{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:32:46Z","timestamp":1785450766894,"version":"3.56.0"},"reference-count":302,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T00:00:00Z","timestamp":1603324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["17\/CDA\/4708, 16\/RC\/3948"],"award-info":[{"award-number":["17\/CDA\/4708, 16\/RC\/3948"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010665","name":"H2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","award":["884956"],"award-info":[{"award-number":["884956"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Neonatal seizures are one of the most common comorbidities of neonatal encephalopathy, with seizures aggravating acute injury and clinical outcomes. Current treatment can control early life seizures; however, a high level of pharmacoresistance remains among infants, with increasing evidence suggesting current anti-seizure medication potentiating brain damage. This emphasises the need to develop safer therapeutic strategies with a different mechanism of action. The purinergic system, characterised by the use of adenosine triphosphate and its metabolites as signalling molecules, consists of the membrane-bound P1 and P2 purinoreceptors and proteins to modulate extracellular purine nucleotides and nucleoside levels. Targeting this system is proving successful at treating many disorders and diseases of the central nervous system, including epilepsy. Mounting evidence demonstrates that drugs targeting the purinergic system provide both convulsive and anticonvulsive effects. With components of the purinergic signalling system being widely expressed during brain development, emerging evidence suggests that purinergic signalling contributes to neonatal seizures. In this review, we first provide an overview on neonatal seizure pathology and purinergic signalling during brain development. We then describe in detail recent evidence demonstrating a role for purinergic signalling during neonatal seizures and discuss possible purine-based avenues for seizure suppression in neonates.<\/jats:p>","DOI":"10.3390\/ijms21217832","type":"journal-article","created":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T10:27:58Z","timestamp":1603362478000},"page":"7832","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Neonatal Seizures and Purinergic Signalling"],"prefix":"10.3390","volume":"21","author":[{"given":"Aida","family":"Men\u00e9ndez M\u00e9ndez","sequence":"first","affiliation":[{"name":"Department of Physiology and Medical Physics, RCSI University of Medicine and Health Sciences, Dublin D02 YN77, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathon","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Physiology and Medical Physics, RCSI University of Medicine and Health Sciences, Dublin D02 YN77, Ireland"},{"name":"FutureNeuro, Science Foundation Ireland Research Centre for Chronic and Rare Neurological Diseases, RCSI University of Medicine and Health Sciences, Dublin D02 YN77, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9137-0637","authenticated-orcid":false,"given":"Tobias","family":"Engel","sequence":"additional","affiliation":[{"name":"Department of Physiology and Medical Physics, RCSI University of Medicine and Health Sciences, Dublin D02 YN77, Ireland"},{"name":"FutureNeuro, Science Foundation Ireland Research Centre for Chronic and Rare Neurological Diseases, RCSI University of Medicine and Health Sciences, Dublin D02 YN77, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/dmcn.12724","article-title":"Neonatal seizures in hypoxic-ischaemic encephalopathy--risks and benefits of anticonvulsant therapy","volume":"57","author":"Shetty","year":"2015","journal-title":"Dev. Med. Child. Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"F493","DOI":"10.1136\/archdischild-2018-315624","article-title":"Characterisation of neonatal seizures and their treatment using continuous EEG monitoring: A multicentre experience","volume":"104","author":"Rennie","year":"2019","journal-title":"Arch. Dis. Child. Fetal. Neonatal Ed."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.pediatrneurol.2018.03.016","article-title":"Outcomes After Acute Symptomatic Seizures in Children Admitted to a Neonatal Neurocritical Care Service","volume":"84","author":"Glass","year":"2018","journal-title":"Pediatr. Neurol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Kang, S.K., and Kadam, S.D. (2015). Neonatal Seizures: Impact on Neurodevelopmental Outcomes. Front. Pediatr., 3.","DOI":"10.3389\/fped.2015.00101"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"9986","DOI":"10.1038\/s41598-018-28044-2","article-title":"Complex spectrum of phenobarbital effects in a mouse model of neonatal hypoxia-induced seizures","volume":"8","author":"Quinlan","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-94-007-4719-7_1","article-title":"Introduction to purinergic signalling in the brain","volume":"986","author":"Burnstock","year":"2013","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.tips.2006.01.005","article-title":"Historical review: ATP as a neurotransmitter","volume":"27","author":"Burnstock","year":"2006","journal-title":"Trends Pharm. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"661","DOI":"10.3389\/fphar.2017.00661","article-title":"Purinergic Signalling: Therapeutic Developments","volume":"8","author":"Burnstock","year":"2017","journal-title":"Front. Pharm."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.neuropharm.2015.11.001","article-title":"ATPergic signalling during seizures and epilepsy","volume":"104","author":"Engel","year":"2016","journal-title":"Neuropharmacology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.neuropharm.2015.05.031","article-title":"An introduction to the roles of purinergic signalling in neurodegeneration, neuroprotection and neuroregeneration","volume":"104","author":"Burnstock","year":"2016","journal-title":"Neuropharmacology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"7063","DOI":"10.1523\/JNEUROSCI.3104-16.2017","article-title":"Neuronal P2X7 Receptor: Involvement in Neuronal Physiology and Pathology","volume":"37","year":"2017","journal-title":"J. Neurosci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.brainresbull.2019.01.030","article-title":"Role of P2 receptors in normal brain development and in neurodevelopmental psychiatric disorders","volume":"151","author":"Huang","year":"2019","journal-title":"Brain Res. Bull."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.semcdb.2018.12.001","article-title":"Purinergic signalling and brain development","volume":"95","author":"Rodrigues","year":"2019","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.neuropharm.2017.01.005","article-title":"Effects of P2X7 receptor antagonists on hypoxia-induced neonatal seizures in mice","volume":"116","author":"Engel","year":"2017","journal-title":"Neuropharmacology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"182","DOI":"10.5455\/medarh.2016.70.182-185","article-title":"Predictors of Mortality in Neonates with Seizures; A Prospective Cohort Study","volume":"70","author":"Heljic","year":"2016","journal-title":"Med. Arch."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"190","DOI":"10.3389\/fncel.2017.00190","article-title":"Effect of Neuroinflammation on Synaptic Organization and Function in the Developing Brain: Implications for Neurodevelopmental and Neurodegenerative Disorders","volume":"11","author":"Mottahedin","year":"2017","journal-title":"Front. Cell Neurosci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nrneurol.2009.80","article-title":"Epileptogenesis in the immature brain: Emerging mechanisms","volume":"5","author":"Rakhade","year":"2009","journal-title":"Nat. Rev. Neurol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.2147\/NDT.S107905","article-title":"The causes of new-onset epilepsy and seizures in the elderly","volume":"12","author":"Liu","year":"2016","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1528-1157.1993.tb02586.x","article-title":"Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota: 1935\u20131984","volume":"34","author":"Hauser","year":"1993","journal-title":"Epilepsia"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.spen.2005.03.004","article-title":"Neonatal seizures: To treat or not to treat?","volume":"12","author":"Wirrell","year":"2005","journal-title":"Semin. Pediatr. Neurol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.siny.2013.05.008","article-title":"Epidemiology and aetiology of neonatal seizures","volume":"18","author":"Vasudevan","year":"2013","journal-title":"Semin. Fetal. Neonatal Med."