{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:44:18Z","timestamp":1791938658502,"version":"4.3.4"},"reference-count":102,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Sleep-wake disorders are highly prevalent disorders, which can lead to negative effects on cognitive, emotional and interpersonal functioning, and can cause maladaptive metabolic changes. Recent studies support the notion that metabolic processes correlate with sleep. The study of metabolite biomarkers (metabolomics) in a large-scale manner offers unique opportunities to provide insights into the pathology of diseases by revealing alterations in metabolic pathways. This review aims to summarize the status of metabolomic analyses-based knowledge on sleep disorders and to present knowledge in understanding the metabolic role of sleep in psychiatric disorders. Overall, findings suggest that sleep-wake disorders lead to pronounced alterations in specific metabolic pathways, which might contribute to the association of sleep disorders with other psychiatric disorders and medical conditions. These alterations are mainly related to changes in the metabolism of branched-chain amino acids, as well as glucose and lipid metabolism. In insomnia, alterations in branched-chain amino acid and glucose metabolism were shown among studies. In obstructive sleep apnea, biomarkers related to lipid metabolism seem to be of special importance. Future studies are needed to examine severity, subtypes and treatment of sleep-wake disorders in the context of metabolite levels.<\/jats:p>","DOI":"10.3390\/ijms21197244","type":"journal-article","created":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T09:04:12Z","timestamp":1601543052000},"page":"7244","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":120,"title":["Metabolomics in Sleep, Insomnia and Sleep Apnea"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9776-0353","authenticated-orcid":false,"given":"Elke","family":"Humer","sequence":"first","affiliation":[{"name":"Department for Psychotherapy and Biopsychosocial Health, Danube University Krems, 3500 Krems, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2708-303X","authenticated-orcid":false,"given":"Christoph","family":"Pieh","sequence":"additional","affiliation":[{"name":"Department for Psychotherapy and Biopsychosocial Health, Danube University Krems, 3500 Krems, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Brandmayr","sequence":"additional","affiliation":[{"name":"Section for Artificial Intelligence and Decision Support, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3233\/NHA-180043","article-title":"Metabolism of sleep and aging: Bridging the gap using metabolomics","volume":"5","author":"Sengupta","year":"2019","journal-title":"Nutr. Heal. Aging"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1037\/bul0000053","article-title":"Sleep and Mental Disorders: A Meta-Analysis of Polysomnographic Research HHS Public Access Author manuscript","volume":"142","author":"Baglioni","year":"2017","journal-title":"Psychol. Bull."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"vii","DOI":"10.1016\/B978-0-444-52006-7.00047-2","article-title":"We spend about one-third of our life either sleeping or attempting to do so","volume":"98","author":"Aminoff","year":"2011","journal-title":"Handb. Clin. Neurol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.psychres.2018.07.009","article-title":"Prevalence and correlates of sleep disorder symptoms in psychiatric disorders","volume":"279","author":"Hombali","year":"2019","journal-title":"Psychiatry Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.paid.2016.11.050","article-title":"Associations between sleep disturbances, personality, and trait emotional intelligence","volume":"107","author":"Emert","year":"2017","journal-title":"Pers. Individ. Dif."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Datta, S. (2010). Cellular and chemical neuroscience of mammalian sleep. Sleep Med.","DOI":"10.1016\/j.sleep.2010.02.002"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"36804","DOI":"10.1038\/srep36804","article-title":"Contribution of sleep to the repair of neuronal DNA double-strand breaks: Evidence from flies and mice","volume":"6","author":"Bellesi","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1378\/chest.09-2954","article-title":"Sleep and Hypertension","volume":"138","author":"Calhoun","year":"2010","journal-title":"Chest"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"54","DOI":"10.2174\/157340310790231635","article-title":"Sleep Duration as a Risk Factor for Cardiovascular Disease\u2014A Review of the Recent