{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T06:23:49Z","timestamp":1791699829118,"version":"4.3.4"},"reference-count":314,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T00:00:00Z","timestamp":1600992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"CIHR","doi-asserted-by":"publisher","award":["MOP-89931, PJT-153146, and PJT-419466"],"award-info":[{"award-number":["MOP-89931, PJT-153146, and PJT-419466"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Epithelial ovarian cancer (EOC) is the deadliest gynecological cancer, and the major cause of death is mainly attributed to metastasis. MicroRNAs (miRNAs) are a group of small non-coding RNAs that exert important regulatory functions in many biological processes through their effects on regulating gene expression. In most cases, miRNAs interact with the 3\u2032 UTRs of target mRNAs to induce their degradation and suppress their translation. Aberrant expression of miRNAs has been detected in EOC tumors and\/or the biological fluids of EOC patients. Such dysregulation occurs as the result of alterations in DNA copy numbers, epigenetic regulation, and miRNA biogenesis. Many studies have demonstrated that miRNAs can promote or suppress events related to EOC metastasis, such as cell migration, invasion, epithelial-to-mesenchymal transition, and interaction with the tumor microenvironment. In this review, we provide a brief overview of miRNA biogenesis and highlight some key events and regulations related to EOC metastasis. We summarize current knowledge on how miRNAs are dysregulated, focusing on those that have been reported to regulate metastasis. Furthermore, we discuss the role of miRNAs in promoting and inhibiting EOC metastasis. Finally, we point out some limitations of current findings and suggest future research directions in the field.<\/jats:p>","DOI":"10.3390\/ijms21197093","type":"journal-article","created":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T22:24:42Z","timestamp":1601245482000},"page":"7093","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["The Role of microRNAs in Epithelial Ovarian Cancer Metastasis"],"prefix":"10.3390","volume":"21","author":[{"given":"Vu Hong Loan","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of Biology, York University, Toronto, ON M3J 1P3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0852-0409","authenticated-orcid":false,"given":"Chenyang","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Biology, York University, Toronto, ON M3J 1P3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin Y.","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Biology, York University, Toronto, ON M3J 1P3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Salem","sequence":"additional","affiliation":[{"name":"Department of Biology, York University, Toronto, ON M3J 1P3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Department of Biology, York University, Toronto, ON M3J 1P3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Biology, York University, Toronto, ON M3J 1P3, Canada"},{"name":"Centre for Research in Biomolecular Interactions, York University, Toronto, ON M3J 1P3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21551","article-title":"Cancer statistics, 2019","volume":"69","author":"Siegel","year":"2019","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.critrevonc.2017.10.007","article-title":"Ovarian sex-cord stromal tumours and small cell tumours: Pathological, genetic and management aspects","volume":"120","author":"Boussios","year":"2017","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_3","unstructured":"National Academies of Sciences, Engineering, and Medicine (2016). Ovarian Cancers: Evolving Paradigms in Research and Care, The National Academies Press."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s12943-017-0638-3","article-title":"Ovarian cancer stem cells: Still an elusive entity?","volume":"16","author":"Lupia","year":"2017","journal-title":"Mol. Cancer"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.bpobgyn.2016.08.006","article-title":"Epidemiology of epithelial ovarian cancer","volume":"41","author":"Webb","year":"2017","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"16061","DOI":"10.1038\/nrdp.2016.61","article-title":"Ovarian cancer","volume":"2","author":"Matulonis","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1126\/science.1064921","article-title":"Identification of novel genes coding for small expressed RNAs","volume":"294","author":"Rauhut","year":"2001","journal-title":"Science"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/S0092-8674(01)00616-X","article-title":"microRNAs: Tiny regulators with great potential","volume":"107","author":"Ambros","year":"2001","journal-title":"Cell"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1101\/gr.082701.108","article-title":"Most mammalian mRNAs are conserved targets of microRNAs","volume":"19","author":"Friedman","year":"2009","journal-title":"Genome Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.tcb.2014.11.004","article-title":"The biological functions of miRNAs: Lessons from in vivo studies","volume":"25","author":"Vidigal","year":"2015","journal-title":"Trends Cell Biol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Staicu, C.E., Predescu, D.V., Rusu, C.M., Radu, B.M., Cretoiu, D., Suciu, N., Cretoiu, S.M., and Voinea, S.C. (2020). Role of microRNAs as Clinical Cancer Biomarkers for Ovarian Cancer: A Short Overview. Cells, 9.","DOI":"10.3390\/cells9010169"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Chen, S.N., Chang, R., Lin, L.T., Chern, C.U., Tsai, H.W., Wen, Z.H., Li, Y.H., Li, C.J., and Tsui, K.H. (2019). MicroRNA in Ovarian Cancer: Biology, Pathogenesis, and Therapeutic Opportunities. Int. J. Environ. Res. Public Health, 16.","DOI":"10.3390\/ijerph16091510"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Roberts, C.M., Cardenas, C., and Tedja, R. (2019). The Role of Intra-Tumoral Heterogeneity and Its Clinical Relevance in Epithelial Ovarian Cancer Recurrence and Metastasis. Cancers, 11.","DOI":"10.3390\/cancers11081083"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Godnic, I., Zorc, M., Jevsinek Skok, D., Calin, G.A., Horvat, S., Dovc, P., Kovac, M., and Kunej, T. (2013). Genome-wide and species-wide in silico screening for intragenic MicroRNAs in human, mouse and chicken. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0065165"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/nbt.3947","article-title":"An integrated expression atlas of miRNAs and their promoters in human and mouse","volume":"35","author":"Abugessaisa","year":"2017","journal-title":"Nat. Biotechnol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/sj.emboj.7601512","article-title":"Processing of intronic microRNAs","volume":"26","author":"Kim","year":"2007","journal-title":"EMBO J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1261\/rna.041814.113","article-title":"Biogenesis of intronic miRNAs located in clusters by independent transcription and alternative splicing","volume":"20","author":"Ramalingam","year":"2014","journal-title":"RNA"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.4049\/jimmunol.1103175","article-title":"Dynamic microRNA gene transcription and processing during T cell development","volume":"188","author":"Kirigin","year":"2012","journal-title":"J. Immunol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"4051","DOI":"10.1038\/sj.emboj.7600385","article-title":"MicroRNA genes are transcribed by RNA polymerase II","volume":"23","author":"Lee","year":"2004","journal-title":"EMBO J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"E1881","DOI":"10.1073\/pnas.1602532113","article-title":"Re-evaluation of the roles of DROSHA, Export in 5, and DICER in microRNA biogenesis","volume":"113","author":"Kim","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nature03120","article-title":"The Microprocessor complex mediates the genesis of microRNAs","volume":"432","author":"Gregory","year":"2004","journal-title":"Nature"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1261\/rna.1591709","article-title":"Post-transcriptional control of DGCR8 expression by the Microprocessor","volume":"15","author":"Triboulet","year":"2009","journal-title":"RNA"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1261\/rna.5167604","article-title":"Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs","volume":"10","author":"Bohnsack","year":"2004","journal-title":"RNA"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1101\/sqb.2006.71.050","article-title":"Substrate selectivity of exportin 5 and Dicer in the biogenesis of microRNAs","volume":"71","author":"Lund","year":"2006","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nature05983","article-title":"Intronic microRNA precursors that bypass Drosha processing","volume":"448","author":"Ruby","year":"2007","journal-title":"Nature"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1101\/gad.1705308","article-title":"Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs","volume":"22","author":"Babiarz","year":"2008","journal-title":"Genes Dev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0092-8674(01)00431-7","article-title":"Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing","volume":"106","author":"Grishok","year":"2001","journal-title":"Cell"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/35053110","article-title":"Role for a bidentate ribonuclease in the initiation step of RNA interference","volume":"409","author":"Bernstein","year":"2001","journal-title":"Nature"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1126\/science.1062039","article-title":"A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans","volume":"293","author":"Knight","year":"2001","journal-title":"Science"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/35005107","article-title":"An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells","volume":"404","author":"Hammond","year":"2000","journal-title":"Nature"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.cell.2005.10.022","article-title":"Human RISC couples microRNA biogenesis and posttranscriptional gene silencing","volume":"123","author":"Gregory","year":"2005","journal-title":"Cell"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/nsmb.1733","article-title":"ATP-dependent human RISC assembly pathways","volume":"17","author":"Yoda","year":"2010","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1126\/science.1064023","article-title":"Argonaute2, a link between genetic and biochemical analyses of RNAi","volume":"293","author":"Hammond","year":"2001","journal-title":"Science"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.tibs.2010.03.009","article-title":"Making RISC","volume":"35","author":"Kawamata","year":"2010","journal-title":"Trends Biochem. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1101\/gad.1749809","article-title":"Essential and overlapping functions for mammalian Argonautes in microRNA silencing","volume":"23","author":"Su","year":"2009","journal-title":"Genes Dev."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.omtn.2019.04.012","article-title":"Synthetic Design of Asymmetric miRNA with an Engineered 3\u2032 Overhang to Improve Strand Selection","volume":"16","author":"Kadekar","year":"2019","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.molcel.2004.07.007","article-title":"Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs","volume":"15","author":"Meister","year":"2004","journal-title":"Mol. Cell."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3389\/fendo.2018.00402","article-title":"Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation","volume":"9","author":"Hayder","year":"2018","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nrg2936","article-title":"Gene silencing by microRNAs: Contributions of translational repression and mRNA decay","volume":"12","author":"Huntzinger","year":"2011","journal-title":"Nat. Rev. Genet."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1042\/BST20130047","article-title":"Argonaute and GW182 proteins: An effective alliance in gene silencing","volume":"41","author":"Pfaff","year":"2013","journal-title":"Biochem. Soc. Trans."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.molcel.2013.07.011","article-title":"Structure of the PAN3 pseudokinase reveals the basis for interactions with the PAN2 deadenylase and the GW182 proteins","volume":"51","author":"Christie","year":"2013","journal-title":"Mol. Cell"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nrg3965","article-title":"Towards a molecular understanding of microRNA-mediated gene silencing","volume":"16","author":"Jonas","year":"2015","journal-title":"Nat. Rev. Genet."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1101\/gad.1424106","article-title":"mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes","volume":"20","author":"Rehwinkel","year":"2006","journal-title":"Genes Dev."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1038\/nsmb.2413","article-title":"A direct interaction between DCP1 and XRN1 couples mRNA decapping to 5\u2019 exonucleolytic degradation","volume":"19","author":"Braun","year":"2012","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/cdd.2014.112","article-title":"The complexity of miRNA-mediated repression","volume":"22","author":"Wilczynska","year":"2015","journal-title":"Cell Death Differ."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Xu, W., San Lucas, A., Wang, Z., and Liu, Y. (2014). Identifying microRNA targets in different gene regions. BMC Bioinform., 15.","DOI":"10.1186\/1471-2105-15-S7-S4"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Dharap, A., Pokrzywa, C., Murali, S., Pandi, G., and Vemuganti, R. (2013). MicroRNA miR-324-3p induces promoter-mediated expression of RelA gene. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0079467"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"14879","DOI":"10.1073\/pnas.0803230105","article-title":"A search for conserved sequences in coding regions reveals that the let-7 microRNA targets Dicer within its coding sequence","volume":"105","author":"Forman","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_49","first-page":"7215","article-title":"Oncogenic role of microRNA-532-5p in human colorectal cancer via targeting of the 5\u2019UTR of RUNX3","volume":"15","author":"Zhang","year":"2018","journal-title":"Oncol. Lett."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1038\/srep00842","article-title":"MicroRNA-mediated mRNA translation activation in quiescent cells and oocytes involves recruitment of a nuclear microRNP","volume":"2","author":"Truesdell","year":"2012","journal-title":"Sci. Rep."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.molcel.2008.05.001","article-title":"MicroRNA-10a binds the 5\u2019UTR of ribosomal protein mRNAs and enhances their translation","volume":"30","author":"Orom","year":"2008","journal-title":"Mol. Cell."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/S1470-2045(06)70939-1","article-title":"Mechanisms of transcoelomic metastasis in ovarian cancer","volume":"7","author":"Tan","year":"2006","journal-title":"Lancet Oncol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"C444","DOI":"10.1152\/ajpcell.00188.2015","article-title":"Cellular and molecular processes in ovarian cancer metastasis. A Review in the Theme: Cell and Molecular Processes in Cancer Metastasis","volume":"309","author":"Yeung","year":"2015","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.2353\/ajpath.2010.100105","article-title":"Ovarian cancer development and metastasis","volume":"177","author":"Lengyel","year":"2010","journal-title":"Am. J. Pathol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s10911-010-9178-9","article-title":"Epithelial-mesenchymal transition in cancer: Parallels between normal development and tumor progression","volume":"15","author":"Micalizzi","year":"2010","journal-title":"J. Mammary Gland Biol. Neoplasia"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"3645","DOI":"10.1158\/0008-5472.CAN-07-2938","article-title":"Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways","volume":"68","author":"Onder","year":"2008","journal-title":"Cancer Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"10069","DOI":"10.1073\/pnas.0703900104","article-title":"Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers","volume":"104","author":"Mani","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3389\/fonc.2012.00033","article-title":"Epithelial-mesenchymal transition in ovarian carcinoma","volume":"2","author":"Davidson","year":"2012","journal-title":"Front. Oncol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.3892\/ijo.2017.3948","article-title":"MicroRNAs driving invasion and metastasis in ovarian cancer: Opportunities for translational medicine (Review)","volume":"50","author":"Marchat","year":"2017","journal-title":"Int. J. Oncol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nrc2131","article-title":"Snail, Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype?","volume":"7","author":"Peinado","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.devcel.2008.05.009","article-title":"Epithelial-mesenchymal transition: At the crossroads of development and tumor metastasis","volume":"14","author":"Yang","year":"2008","journal-title":"Dev. Cell"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1101\/gad.225334.113","article-title":"Epithelial-mesenchymal plasticity in carcinoma metastasis","volume":"27","author":"Tsai","year":"2013","journal-title":"Genes Dev."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/path.4443","article-title":"MiR-506 inhibits multiple targets in the epithelial-to-mesenchymal transition network and is associated with good prognosis in epithelial ovarian cancer","volume":"235","author":"Sun","year":"2015","journal-title":"J. Pathol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1172\/JCI39104","article-title":"The basics of epithelial-mesenchymal transition","volume":"119","author":"Kalluri","year":"2009","journal-title":"J. Clin. Investig."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.cell.2017.05.016","article-title":"Wnt\/beta-Catenin Signaling, Disease, and Emerging Therapeutic Modalities","volume":"169","author":"Nusse","year":"2017","journal-title":"Cell"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s13048-019-0596-z","article-title":"Wnt\/beta-catenin signalling in ovarian cancer: Insights into its hyperactivation and function in tumorigenesis","volume":"12","author":"Nguyen","year":"2019","journal-title":"J. Ovarian Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1530\/ERC-15-0383","article-title":"TGFbeta signaling regulates epithelial-mesenchymal plasticity in ovarian cancer ascites-derived spheroids","volume":"23","author":"Rafehi","year":"2016","journal-title":"Endocr. Relat. Cancer"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Zhou, X., Hu, Y., Dai, L., Wang, Y., Zhou, J., Wang, W., Di, W., and Qiu, L. (2014). MicroRNA-7 inhibits tumor metastasis and reverses epithelial-mesenchymal transition through AKT\/ERK1\/2 inactivation by targeting EGFR in epithelial ovarian cancer. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0096718"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s40291-016-0201-8","article-title":"The Therapeutic Potential of Targeting the HGF\/cMET Axis in Ovarian Cancer","volume":"20","year":"2016","journal-title":"Mol. Diagn. Ther."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1186\/s13046-019-1494-3","article-title":"MicroRNA-338-3p suppresses ovarian cancer cells growth and metastasis: Implication of Wnt\/catenin beta and MEK\/ERK signaling pathways","volume":"38","author":"Zhang","year":"2019","journal-title":"J. Exp. Clin. Cancer Res. CR"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s12943-018-0796-y","article-title":"Function of the c-Met receptor tyrosine kinase in carcinogenesis and associated therapeutic opportunities","volume":"17","author":"Zhang","year":"2018","journal-title":"Mol. Cancer"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1007\/s12032-014-0368-y","article-title":"Sonic hedgehog-Gli1 signals promote epithelial-mesenchymal transition in ovarian cancer by mediating PI3K\/AKT pathway","volume":"32","author":"Ke","year":"2015","journal-title":"Med. Oncol. (Northwood Lond. Engl.)"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/onc.2012.632","article-title":"Aurora kinase A mediates epithelial ovarian cancer cell migration and adhesion","volume":"33","author":"Do","year":"2014","journal-title":"Oncogene"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Boussios, S., Mikropoulos, C., Samartzis, E., Karihtala, P., Moschetta, M., Sheriff, M., Karathanasi, A., Sadauskaite, A., Rassy, E., and Pavlidis, N. (2020). Wise Management of Ovarian Cancer: On the Cutting Edge. J. Pers. Med., 10.","DOI":"10.3390\/jpm10020041"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nrm1549","article-title":"Focal adhesion kinase: In command and control of cell motility","volume":"6","author":"Mitra","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"pe22","DOI":"10.1126\/stke.120pe22","article-title":"Focal adhesion kinase versus p53: Apoptosis or survival?","volume":"1","author":"Cance","year":"2008","journal-title":"Sci. Signal."