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Numis, A.L., Foster-Barber, A., Deng, X., Rogers, E.E., Barkovich, A.J., Ferriero, D.M., and Glass, H.C. (2019). Early changes in pro-inflammatory cytokine levels in neonates with encephalopathy are associated with remote epilepsy. Pediatr. Res.","DOI":"10.1038\/s41390-019-0473-x"},{"key":"ref_23","first-page":"372","article-title":"The role of inflammation in schizophrenia","volume":"9","author":"Weidinger","year":"2015","journal-title":"Front. Neurosci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.yebeh.2012.12.015","article-title":"Neonatal immune challenge exacerbates seizure-induced hippocampus-dependent memory impairment in adult rats","volume":"27","author":"Yin","year":"2013","journal-title":"Epilepsy Behav."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1111\/dmcn.13215","article-title":"Seizure burden and neurodevelopmental outcome in neonates with hypoxic-ischemic encephalopathy","volume":"58","author":"Kharoshankaya","year":"2016","journal-title":"Dev. Med. Child. Neurol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ejpn.2014.10.001","article-title":"Epilepsy after neonatal seizures: Literature review","volume":"19","author":"Pisani","year":"2015","journal-title":"Eur. J. Paediatr. Neurol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.siny.2018.02.002","article-title":"Acute symptomatic seizures in term neonates: Etiologies and treatments","volume":"23","author":"Soul","year":"2018","journal-title":"Semin. Fetal. Neonatal Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1136\/adc.61.1.78","article-title":"Cause of neonatal convulsions. Towards more precise diagnosis","volume":"61","author":"Levene","year":"1986","journal-title":"Arch. Dis. Child."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Han, J.Y., Moon, C.J., Youn, Y.A., Sung, I.K., and Lee, I.G. (2018). Efficacy of levetiracetam for neonatal seizures in preterm infants. BMC Pediatr., 18.","DOI":"10.1186\/s12887-018-1103-1"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"881-vii","DOI":"10.1016\/j.clp.2009.08.001","article-title":"Neonatal seizures: An update on mechanisms and management","volume":"36","author":"Jensen","year":"2009","journal-title":"Clin. Perinatol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"130","DOI":"10.2471\/BLT.08.050963","article-title":"Neonatal mortality, risk factors and causes: A prospective population-based cohort study in urban Pakistan","volume":"87","author":"Jehan","year":"2009","journal-title":"Bull. World Health Organ."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1001\/archneur.1976.00500100030012","article-title":"Neonatal encephalopathy following fetal distress. A clinical and electroencephalographic study","volume":"33","author":"Sarnat","year":"1976","journal-title":"Arch. Neurol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0378-3782(85)90115-X","article-title":"The incidence and severity of post-asphyxial encephalopathy in full-term infants","volume":"11","author":"Levene","year":"1985","journal-title":"Early Hum. Dev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"98.e101","DOI":"10.1016\/j.jpeds.2016.03.035","article-title":"Contemporary Profile of Seizures in Neonates: A Prospective Cohort Study","volume":"174","author":"Glass","year":"2016","journal-title":"J. Pediatr."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0165-3806(99)00135-2","article-title":"Long-term effects of neonatal seizures: A behavioral, electrophysiological, and histological study","volume":"118","author":"Huang","year":"1999","journal-title":"Brain Res. Dev. Brain Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.expneurol.2016.05.015","article-title":"Neonatal seizures induced by pentylenetetrazol or kainic acid disrupt primary cilia growth on developing mouse cortical neurons","volume":"282","author":"Parker","year":"2016","journal-title":"Exp. Neurol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1002\/(SICI)1096-9861(19990222)404:4<537::AID-CNE9>3.0.CO;2-#","article-title":"Mossy fiber sprouting after recurrent seizures during early development in rats","volume":"404","author":"Holmes","year":"1999","journal-title":"J. Comp. Neurol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0165-3806(92)90184-X","article-title":"Kainic acid seizures in the developing brain: Status epilepticus and spontaneous recurrent seizures","volume":"65","author":"Stafstrom","year":"1992","journal-title":"Brain Res. Dev. Brain Res."},{"key":"ref_39","first-page":"813","article-title":"Epileptogenic action of intra-amygdaloid injection of kainic acid","volume":"287","author":"Lagowska","year":"1978","journal-title":"C R Acad. Hebd. Seances Acad. Sci. D"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1111\/cns.12272","article-title":"P2X7 receptor inhibition interrupts the progression of seizures in immature rats and reduces hippocampal damage","volume":"20","author":"Mesuret","year":"2014","journal-title":"CNS Neurosci. Ther."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0031-9384(00)00425-X","article-title":"PTZ-induced seizures in rats: Effects of age and strain","volume":"72","author":"Klioueva","year":"2001","journal-title":"Physiol. Behav."},{"key":"ref_42","first-page":"256","article-title":"Influence of clonazepam on electrocorticographic changes induced by metrazol in rats during ontogenesis","volume":"288","author":"Mares","year":"1987","journal-title":"Arch. Int. Pharm. Ther."},{"key":"ref_43","unstructured":"Pitk\u00e4nen, A., Buckmaster, P.S., Galanopoulou, A.S., and Mosh\u00e9, S.L. (2017). Chapter 38 - Models of Seizures and Status Epilepticus Early in Life. Models of Seizures and Epilepsy, Academic Press. [2nd ed.]."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0165-3806(98)00158-8","article-title":"Pentylenetetrazol seizures induce cell suffering but not death in the immature rat brain","volume":"112","author":"Pineau","year":"1999","journal-title":"Brain Res. Dev. Brain Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/ana.410090206","article-title":"The influence of immaturity on hypoxic-ischemic brain damage in the rat","volume":"9","author":"Rice","year":"1981","journal-title":"Ann. Neurol."},{"key":"ref_46","first-page":"1","article-title":"Anoxic-ischemic encephalopathy in rats","volume":"36","author":"Levine","year":"1960","journal-title":"Am. J. Pathol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1159\/000331646","article-title":"A novel approach to the study of hypoxia-ischemia-induced clinical and subclinical seizures in the neonatal rat","volume":"33","author":"Cuaycong","year":"2011","journal-title":"Dev. Neurosci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1523\/JNEUROSCI.4093-09.2010","article-title":"Continuous electroencephalographic monitoring with radio-telemetry in a rat model of perinatal hypoxia-ischemia reveals progressive post-stroke epilepsy","volume":"30","author":"Kadam","year":"2010","journal-title":"J. Neurosci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0378-3782(91)90044-4","article-title":"At what age is the developing cerebral cortex of the rat comparable to that of the full-term newborn human baby?","volume":"26","author":"Romijn","year":"1991","journal-title":"Early Hum. Dev."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.eplepsyres.2015.01.009","article-title":"Effects of neonatal hypoxic-ischemic episodes on late seizure outcomes in C57 black mice","volume":"111","author":"Peng","year":"2015","journal-title":"Epilepsy Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.nbd.2014.03.005","article-title":"Impact of transient acute hypoxia on the developing mouse EEG","volume":"68","author":"Zanelli","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1111\/epi.12347","article-title":"Seizure predisposition after perinatal hypoxia: Effects of subsequent age and of an epilepsy predisposing gene mutation","volume":"54","author":"Leonard","year":"2013","journal-title":"Epilepsia"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.nbd.2015.08.023","article-title":"Effects of hypoxia-induced neonatal seizures on acute hippocampal injury and later-life seizure susceptibility and anxiety-related behavior in mice","volume":"83","author":"Dunleavy","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"34","DOI":"10.4274\/jcrpe.473","article-title":"Hypophosphatasia presenting with pyridoxine-responsive seizures, hypercalcemia, and pseudotumor cerebri: Case report","volume":"4","author":"Demirbilek","year":"2012","journal-title":"J. Clin. Res. Pediatr. Endocrinol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/8904_2013_217","article-title":"Infantile hypophosphatasia secondary to a novel compound heterozygous mutation presenting with pyridoxine-responsive seizures","volume":"11","author":"Belachew","year":"2013","journal-title":"JIMD Rep."