{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T12:22:12Z","timestamp":1784031732960,"version":"3.55.0"},"reference-count":67,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T00:00:00Z","timestamp":1602115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fondos de Investigaci\u00f3n Sanitaria","award":["PI16\/02124 and RIER"],"award-info":[{"award-number":["PI16\/02124 and RIER"]}]},{"DOI":"10.13039\/501100010801","name":"Xunta de Galicia","doi-asserted-by":"publisher","award":["AGRUP2015\/05 CICA-INIBIC"],"award-info":[{"award-number":["AGRUP2015\/05 CICA-INIBIC"]}],"id":[{"id":"10.13039\/501100010801","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010801","name":"Xunta de Galicia","doi-asserted-by":"publisher","award":["IN607A 2017\/11(GPC)"],"award-info":[{"award-number":["IN607A 2017\/11(GPC)"]}],"id":[{"id":"10.13039\/501100010801","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008425","name":"Conseller\u00eda de Cultura, Educaci\u00f3n e Ordenaci\u00f3n Universitaria, Xunta de Galicia","doi-asserted-by":"publisher","award":["ED481D2017\/023"],"award-info":[{"award-number":["ED481D2017\/023"]}],"id":[{"id":"10.13039\/501100008425","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Osteoarthritis (OA) is the most common articular chronic disease. However, its current treatment is limited and mostly symptomatic. Hydrogen sulfide (H2S) is an endogenous gas with recognized physiological activities. The purpose here was to evaluate the effects of the intraarticular administration of a slow-releasing H2S compound (GYY-4137) on an OA experimental model. OA was induced in Wistar rats by the transection of medial collateral ligament and the removal of the medial meniscus of the left joint. The animals were randomized into three groups: non-treated and intraarticularly injected with saline or GYY-4137. Joint destabilization induced articular thickening (\u22485% increment), the loss of joint mobility and flexion (\u224812-degree angle), and increased levels of pain (\u22481.5 points on a scale of 0 to 3). Animals treated with GYY-4137 presented improved motor function of the joint, as well as lower pain levels (\u224875% recovery). We also observed that cartilage deterioration was attenuated in the GYY-4137 group (\u224830% compared with the saline group). Likewise, these animals showed a reduced presence of pro-inflammatory mediators (cyclooxygenase-2, inducible nitric oxide synthase, and metalloproteinase-13) and lower oxidative damage in the cartilage. The increment of the nuclear factor-erythroid 2-related factor 2 (Nrf-2) levels and Nrf-2-regulated gene expression (\u224830%) in the GYY-4137 group seem to be underlying its chondroprotective effects. Our results suggest the beneficial impact of the intraarticular administration of H2S on experimental OA, showing a reduced cartilage destruction and oxidative damage, and supporting the use of slow H2S-producing molecules as a complementary treatment in OA.<\/jats:p>","DOI":"10.3390\/ijms21197421","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T08:52:41Z","timestamp":1602147161000},"page":"7421","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Intraarticular Administration Effect of Hydrogen Sulfide on an In Vivo Rat Model of Osteoarthritis"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8658-5502","authenticated-orcid":false,"given":"Carlos","family":"Vaamonde-Garc\u00eda","sequence":"first","affiliation":[{"name":"Grupo de Terapia Celular y Medicina Regenerativa, Universidad de A Coru\u00f1a, Agrupaci\u00f3n Estrat\u00e9gica CICA- INIBIC, Complexo Hospitalario Universitario A Coru\u00f1a, Campus Oza, 15006 A Coru\u00f1a, Spain"},{"name":"Grupo de Investigaci\u00f3n en Reumatolog\u00eda (GIR), INIBIC-Complexo Hospitalario Universitario A Coru\u00f1a, Sergas, As Xubias, 15006 A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena F.","family":"Burguera","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Reumatolog\u00eda (GIR), INIBIC-Complexo Hospitalario Universitario A Coru\u00f1a, Sergas, As Xubias, 15006 A Coru\u00f1a, Spain"},{"name":"Centro de investigaci\u00f3n biom\u00e9dica en Red, Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER-BBN), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngela","family":"Vela-Anero","sequence":"additional","affiliation":[{"name":"Grupo de Terapia Celular y Medicina Regenerativa, Universidad de A Coru\u00f1a, Agrupaci\u00f3n Estrat\u00e9gica CICA- INIBIC, Complexo Hospitalario Universitario A Coru\u00f1a, Campus Oza, 15006 A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Hermida-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Reumatolog\u00eda (GIR), INIBIC-Complexo Hospitalario Universitario A Coru\u00f1a, Sergas, As Xubias, 15006 A Coru\u00f1a, Spain"},{"name":"Centro de investigaci\u00f3n biom\u00e9dica en Red, Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER-BBN), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Purificaci\u00f3n","family":"Filgueira-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Reumatolog\u00eda (GIR), INIBIC-Complexo Hospitalario Universitario A Coru\u00f1a, Sergas, As Xubias, 15006 A Coru\u00f1a, Spain"},{"name":"Centro de investigaci\u00f3n biom\u00e9dica en Red, Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER-BBN), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Fern\u00e1ndez-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Grupo de Envejecimiento e Inflamaci\u00f3n, Agrupaci\u00f3n Estrat\u00e9gica CICA- INIBIC, Complexo Hospitalario Universitario A Coru\u00f1a, Sergas, Universidad de A Coru\u00f1a, As Xubias, 15006 A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8516-9419","authenticated-orcid":false,"given":"Rosa","family":"Meijide-Fa\u00edlde","sequence":"additional","affiliation":[{"name":"Grupo de Terapia Celular y Medicina Regenerativa, Universidad de A Coru\u00f1a, Agrupaci\u00f3n Estrat\u00e9gica CICA- INIBIC, Complexo Hospitalario Universitario A Coru\u00f1a, Campus Oza, 15006 A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9821-7635","authenticated-orcid":false,"given":"Francisco J.","family":"Blanco","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Reumatolog\u00eda (GIR), INIBIC-Complexo Hospitalario Universitario A Coru\u00f1a, Sergas, As Xubias, 15006 A Coru\u00f1a, Spain"},{"name":"Grupo de Investigaci\u00f3n de Reumatolog\u00eda y Salud (GIR), Departamento de Fisioterapia, Medicina y Ciencias Biom\u00e9dicas, Facultad de Fisioterapia, Agrupaci\u00f3n Estrategica CICA-INIBIC, Universidade da Coru\u00f1a, Campus de Oza, 15006 A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/j.joca.2015.03.036","article-title":"Call for standardized definitions of osteoarthritis and risk stratification for clinical trials and clinical use","volume":"23","author":"Kraus","year":"2015","journal-title":"Osteoarthr. 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