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1242\/jcs.120907","article-title":"Mechanisms that link the oncogenic epithelial-mesenchymal transition to suppression of anoikis","volume":"126","author":"Frisch","year":"2013","journal-title":"J. Cell Sci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1158\/2159-8290.CD-11-0239","article-title":"The outgrowth of micrometastases is enabled by the formation of filopodium-like protrusions","volume":"2","author":"Shibue","year":"2012","journal-title":"Cancer Discov."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/S0002-9440(10)63370-6","article-title":"Biological significance of focal adhesion kinase in ovarian cancer: Role in migration and invasion","volume":"165","author":"Sood","year":"2004","journal-title":"Am. J. Pathol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s10555-008-9165-4","article-title":"Signal transduction by focal adhesion kinase in cancer","volume":"28","author":"Zhao","year":"2009","journal-title":"Cancer Metastasis Rev."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"5917","DOI":"10.1038\/ncomms6917","article-title":"Glucocorticoids mediate induction of microRNA-708 to suppress ovarian cancer metastasis through targeting Rap1B","volume":"6","author":"Lin","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"152452","DOI":"10.1016\/j.prp.2019.152452","article-title":"DAAM1-mediated migration and invasion of ovarian cancer cells are suppressed by miR-208a-5p","volume":"215","author":"Mei","year":"2019","journal-title":"Pathol. Res. Pract."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.3892\/or.2014.3461","article-title":"Upregulation of Limk1 caused by microRNA-138 loss aggravates the metastasis of ovarian cancer by activation of Limk1\/cofilin signaling","volume":"32","author":"Chen","year":"2014","journal-title":"Oncol. Rep."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"41749","DOI":"10.18632\/oncotarget.16978","article-title":"LIM kinases: Cofilin and beyond","volume":"8","author":"Prunier","year":"2017","journal-title":"Oncotarget"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ygyno.2014.04.055","article-title":"Ectopic over-expression of miR-429 induces mesenchymal-to-epithelial transition (MET) and increased drug sensitivity in metastasizing ovarian cancer cells","volume":"134","author":"Wang","year":"2014","journal-title":"Gynecol. Oncol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1111\/cpr.12038","article-title":"Enrichment of ovarian cancer stem-like cells is associated with epithelial to mesenchymal transition through an miRNA-activated AKT pathway","volume":"46","author":"Luo","year":"2013","journal-title":"Cell Prolif."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1023\/A:1023777013659","article-title":"The role of integrin-linked kinase (ILK) in cancer progression","volume":"22","author":"Persad","year":"2003","journal-title":"Cancer Metastasis Rev."},{"key":"ref_88","first-page":"9423907","article-title":"The Role of Matrix Metalloproteinases in the Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma","volume":"2019","author":"Scheau","year":"2019","journal-title":"Anal. Cell Pathol. (Amst.)"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1002\/ijc.24901","article-title":"Snail is critical for tumor growth and metastasis of ovarian carcinoma","volume":"126","author":"Jin","year":"2010","journal-title":"Int. J. Cancer"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"3481","DOI":"10.1016\/j.bbamcr.2013.06.026","article-title":"Anoikis molecular pathways and its role in cancer progression","volume":"1833","author":"Paoli","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_91","first-page":"529","article-title":"Molecular Mechanisms of Ovarian Carcinoma Metastasis: Key Genes and Regulatory MicroRNAs","volume":"82","author":"Braga","year":"2017","journal-title":"Biochemistry"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.tips.2012.01.005","article-title":"Hypoxia-inducible factors: Mediators of cancer progression and targets for cancer therapy","volume":"33","author":"Semenza","year":"2012","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nrc3183","article-title":"HIF1alpha and HIF2alpha: Sibling rivalry in hypoxic tumour growth and progression","volume":"12","author":"Keith","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"5331","DOI":"10.1073\/pnas.1317242111","article-title":"Dynamin 2 along with microRNA-199a reciprocally regulate hypoxia-inducible factors and ovarian cancer metastasis","volume":"111","author":"Joshi","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"6658","DOI":"10.1074\/jbc.M109.042424","article-title":"The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: Insights into cellular transformation processes mediated by HIF-1","volume":"285","author":"Schietke","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"11597","DOI":"10.1158\/0008-5472.CAN-05-2119","article-title":"Hypoxia-induced down-regulation of BRCA1 expression by E2Fs","volume":"65","author":"Bindra","year":"2005","journal-title":"Cancer Res."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Boussios, S., Karihtala, P., Moschetta, M., Karathanasi, A., Sadauskaite, A., Rassy, E., and Pavlidis, N. (2019). Combined Strategies with Poly (ADP-Ribose) Polymerase (PARP) Inhibitors for the Treatment of Ovarian Cancer: A Literature Review. Diagnostics, 9.","DOI":"10.3390\/diagnostics9030087"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nrc1388","article-title":"Cancer and the chemokine network","volume":"4","author":"Balkwill","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1007\/s12094-015-1325-8","article-title":"miR-448 negatively regulates ovarian cancer cell growth and metastasis by targeting CXCL12","volume":"17","author":"Lv","year":"2015","journal-title":"Clin. Transl. Oncol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1023\/A:1026519016213","article-title":"CD44 and beta1 integrins mediate ovarian carcinoma cell migration toward extracellular matrix proteins","volume":"18","author":"Casey","year":"2000","journal-title":"Clin. Exp. Metastasis"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1080\/15384047.2015.1040960","article-title":"Tumor infiltrating lymphocytes in ovarian cancer","volume":"16","author":"Santoiemma","year":"2015","journal-title":"Cancer Biol. Ther."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1158\/2326-6066.CIR-17-0479","article-title":"Exosomes Released from Tumor-Associated Macrophages Transfer miRNAs That Induce a Treg\/Th17 Cell Imbalance in Epithelial Ovarian Cancer","volume":"6","author":"Zhou","year":"2018","journal-title":"Cancer Immunol. Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1038\/bjc.2017.297","article-title":"Crosstalk between TEMs and endothelial cells modulates angiogenesis and metastasis via IGF1-IGF1R signalling in epithelial ovarian cancer","volume":"117","author":"Wang","year":"2017","journal-title":"Br. J. Cancer"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S1471-4906(02)02302-5","article-title":"Macrophage polarization: Tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes","volume":"23","author":"Mantovani","year":"2002","journal-title":"Trends. Immunol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1007\/s10753-019-01004-2","article-title":"MiR-217 Inhibits M2-Like Macrophage Polarization by Suppressing Secretion of Interleukin-6 in Ovarian Cancer","volume":"42","author":"Jiang","year":"2019","journal-title":"Inflammation"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/cmi.2014.30","article-title":"Ovarian tumor-associated microRNA-20a decreases natural killer cell cytotoxicity by downregulating MICA\/B expression","volume":"11","author":"Xie","year":"2014","journal-title":"Cell Mol. Immunol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1038\/bjc.2017.79","article-title":"MHC class I chain-related protein A and B (MICA and MICB) are predominantly expressed intracellularly in tumour and normal tissue","volume":"116","author":"Ghadially","year":"2017","journal-title":"Br. J. Cancer"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.molcel.2014.02.013","article-title":"Global analyses of the effect of different cellular contexts on microRNA targeting","volume":"53","author":"Nam","year":"2014","journal-title":"Mol. Cell"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.neuron.2011.11.010","article-title":"Cell-type-based analysis of microRNA profiles in the mouse brain","volume":"73","author":"He","year":"2012","journal-title":"Neuron"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1038\/ncomms3977","article-title":"microRNA-181a has a critical role in ovarian cancer progression through the regulation of the epithelial-mesenchymal transition","volume":"5","author":"Parikh","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_111","first-page":"2960","article-title":"MicroRNA-616 promotes the progression of ovarian cancer by targeting TIMP2","volume":"39","author":"Chen","year":"2018","journal-title":"Oncol. Rep."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"4175","DOI":"10.1158\/0008-5472.CAN-17-3014","article-title":"miR-590-3p Promotes Ovarian Cancer Growth and Metastasis via a Novel FOXA2-Versican Pathway","volume":"78","author":"Salem","year":"2018","journal-title":"Cancer Res."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1159\/000445642","article-title":"MicroRNA-125b Suppresses Ovarian Cancer Progression via Suppression of the Epithelial-Mesenchymal Transition Pathway by Targeting the SET Protein","volume":"39","author":"Ying","year":"2016","journal-title":"Cell. Physiol. Biochem. Int. J. Exp. Cell. Physiol. Biochem. Pharmacol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"109423","DOI":"10.1016\/j.biopha.2019.109423","article-title":"LINC00339 promotes cell proliferation, migration, and invasion of ovarian cancer cells via miR-148a-3p\/ROCK1 axes","volume":"120","author":"Pan","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/s13046-018-0910-4","article-title":"Long noncoding RNA MLK7-AS1 promotes ovarian cancer cells progression by modulating miR-375\/YAP1 axis","volume":"37","author":"Yan","year":"2018","journal-title":"J. Exp. Clin. Cancer Res. CR"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.gene.2018.04.005","article-title":"Novel miRNA genes deregulated by aberrant methylation in ovarian carcinoma are involved in metastasis","volume":"662","author":"Loginov","year":"2018","journal-title":"Gene"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/1757-2215-6-84","article-title":"MiR-124 inhibits the migration and invasion of ovarian cancer cells by targeting SphK1","volume":"6","author":"Zhang","year":"2013","journal-title":"J. Ovarian Res."