{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:04:51Z","timestamp":1788998691644,"version":"build-2803163510"},"reference-count":168,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T00:00:00Z","timestamp":1602633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Aging and sedentary life style are considered independent risk factors for many disorders. Under these conditions, accumulation of dysfunctional and damaged cellular proteins and organelles occurs, resulting in a cellular degeneration and cell death. Autophagy is a conserved recycling pathway responsible for the degradation, then turnover of cellular proteins and organelles. This process is a part of the molecular underpinnings by which exercise promotes healthy aging and mitigate age-related pathologies. Irisin is a myokine released during physical activity and acts as a link between muscles and other tissues and organs. Its main beneficial function is the change of subcutaneous and visceral adipose tissue into brown adipose tissue, with a consequential increase in thermogenesis. Irisin modulates metabolic processes, acting on glucose homeostasis, reduces systemic inflammation, maintains the balance between resorption and bone formation, and regulates the functioning of the nervous system. Recently, some of its pleiotropic and favorable properties have been attributed to autophagy induction, posing irisin as an important regulator of autophagy by exercise. This review article proposes to bring together for the first time the \u201cstate of the art\u201d knowledge regarding the effects of irisin and autophagy. Furthermore, treatments on relation between exercise\/myokines and autophagy have been also achieved.<\/jats:p>","DOI":"10.3390\/ijms21207587","type":"journal-article","created":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T21:24:39Z","timestamp":1602710679000},"page":"7587","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Irisin and Autophagy: First Update"],"prefix":"10.3390","volume":"21","author":[{"given":"Mirko","family":"Pesce","sequence":"first","affiliation":[{"name":"Department of Medicine and Aging Sciences, University G. d\u2019Annunzio, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Ballerini","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Imaging and Clinical Sciences, University G. d\u2019Annunzio, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8694-1404","authenticated-orcid":false,"given":"Teresa","family":"Paolucci","sequence":"additional","affiliation":[{"name":"Department of Oral, Medical and Biotechnological Sciences, University G. d\u2019Annunzio, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Puca","sequence":"additional","affiliation":[{"name":"Sport Academy SSD, 65010 Pescara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7081-6521","authenticated-orcid":false,"given":"Mohammad Hosein","family":"Farzaei","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, 67146 Kermanshah, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Patruno","sequence":"additional","affiliation":[{"name":"Department of Medicine and Aging Sciences, University G. d\u2019Annunzio, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00223-014-9915-y","article-title":"Skeletal muscle: A brief review of structure and function","volume":"96","author":"Frontera","year":"2015","journal-title":"Calcif. 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