Literature","volume":"6","author":"Nagai","year":"2010","journal-title":"Curr. Cardiol. Rev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"414","DOI":"10.2337\/dc09-1124","article-title":"Quantity and Quality of Sleep and Incidence of Type 2 Diabetes: A systematic review and meta-analysis","volume":"33","author":"Cappuccio","year":"2010","journal-title":"Diabetes Care"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1378\/chest.09-0360","article-title":"Interactions Between Obesity and Obstructive Sleep Apnea","volume":"137","author":"Caples","year":"2010","journal-title":"Chest"},{"key":"ref_12","first-page":"E1132","article-title":"Effects of insufficient sleep on circadian rhythmicity and expression amplitude of the human blood transcriptome","volume":"110","author":"Archer","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.bbi.2015.08.024","article-title":"Partial sleep deprivation activates the DNA damage response (DDR) and the senescence-associated secretory phenotype (SASP) in aged adult humans","volume":"51","author":"Carroll","year":"2016","journal-title":"Brain. Behav. Immun."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1152\/physrev.00032.2012","article-title":"About Sleep\u2019s Role in Memory","volume":"93","author":"Rasch","year":"2013","journal-title":"Physiol. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Dorffner, G., Vitr, M., and Anderer, P. (2015). The effects of aging on sleep architecture in healthy subjects. Adv. Exp. Med. Biol.","DOI":"10.1007\/978-3-319-08939-3_13"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Wimmer, M.E., Rising, J., Galante, R.J., Wyner, A., Pack, A.I., and Abel, T. (2013). Aging in Mice Reduces the Ability to Sustain Sleep\/Wake States. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0081880"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Zdanys, K.F., and Steffens, D.C. (2015). Sleep Disturbances in the Elderly. Psychiatr. Clin. N. Am.","DOI":"10.1016\/j.psc.2015.07.010"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nn.3324","article-title":"Prefrontal atrophy, disrupted NREM slow waves and impaired hippocampal-dependent memory in aging","volume":"16","author":"Mander","year":"2013","journal-title":"Nat. Neurosci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"215ra173","DOI":"10.1126\/scitranslmed.3007092","article-title":"Dietary Therapy Mitigates Persistent Wake Deficits Caused by Mild Traumatic Brain Injury","volume":"5","author":"Lim","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Roach, M., Juday, T., Tuly, R., Chou, J.W., Jena, A.B., and Doghramji, P.P. (2020). Challenges and opportunities in insomnia disorder. Int. J. Neurosci., 1\u20138.","DOI":"10.1080\/00207454.2020.1773460"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/sleep\/zsy144","article-title":"Acute sleep deprivation and culpable motor vehicle crash involvement","volume":"41","author":"Tefft","year":"2018","journal-title":"Sleep"},{"key":"ref_22","first-page":"1521","article-title":"Prevalence and comorbidity of sleep disorders in general population","volume":"57","author":"Ohayon","year":"2007","journal-title":"Rev. Prat."},{"key":"ref_23","first-page":"16","article-title":"A Review of Changes in DSM-5 Sleep-Wake Disorders","volume":"32","author":"Khurshid","year":"2015","journal-title":"Psychiatr. Times"},{"key":"ref_24","unstructured":"APA (2013). Sleep-Wake Disorders Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. Am. Psychiatr. Assoc. Publ."},{"key":"ref_25","unstructured":"Association, A.P. (2013). Diagnostic and Statistical Manual of Mental Disorders, American Psychiatric Publishing. [5th ed.]."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Huang, W., Ramsey, K.M., Marcheva, B., and Bass, J. (2011). Circadian rhythms, sleep, and metabolism. J. Clin. Investig.","DOI":"10.1172\/JCI46043"},{"key":"ref_27","first-page":"28","article-title":"Comorbid insomnia and psychiatric disorders: An update","volume":"15","author":"Khurshid","year":"2018","journal-title":"Innov. Clin. Neurosci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/sleep\/zsy043","article-title":"Altered diurnal states in insomnia reflect peripheral hyperarousal and metabolic desynchrony: A preliminary study","volume":"41","author":"Gehrman","year":"2018","journal-title":"Sleep"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s11306-017-1205-z","article-title":"Habitual sleep and human plasma metabolomics","volume":"13","author":"Xiao","year":"2017","journal-title":"Metabolomics"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"10761","DOI":"10.1073\/pnas.1402663111","article-title":"Effect of sleep deprivation on the human metabolome","volume":"111","author":"Davies","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.physbeh.2013.08.007","article-title":"Effects of sleep restriction on the human plasma metabolome","volume":"122","author":"Bell","year":"2013","journal-title":"Physiol. Behav."