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"14989","DOI":"10.1007\/s13277-016-5415-1","article-title":"MiR-203 promotes the growth and migration of ovarian cancer cells by enhancing glycolytic pathway","volume":"37","author":"Xiaohong","year":"2016","journal-title":"Tumour Biol. J. Int. Soc. Oncodev. Biol. Med."},{"key":"ref_119","first-page":"34","article-title":"miR-203 Functions as a Tumor Suppressor by Inhibiting Epithelial to Mesenchymal Transition in Ovarian Cancer","volume":"7","author":"Zhao","year":"2015","journal-title":"J. Cancer Sci. Ther."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"8699","DOI":"10.1158\/0008-5472.CAN-07-1936","article-title":"MicroRNA signatures in human ovarian cancer","volume":"67","author":"Iorio","year":"2007","journal-title":"Cancer Res."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"8021","DOI":"10.3892\/mmr.2015.4485","article-title":"Profile of differentially expressed miRNAs in high-grade serous carcinoma and clear cell ovarian carcinoma, and the expression of miR-510 in ovarian carcinoma","volume":"12","author":"Zhang","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Ye, G., Bernaudo, S., and Peng, C. (2012). Etiology and overview. Advances in Ovarian Cancer Management, Future Medicine Ltd.","DOI":"10.2217\/ebo.11.356"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"4225","DOI":"10.2147\/OTT.S137107","article-title":"miRNA expression profiling in formalin-fixed paraffin-embedded endometriosis and ovarian cancer samples","volume":"10","author":"Braicu","year":"2017","journal-title":"Onco Targets Ther."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s12943-019-1049-4","article-title":"Exosomes promote pre-metastatic niche formation in ovarian cancer","volume":"18","author":"Feng","year":"2019","journal-title":"Mol. Cancer"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.lfs.2016.12.007","article-title":"MiR-376a promotion of proliferation and metastases in ovarian cancer: Potential role as a biomarker","volume":"173","author":"Yang","year":"2017","journal-title":"Life Sci."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1007\/s12094-015-1303-1","article-title":"Expression of serum miR-200a, miR-200b, and miR-200c as candidate biomarkers in epithelial ovarian cancer and their association with clinicopathological features","volume":"17","author":"Zuberi","year":"2015","journal-title":"Clin. Transl. Oncol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.canlet.2014.10.010","article-title":"A novel serum microRNA panel to discriminate benign from malignant ovarian disease","volume":"356","author":"Langhe","year":"2015","journal-title":"Cancer Lett."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"11259","DOI":"10.1007\/s13277-016-4993-2","article-title":"The conglomeration of diagnostic, prognostic and therapeutic potential of serum miR-199a and its association with clinicopathological features in epithelial ovarian cancer","volume":"37","author":"Zuberi","year":"2016","journal-title":"Tumour Biol. J. Int. Soc. Oncodev. Biol. Med."},{"key":"ref_129","first-page":"539","article-title":"Characterizing the landscape of peritoneal exosomal microRNAs in patients with ovarian cancer by high-throughput sequencing","volume":"17","author":"Li","year":"2019","journal-title":"Oncol. Lett."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1038\/s41419-018-0946-6","article-title":"The activation of microRNA-520h-associated TGF-beta1\/c-Myb\/Smad7 axis promotes epithelial ovarian cancer progression","volume":"9","author":"Zhang","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"23793","DOI":"10.18632\/oncotarget.4363","article-title":"MiR-26b\/KPNA2 axis inhibits epithelial ovarian carcinoma proliferation and metastasis through downregulating OCT4","volume":"6","author":"Lin","year":"2015","journal-title":"Oncotarget"},{"key":"ref_132","first-page":"4417","article-title":"Expression of miR-26b in ovarian carcinoma tissues and its correlation with clinicopathology","volume":"17","author":"Lu","year":"2019","journal-title":"Oncol. Lett."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Vang, S., Wu, H.T., Fischer, A., Miller, D.H., MacLaughlan, S., Douglass, E., Comisar, L., Steinhoff, M., Collins, C., and Smith, P.J. (2013). Identification of ovarian cancer metastatic miRNAs. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0058226"},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Wahab, N.A., Othman, Z., Nasri, N.W.M., Mokhtar, M.H., Ibrahim, S.F., Hamid, A.A., Raja Ali, R.A., and Mokhtar, N.M. (2020). Inhibition of miR-141 and miR-200a Increase DLC-1 and ZEB2 Expression, Enhance Migration and Invasion in Metastatic Serous Ovarian Cancer. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17082766"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1038\/modpathol.2012.118","article-title":"Expression analysis of MIR182 and its associated target genes in advanced ovarian carcinoma","volume":"25","author":"McMillen","year":"2012","journal-title":"Mod. Pathol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/path.4000","article-title":"MiR-182 overexpression in tumourigenesis of high-grade serous ovarian carcinoma","volume":"228","author":"Liu","year":"2012","journal-title":"J. Pathol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1158\/0008-5472.CAN-18-3668","article-title":"Inhibition of miR-328-3p Impairs Cancer Stem Cell Function and Prevents Metastasis in Ovarian Cancer","volume":"79","author":"Srivastava","year":"2019","journal-title":"Cancer Res."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1038\/cdd.2017.129","article-title":"miR-130a upregulates mTOR pathway by targeting TSC1 and is transactivated by NF-kappaB in high-grade serous ovarian carcinoma","volume":"24","author":"Wang","year":"2017","journal-title":"Cell Death Differ."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"12618","DOI":"10.1002\/jcb.28528","article-title":"miRNA-301b-3p accelerates migration and invasion of high-grade ovarian serous tumor via targeting CPEB3\/EGFR axis","volume":"120","author":"Liu","year":"2019","journal-title":"J. Cell Biochem."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"819","DOI":"10.3892\/ijmm_00000530","article-title":"MicroRNA-21 promotes the cell proliferation, invasion and migration abilities in ovarian epithelial carcinomas through inhibiting the expression of PTEN protein","volume":"26","author":"Lou","year":"2010","journal-title":"Int. J. Mol. Med."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.3892\/or.2013.2400","article-title":"miR-205 promotes tumor proliferation and invasion through targeting ESRRG in endometrial carcinoma","volume":"29","author":"Su","year":"2013","journal-title":"Oncol. Rep."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s12032-016-0842-9","article-title":"Downregulation of Foxo3 and TRIM31 by miR-551b in side population promotes cell proliferation, invasion, and drug resistance of ovarian cancer","volume":"33","author":"Wei","year":"2016","journal-title":"Med. Oncol. (Northwood Lond. Engl.)"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.celrep.2016.04.034","article-title":"Direct Upregulation of STAT3 by MicroRNA-551b-3p Deregulates Growth and Metastasis of Ovarian Cancer","volume":"15","author":"Jeong","year":"2016","journal-title":"Cell Rep."},{"key":"ref_144","first-page":"5631","article-title":"Upregulation of microRNA-18b induces phosphatase and tensin homolog to accelerate the migration and invasion abilities of ovarian cancer","volume":"14","author":"Han","year":"2017","journal-title":"Oncol. Lett."},{"key":"ref_145","first-page":"559","article-title":"MicroRNA-19b promotes the migration and invasion of ovarian cancer cells by inhibiting the PTEN\/AKT signaling pathway","volume":"16","author":"Liu","year":"2018","journal-title":"Oncol. Lett."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1080\/15384047.2019.1579960","article-title":"MicroRNA-23a depletion promotes apoptosis of ovarian cancer stem cell and inhibits cell migration by targeting DLG2","volume":"20","author":"Zhuang","year":"2019","journal-title":"Cancer Biol. Ther."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.bbrc.2014.04.027","article-title":"MicroRNA-181b promotes ovarian cancer cell growth and invasion by targeting LATS2","volume":"447","author":"Xia","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1016\/j.ijbiomac.2018.09.179","article-title":"LncRNA ADAMTS9-AS2 regulates ovarian cancer progression by targeting miR-182-5p\/FOXF2 signaling pathway","volume":"120","author":"Wang","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"4307","DOI":"10.2147\/OTT.S90976","article-title":"MicroRNA-194 promotes the growth, migration, and invasion of ovarian carcinoma cells by targeting protein tyrosine phosphatase nonreceptor type 12","volume":"9","author":"Liang","year":"2016","journal-title":"Onco. Targets Ther."},{"key":"ref_150","first-page":"4132","article-title":"Increased expression of microRNA-196a predicts poor prognosis in human ovarian carcinoma","volume":"8","author":"Fan","year":"2015","journal-title":"Int. J. Clin Exp. Pathol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13048-017-0328-1","article-title":"MicroRNA-205 promotes cell invasion by repressing TCF21 in human ovarian cancer","volume":"10","author":"Wei","year":"2017","journal-title":"J. Ovarian Res."},{"key":"ref_152","first-page":"7571","article-title":"miR-205 regulates the proliferation and invasion of ovarian cancer cells via suppressing PTEN\/SMAD4 expression","volume":"15","author":"Chu","year":"2018","journal-title":"Oncol. Lett."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"41330","DOI":"10.1038\/srep41330","article-title":"Upregulation of MiR-205 transcriptionally suppresses SMAD4 and PTEN and contributes to human ovarian cancer progression","volume":"7","author":"Li","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.2147\/OTT.S114318","article-title":"MicroRNA-216a promotes the metastasis and epithelial-mesenchymal transition of ovarian cancer by suppressing the PTEN\/AKT pathway","volume":"10","author":"Liu","year":"2017","journal-title":"Onco. Targets Ther."