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1177\/0883073810380915","article-title":"Clinical seizures in neonatal hypoxic-ischemic encephalopathy have no independent impact on neurodevelopmental outcome: Secondary analyses of data from the neonatal research network hypothermia trial","volume":"26","author":"Kwon","year":"2011","journal-title":"J. Child. Neurol."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Dizon, M.L.V., Rao, R., Hamrick, S.E., Zaniletti, I., DiGeronimo, R., Natarajan, G., Kaiser, J.R., Flibotte, J., Lee, K.S., and Smith, D. (2019). Practice variation in anti-epileptic drug use for neonatal hypoxic-ischemic encephalopathy among regional NICUs. BMC Pediatr., 19.","DOI":"10.1186\/s12887-019-1441-7"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1177\/0883073813507978","article-title":"Lower incidence of seizure among neonates treated with therapeutic hypothermia","volume":"29","author":"Orbach","year":"2014","journal-title":"J. Child. Neurol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"F267-272","DOI":"10.1136\/archdischild-2011-300716","article-title":"Cooling and seizure burden in term neonates: An observational study","volume":"97","author":"Low","year":"2012","journal-title":"Arch. Dis. Child. Fetal. Neonatal Ed."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1056\/NEJMcps050929","article-title":"Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy","volume":"353","author":"Shankaran","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1056\/NEJMoa1112066","article-title":"Childhood outcomes after hypothermia for neonatal encephalopathy","volume":"366","author":"Shankaran","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1177\/0883073812470734","article-title":"Pharmacological Treatment of Neonatal Seizures: A Systematic Review","volume":"28","author":"Slaughter","year":"2013","journal-title":"J. Child. Neurol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1749-6632.2003.tb07517.x","article-title":"Antiepileptic drugs and apoptosis in the developing brain","volume":"993","author":"Bittigau","year":"2003","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1056\/NEJM199908123410704","article-title":"Phenobarbital compared with phenytoin for the treatment of neonatal seizures","volume":"341","author":"Painter","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/nrn920","article-title":"Excitatory actions of gaba during development: The nature of the nurture","volume":"3","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/nrn919","article-title":"Is there more to GABA than synaptic inhibition?","volume":"3","author":"Owens","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.yebeh.2014.07.010","article-title":"Brief postnatal exposure to phenobarbital impairs passive avoidance learning and sensorimotor gating in rats","volume":"37","author":"Gutherz","year":"2014","journal-title":"Epilepsy Behav."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/ana.24967","article-title":"Phenobarbital and midazolam increase neonatal seizure-associated neuronal injury","volume":"82","author":"Torolira","year":"2017","journal-title":"Ann. Neurol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1056\/NEJM199002083220604","article-title":"Phenobarbital for febrile seizures--effects on intelligence and on seizure recurrence","volume":"322","author":"Farwell","year":"1990","journal-title":"N. Engl. J. Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1111\/epi.13107","article-title":"Epileptic encephalopathies: Optimizing seizure control and developmental outcome","volume":"56","author":"Jehi","year":"2015","journal-title":"Epilepsia"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1055\/s-0039-1693149","article-title":"Neonatal Seizures-Are We there Yet?","volume":"50","author":"Ramantani","year":"2019","journal-title":"Neuropediatrics"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1684\/epd.2013.0619","article-title":"Neonatal epilepsy and underlying aetiology: To what extent do seizures and EEG abnormalities influence outcome?","volume":"15","author":"Ramantani","year":"2013","journal-title":"Epileptic Disord."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1002\/bies.201400024","article-title":"Biology of purinergic signalling: Its ancient evolutionary roots, its omnipresence and its multiple functional significance","volume":"36","author":"Verkhratsky","year":"2014","journal-title":"Bioessays"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.neuropharm.2009.06.031","article-title":"Tripartite synapses: Roles for astrocytic purines in the control of synaptic physiology and behavior","volume":"57","author":"Halassa","year":"2009","journal-title":"Neuropharmacology"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.pneurobio.2011.08.006","article-title":"Purinergic signalling: From normal behaviour to pathological brain function","volume":"95","author":"Burnstock","year":"2011","journal-title":"Prog. Neurobiol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.neuron.2012.09.024","article-title":"Neuromodulation by extracellular ATP and P2X receptors in the CNS","volume":"76","author":"Khakh","year":"2012","journal-title":"Neuron"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.neuropharm.2013.05.035","article-title":"Adenosine A\u2082A receptors inhibit delayed rectifier potassium currents and cell differentiation in primary purified oligodendrocyte cultures","volume":"73","author":"Coppi","year":"2013","journal-title":"Neuropharmacology"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.neuropharm.2015.10.005","article-title":"CNS remyelination as a novel reparative approach to neurodegenerative diseases: The roles of purinergic signaling and the P2Y-like receptor GPR17","volume":"104","author":"Fumagalli","year":"2016","journal-title":"Neuropharmacology"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"8794","DOI":"10.1523\/JNEUROSCI.18-21-08794.1998","article-title":"Cytoskeletal assembly and ATP release regulate astrocytic calcium signaling","volume":"18","author":"Cotrina","year":"1998","journal-title":"J. Neurosci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"11023","DOI":"10.1073\/pnas.1834448100","article-title":"Dynamic inhibition of excitatory synaptic transmission by astrocyte-derived ATP in hippocampal cultures","volume":"100","author":"Koizumi","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s11302-005-6321-y","article-title":"Regulation of cell-to-cell communication mediated by astrocytic ATP in the CNS","volume":"1","author":"Koizumi","year":"2005","journal-title":"Purinergic Signal."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1084\/jem.185.3.579","article-title":"Purinergic modulation of interleukin-1 beta release from microglial cells stimulated with bacterial endotoxin","volume":"185","author":"Ferrari","year":"1997","journal-title":"J. Exp. Med."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1038\/nature05704","article-title":"UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis","volume":"446","author":"Koizumi","year":"2007","journal-title":"Nature"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1002\/jnr.21610","article-title":"Akt activation is involved in P2Y12 receptor-mediated chemotaxis of microglia","volume":"86","author":"Irino","year":"2008","journal-title":"J. Neurosci. Res."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.eplepsyres.2010.09.003","article-title":"Prognostic factors, morbidity and mortality in tonic-clonic status epilepticus: A review","volume":"93","author":"Neligan","year":"2011","journal-title":"Epilepsy Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/nn.2341","article-title":"Adenosine A(2A) receptor mediates microglial process retraction","volume":"12","author":"Orr","year":"2009","journal-title":"Nat. Neurosci."