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1176\/appi.ajp.161.11.2126","article-title":"Functional Neuroimaging Evidence for Hyperarousal in Insomnia","volume":"161","author":"Nofzinger","year":"2004","journal-title":"Am. J. Psychiatry"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"7825","DOI":"10.1073\/pnas.1801183115","article-title":"Separation of circadian- and behavior-driven metabolite rhythms in humans provides a window on peripheral oscillators and metabolism","volume":"115","author":"Skene","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.smrv.2016.07.002","article-title":"Prevalence of obstructive sleep apnea in the general population: A systematic review","volume":"34","author":"Senaratna","year":"2017","journal-title":"Sleep Med. Rev."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1093\/sleep\/28.11.1405","article-title":"Association of Psychiatric Disorders and Sleep Apnea in a Large Cohort","volume":"28","author":"Sharafkhaneh","year":"2005","journal-title":"Sleep"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.sleh.2017.04.003","article-title":"Sleep apnea, psychopathology, and mental health care","volume":"3","author":"Kaufmann","year":"2017","journal-title":"Sleep Heal."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Diallo, I., and Pak, V.M. (2020). Metabolomics, sleepiness, and sleep duration in sleep apnea. Sleep Breath.","DOI":"10.1007\/s11325-019-01969-2"},{"key":"ref_38","first-page":"362","article-title":"Prospective analyses of volatile organic compounds in obstructive sleep apnea patients","volume":"156","author":"Aoki","year":"2017","journal-title":"Toxicol. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"026005","DOI":"10.1088\/1752-7155\/9\/2\/026005","article-title":"An electronic nose in the discrimination of obese patients with and without obstructive sleep apnoea","volume":"9","author":"Dragonieri","year":"2015","journal-title":"J. Breath Res."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Schwarz, E.I., Engler, A., and Kohler, M. (2017). Exhaled breath analysis in obstructive sleep apnea. Expert Rev. Respir. Med.","DOI":"10.1080\/17476348.2017.1338950"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1002\/elps.201300081","article-title":"Fingerprinting-based metabolomic approach with LC -MS to sleep apnea and hypopnea syndrome: A pilot study","volume":"34","author":"Ferrarini","year":"2013","journal-title":"Electrophoresis"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1007\/s11306-015-0808-5","article-title":"Fusion of the 1H NMR data of serum, urine and exhaled breath condensate in order to discriminate chronic obstructive pulmonary disease and obstructive sleep apnea syndrome","volume":"11","author":"Stanimirova","year":"2015","journal-title":"Metabolomics"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"30958","DOI":"10.1038\/srep30958","article-title":"Metabolomics Profiling for Obstructive Sleep Apnea and Simple Snorers","volume":"6","author":"Xu","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.5664\/jcsm.7336","article-title":"Pediatric obstructive sleep apnea is associated with changes in the oral microbiome and urinary metabolomics profile: A pilot study","volume":"14","author":"Xu","year":"2018","journal-title":"J. Clin. Sleep Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/bs.acc.2018.10.002","article-title":"Clinical metabolomics of exhaled breath condensate in chronic respiratory diseases","volume":"88","author":"Maniscalco","year":"2019","journal-title":"Adv. Clin. Chem."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Horv\u00e1th, I., Hunt, J., Barnes, P.J., Alving, K., Antczak, A., Baraldi, E., Becher, G., van Beurden, W.J.C., Corradi, M., and Dekhuijzen, R. (2005). Exhaled breath condensate: Methodological recommendations and unresolved questions. Eur. Respir. J.","DOI":"10.1183\/09031936.05.00029705"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Panaiotis, F., Simone, S., Vittorio, C., and Raffaele, A.I. (2019). Exhaled Breath Analysis in Obstructive Sleep Apnea Syndrome: A Review of the Literature. Medicina, 55.","DOI":"10.3390\/medicina55090538"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e1541","DOI":"10.1097\/MD.0000000000001541","article-title":"Chromatography\/Mass Spectrometry-Based Biomarkers in the Field of Obstructive Sleep Apnea","volume":"94","author":"Xu","year":"2015","journal-title":"Medicine (Baltimore)"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1378\/chest.10-2223","article-title":"Obstructive Sleep Apnea","volume":"140","author":"Drager","year":"2011","journal-title":"Chest"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1183\/09031936.00043614","article-title":"Obstructive sleep apnoea treatment and fasting lipids: A comparative effectiveness study","volume":"44","author":"Keenan","year":"2014","journal-title":"Eur. Respir. J."