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s13048-019-0589-y","article-title":"miR-552 promotes ovarian cancer progression by regulating PTEN pathway","volume":"12","author":"Zhao","year":"2019","journal-title":"J. Ovarian Res."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"4312","DOI":"10.1038\/onc.2015.492","article-title":"Hypoxia-upregulated microRNA-630 targets Dicer, leading to increased tumor progression","volume":"35","author":"Rupaimoole","year":"2016","journal-title":"Oncogene"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.biopha.2015.02.020","article-title":"MiR-939 promotes the proliferation of human ovarian cancer cells by repressing APC2 expression","volume":"71","author":"Ying","year":"2015","journal-title":"Biomed. Pharmacother."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"97464","DOI":"10.18632\/oncotarget.22136","article-title":"Platelet microparticle-mediated transfer of miR-939 to epithelial ovarian cancer cells promotes epithelial to mesenchymal transition","volume":"8","author":"Tang","year":"2017","journal-title":"Oncotarget"},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Salem, M., Shan, Y., Bernaudo, S., and Peng, C. (2019). miR-590-3p Targets Cyclin G2 and FOXO3 to Promote Ovarian Cancer Cell Proliferation, Invasion, and Spheroid Formation. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20081810"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.3892\/or.2015.3937","article-title":"Urinary microRNA-30a-5p is a potential biomarker for ovarian serous adenocarcinoma","volume":"33","author":"Zhou","year":"2015","journal-title":"Oncol. Rep."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"10816","DOI":"10.18632\/oncotarget.2522","article-title":"miR-145 inhibits tumor growth and metastasis by targeting metadherin in high-grade serous ovarian carcinoma","volume":"5","author":"Dong","year":"2014","journal-title":"Oncotarget"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"38064","DOI":"10.18632\/oncotarget.9345","article-title":"A novel p70 S6 kinase-microRNA biogenesis axis mediates multicellular spheroid formation in ovarian cancer progression","volume":"7","author":"Lam","year":"2016","journal-title":"Oncotarget"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.canlet.2014.11.011","article-title":"miR-145, targeting high-mobility group A2, is a powerful predictor of patient outcome in ovarian carcinoma","volume":"356","author":"Kim","year":"2015","journal-title":"Cancer Lett."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"25930","DOI":"10.18632\/oncotarget.8412","article-title":"miR-509-3p is clinically significant and strongly attenuates cellular migration and multi-cellular spheroids in ovarian cancer","volume":"7","author":"Pan","year":"2016","journal-title":"Oncotarget"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.3892\/or.2014.3046","article-title":"miR-1236-3p represses the cell migration and invasion abilities by targeting ZEB1 in high-grade serous ovarian carcinoma","volume":"31","author":"Wang","year":"2014","journal-title":"Oncol. Rep."},{"key":"ref_166","first-page":"4151","article-title":"miRNA-574-3p inhibits metastasis and chemoresistance of epithelial ovarian cancer (EOC) by negatively regulating epidermal growth factor receptor (EGFR)","volume":"11","author":"Zhang","year":"2019","journal-title":"Am. J. Transl. Res."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s12943-018-0844-7","article-title":"Systematic analyses reveal long non-coding RNA (PTAF)-mediated promotion of EMT and invasion-metastasis in serous ovarian cancer","volume":"17","author":"Liang","year":"2018","journal-title":"Mol. Cancer"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s12943-018-0870-5","article-title":"LncRNA PTAR promotes EMT and invasion-metastasis in serous ovarian cancer by competitively binding miR-101-3p to regulate ZEB1 expression","volume":"17","author":"Liang","year":"2018","journal-title":"Mol. Cancer"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.omto.2019.12.002","article-title":"A PTAL-miR-101-FN1 Axis Promotes EMT and Invasion-Metastasis in Serous Ovarian Cancer","volume":"16","author":"Liang","year":"2020","journal-title":"Mol. Ther. Oncolytics"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.3892\/or.2016.4985","article-title":"miR-17 inhibits ovarian cancer cell peritoneal metastasis by targeting ITGA5 and ITGB1","volume":"36","author":"Gong","year":"2016","journal-title":"Oncol. Rep."},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Chen, S., Chen, X., Xiu, Y.L., Sun, K.X., and Zhao, Y. (2015). Inhibition of Ovarian Epithelial Carcinoma Tumorigenesis and Progression by microRNA 106b Mediated through the RhoC Pathway. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0125714"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13046-016-0307-1","article-title":"MiR-23b targets cyclin G1 and suppresses ovarian cancer tumorigenesis and progression","volume":"35","author":"Yan","year":"2016","journal-title":"J. Exp. Clin. Cancer Res. CR"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13048-020-00631-w","article-title":"MiR-29c-3p, a target miRNA of LINC01296, accelerates tumor malignancy: Therapeutic potential of a LINC01296\/miR-29c-3p axis in ovarian cancer","volume":"13","author":"Xu","year":"2020","journal-title":"J. Ovarian Res."},{"key":"ref_174","first-page":"4671","article-title":"Overexpression of miR-32 inhibits the proliferation and metastasis of ovarian cancer cells by targeting BTLA","volume":"24","author":"Zhang","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/s13046-016-0415-y","article-title":"MiR-137 and miR-34a directly target Snail and inhibit EMT, invasion and sphere-forming ability of ovarian cancer cells","volume":"35","author":"Dong","year":"2016","journal-title":"J. Exp. Clin. Cancer Res. CR"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.3892\/or.2012.1625","article-title":"Prognostic implications of microRNA-100 and its functional roles in human epithelial ovarian cancer","volume":"27","author":"Peng","year":"2012","journal-title":"Oncol. Rep."},{"key":"ref_177","first-page":"7311","article-title":"MiR-124 inhibits invasion and induces apoptosis of ovarian cancer cells by targeting programmed cell death 6","volume":"14","author":"Yuan","year":"2017","journal-title":"Oncol. Lett."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.yexcr.2017.07.030","article-title":"Long non-coding RNA CCAT1 promotes metastasis and poor prognosis in epithelial ovarian cancer","volume":"359","author":"Cao","year":"2017","journal-title":"Exp. Cell Res."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.3892\/ol.2014.1841","article-title":"Role of microRNA-133a in epithelial ovarian cancer pathogenesis and progression","volume":"7","author":"Luo","year":"2014","journal-title":"Oncol. Lett."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.biopha.2017.11.096","article-title":"LncRNA HOXD-AS1 promotes epithelial ovarian cancer cells proliferation and invasion by targeting miR-133a-3p and activating Wnt\/beta-catenin signaling pathway","volume":"96","author":"Zhang","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_181","first-page":"5602","article-title":"MiR-133b regulates the expression of CTGF in epithelial-mesenchymal transition of ovarian cancer","volume":"21","author":"Yang","year":"2017","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1016\/j.cellsig.2014.03.002","article-title":"MiR-135a functions as a tumor suppressor in epithelial ovarian cancer and regulates HOXA10 expression","volume":"26","author":"Tang","year":"2014","journal-title":"Cell Signal."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.biopha.2018.08.044","article-title":"MicroRNA-135a-3p is downregulated and serves as a tumour suppressor in ovarian cancer by targeting CCR2","volume":"107","author":"Duan","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1002\/ijc.28086","article-title":"MicroRNA-138 suppresses ovarian cancer cell invasion and metastasis by targeting SOX4 and HIF-1alpha","volume":"133","author":"Yeh","year":"2013","journal-title":"Int. J. Cancer"},{"key":"ref_185","first-page":"1629","article-title":"MicroRNA-138 inhibits SOX12 expression and the proliferation, invasion and migration of ovarian cancer cells","volume":"16","author":"Qu","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"3379","DOI":"10.3892\/mmr.2017.6956","article-title":"MicroRNA139 suppressed tumor cell proliferation, migration and invasion by directly targeting HDGF in epithelial ovarian cancer","volume":"16","author":"Liu","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"8935","DOI":"10.2147\/OTT.S210739","article-title":"MicroRNA-139-3p Inhibits the Growth and Metastasis of Ovarian Cancer by Inhibiting ELAVL1","volume":"12","author":"Xue","year":"2019","journal-title":"Onco Targets Ther."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3727\/096504017X14974343584989","article-title":"MicroRNA-139-5p Inhibits Cell Proliferation and Invasion by Targeting RHO-Associated Coiled-Coil-Containing Protein Kinase 2 in Ovarian Cancer","volume":"26","author":"Wang","year":"2018","journal-title":"Oncol. Res."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"109882","DOI":"10.1016\/j.biopha.2020.109882","article-title":"Long non-coding RNA TTN-AS1 promotes tumorigenesis of ovarian cancer through modulating the miR-139-5p\/ROCK2 axis","volume":"125","author":"Liu","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s13048-020-00656-1","article-title":"MicroRNA-145-5p regulates the proliferation of epithelial ovarian cancer cells via targeting SMAD4","volume":"13","author":"Zhou","year":"2020","journal-title":"J. Ovarian Res."},{"key":"ref_191","first-page":"1529","article-title":"miR-152 is involved in the proliferation and metastasis of ovarian cancer through repression of ERBB3","volume":"41","author":"Li","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"ref_192","doi-asserted-by":"crossref","unstructured":"Jin, M., Yang, Z., Ye, W., Xu, H., and Hua, X. (2014). MicroRNA-150 predicts a favorable prognosis in patients with epithelial ovarian cancer, and inhibits cell invasion and metastasis by suppressing transcriptional repressor ZEB1. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0103965"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/onc.2015.84","article-title":"miR-186 regulation of Twist1 and ovarian cancer sensitivity to cisplatin","volume":"35","author":"Zhu","year":"2016","journal-title":"Oncogene"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"5923","DOI":"10.1038\/onc.2015.43","article-title":"Microenvironment-induced downregulation of miR-193b drives ovarian cancer metastasis","volume":"34","author":"Mitra","year":"2015","journal-title":"Oncogene"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"3929","DOI":"10.12659\/MSM.895407","article-title":"Tissue miR-193b as a Novel Biomarker for Patients with Ovarian Cancer","volume":"21","author":"Li","year":"2015","journal-title":"Med. Sci. Monit."},{"key":"ref_196","first-page":"2256","article-title":"MiR-202-5p suppressed cell proliferation, migration and invasion in ovarian cancer via regulating HOXB2","volume":"24","author":"Yu","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.biopha.2018.05.077","article-title":"MiR-206 inhibits epithelial ovarian cancer cells growth and invasion via blocking c-Met\/AKT\/mTOR signaling pathway","volume":"104","author":"Dai","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1159\/000493408","article-title":"LncRNA HOTAIR Regulates CCND1 and CCND2 Expression by Sponging miR-206 in Ovarian Cancer","volume":"49","author":"Chang","year":"2018","journal-title":"Cell. Physiol. Biochem. Int. J. Exp. Cell. Physiol. Biochem. Pharmacol."},{"key":"ref_199","first-page":"466","article-title":"MicroRNA-215 targets NOB1 and inhibits growth and invasion of epithelial ovarian cancer","volume":"9","author":"Lin","year":"2017","journal-title":"Am. J. Transl. Res."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.3892\/or.2015.4498","article-title":"Tumor suppressor role of miR-217 in human epithelial ovarian cancer by targeting IGF1R","volume":"35","author":"Li","year":"2016","journal-title":"Oncol. Rep."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"91530","DOI":"10.18632\/oncotarget.21069","article-title":"MicroRNA-218 inhibits proliferation and invasion in ovarian cancer by targeting Runx2","volume":"8","author":"Li","year":"2017","journal-title":"Oncotarget"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.gene.2017.09.012","article-title":"MicroRNA-219-5p inhibits the proliferation, migration, and invasion of epithelial ovarian cancer cells by targeting the Twist\/Wnt\/beta-catenin signaling pathway","volume":"637","author":"Wei","year":"2017","journal-title":"Gene"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s40659-018-0199-y","article-title":"MiR-219-5p inhibits growth and metastasis of ovarian cancer cells by targeting HMGA2","volume":"51","author":"Xing","year":"2018","journal-title":"Biol. Res."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1309\/AJCPLYTZGB54ISZC","article-title":"miR-335 represents an independent prognostic marker in epithelial ovarian cancer","volume":"141","author":"Cao","year":"2014","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.7150\/jca.29502","article-title":"Down-regulation of miR-338-3p and Up-regulation of MACC1 Indicated Poor Prognosis of Epithelial Ovarian Cancer Patients","volume":"10","author":"Zhang","year":"2019","journal-title":"J. Cancer"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.3892\/ijo.2015.2929","article-title":"miR3383p suppresses tumor growth of ovarian epithelial carcinoma by targeting Runx2","volume":"46","author":"Wen","year":"2015","journal-title":"Int. J. Oncol."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/s41419-019-1604-3","article-title":"miR-340-FHL2 axis inhibits cell growth and metastasis in ovarian cancer","volume":"10","author":"Huang","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1159\/000445553","article-title":"MicroRNA-340 Induces Apoptosis and Inhibits Metastasis of Ovarian Cancer Cells by Inactivation of NF-x03BA;B1","volume":"38","author":"Li","year":"2016","journal-title":"Cell. Physiol. Biochem. Int. J. Exp. Cell. Physiol. Biochem. Pharmacol."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"101649","DOI":"10.18632\/oncotarget.21417","article-title":"MicroRNA-363 inhibits ovarian cancer progression by inhibiting NOB1","volume":"8","author":"Lin","year":"2017","journal-title":"Oncotarget"},{"key":"ref_210","first-page":"1096","article-title":"MicroRNA-365 inhibits ovarian cancer progression by targeting Wnt5a","volume":"7","author":"Wang","year":"2017","journal-title":"Am. J. Cancer Res."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"12291","DOI":"10.18632\/oncotarget.2577","article-title":"MiR-373 targeting of the Rab22a oncogene suppresses tumor invasion and metastasis in ovarian cancer","volume":"5","author":"Zhang","year":"2014","journal-title":"Oncotarget"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.3892\/mmr.2016.5572","article-title":"LncRNA HOTAIR controls the expression of Rab22a by sponging miR-373 in ovarian cancer","volume":"14","author":"Zhang","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"ref_213","first-page":"3147","article-title":"miR377 targets CUL4A and regulates metastatic capability in ovarian cancer","volume":"41","author":"Yu","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.3892\/ol.2017.6501","article-title":"microRNA-494 is a potential prognostic marker and inhibits cellular proliferation, migration and invasion by targeting SIRT1 in epithelial ovarian cancer","volume":"14","author":"Yang","year":"2017","journal-title":"Oncol. Lett."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"463","DOI":"10.2147\/CMAR.S229083","article-title":"LINC00963 Promotes Ovarian Cancer Proliferation, Migration and EMT via the miR-378g \/CHI3L1 Axis","volume":"12","author":"Liu","year":"2020","journal-title":"Cancer Manag. Res."},{"key":"ref_216","first-page":"1296","article-title":"Anisomycin inhibits angiogenesis in ovarian cancer by attenuating the molecular sponge effect of the lncRNAMeg3\/miR421\/PDGFRA axis","volume":"55","author":"Ye","year":"2019","journal-title":"Int. J. Oncol."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.1158\/0008-5472.CAN-19-0490","article-title":"miR-450a Acts as a Tumor Suppressor in Ovarian Cancer by Regulating Energy Metabolism","volume":"79","author":"Muys","year":"2019","journal-title":"Cancer Res."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"9777","DOI":"10.3892\/mmr.2017.7790","article-title":"MicroRNA455 inhibits cell proliferation and invasion of epithelial ovarian cancer by directly targeting Notch1","volume":"16","author":"Xu","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"ref_219","first-page":"4113","article-title":"MicroRNA-489 targets XIAP to inhibit the biological progression of ovarian cancer via regulating PI3K\/Akt signaling pathway and epithelial-to-mesenchymal transition","volume":"24","author":"Jiang","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.bbrc.2014.05.053","article-title":"MicroRNA-497 inhibition of ovarian cancer cell migration and invasion through targeting of SMAD specific E3 ubiquitin protein ligase 1","volume":"449","author":"Wang","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.neo.2018.12.005","article-title":"MicroRNA-503-5p Inhibits the CD97-Mediated JAK2\/STAT3 Pathway in Metastatic or Paclitaxel-Resistant Ovarian Cancer Cells","volume":"21","author":"Park","year":"2019","journal-title":"Neoplasia"},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.ccr.2012.12.020","article-title":"Integrated analyses identify a master microRNA regulatory network for the mesenchymal subtype in serous ovarian cancer","volume":"23","author":"Yang","year":"2013","journal-title":"Cancer Cell"},{"key":"ref_223","first-page":"5842","article-title":"miR-532-5p is a prognostic marker and suppresses cells proliferation and invasion by targeting TWIST1 in epithelial ovarian cancer","volume":"22","author":"Wei","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13046-016-0288-0","article-title":"MiR-548c impairs migration and invasion of endometrial and ovarian cancer cells via downregulation of Twist","volume":"35","author":"Sun","year":"2016","journal-title":"J. Exp. Clin. Cancer Res. CR"},{"key":"ref_225","first-page":"1062","article-title":"MiRNA-584 suppresses the progression of ovarian cancer by negatively regulating LPIN1","volume":"24","author":"Yang","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"4558","DOI":"10.18632\/aging.102911","article-title":"Long non-coding RNA RHPN1-AS1 promotes tumorigenesis and metastasis of ovarian cancer by acting as a ceRNA against miR-596 and upregulating LETM1","volume":"12","author":"Wang","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/j.bbrc.2018.07.165","article-title":"Long noncoding RNA LUCAT1 promotes malignancy of ovarian cancer through regulation of miR-612\/HOXA13 pathway","volume":"503","author":"Yu","year":"2018","journal-title":"Biochem Biophys. Res. Commun."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.2147\/CMAR.S229013","article-title":"LncRNA EMX2OS Induces Proliferation, Invasion and Sphere Formation of Ovarian Cancer Cells via Regulating the miR-654-3p\/AKT3\/PD-L1 Axis","volume":"12","author":"Duan","year":"2020","journal-title":"Cancer Manag. Res."},{"key":"ref_229","first-page":"2661","article-title":"MicroRNA665 suppresses the growth and migration of ovarian cancer cells by targeting HOXA10","volume":"18","author":"Liu","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"e22168","DOI":"10.1002\/jbt.22168","article-title":"Upregulation of miR-874-3p and miR-874-5p inhibits epithelial ovarian cancer malignancy via SIK2","volume":"32","author":"Xia","year":"2018","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"5311","DOI":"10.2147\/OTT.S213231","article-title":"MicroRNA-936 targets FGF2 to inhibit epithelial ovarian cancer aggressiveness by deactivating the PI3K\/Akt pathway","volume":"12","author":"Li","year":"2019","journal-title":"Onco Targets Ther."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1158\/1541-7786.MCR-19-1162","article-title":"Signals from the Metastatic Niche Regulate Early and Advanced Ovarian Cancer Metastasis through miR-4454 Downregulation","volume":"18","author":"Dasari","year":"2020","journal-title":"Mol. Cancer Res. MCR"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"109865","DOI":"10.1016\/j.biopha.2020.109865","article-title":"miR-6089\/MYH9\/beta-catenin\/c-Jun negative feedback loop inhibits ovarian cancer carcinogenesis and progression","volume":"125","author":"Liu","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"7194","DOI":"10.1158\/0008-5472.CAN-16-0714","article-title":"Ubiquitous Release of Exosomal Tumor Suppressor miR-6126 from Ovarian Cancer Cells","volume":"76","author":"Kanlikilicer","year":"2016","journal-title":"Cancer Res."