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1152\/ajplung.00299.2004","article-title":"Voltage-gated proton channels help regulate pHi in rat alveolar epithelium","volume":"288","author":"Murphy","year":"2005","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"4964","DOI":"10.1073\/pnas.0600855103","article-title":"Functional ion channels in pulmonary alveolar type I cells support a role for type I cells in lung ion transport","volume":"103","author":"Johnson","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"3659","DOI":"10.1091\/mbc.e05-03-0222","article-title":"A novel recombinant plasma membrane-targeted luciferase reveals a new pathway for ATP secretion","volume":"16","author":"Pellegatti","year":"2005","journal-title":"Mol. Biol. Cell"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1523\/JNEUROSCI.3902-05.2006","article-title":"P2X7 receptors mediate ATP release and amplification of astrocytic intercellular Ca2+ signaling","volume":"26","author":"Suadicani","year":"2006","journal-title":"J. Neurosci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"4702","DOI":"10.1523\/JNEUROSCI.5048-07.2008","article-title":"Connexin 43 hemichannels are permeable to ATP","volume":"28","author":"Kang","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.febslet.2004.07.009","article-title":"Pannexin membrane channels are mechanosensitive conduits for ATP","volume":"572","author":"Bao","year":"2004","journal-title":"FEBS Lett."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.febslet.2006.12.056","article-title":"Pannexin1 is part of the pore forming unit of the P2X(7) receptor death complex","volume":"581","author":"Locovei","year":"2007","journal-title":"FEBS Lett."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.ygeno.2003.09.025","article-title":"The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins","volume":"83","author":"Baranova","year":"2004","journal-title":"Genomics"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.molbrainres.2005.08.002","article-title":"Pannexin1 and Pannexin2 expression in the developing and mature rat brain","volume":"141","author":"Vogt","year":"2005","journal-title":"Brain Res. Mol. Brain Res."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.neuroscience.2006.03.053","article-title":"Expression of pannexin1 in the CNS of adult mouse: Cellular localization and effect of 4-aminopyridine-induced seizures","volume":"141","author":"Cicero","year":"2006","journal-title":"Neuroscience"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1002\/bies.200800236","article-title":"Pannexins, distant relatives of the connexin family with specific cellular functions?","volume":"31","author":"Ponsaerts","year":"2009","journal-title":"Bioessays"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3389\/fphar.2013.00088","article-title":"Connexin and pannexin hemichannels in brain glial cells: Properties, pharmacology, and roles","volume":"4","author":"Giaume","year":"2013","journal-title":"Front. Pharm."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.bbamem.2012.07.002","article-title":"Paracrine signaling through plasma membrane hemichannels","volume":"1828","author":"Wang","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.tins.2009.11.007","article-title":"Non-junction functions of pannexin-1 channels","volume":"33","author":"MacVicar","year":"2010","journal-title":"Trends Neurosci."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"5071","DOI":"10.1038\/sj.emboj.7601378","article-title":"Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor","volume":"25","author":"Pelegrin","year":"2006","journal-title":"EMBO J."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"389","DOI":"10.3389\/fncel.2015.00389","article-title":"Vesicular expression and release of ATP from dopaminergic neurons of the mouse retina and midbrain","volume":"9","author":"Ho","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1093\/cercor\/bhr203","article-title":"Functional and anatomical identification of a vesicular transporter mediating neuronal ATP release","volume":"22","author":"Larsson","year":"2012","journal-title":"Cereb. Cortex"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.bbrc.2013.07.043","article-title":"Vesicular nucleotide transporter is involved in ATP storage of secretory lysosomes in astrocytes","volume":"438","author":"Oya","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1002\/glia.22517","article-title":"Microglia release ATP by exocytosis","volume":"61","author":"Imura","year":"2013","journal-title":"Glia"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"5683","DOI":"10.1073\/pnas.0800141105","article-title":"Identification of a vesicular nucleotide transporter","volume":"105","author":"Sawada","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"951","DOI":"10.3389\/fphar.2017.00951","article-title":"Specific Temporal Distribution and Subcellular Localization of a Functional Vesicular Nucleotide Transporter (VNUT) in Cerebellar Granule Neurons","volume":"8","author":"Ortega","year":"2017","journal-title":"Front. Pharm."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Vessey, K.A., and Fletcher, E.L. (2012). Rod and cone pathway signalling is altered in the P2X7 receptor knock out mouse. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0029990"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1248\/bpb.b15-00872","article-title":"Expression of Vesicular Nucleotide Transporter in the Mouse Retina","volume":"39","author":"Moriyama","year":"2016","journal-title":"Biol. Pharm. Bull."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0163-7258(99)00051-0","article-title":"The role of receptor structure in determining adenosine receptor activity","volume":"85","author":"Olah","year":"2000","journal-title":"Pharm. Ther."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/jcp.20138","article-title":"Animal models for the study of adenosine receptor function","volume":"202","author":"Yaar","year":"2005","journal-title":"J. Cell Physiol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0301-0082(02)00155-7","article-title":"Adenosine receptors in the nervous system: Pathophysiological implications","volume":"68","author":"Ribeiro","year":"2002","journal-title":"Prog. Neurobiol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1046\/j.1460-9568.2002.02020.x","article-title":"Modulation by adenosine of both muscarinic M1-facilitation and M2-inhibition of [3H]-acetylcholine release from the rat motor nerve terminals","volume":"15","author":"Oliveira","year":"2002","journal-title":"Eur. J. Neurosci."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0165-6147(00)01517-0","article-title":"Fine-tuning neuromodulation by adenosine","volume":"21","author":"Ribeiro","year":"2000","journal-title":"Trends Pharm. Sci."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.physbeh.2007.05.031","article-title":"Modulation of glial cell functions by adenosine receptors","volume":"92","author":"Schulte","year":"2007","journal-title":"Physiol. Behav."},{"key":"ref_116","first-page":"208","article-title":"Astrocytes coordinate synaptic networks: Balanced excitation and inhibition","volume":"21","author":"Fellin","year":"2006","journal-title":"Physiology (Bethesda)"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1046\/j.1460-9568.2003.02815.x","article-title":"Decrease of adenosine A1 receptor density and of adenosine neuromodulation in the hippocampus of kindled rats","volume":"18","author":"Rebola","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0014-2999(95)00679-6","article-title":"Adenosine A2A receptor stimulation enhances striatal extracellular glutamate levels in rats","volume":"287","author":"Popoli","year":"1995","journal-title":"Eur. J. Pharm."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1212\/01.wnl.0000297939.18236.ec","article-title":"Adenosine and its receptors: Multiple modulatory functions and potential therapeutic targets for neurologic disease","volume":"70","author":"Benarroch","year":"2008","journal-title":"Neurology"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s11302-005-0649-1","article-title":"Neuroprotection by adenosine in the brain: From A(1) receptor activation to A (2A) receptor blockade","volume":"1","author":"Cunha","year":"2005","journal-title":"Purinergic Signal."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1358\/dnp.2003.16.5.829316","article-title":"Adenosine receptors as targets for drug development","volume":"16","author":"Fredholm","year":"2003","journal-title":"Drug News Perspect."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1080\/13543776.2017.1341018","article-title":"Highly selective A3 adenosine receptor agonists relieve chronic neuropathic pain","volume":"27","author":"Salvemini","year":"2017","journal-title":"Expert Opin. Ther. Pat."