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1164\/rccm.201102-0316OC","article-title":"Continuous Positive Airway Pressure Reduces Postprandial Lipidemia in Obstructive Sleep Apnea","volume":"184","author":"Phillips","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/S0140-6736(05)71141-7","article-title":"Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: An observational study","volume":"365","author":"Marin","year":"2005","journal-title":"Lancet"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1161\/CIRCRESAHA.108.178533","article-title":"Dyslipidemia and Atherosclerosis Induced by Chronic Intermittent Hypoxia Are Attenuated by Deficiency of Stearoyl Coenzyme A Desaturase","volume":"103","author":"Savransky","year":"2008","journal-title":"Circ. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1164\/rccm.200612-1771OC","article-title":"Chronic Intermittent Hypoxia Induces Atherosclerosis","volume":"175","author":"Savransky","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_55","first-page":"19","article-title":"A nationwide survey of psychological distress among Chinese people in the COVID-19 epidemic: Implications and policy recommendations","volume":"33","author":"Qiu","year":"2020","journal-title":"Gen. Psychiatry"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"11270","DOI":"10.1038\/s41598-018-29727-6","article-title":"Metabolomic and lipidomic profile in men with obstructive sleep apnoea: Implications for diagnosis and biomarkers of cardiovascular risk","volume":"8","author":"Lebkuchen","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1097\/HJH.0b013e3283591595","article-title":"Circulating anandamide and blood pressure in patients with obstructive sleep apnea","volume":"30","author":"Engeli","year":"2012","journal-title":"J. Hypertens."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/s11306-017-1216-9","article-title":"Urinary Metabolomic Signatures in Obstructive Sleep Apnea through Targeted Metabolomic Analysis: A Pilot Study","volume":"13","author":"Cho","year":"2017","journal-title":"Metabolomics"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1002\/ppul.23753","article-title":"Circulating branched-chain amino acids in children with obstructive sleep apnea","volume":"52","author":"Toledo","year":"2017","journal-title":"Pediatr. Pulmonol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1700257","DOI":"10.1183\/13993003.00257-2017","article-title":"Effect of continuous positive airway pressure on blood pressure and metabolic profile in women with sleep apnoea","volume":"50","author":"Troncoso","year":"2017","journal-title":"Eur. Respir. J."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1164\/rccm.201510-1942OC","article-title":"Effect of Continuous Positive Airway Pressure on Glycemic Control in Patients with Obstructive Sleep Apnea and Type 2 Diabetes. A Randomized Clinical Trial","volume":"194","author":"Barquiel","year":"2016","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.5664\/jcsm.4282","article-title":"Effect of CPAP Treatment for Obstructive Sleep Apnea Hypopnea Syndrome on Lipid Profile: A Meta-Regression Analysis","volume":"10","author":"Nadeem","year":"2014","journal-title":"J. Clin. Sleep Med."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Potter, G.D.M., Skene, D.J., Arendt, J., Cade, J.E., Grant, P.J., and Hardie, L.J. (2016). Circadian rhythm and sleep disruption: Causes, metabolic consequences, and countermeasures. Endocr. Rev.","DOI":"10.1210\/er.2016-1083"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"3578","DOI":"10.1016\/j.jmb.2020.04.027","article-title":"Circadian and Sleep Metabolomics Across Species","volume":"432","author":"Malik","year":"2020","journal-title":"J. Mol. Biol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"14843","DOI":"10.1038\/srep14843","article-title":"Diurnal rhythms in the human urine metabolome during sleep and total sleep deprivation","volume":"5","author":"Davies","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e1020","DOI":"10.4088\/JCP.16r11332","article-title":"Meta-Analysis of the Antidepressant Effects of Acute Sleep Deprivation","volume":"78","author":"Boland","year":"2017","journal-title":"J. Clin. Psychiatry"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"11225","DOI":"10.1038\/s41598-018-29511-6","article-title":"Metabolomic analysis of mouse prefrontal cortex reveals upregulated analytes during wakefulness compared to sleep","volume":"8","author":"Bourdon","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/5179271","article-title":"Serum and Brain Metabolomic Variations Reveal Perturbation of Sleep Deprivation on Rats and Ameliorate Effect of Total Ginsenoside Treatment","volume":"2017","author":"Gou","year":"2017","journal-title":"Int. J. Genom."