggold","year":"2019","journal-title":"Bone"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"873628","DOI":"10.1155\/2015\/873628","article-title":"Phylogenetic and Ontogenetic View of Erythroblastic Islands","volume":"2015","author":"Giger","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1146\/annurev.nutr.24.012003.132306","article-title":"New insights into erythropoiesis: The roles of folate, vitamin B12, and iron","volume":"24","author":"Koury","year":"2004","journal-title":"Annu Rev. Nutr."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1172\/JCI101062","article-title":"The magnesium content of the erythrocytes in pernicious and some other anemias","volume":"18","author":"Bang","year":"1939","journal-title":"J. Clin. Investig."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1182\/blood.V36.4.500.500","article-title":"Microcytic anemia with erythroblastosis in offspring of magnesium-deprived rats","volume":"36","author":"Cohlan","year":"1970","journal-title":"Blood"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1182\/blood.V41.3.451.451","article-title":"The hemolytic anemia of magnesium deficiency in adult rats","volume":"41","author":"Piomelli","year":"1973","journal-title":"Blood."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1203\/00006450-197706000-00013","article-title":"Magnesium deficiency anemia in the rat fetus","volume":"11","author":"Cosens","year":"1977","journal-title":"Pediatr. Res."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/0026-0495(87)90118-1","article-title":"Dietary magnesium intake influences exercise capacity and hematologic parameters in rats","volume":"36","author":"Keen","year":"1987","journal-title":"Metabolism"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"2738","DOI":"10.1182\/blood.V88.7.2738.bloodjournal8872738","article-title":"Modulation of erythrocyte potassium chloride cotransport, potassium content, and density by dietary magnesium intake in transgenic SAD mouse","volume":"88","author":"Beuzard","year":"1996","journal-title":"Blood"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"C1366","DOI":"10.1152\/ajpcell.1994.267.5.C1366","article-title":"Loss of red blood cell glutathione during Mg deficiency: Prevention by vitamin, E.; D-propranolol, and chloroquine","volume":"267","author":"Mak","year":"1994","journal-title":"Am. J. Physiol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"C385","DOI":"10.1152\/ajpcell.1996.271.1.C385","article-title":"Enhanced NO production during Mg deficiency and its role in mediating red blood cell glutathione loss","volume":"271","author":"Mak","year":"1996","journal-title":"Am. J. Physiol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1081\/PRG-200030319","article-title":"Evaluation of red blood cell deformability and uterine blood flow in pregnant women with preeclampsia or iugr and reduced uterine blood flow following the intravenous application of magnesium","volume":"23","author":"Schauf","year":"2004","journal-title":"Hypertens. Pregnancy"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1081\/PRG-45767","article-title":"Effect of magnesium on red blood cell deformability in pregnancy","volume":"24","author":"Schauf","year":"2005","journal-title":"Hypertens. Pregnancy"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.clnu.2015.12.015","article-title":"Dietary pattern, serum magnesium, ferritin, C-reactive protein and anaemia among older people","volume":"36","author":"Xu","year":"2017","journal-title":"Clin Nutr."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1113\/jphysiol.2010.195057","article-title":"Regulation of erythropoietin production","volume":"589","author":"Jelkmann","year":"2011","journal-title":"J. Physiol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1159\/000500921","article-title":"Association between Serum Magnesium and Erythropoietin Responsiveness in Hemodialysis Patients: A Cross-Sectional Study","volume":"44","author":"Yu","year":"2019","journal-title":"Kidney Blood Press Res."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"19077","DOI":"10.1074\/jbc.M109.004424","article-title":"Magnesium deficiency causes loss of response to intermittent hypoxia in paraganglion cells","volume":"284","author":"Torii","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.blre.2012.12.003","article-title":"Regulation of erythropoiesis by hypoxia-inducible factors","volume":"27","author":"Haase","year":"2013","journal-title":"Blood Rev."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"560","DOI":"10.3177\/jnsv.59.560","article-title":"Magnesium deficiency induces the emergence of mast cells in the liver of rats","volume":"59","author":"Takemoto","year":"2013","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1079\/BJN19970200","article-title":"Marked alterations in circulating inflammatory cells during cardiomyopathy development in a magnesium-deficient rat model","volume":"78","author":"Cassidy","year":"1997","journal-title":"Br. J. Nutr."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s12026-008-8049-6","article-title":"Neutrophil apoptosis and the resolution of infection","volume":"43","author":"Kennedy","year":"2009","journal-title":"Immunol. Res."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/nri3660","article-title":"Emergency granulopoiesis","volume":"14","author":"Manz","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"3682","DOI":"10.1182\/blood-2006-02-003012","article-title":"STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils","volume":"108","author":"Panopoulos","year":"2006","journal-title":"Blood"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.it.2019.05.004","article-title":"Granulopoiesis and Neutrophil Homeostasis: A Metabolic, Daily Balancing Act","volume":"40","author":"Ng","year":"2019","journal-title":"Trends Immunol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"e12949","DOI":"10.1111\/eci.12949","article-title":"CXCR4, the master regulator of neutrophil trafficking in homeostasis and disease","volume":"48","author":"Rankin","year":"2018","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1038\/ni.2921","article-title":"Neutrophils at work","volume":"15","author":"Nauseef","year":"2014","journal-title":"Nat. Immunol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1042\/bj2890373","article-title":"Changes in free cytoplasmic magnesium following activation of human lymphocytes","volume":"289","author":"Rijkers","year":"1993","journal-title":"Biochem. J."