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.tins.2006.09.004","article-title":"Targeting adenosine A2A receptors in Parkinson\u2019s disease","volume":"29","author":"Schwarzschild","year":"2006","journal-title":"Trends Neurosci."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1002\/ddr.20101","article-title":"Purinergic control of neuropathic pain","volume":"67","author":"McGaraughty","year":"2006","journal-title":"Drug Dev. Res."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2174\/157015907780866938","article-title":"Cell and gene therapies for refractory epilepsy","volume":"5","author":"Boison","year":"2007","journal-title":"Curr. Neuropharmacol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/glia.20204","article-title":"Neuroprotective role of astrocytes in cerebral ischemia: Focus on ischemic preconditioning","volume":"50","author":"Trendelenburg","year":"2005","journal-title":"Glia"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/pr.110.003285","article-title":"International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and classification of adenosine receptors--an update","volume":"63","author":"Fredholm","year":"2011","journal-title":"Pharm. Rev."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s11302-013-9364-5","article-title":"A1R-A2AR heteromers coupled to Gs and G i\/0 proteins modulate GABA transport into astrocytes","volume":"9","author":"Navarro","year":"2013","journal-title":"Purinergic Signal."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1046\/j.0962-1105.2003.00367.x","article-title":"Sleep and its homeostatic regulation in mice lacking the adenosine A1 receptor","volume":"12","author":"Stenberg","year":"2003","journal-title":"J. Sleep Res."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1523\/JNEUROSCI.3574-05.2006","article-title":"Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers","volume":"26","author":"Ciruela","year":"2006","journal-title":"J. Neurosci."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1517\/13543784.2011.627853","article-title":"Adenosine receptor targeting in health and disease","volume":"20","author":"Gessi","year":"2011","journal-title":"Expert Opin. Investig. Drugs"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1111\/jnc.13724","article-title":"How does adenosine control neuronal dysfunction and neurodegeneration?","volume":"139","author":"Cunha","year":"2016","journal-title":"J. Neurochem."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2015.10.031","article-title":"Adenosine receptor targets for pain","volume":"338","author":"Sawynok","year":"2016","journal-title":"Neuroscience"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/0896-6273(94)90321-2","article-title":"Adenosine inhibits evoked synaptic transmission primarily by reducing presynaptic calcium influx in area CA1 of hippocampus","volume":"12","author":"Wu","year":"1994","journal-title":"Neuron"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1113\/jphysiol.2007.132613","article-title":"Adenosine modulates transmission at the hippocampal mossy fibre synapse via direct inhibition of presynaptic calcium channels","volume":"582","author":"Gundlfinger","year":"2007","journal-title":"J. Physiol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1523\/JNEUROSCI.11-05-01375.1991","article-title":"Adenosine inhibits excitatory but not inhibitory synaptic transmission in the hippocampus","volume":"11","author":"Yoon","year":"1991","journal-title":"J. Neurosci."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0014-2999(94)90762-5","article-title":"Chronic adenosine A1 receptor agonist and antagonist: Effect on receptor density and N-methyl-D-aspartate induced seizures in mice","volume":"253","author":"Paul","year":"1994","journal-title":"Eur. J. Pharm."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1124\/mol.58.4.771","article-title":"Adenosine A(2A) receptors are colocalized with and activate g(olf) in rat striatum","volume":"58","author":"Kull","year":"2000","journal-title":"Mol. Pharm."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0306-4522(02)00080-5","article-title":"Adenosine A(2A) receptor facilitation of hippocampal synaptic transmission is dependent on tonic A(1) receptor inhibition","volume":"112","author":"Lopes","year":"2002","journal-title":"Neuroscience"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/sj.bjp.0704712","article-title":"Effects of adenosine A1 and A2A receptor activation on the evoked release of glutamate from rat cerebrocortical synaptosomes","volume":"136","author":"Marchi","year":"2002","journal-title":"Br. J. Pharm."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.neuron.2007.11.023","article-title":"Adenosine A2A receptors are essential for long-term potentiation of NMDA-EPSCs at hippocampal mossy fiber synapses","volume":"57","author":"Rebola","year":"2008","journal-title":"Neuron"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/j.1471-4159.2011.07178.x","article-title":"Adenosine A2A receptors control neuroinflammation and consequent hippocampal neuronal dysfunction","volume":"117","author":"Rebola","year":"2011","journal-title":"J. Neurochem."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1523\/JNEUROSCI.17-02-00607.1997","article-title":"Activation of hippocampal adenosine A3 receptors produces a desensitization of A1 receptor-mediated responses in rat hippocampus","volume":"17","author":"Dunwiddie","year":"1997","journal-title":"J. Neurosci."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/s002100000313","article-title":"Structure and function of adenosine receptors and their genes","volume":"362","author":"Fredholm","year":"2000","journal-title":"Naunyn Schmiedebergs Arch. Pharm."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1006\/bbrc.1997.7705","article-title":"The A3 adenosine receptor mediates cell spreading, reorganization of actin cytoskeleton, and distribution of Bcl-XL: Studies in human astroglioma cells","volume":"241","author":"Abbracchio","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1046\/j.1471-4159.2003.01919.x","article-title":"Evidence for functional adenosine A3 receptors in microglia cells","volume":"86","author":"Hammarberg","year":"2003","journal-title":"J. Neurochem."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/nature04886","article-title":"P2X receptors as cell-surface ATP sensors in health and disease","volume":"442","author":"Khakh","year":"2006","journal-title":"Nature"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.2174\/138161207781368747","article-title":"Purine ionotropic (P2X) receptors","volume":"13","author":"Illes","year":"2007","journal-title":"Curr. Pharm. Des."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.2174\/092986707782023695","article-title":"P2Y receptors: Focus on structural, pharmacological and functional aspects in the brain","volume":"14","author":"Fischer","year":"2007","journal-title":"Curr. Med. Chem."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1124\/pr.58.3.3","article-title":"International Union of Pharmacology LVIII: Update on the P2Y G protein-coupled nucleotide receptors: From molecular mechanisms and pathophysiology to therapy","volume":"58","author":"Abbracchio","year":"2006","journal-title":"Pharm. Rev."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"289","DOI":"10.2174\/092986706775476052","article-title":"P2 receptors activated by uracil nucleotides--an update","volume":"13","author":"Brunschweiger","year":"2006","journal-title":"Curr. Med. Chem."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1124\/mol.61.2.303","article-title":"Conserved cysteine residues in the extracellular loop of the human P2X(1) receptor form disulfide bonds and are involved in receptor trafficking to the cell surface","volume":"61","author":"Ennion","year":"2002","journal-title":"Mol. Pharm."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"3873","DOI":"10.1523\/JNEUROSCI.22-10-03873.2002","article-title":"Mutational analysis of the conserved cysteines of the rat P2X2 purinoceptor","volume":"22","author":"Clyne","year":"2002","journal-title":"J. Neurosci."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.tibs.2009.09.006","article-title":"P2X receptors: Dawn of the post-structure era","volume":"35","author":"Young","year":"2010","journal-title":"Trends Biochem. Sci."