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Zhan, S., Wu, Y., Sun, P., Lin, H., Zhu, Y., and Han, X. (2016). Decrease in Circulating Fatty Acids Is Associated with Islet Dysfunction in Chronically Sleep-Restricted Rats. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17122102"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.neuroscience.2011.03.048","article-title":"Long-term ginsenoside administration prevents memory loss in aged female C57BL\/6J mice by modulating the redox status and up-regulating the plasticity-related proteins in hippocampus","volume":"183","author":"Zhao","year":"2011","journal-title":"Neuroscience"},{"key":"ref_71","unstructured":"Provalova, N.V., Skurikhin, E.G., Pershina, O.V., Suslov, N.I., Minakova, M.Y., Dygai, A.M., and Gol\u2019dberg, E.D. (2002). Mechanisms underlying the effects of adaptogens on erythropoiesis during paradoxical sleep deprivation. Bull. Exp. Biol. Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/sleep\/zsz321","article-title":"Developing preliminary blood metabolomics-based biomarkers of insufficient sleep in humans","volume":"43","author":"Depner","year":"2020","journal-title":"Sleep"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1073\/pnas.1417432112","article-title":"Oxalic acid and diacylglycerol 36:3 are cross-species markers of sleep debt","volume":"112","author":"Weljie","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.abb.2015.09.017","article-title":"A single night of sleep curtailment increases plasma acylcarnitines: Novel insights in the relationship between sleep and insulin resistance","volume":"589","author":"Donga","year":"2016","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"24828","DOI":"10.1038\/srep24828","article-title":"Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses","volume":"6","author":"Aho","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.biocel.2017.08.014","article-title":"Sleep restriction induced energy, methylation and lipogenesis metabolic switches in rat liver","volume":"93","author":"Sengupta","year":"2017","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.brainresbull.2019.08.008","article-title":"Untargeted metabolomics analysis of rat hippocampus subjected to sleep fragmentation","volume":"153","author":"Yoon","year":"2019","journal-title":"Brain Res. Bull."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1093\/sleep\/7.1.18","article-title":"Sleep fragmentation and daytime sleepiness","volume":"7","author":"Stepanski","year":"1984","journal-title":"Sleep"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1093\/sleep\/25.3.268","article-title":"The effect of sleep fragmentation on daytime function","volume":"25","author":"Stepanski","year":"2002","journal-title":"Sleep"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.bbr.2015.12.039","article-title":"Chronical sleep interruption-induced cognitive decline assessed by a metabolomics method","volume":"302","author":"Feng","year":"2016","journal-title":"Behav. Brain Res."},{"key":"ref_81","first-page":"1","article-title":"Modulation of Adult Hippocampal Neurogenesis by Sleep: Impact on Mental Health","volume":"11","author":"Brock","year":"2017","journal-title":"Front. Neural Circuits"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1152\/physiolgenomics.00039.2020","article-title":"Sleep fragmentation increases blood pressure and is associated with alterations in the gut microbiome and fecal metabolome in rats","volume":"52","author":"Maki","year":"2020","journal-title":"Physiol. Genom."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Bowers, S.J., Vargas, F., Gonz\u00e1lez, A., He, S., Jiang, P., Dorrestein, P.C., Knight, R., Wright, K.P., Lowry, C.A., and Fleshner, M. (2020). Repeated sleep disruption in mice leads to persistent shifts in the fecal microbiome and metabolome. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0229001"},{"key":"ref_84","first-page":"1548250","article-title":"Gut thinking: The gut microbiome and mental health beyond the head","volume":"29","author":"Lucas","year":"2018","journal-title":"Microb. Ecol. Health Dis."