{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:41:56Z","timestamp":1790624516708,"version":"4.1.0"},"reference-count":113,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T00:00:00Z","timestamp":1602720000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The growth arrest-specific transcript 5 (GAS5) is a &gt;200-nt lncRNA molecule that regulates several cellular functions, including proliferation, apoptosis, invasion and metastasis, across different types of human cancers. Here, we reviewed the current literature on the expression of GAS5 in leukemia, cervical, breast, ovarian, prostate, urinary bladder, lung, gastric, colorectal, liver, osteosarcoma and brain cancers, as well as its interaction with various miRNAs and its effect on therapy-related resistance in these malignancies. The general consensus is that GAS5 acts as a tumor suppressor across different tumor types and that its up-regulation results in tumor sensitization to chemotherapy or radiotherapy. GAS5 seems to play a previously unappreciated, but significant role in tumor therapy-induced resistance.<\/jats:p>","DOI":"10.3390\/ijms21207633","type":"journal-article","created":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T09:02:03Z","timestamp":1602752523000},"page":"7633","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["The Non-Coding RNA GAS5 and Its Role in Tumor Therapy-Induced Resistance"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8389-1360","authenticated-orcid":false,"given":"George I.","family":"Lambrou","sequence":"first","affiliation":[{"name":"Choremeio Research Laboratory, First Department of Pediatrics, National and Kapodistrian University of Athens, Thivon &amp; Levadeias 8, 11527 Goudi, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1469-1928","authenticated-orcid":false,"given":"Kyriaki","family":"Hatziagapiou","sequence":"additional","affiliation":[{"name":"Choremeio Research Laboratory, First Department of Pediatrics, National and Kapodistrian University of Athens, Thivon &amp; Levadeias 8, 11527 Goudi, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4625-5562","authenticated-orcid":false,"given":"Apostolos","family":"Zaravinos","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, College of Medicine, Member of QU Health, Qatar University, 2713 Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/35015701","article-title":"Genomics, gene expression and DNA arrays","volume":"405","author":"Lockhart","year":"2000","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1750005","DOI":"10.1142\/S0219720017500056","article-title":"The origins and evolutionary history of human non-coding rna regulatory networks","volume":"15","author":"Sherafatian","year":"2017","journal-title":"J. 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