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.biopha.2015.12.027","article-title":"MiR-125a regulates ovarian cancer proliferation and invasion by repressing GALNT14 expression","volume":"80","author":"Yang","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1593\/neo.09942","article-title":"The epidermal growth factor receptor responsive miR-125a represses mesenchymal morphology in ovarian cancer cells","volume":"11","author":"Dahl","year":"2009","journal-title":"Neoplasia"},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"51008","DOI":"10.18632\/oncotarget.16846","article-title":"Ascites promotes cell migration through the repression of miR-125b in ovarian cancer","volume":"8","author":"Yang","year":"2017","journal-title":"Oncotarget"},{"key":"ref_238","doi-asserted-by":"crossref","unstructured":"Zuberi, M., Khan, I., Mir, R., Gandhi, G., Ray, P.C., and Saxena, A. (2016). Utility of Serum miR-125b as a Diagnostic and Prognostic Indicator and Its Alliance with a Panel of Tumor Suppressor Genes in Epithelial Ovarian Cancer. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0153902"},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"12427","DOI":"10.1007\/s13277-014-2560-2","article-title":"MiR-212 exerts suppressive effect on SKOV3 ovarian cancer cells through targeting HBEGF","volume":"35","author":"Wei","year":"2014","journal-title":"Tumour Biol. J. Int. Soc. Oncodev. Biol. Med."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1002\/cbin.11052","article-title":"MiR-122 inhibits epithelial mesenchymal transition by regulating P4HA1 in ovarian cancer cells","volume":"42","author":"Duan","year":"2018","journal-title":"Cell Biol. Int."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.biopha.2016.05.049","article-title":"Decreased expression of microRNA-148a predicts poor prognosis in ovarian cancer and associates with tumor growth and metastasis","volume":"83","author":"Gong","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1007\/s11684-017-0518-7","article-title":"Overexpressed miR-9 promotes tumor metastasis via targeting E-cadherin in serous ovarian cancer","volume":"11","author":"Zhou","year":"2017","journal-title":"Front. Med."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1476-4598-7-35","article-title":"Potential role of miR-9 and miR-223 in recurrent ovarian cancer","volume":"7","author":"Laios","year":"2008","journal-title":"Mol. Cancer"},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3892\/ijmm.2013.1400","article-title":"miR-9 functions as a tumor suppressor in ovarian serous carcinoma by targeting TLN1","volume":"32","author":"Tang","year":"2013","journal-title":"Int. J. Mol. Med."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12943-017-0582-2","article-title":"MicroRNA-141 enhances anoikis resistance in metastatic progression of ovarian cancer through targeting KLF12\/Sp1\/survivin axis","volume":"16","author":"Mak","year":"2017","journal-title":"Mol. Cancer"},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1038\/nm.2512","article-title":"miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response","volume":"17","author":"Mateescu","year":"2011","journal-title":"Nat. Med."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"6743","DOI":"10.3892\/mmr.2017.7482","article-title":"MicroRNA141 inhibits epithelialmesenchymal transition, and ovarian cancer cell migration and invasion","volume":"16","author":"Ye","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"ref_248","first-page":"4080","article-title":"MiR-200a promotes cell invasion and migration of ovarian carcinoma by targeting PTEN","volume":"22","author":"Suo","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1038\/ncomms3427","article-title":"Tumour angiogenesis regulation by the miR-200 family","volume":"4","author":"Pecot","year":"2013","journal-title":"Nat. Commun."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.ygyno.2014.01.047","article-title":"The role of miR-200a in vasculogenic mimicry and its clinical significance in ovarian cancer","volume":"132","author":"Sun","year":"2014","journal-title":"Gynecol. Oncol."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1158\/1078-0432.CCR-07-1731","article-title":"MicroRNA expression profiles in serous ovarian carcinoma","volume":"14","author":"Nam","year":"2008","journal-title":"Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1007\/s12032-014-0134-1","article-title":"miR-200c modulates ovarian cancer cell metastasis potential by targeting zinc finger E-box-binding homeobox 2 (ZEB2) expression","volume":"31","author":"Lu","year":"2014","journal-title":"Med. Oncol. (Northwood Lond. Engl.)"},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1158\/1535-7163.MCT-08-1046","article-title":"MicroRNA-200c mitigates invasiveness and restores sensitivity to microtubule-targeting chemotherapeutic agents","volume":"8","author":"Cochrane","year":"2009","journal-title":"Mol. Cancer Ther."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1186\/s13046-018-0906-0","article-title":"miR-203 inhibits ovarian tumor metastasis by targeting BIRC5 and attenuating the TGFbeta pathway","volume":"37","author":"Wang","year":"2018","journal-title":"J. Exp. Clin. Cancer Res. CR"},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"9136","DOI":"10.1073\/pnas.0508889103","article-title":"microRNAs exhibit high frequency genomic alterations in human cancer","volume":"103","author":"Zhang","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_256","doi-asserted-by":"crossref","unstructured":"Hirata, Y., Murai, N., Yanaihara, N., Saito, M., Saito, M., Urashima, M., Murakami, Y., Matsufuji, S., and Okamoto, A. (2014). MicroRNA-21 is a candidate driver gene for 17q23-25 amplification in ovarian clear cell carcinoma. BMC Cancer, 14.","DOI":"10.1186\/1471-2407-14-799"},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s10517-019-04465-5","article-title":"Hypermethylated Genes of MicroRNA in Ovarian Carcinoma: Metastasis Prediction Marker Systems","volume":"167","author":"Filippova","year":"2019","journal-title":"Bull. Exp. Biol. Med."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s10517-018-4326-0","article-title":"Diagnostic Value of a Group of MicroRNA Genes Hypermethylated in Ovarian Carcinoma","volume":"166","author":"Braga","year":"2018","journal-title":"Bull. Exp. Biol. Med."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/nrc3318","article-title":"MicroRNAs in the p53 network: Micromanagement of tumour suppression","volume":"12","author":"Hermeking","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.7150\/jca.33831","article-title":"The miR-34 family and its clinical significance in ovarian cancer","volume":"11","author":"Welponer","year":"2020","journal-title":"J. Cancer"},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"21126","DOI":"10.1002\/jcp.28715","article-title":"Modulation of Myb-induced NF-kB -STAT3 signaling and resulting cisplatin resistance in ovarian cancer by dietary factors","volume":"234","author":"Tian","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.bbrc.2015.04.023","article-title":"PPARgamma inhibits ovarian cancer cells proliferation through upregulation of miR-125b","volume":"462","author":"Luo","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1593\/neo.06433","article-title":"Cellular and molecular consequences of peroxisome proliferator-activated receptor-gamma activation in ovarian cancer cells","volume":"8","author":"Vignati","year":"2006","journal-title":"Neoplasia"},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.bbrc.2011.02.052","article-title":"PPARgamma ligands induce growth inhibition and apoptosis through p63 and p73 in human ovarian cancer cells","volume":"406","author":"Kim","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"414676","DOI":"10.1155\/2010\/414676","article-title":"Targeting the EGF receptor for ovarian cancer therapy","volume":"2010","author":"Zeineldin","year":"2010","journal-title":"J. Oncol."},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1056\/NEJMoa0803785","article-title":"Dicer, Drosha, and outcomes in patients with ovarian cancer","volume":"359","author":"Merritt","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.cell.2013.12.043","article-title":"Hippo signaling regulates microprocessor and links cell-density-dependent miRNA biogenesis to cancer","volume":"156","author":"Mori","year":"2014","journal-title":"Cell"},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nature08199","article-title":"Modulation of microRNA processing by p53","volume":"460","author":"Suzuki","year":"2009","journal-title":"Nature"},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/j.celrep.2014.07.058","article-title":"The RNA-binding protein DDX1 promotes primary microRNA maturation and inhibits ovarian tumor progression","volume":"8","author":"Han","year":"2014","journal-title":"Cell Rep."},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1007\/s10620-009-1007-x","article-title":"Association of microRNA-196a-2 gene polymorphism with gastric cancer risk in a Chinese population","volume":"55","author":"Peng","year":"2010","journal-title":"Dig. Dis. Sci."},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"3713","DOI":"10.1158\/1078-0432.CCR-10-0657","article-title":"Mature microRNA sequence polymorphism in MIR196A2 is associated with risk and prognosis of head and neck cancer","volume":"16","author":"Christensen","year":"2010","journal-title":"Clin. Cancer Res. Off."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"5970","DOI":"10.1158\/0008-5472.CAN-09-0236","article-title":"microRNA miR-196a-2 and breast cancer: A genetic and epigenetic association study and functional analysis","volume":"69","author":"Hoffman","year":"2009","journal-title":"Cancer Res."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"194","DOI":"10.3892\/ol.2015.3877","article-title":"Association between the rs11614913 variant of miRNA-196a-2 and the risk of epithelial ovarian cancer","volume":"11","author":"Song","year":"2016","journal-title":"Oncol. Lett."},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jbiotec.2019.03.016","article-title":"Identification of miR-146a and miR-196a-2 single nucleotide polymorphisms at patients with high-grade serous ovarian cancer","volume":"297","author":"Lukacs","year":"2019","journal-title":"J. Biotechnol."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.3892\/ijo.2015.3121","article-title":"Metastasis suppressor 1 expression in human ovarian cancer: The impact on cellular migration and metastasis","volume":"47","author":"Liu","year":"2015","journal-title":"Int. J. Oncol."