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.cca.2015.01.003","article-title":"The role of the gut microbiome in the healthy adult status","volume":"451","author":"Salvatore","year":"2015","journal-title":"Clin. Chim. Acta"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1093\/ajh\/hpv154","article-title":"Sympathetic Hyperactivity, Sleep Fragmentation, and Wake-Related Blood Pressure Surge During Late-Light Sleep in Spontaneously Hypertensive Rats","volume":"29","author":"Lai","year":"2016","journal-title":"Am. J. Hypertens."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Wolfe, R.R. (2017). Branched-chain amino acids and muscle protein synthesis in humans: Myth or reality?. J. Int. Soc. Sports Nutr.","DOI":"10.1186\/s12970-017-0184-9"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.molmet.2016.04.006","article-title":"Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export","volume":"5","author":"White","year":"2016","journal-title":"Mol. Metab."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Batch, B.C., Hyland, K., and Svetkey, L.P. (2013). Branch chain amino acids. Curr. Opin. Clin. Nutr. Metab. Care, 1.","DOI":"10.1097\/MCO.0000000000000010"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Scalise, M., Galluccio, M., Console, L., Pochini, L., and Indiveri, C. (2018). The human SLC7A5 (LAT1): The intriguing histidine\/large neutral amino acid transporter and its relevance to human health. Front. Chem.","DOI":"10.3389\/fchem.2018.00243"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1539S","DOI":"10.1093\/jn\/135.6.1539S","article-title":"Branched-Chain Amino Acids and Brain Function","volume":"135","author":"Fernstrom","year":"2005","journal-title":"J. Nutr."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/pr.2017.115","article-title":"Branched-chain and aromatic amino acids in relation to behavioral problems among young Inuit from Nunavik, Canada: A cohort study","volume":"82","author":"Meziou","year":"2017","journal-title":"Pediatr. Res."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s11064-016-2057-z","article-title":"Interactions in the Metabolism of Glutamate and the Branched-Chain Amino Acids and Ketoacids in the CNS","volume":"42","author":"Yudkoff","year":"2017","journal-title":"Neurochem. Res."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.psyneuen.2015.02.010","article-title":"Improved sleep quality in older adults with insomnia reduces biomarkers of disease risk: Pilot results from a randomized controlled comparative efficacy trial","volume":"55","author":"Carroll","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.neures.2017.04.008","article-title":"The control of sleep and wakefulness by mesolimbic dopamine systems","volume":"118","author":"Oishi","year":"2017","journal-title":"Neurosci. Res."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Sandsmark, D.K., Elliott, J.E., and Lim, M.M. (2017). Sleep-Wake Disturbances After Traumatic Brain Injury: Synthesis of Human and Animal Studies. Sleep.","DOI":"10.1093\/sleep\/zsx044"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1073\/pnas.0910280107","article-title":"Dietary branched chain amino acids ameliorate injury-induced cognitive impairment","volume":"107","author":"Cole","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.neuron.2011.08.027","article-title":"Activation of central orexin\/hypocretin neurons by dietary amino acids","volume":"72","author":"Karnani","year":"2011","journal-title":"Neuron"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/npp.2013.167","article-title":"Mass Spectrometry Strategies for Clinical Metabolomics and Lipidomics in Psychiatry, Neurology, and Neuro-Oncology","volume":"39","author":"Wood","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Adamski, J. (2016). Key elements of metabolomics in the study of biomarkers of diabetes. Diabetologia.","DOI":"10.1007\/s00125-016-4044-y"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Guest, P.C., Guest, F.L., and Martins-de Souza, D. (2015). Making Sense of Blood-Based Proteomics and Metabolomics in Psychiatric Research. Int. J. Neuropsychopharmacol., pyv138.","DOI":"10.1093\/ijnp\/pyv138"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Humer, E., Probst, T., and Pieh, C. (2020). Metabolomics in psychiatric disorders: What we learn from animal models. Metabolites.","DOI":"10.3390\/metabo10020072"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/21\/19\/7244\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:15:22Z","timestamp":1760177722000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/21\/19\/7244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,30]]},"references-count":102,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2020,10]]}},"alternative-id":["ijms21197244"],"URL":"https:\/\/doi.org\/10.3390\/ijms21197244","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,30]]}}}