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.1093\/emboj\/17.11.3016","article-title":"P2X1 and P2X3 receptors form stable trimers: A novel structural motif of ligand-gated ion channels","volume":"17","author":"Nicke","year":"1998","journal-title":"EMBO J."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1007\/s00424-006-0073-6","article-title":"Molecular properties of P2X receptors","volume":"452","author":"Roberts","year":"2006","journal-title":"Pflugers Arch."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1152\/physrev.00015.2002","article-title":"Molecular physiology of P2X receptors","volume":"82","author":"North","year":"2002","journal-title":"Physiol. Rev."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1124\/mol.107.035980","article-title":"Evidence for functional P2X4\/P2X7 heteromeric receptors","volume":"72","author":"Guo","year":"2007","journal-title":"Mol. Pharm."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.pneurobio.2006.03.007","article-title":"P2X7 receptors in the nervous system","volume":"78","author":"Sperlagh","year":"2006","journal-title":"Prog. Neurobiol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1152\/physrev.00043.2006","article-title":"Physiology and pathophysiology of purinergic neurotransmission","volume":"87","author":"Burnstock","year":"2007","journal-title":"Physiol. Rev."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.neuroscience.2008.03.076","article-title":"P2X receptors and synaptic plasticity","volume":"158","author":"Pankratov","year":"2009","journal-title":"Neuroscience"},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Lalo, U., Palygin, O., Rasooli-Nejad, S., Andrew, J., Haydon, P.G., and Pankratov, Y. (2014). Exocytosis of ATP from astrocytes modulates phasic and tonic inhibition in the neocortex. PLoS Biol., 12.","DOI":"10.1371\/journal.pbio.1001747"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s00424-006-0060-y","article-title":"Purinergic transmission in the central nervous system","volume":"452","author":"North","year":"2006","journal-title":"Pflugers Arch."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.neuroscience.2007.07.035","article-title":"Purinergic modulation of glutamate release under ischemic-like conditions in the hippocampus","volume":"149","author":"Zsilla","year":"2007","journal-title":"Neuroscience"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.brainresbull.2012.09.016","article-title":"The role of glutamate release mediated by extrasynaptic P2X7 receptors in animal models of neuropathic pain","volume":"93","year":"2013","journal-title":"Brain Res. Bull."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s11302-015-9493-0","article-title":"P2X ion channel receptors and inflammation","volume":"12","author":"Burnstock","year":"2016","journal-title":"Purinergic Signal."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1042\/BJ20070671","article-title":"Hetero-oligomerization of the P2Y11 receptor with the P2Y1 receptor controls the internalization and ligand selectivity of the P2Y11 receptor","volume":"409","author":"Ecke","year":"2008","journal-title":"Biochem. J."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1152\/physrev.00004.2004","article-title":"Physiology and pathophysiology of the calcium store in the endoplasmic reticulum of neurons","volume":"85","author":"Verkhratsky","year":"2005","journal-title":"Physiol. Rev."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.pharmthera.2005.08.014","article-title":"Pharmacological profiles of cloned mammalian P2Y-receptor subtypes","volume":"110","year":"2006","journal-title":"Pharm. Ther."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1007\/s00018-007-6497-0","article-title":"Purine and pyrimidine receptors","volume":"64","author":"Burnstock","year":"2007","journal-title":"Cell Mol. Life Sci."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/B978-0-12-385526-8.00012-6","article-title":"Molecular pharmacology, physiology, and structure of the P2Y receptors","volume":"61","author":"Harden","year":"2011","journal-title":"Adv. Pharm."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"722","DOI":"10.2174\/187152712803581047","article-title":"P2Y receptors in the mammalian nervous system: Pharmacology, ligands and therapeutic potential","volume":"11","author":"Weisman","year":"2012","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/S0028-3908(01)00033-8","article-title":"Stimulation of P2 receptors in the ventral tegmental area enhances dopaminergic mechanisms in vivo","volume":"40","author":"Kittner","year":"2001","journal-title":"Neuropharmacology"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/npp.2014.173","article-title":"Impaired cognition after stimulation of P2Y1 receptors in the rat medial prefrontal cortex","volume":"40","author":"Koch","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.drudis.2010.05.011","article-title":"P2Y nucleotide receptors: Promise of therapeutic applications","volume":"15","author":"Jacobson","year":"2010","journal-title":"Drug Discov. Today"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"1207393","DOI":"10.1155\/2016\/1207393","article-title":"P2Y Receptors in Synaptic Transmission and Plasticity: Therapeutic Potential in Cognitive Dysfunction","volume":"2016","author":"Guzman","year":"2016","journal-title":"Neural Plast."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.neuroscience.2018.12.021","article-title":"Microglia and the Purinergic Signaling System","volume":"405","author":"Calovi","year":"2019","journal-title":"Neuroscience"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/glia.22592","article-title":"The A1 adenosine receptor as a new player in microglia physiology","volume":"62","author":"Luongo","year":"2014","journal-title":"Glia"},{"key":"ref_179","doi-asserted-by":"crossref","unstructured":"Kaczmarek-Hajek, K., Zhang, J., Kopp, R., Grosche, A., Rissiek, B., Saul, A., Bruzzone, S., Engel, T., Jooss, T., and Krautloher, A. (2018). Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody. Elife, 7.","DOI":"10.7554\/eLife.36217"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s12974-017-0904-8","article-title":"The role of microglial P2X7: Modulation of cell death and cytokine release","volume":"14","author":"He","year":"2017","journal-title":"J. Neuroinflammation"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.1523\/JNEUROSCI.5512-08.2009","article-title":"The P2X7 receptor drives microglial activation and proliferation: A trophic role for P2X7R pore","volume":"29","author":"Monif","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1002\/glia.20489","article-title":"Involvement of P2X4 and P2Y12 receptors in ATP-induced microglial chemotaxis","volume":"55","author":"Ohsawa","year":"2007","journal-title":"Glia"},{"key":"ref_183","doi-asserted-by":"crossref","unstructured":"Zabala, A., Vazquez-Villoldo, N., Rissiek, B., Gejo, J., Martin, A., Palomino, A., Perez-Samart\u00edn, A., Pulagam, K.R., Lukowiak, M., and Capetillo-Zarate, E. (2018). P2X4 receptor controls microglia activation and favors remyelination in autoimmune encephalitis. EMBO Mol. Med., 10.","DOI":"10.15252\/emmm.201708743"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/nn1472","article-title":"ATP mediates rapid microglial response to local brain injury in vivo","volume":"8","author":"Davalos","year":"2005","journal-title":"Nat. Neurosci."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1096\/fj.11-196089","article-title":"Seizure suppression and neuroprotection by targeting the purinergic P2X7 receptor during status epilepticus in mice","volume":"26","author":"Engel","year":"2012","journal-title":"FASEB J."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.neuroscience.2016.01.008","article-title":"Activation of microglial P2Y12 receptor is required for outward potassium currents in response to neuronal injury","volume":"318","author":"Swiatkowski","year":"2016","journal-title":"Neuroscience"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"131","DOI":"10.4161\/cam.1.3.4937","article-title":"UDP facilitates microglial phagocytosis through P2Y6 receptors","volume":"1","author":"Inoue","year":"2007","journal-title":"Cell Adh. Migr."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"5377","DOI":"10.1523\/JNEUROSCI.0089-19.2019","article-title":"Context-Specific Switch from Anti- to Pro-epileptogenic Function of the P2Y(1) Receptor in Experimental Epilepsy","volume":"39","author":"Alves","year":"2019","journal-title":"J. Neurosci."