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s12026-012-8371-x","article-title":"The role of Mg2+ in immune cells","volume":"55","author":"Brandao","year":"2013","journal-title":"Immunol. Res."},{"key":"ref_157","first-page":"217","article-title":"Recent Advances: Immunopathology of Magnesium Deficiency in Rats. Induction of Tumors; Incidence, Transmission and Prevention of Lymphoma-Leukemia","volume":"3","author":"Hass","year":"1981","journal-title":"Magnes. Bull."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/BF02783816","article-title":"Thymic lymphosarcoma in magnesium-deficient rats","volume":"1","author":"Jasmin","year":"1979","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/BF00402054","article-title":"Development and properties of malignant lymphoma induced by magnesium deficiency in rats","volume":"104","author":"Averdunk","year":"1982","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1038\/2041316a0","article-title":"Tumour of the thymus in magnesium-deficient rats","volume":"204","author":"BOIS","year":"1964","journal-title":"Nature"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"555","DOI":"10.3109\/10428190009113385","article-title":"High prevelance of chronic magnesium deficiency in T cell lymphoblastic leukemia and chronic zinc deficiency in children with acute lymphoblastic leukemia and malignant lymphoma","volume":"39","author":"Sahin","year":"2000","journal-title":"Leuk. Lymphoma"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"101","DOI":"10.32007\/jfacmedbagdad.5111193","article-title":"Serum Magnesium Concentration in Patients with Leukemia and Lymphoma","volume":"51","author":"Merza","year":"2009","journal-title":"Fac. Med. Baghdad."},{"key":"ref_163","first-page":"185","article-title":"Hypomagnesemia associated with chemotherapy in patients treated for acute lymphoblastic leukemia: Possible mechanisms","volume":"11","author":"Guo","year":"2004","journal-title":"Oncol. Rep."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s12011-018-1340-z","article-title":"Correlation of Calcium and Magnesium Levels in the Biological Samples of Different Types of Acute Leukemia Children","volume":"186","author":"Afridi","year":"2018","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/nri3233","article-title":"Ion channels and transporters in lymphocyte function and immunity","volume":"12","author":"Feske","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.cmet.2008.06.002","article-title":"TRPM7 ion channels are required for sustained phosphoinositide 3-kinase signaling in lymphocytes","volume":"8","author":"Sahni","year":"2008","journal-title":"Cell Metab."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"eaan2693","DOI":"10.1126\/scisignal.aan2693","article-title":"The ion channel TRPM7 is required for B cell lymphopoiesis","volume":"11","author":"Krishnamoorthy","year":"2018","journal-title":"Sci. Signal."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1182\/blood-2013-11-538686","article-title":"XMEN disease: A new primary immunodeficiency affecting Mg2+ regulation of immunity against Epstein-Barr virus","volume":"123","author":"Li","year":"2014","journal-title":"Blood"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1172\/JCI131116","article-title":"Defective glycosylation and multisystem abnormalities characterize the primary immunodeficiency XMEN disease","volume":"130","author":"Ravell","year":"2020","journal-title":"J. Clin. Investig."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"9865","DOI":"10.1073\/pnas.1817815116","article-title":"Mutations in MAGT1 lead to a glycosylation disorder with a variable phenotype","volume":"116","author":"Blommaert","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1007\/s10875-020-00790-x","article-title":"An Update on XMEN Disease","volume":"40","author":"Ravell","year":"2020","journal-title":"J. Clin. Immunol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"13638","DOI":"10.1074\/jbc.RA119.008903","article-title":"Magnesium transporter 1 (MAGT1) deficiency causes selective defects in N-linked glycosylation and expression of immune-response genes","volume":"294","author":"Biancalana","year":"2019","journal-title":"J. Boil. Chem."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1126\/science.1240094","article-title":"Mg2+ Regulates Cytotoxic Functions of NK and CD8 T Cells in Chronic EBV Infection Through NKG2D","volume":"341","author":"Li","year":"2013","journal-title":"Science"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1067\/mhj.2000.107553","article-title":"Low intracellular magnesium levels promote platelet-dependent thrombosis in patients with coronary artery disease","volume":"140","author":"Shechter","year":"2000","journal-title":"Am. Heart J."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1097\/00001721-199603000-00033","article-title":"Magnesium inhibits human platelets","volume":"7","author":"Ravn","year":"1996","journal-title":"Blood Coagul. Fibrinolysis"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"835","DOI":"10.2337\/diacare.15.7.835","article-title":"Intracellular free magnesium deficiency plays a key role in increased platelet reactivity in type II diabetes mellitus","volume":"15","author":"Nadler","year":"1992","journal-title":"Diabetes Care"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1016\/j.metabol.2004.06.021","article-title":"Relationship of intracellular magnesium of cord blood platelets to birth weight","volume":"53","author":"Takaya","year":"2004","journal-title":"Metabolism"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1017\/S0954422418000112","article-title":"A review of select minerals influencing the haematopoietic process","volume":"31","author":"Oliveira","year":"2018","journal-title":"Nutr. Res. Rev."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/21\/19\/7084\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:13:45Z","timestamp":1760177625000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/21\/19\/7084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,25]]},"references-count":178,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2020,10]]}},"alternative-id":["ijms21197084"],"URL":"https:\/\/doi.org\/10.3390\/ijms21197084","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,25]]}}}