{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T21:03:30Z","timestamp":1790975010167,"version":"4.1.0"},"reference-count":56,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T00:00:00Z","timestamp":1601337600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002628","name":"Incheon National University","doi-asserted-by":"publisher","award":["Incheon National University Research grant in 2018"],"award-info":[{"award-number":["Incheon National University Research grant in 2018"]}],"id":[{"id":"10.13039\/501100002628","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Exercise is an effective intervention for both the prevention and the treatment of obesity and insulin resistance because skeletal muscle secretes many bioactive proteins that contribute to the beneficial effect of exercise. It has been revealed that irisin plays an important role in metabolic homeostasis and both acute and chronic exercises increase circulating irisin in experimental animal models and in humans. Although previous studies have reported that the irisin-related signaling mechanism may play a beneficial role in the treatment of metabolic diseases including obesity, metabolic syndrome, insulin resistance, and diabetes mellitus, studies on whether irisin plays a key role in vascular function and vascular complications are still insufficient. Therefore, the current review aims to summarize the accumulating evidence showing the potential role of irisin, especially in vascular reactivity and vascular abnormalities such as atherosclerosis.<\/jats:p>","DOI":"10.3390\/ijms21197184","type":"journal-article","created":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T08:43:27Z","timestamp":1601369007000},"page":"7184","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["The Potential Role of Irisin in Vascular Function and Atherosclerosis: A Review"],"prefix":"10.3390","volume":"21","author":[{"given":"Kyeongho","family":"Byun","sequence":"first","affiliation":[{"name":"Division of Sport Science, College of Arts &amp; Physical Education, Incheon National University, Incheon 22012, Korea"},{"name":"Sport Science Institute, College of Arts &amp; Physical Education, Incheon National University, Incheon 22012, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6179-5156","authenticated-orcid":false,"given":"Sewon","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Sport Science, College of Arts &amp; Physical Education, Incheon National University, Incheon 22012, Korea"},{"name":"Sport Science Institute, College of Arts &amp; Physical Education, Incheon National University, Incheon 22012, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nature10777","article-title":"A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis","volume":"481","author":"Bostrom","year":"2012","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1080\/17461391.2018.1506504","article-title":"Plasma irisin is increased following 12 weeks of Nordic walking and associates with glucose homoeostasis in overweight\/obese men with impaired glucose regulation","volume":"19","author":"Korkmaz","year":"2019","journal-title":"Eur. 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