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"446","DOI":"10.3389\/fncel.2018.00446","article-title":"Astroglial Ca(2+)-Dependent Hyperexcitability Requires P2Y(1) Purinergic Receptors and Pannexin-1 Channel Activation in a Chronic Model of Epilepsy","volume":"12","author":"Wellmann","year":"2018","journal-title":"Front. Cell Neurosci."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"e80","DOI":"10.1212\/NXI.0000000000000080","article-title":"P2Y12 expression and function in alternatively activated human microglia","volume":"2","author":"Moore","year":"2015","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nrneurol.2010.178","article-title":"The role of inflammation in epilepsy","volume":"7","author":"Vezzani","year":"2011","journal-title":"Nat. Rev. Neurol."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s00424-006-0067-4","article-title":"Nucleotide signaling in nervous system development","volume":"452","author":"Zimmermann","year":"2006","journal-title":"Pflugers Arch."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s11302-006-9003-5","article-title":"The E-NTPDase family of ectonucleotidases: Structure function relationships and pathophysiological significance","volume":"2","author":"Robson","year":"2006","journal-title":"Purinergic Signal."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1387\/ijdb.092879km","article-title":"Ectophosphodiesterase\/nucleotide phosphohydrolase (Enpp) nucleotidases: Cloning, conservation and developmental restriction","volume":"54","author":"Bhamra","year":"2010","journal-title":"Int. J. Dev. Biol."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s11302-006-9000-8","article-title":"Ecto-5\u2032-nucleotidase: Structure function relationships","volume":"2","year":"2006","journal-title":"Purinergic Signal."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1093\/cercor\/bhh021","article-title":"Areal and subcellular localization of the ubiquitous alkaline phosphatase in the primate cerebral cortex: Evidence for a role in neurotransmission","volume":"14","author":"Fonta","year":"2004","journal-title":"Cereb. Cortex"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s00441-008-0681-x","article-title":"Distribution of ectonucleotidases in the rodent brain revisited","volume":"334","author":"Langer","year":"2008","journal-title":"Cell Tissue Res."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"6265","DOI":"10.1073\/pnas.1120997109","article-title":"Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity","volume":"109","author":"Lovatt","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/glia.20431","article-title":"Adenosine released by astrocytes contributes to hypoxia-induced modulation of synaptic transmission","volume":"55","author":"Perea","year":"2007","journal-title":"Glia"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0197-0186(94)00144-J","article-title":"Involvement of adenosine deaminase and adenosine kinase in regulating extracellular adenosine concentration in rat hippocampal slices","volume":"26","author":"Lloyd","year":"1995","journal-title":"Neurochem. Int."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.neuron.2004.08.015","article-title":"Calcium waves propagate through radial glial cells and modulate proliferation in the developing neocortex","volume":"43","author":"Weissman","year":"2004","journal-title":"Neuron"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"11444","DOI":"10.1523\/JNEUROSCI.23-36-11444.2003","article-title":"Reduced expression of P2Y1 receptors in connexin43-null mice alters calcium signaling and migration of neural progenitor cells","volume":"23","author":"Scemes","year":"2003","journal-title":"J. Neurosci."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"11802","DOI":"10.1073\/pnas.0805180105","article-title":"The role of ATP signaling in the migration of intermediate neuronal progenitors to the neocortical subventricular zone","volume":"105","author":"Liu","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/nn1172","article-title":"Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases","volume":"7","author":"Noctor","year":"2004","journal-title":"Nat. Neurosci."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.neuropharm.2015.10.022","article-title":"Purines in neurite growth and astroglia activation","volume":"104","author":"Heine","year":"2016","journal-title":"Neuropharmacology"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1007\/s12035-010-8115-7","article-title":"P2Y2 nucleotide receptor-mediated responses in brain cells","volume":"41","author":"Peterson","year":"2010","journal-title":"Mol. Neurobiol."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"216","DOI":"10.4103\/1673-5374.200803","article-title":"Neonatal seizures and disruption to neurotransmitter systems","volume":"12","author":"Miller","year":"2017","journal-title":"Neural Regen Res."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.eplepsyres.2009.03.008","article-title":"Effect of age on cognitive sequelae following early life seizures in rats","volume":"85","author":"Karnam","year":"2009","journal-title":"Epilepsy Res."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.eplepsyres.2013.03.011","article-title":"Alteration of synaptic plasticity by neonatal seizures in rat somatosensory cortex","volume":"106","author":"Isaeva","year":"2013","journal-title":"Epilepsy Res."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"3823","DOI":"10.1097\/00001756-200011270-00045","article-title":"Cx36 is dynamically expressed during early development of mouse brain and nervous system","volume":"11","author":"Gulisano","year":"2000","journal-title":"Neuroreport"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"3096","DOI":"10.1523\/JNEUROSCI.17-09-03096.1997","article-title":"Differential expression of connexins during neocortical development and neuronal circuit formation","volume":"17","author":"Nadarajah","year":"1997","journal-title":"J. Neurosci."},{"key":"ref_212","first-page":"973","article-title":"The mouse gap junction gene connexin29 is highly expressed in sciatic nerve and regulated during brain development","volume":"382","author":"Eiberger","year":"2001","journal-title":"Biol. Chem."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1006\/excr.2001.5209","article-title":"A new alternatively spliced transcript of the mouse connexin32 gene is expressed in embryonic stem cells, oocytes, and liver","volume":"266","author":"Theis","year":"2001","journal-title":"Exp. Cell Res."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0248-4900(02)00016-3","article-title":"Gap junctions and connexin expression in the normal and pathological central nervous system","volume":"94","author":"Rouach","year":"2002","journal-title":"Biol. Cell."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/BF02110114","article-title":"The role of gap junction membrane channels in development","volume":"28","author":"Lo","year":"1996","journal-title":"J. Bioenerg. Biomembr."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1749-8104-7-11","article-title":"Pannexin 1 regulates postnatal neural stem and progenitor cell proliferation","volume":"7","author":"Dzugalo","year":"2012","journal-title":"Neural Dev."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/1478-811X-11-62","article-title":"Panx1 regulates neural stem and progenitor cell behaviours associated with cytoskeletal dynamics and interacts with multiple cytoskeletal elements","volume":"11","author":"Swayne","year":"2013","journal-title":"Cell. Commun. Signal."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"24977","DOI":"10.1074\/jbc.M110.130054","article-title":"Pannexin 2 is expressed by postnatal hippocampal neural progenitors and modulates neuronal commitment","volume":"285","author":"Swayne","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/0165-3806(95)00120-3","article-title":"The ontogeny of cardiac and neural A1 adenosine receptor expression in rats","volume":"89","author":"Rivkees","year":"1995","journal-title":"Brain Res. Dev. Brain Res."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0165-3806(96)80013-7","article-title":"A1-adenosine receptor gene expression in fetal rat brain","volume":"94","author":"Weaver","year":"1996","journal-title":"Brain Res. Dev. Brain Res."