},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1177\/1947601911407325","article-title":"PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control","volume":"1","author":"Georgescu","year":"2010","journal-title":"Genes Cancer"},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.gene.2015.08.017","article-title":"MiR-205 promotes motility of ovarian cancer cells via targeting ZEB1","volume":"574","author":"Niu","year":"2015","journal-title":"Gene"},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ygyno.2015.01.531","article-title":"The role of miR-205 in the VEGF-mediated promotion of human ovarian cancer cell invasion","volume":"137","author":"Li","year":"2015","journal-title":"Gynecol. Oncol."},{"key":"ref_279","doi-asserted-by":"crossref","unstructured":"Ghoneum, A., and Said, N. (2019). PI3K-AKT-mTOR and NFkappaB Pathways in Ovarian Cancer: Implications for Targeted Therapeutics. Cancers, 11.","DOI":"10.3390\/cancers11070949"},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"4968","DOI":"10.1091\/mbc.e08-03-0259","article-title":"Cyclin G2 is degraded through the ubiquitin-proteasome pathway and mediates the antiproliferative effect of activin receptor-like kinase 7","volume":"19","author":"Xu","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"4816","DOI":"10.1038\/onc.2016.15","article-title":"Cyclin G2 inhibits epithelial-to-mesenchymal transition by disrupting Wnt\/beta-catenin signaling","volume":"35","author":"Bernaudo","year":"2016","journal-title":"Oncogene"},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"3953","DOI":"10.1038\/onc.2011.127","article-title":"Nodal enhances the activity of FoxO3a and its synergistic interaction with Smads to regulate cyclin G2 transcription in ovarian cancer cells","volume":"30","author":"Fu","year":"2011","journal-title":"Oncogene"},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"e6104","DOI":"10.1590\/1414-431x20176104","article-title":"Relationship between matrix metalloproteinases and the occurrence and development of ovarian cancer","volume":"50","author":"Zhang","year":"2017","journal-title":"Braz. J. Med. Biol. Res."},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.canlet.2017.11.026","article-title":"Dicer reprograms stromal fibroblasts to a pro-inflammatory and tumor-promoting phenotype in ovarian cancer","volume":"415","author":"Yang","year":"2018","journal-title":"Cancer Lett."},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1056\/NEJMoa1110352","article-title":"Paraneoplastic thrombocytosis in ovarian cancer","volume":"366","author":"Stone","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"837","DOI":"10.7150\/jca.35011","article-title":"STAT3 signaling in ovarian cancer: A potential therapeutic target","volume":"11","author":"Liang","year":"2020","journal-title":"J. Cancer"},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1002\/ijc.27708","article-title":"ZEB\/miR-200 feedback loop: At the crossroads of signal transduction in cancer","volume":"132","author":"Hill","year":"2013","journal-title":"Int. J. Cancer"},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/j.1399-0039.1997.tb02897.x","article-title":"Expression characteristics of the human CD97 antigen","volume":"50","author":"Eichler","year":"1997","journal-title":"Tissue Antigens"},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.tibs.2008.07.005","article-title":"Adhesion-GPCRs: Emerging roles for novel receptors","volume":"33","author":"Yona","year":"2008","journal-title":"Trends Biochem. Sci."},{"key":"ref_290","doi-asserted-by":"crossref","unstructured":"Li, J., and Zhou, B.P. (2011). Activation of beta-catenin and Akt pathways by Twist are critical for the maintenance of EMT associated cancer stem cell-like characters. BMC Cancer, 11.","DOI":"10.1186\/1471-2407-11-49"},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s12943-018-0853-6","article-title":"RASAL2 promotes tumor progression through LATS2\/YAP1 axis of hippo signaling pathway in colorectal cancer","volume":"17","author":"Pan","year":"2018","journal-title":"Mol. Cancer"},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"427.e1","DOI":"10.1016\/j.urolonc.2015.06.003","article-title":"The YAP1 oncogene contributes to bladder cancer cell proliferation and migration by regulating the H19 long noncoding RNA","volume":"33","author":"Li","year":"2015","journal-title":"Urol. Oncol."},{"key":"ref_293","first-page":"1690","article-title":"LATS2-mediated YAP1 phosphorylation is involved in HCC tumorigenesis","volume":"8","author":"Guo","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.2174\/092986709787846569","article-title":"Signaling through Rho GTPase pathway as viable drug target","volume":"16","author":"Lu","year":"2009","journal-title":"Curr. Med. Chem."},{"key":"ref_295","doi-asserted-by":"crossref","first-page":"13948","DOI":"10.1073\/pnas.1400821111","article-title":"Deep, noninvasive imaging and surgical guidance of submillimeter tumors using targeted M13-stabilized single-walled carbon nanotubes","volume":"111","author":"Ghosh","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/S0002-9440(10)65406-5","article-title":"CD44 and beta1 integrin mediate ovarian carcinoma cell adhesion to peritoneal mesothelial cells","volume":"154","author":"Lessan","year":"1999","journal-title":"Am. J. Pathol."},{"key":"ref_297","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1002\/iub.200","article-title":"Giving off mixed signals--distinct functions of alpha5beta1 and alphavbeta3 integrins in regulating cell behaviour","volume":"61","author":"Morgan","year":"2009","journal-title":"IUBMB Life"},{"key":"ref_298","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1158\/2159-8274.CD-11-0010","article-title":"Ovarian cancer spheroids use myosin-generated force to clear the mesothelium","volume":"1","author":"Iwanicki","year":"2011","journal-title":"Cancer Discov."},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/nrc907","article-title":"Deregulated homeobox gene expression in cancer: Cause or consequence?","volume":"2","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"ref_300","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1111\/IGC.0b013e3181a83f1d","article-title":"HOXA10 is overexpressed in human ovarian clear cell adenocarcinoma and correlates with poor survival","volume":"19","author":"Li","year":"2009","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_301","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.critrevonc.2010.05.003","article-title":"The role of hypoxia inducible factor-1alpha in gynecological cancer","volume":"78","author":"Seeber","year":"2011","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_302","doi-asserted-by":"crossref","first-page":"e397","DOI":"10.1038\/cddis.2012.140","article-title":"Proliferation and tissue remodeling in cancer: The hallmarks revisited","volume":"3","author":"Markert","year":"2012","journal-title":"Cell Death Dis."},{"key":"ref_303","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.ygyno.2009.05.022","article-title":"A miR-200 microRNA cluster as prognostic marker in advanced ovarian cancer","volume":"114","author":"Hu","year":"2009","journal-title":"Gynecol. Oncol."},{"key":"ref_304","doi-asserted-by":"crossref","first-page":"4284","DOI":"10.1038\/onc.2012.433","article-title":"miR-141 regulates KEAP1 and modulates cisplatin sensitivity in ovarian cancer cells","volume":"32","author":"Helleman","year":"2013","journal-title":"Oncogene"},{"key":"ref_305","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.3892\/ijmm.2016.2553","article-title":"Suppression of SIK1 by miR-141 in human ovarian cancer cell lines and tissues","volume":"37","author":"Chen","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"ref_306","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1038\/onc.2013.128","article-title":"Multilayer control of the EMT master regulators","volume":"33","author":"Zheng","year":"2014","journal-title":"Oncogene"},{"key":"ref_307","doi-asserted-by":"crossref","first-page":"6401","DOI":"10.1158\/0008-5472.CAN-10-1346","article-title":"MicroRNAs and metastasis: Little RNAs go a long way","volume":"70","author":"Dykxhoorn","year":"2010","journal-title":"Cancer Res."},{"key":"ref_308","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1101\/gad.1820109","article-title":"MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities of cancer","volume":"23","author":"Olson","year":"2009","journal-title":"Genes Dev."},{"key":"ref_309","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.humpath.2004.09.014","article-title":"Elevated expression of E-cadherin and alpha-, beta-, and gamma-catenins in metastatic lesions compared with primary epithelial ovarian carcinomas","volume":"35","author":"Imai","year":"2004","journal-title":"Hum. Pathol."},{"key":"ref_310","doi-asserted-by":"crossref","first-page":"20838","DOI":"10.18632\/oncotarget.24889","article-title":"The versatile nature of miR-9\/9(*) in human cancer","volume":"9","author":"Nowek","year":"2018","journal-title":"Oncotarget"},{"key":"ref_311","first-page":"218","article-title":"Inhibition of miR-9 decreases osteosarcoma cell proliferation","volume":"20","author":"Gang","year":"2020","journal-title":"Bosn. J. Basic Med. Sci."},{"key":"ref_312","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1002\/1878-0261.12352","article-title":"MicroRNA-9 inhibits growth and invasion of head and neck cancer cells and is a predictive biomarker of response to plerixafor, an inhibitor of its target CXCR4","volume":"12","author":"Hersi","year":"2018","journal-title":"Mol. Oncol."},{"key":"ref_313","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s13048-019-0503-7","article-title":"Biomarkers and algorithms for diagnosis of ovarian cancer: CA125, HE4, RMI and ROMA, a review","volume":"12","author":"Dochez","year":"2019","journal-title":"J. Ovarian Res."},{"key":"ref_314","doi-asserted-by":"crossref","unstructured":"Wu, S.G., Chang, T.H., Liu, Y.N., and Shih, J.Y. (2019). MicroRNA in Lung Cancer Metastasis. Cancers, 11.","DOI":"10.3390\/cancers11020265"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/21\/19\/7093\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:13:52Z","timestamp":1760177632000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/21\/19\/7093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,25]]},"references-count":314,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2020,10]]}},"alternative-id":["ijms21197093"],"URL":"https:\/\/doi.org\/10.3390\/ijms21197093","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,25]]}}}