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1126\/scitranslmed.3006258","article-title":"Adenosine receptor antagonists including caffeine alter fetal brain development in mice","volume":"5","author":"Silva","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1097\/00001756-200110080-00015","article-title":"A1 adenosine receptor activation inhibits neurite process formation by Rho kinase-mediated pathways","volume":"12","author":"Thevananther","year":"2001","journal-title":"Neuroreport"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1007\/s11064-011-0550-y","article-title":"Activation of adenosine A2A receptor up-regulates BDNF expression in rat primary cortical neurons","volume":"36","author":"Jeon","year":"2011","journal-title":"Neurochem. Res."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1007\/s00429-015-1072-1","article-title":"Axonal elongation and dendritic branching is enhanced by adenosine A2A receptors activation in cerebral cortical neurons","volume":"221","author":"Ribeiro","year":"2016","journal-title":"Brain Struct. Funct."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1152\/jn.00516.2002","article-title":"Adenosine A1 receptor-mediated presynaptic inhibition of GABAergic transmission in immature rat hippocampal CA1 neurons","volume":"89","author":"Jeong","year":"2003","journal-title":"J. Neurophysiol."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0304-3940(83)90127-1","article-title":"An adenosine agonist inhibits and a cyclic AMP analogue enhances the release of glutamate but not GABA from slices of rat dentate gyrus","volume":"43","author":"Dolphin","year":"1983","journal-title":"Neurosci. Lett."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/0304-3940(91)90190-5","article-title":"Adenosine depresses excitatory but not fast inhibitory synaptic transmission in area CA1 of the rat hippocampus","volume":"122","author":"Lambert","year":"1991","journal-title":"Neurosci. Lett."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1113\/jphysiol.1992.sp019168","article-title":"Comparison of the actions of adenosine at pre- and postsynaptic receptors in the rat hippocampus in vitro","volume":"451","author":"Thompson","year":"1992","journal-title":"J. Physiol."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/0896-6273(92)90244-8","article-title":"Presynaptic inhibition of miniature excitatory synaptic currents by baclofen and adenosine in the hippocampus","volume":"9","author":"Scanziani","year":"1992","journal-title":"Neuron"},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1093\/cercor\/bhm077","article-title":"Developmental downregulation of excitatory GABAergic transmission in neocortical layer I via presynaptic adenosine A(1) receptors","volume":"18","author":"Kirmse","year":"2008","journal-title":"Cereb. Cortex"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/S0896-6273(02)01067-X","article-title":"Adenosine: A neuron-glial transmitter promoting myelination in the CNS in response to action potentials","volume":"36","author":"Stevens","year":"2002","journal-title":"Neuron"},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/glia.10281","article-title":"Oligodendrocytes express functional A1 adenosine receptors that stimulate cellular migration","volume":"44","author":"Othman","year":"2003","journal-title":"Glia"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0925-4773(02)00280-0","article-title":"P2X(3) receptor expression at early stage of mouse embryogenesis","volume":"118","author":"Boldogkoi","year":"2002","journal-title":"Mech. Dev."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1002\/cne.10123","article-title":"Localization of P2X3 receptors and coexpression with P2X2 receptors during rat embryonic neurogenesis","volume":"443","author":"Cheung","year":"2002","journal-title":"J. Comp. Neurol."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.neuroscience.2005.03.032","article-title":"Expression of P2X purinoceptors during rat brain development and their inhibitory role on motor axon outgrowth in neural tube explant cultures","volume":"133","author":"Cheung","year":"2005","journal-title":"Neuroscience"},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1634\/stemcells.2005-0588","article-title":"ATP stimulates mouse embryonic stem cell proliferation via protein kinase C, phosphatidylinositol 3-kinase\/Akt, and mitogen-activated protein kinase signaling pathways","volume":"24","author":"Heo","year":"2006","journal-title":"Stem Cells"},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ijdevneu.2011.12.010","article-title":"Regulation of neurogenesis and gliogenesis of retinoic acid-induced P19 embryonal carcinoma cells by P2X2 and P2X7 receptors studied by RNA interference","volume":"30","author":"Yuahasi","year":"2012","journal-title":"Int. J. Dev. Neurosci."},{"key":"ref_238","doi-asserted-by":"crossref","unstructured":"Glaser, T., de Oliveira, S.L., Cheffer, A., Beco, R., Martins, P., Fornazari, M., Lameu, C., Junior, H.M., Coutinho-Silva, R., and Ulrich, H. (2014). Modulation of mouse embryonic stem cell proliferation and neural differentiation by the P2X7 receptor. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0096281"},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"7049","DOI":"10.1523\/JNEUROSCI.3103-16.2017","article-title":"Neuronal P2X7 Receptors Revisited: Do They Really Exist?","volume":"37","author":"Illes","year":"2017","journal-title":"J. Neurosci."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"7143","DOI":"10.1523\/JNEUROSCI.21-18-07143.2001","article-title":"Neuronal P2X7 receptors are targeted to presynaptic terminals in the central and peripheral nervous systems","volume":"21","author":"Deuchars","year":"2001","journal-title":"J. Neurosci."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1023\/A:1025690913206","article-title":"P2X7 receptors in rat brain: Presence in synaptic terminals and granule cells","volume":"28","author":"Sen","year":"2003","journal-title":"Neurochem. Res."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s11302-016-9546-z","article-title":"Genetically dissecting P2rx7 expression within the central nervous system using conditional humanized mice","volume":"13","author":"Metzger","year":"2017","journal-title":"Purinergic Signal."},{"key":"ref_243","doi-asserted-by":"crossref","unstructured":"Morgan, J., Alves, M., Conte, G., Men\u00e9ndez-M\u00e9ndez, A., de Diego-Garcia, L., de Leo, G., Beamer, E., Smith, J., Nicke, A., and Engel, T. (2020). Characterization of the Expression of the ATP-Gated P2X7 Receptor Following Status Epilepticus and during Epilepsy Using a P2X7-EGFP Reporter Mouse. Neurosci. Bull.","DOI":"10.1007\/s12264-020-00573-9"},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3389\/fnins.2017.00021","article-title":"The ATP-Gated P2X7 Receptor As a Target for the Treatment of Drug-Resistant Epilepsy","volume":"11","author":"Beamer","year":"2017","journal-title":"Front. Neurosci."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/dvdy.10378","article-title":"Abundant and dynamic expression of G protein-coupled P2Y receptors in mammalian development","volume":"228","author":"Cheung","year":"2003","journal-title":"Dev. Dyn."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1242\/dev.02233","article-title":"Extracellular nucleotide signaling in adult neural stem cells: Synergism with growth factor-mediated cellular proliferation","volume":"133","author":"Mishra","year":"2006","journal-title":"Development"},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.devbrainres.2005.02.015","article-title":"Changes in expression of P2X purinoceptors in rat cerebellum during postnatal development","volume":"156","author":"Xiang","year":"2005","journal-title":"Brain Res. Dev. Brain Res."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1113\/jphysiol.2005.085621","article-title":"ATP contributes to the generation of network-driven giant depolarizing potentials in the neonatal rat hippocampus","volume":"565","author":"Safiulina","year":"2005","journal-title":"J. Physiol."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.neuropharm.2015.02.001","article-title":"P2Y(1) receptor mediated neuronal fibre outgrowth in organotypic brain slice co-cultures","volume":"93","author":"Heine","year":"2015","journal-title":"Neuropharmacology"},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.brainresbull.2017.10.006","article-title":"ATP released from astrocytes modulates action potential threshold and spontaneous excitatory postsynaptic currents in the neonatal rat prefrontal cortex","volume":"135","author":"Beamer","year":"2017","journal-title":"Brain Res. Bull."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1111\/j.1471-4159.2009.06008.x","article-title":"Neural progenitor cell death is induced by extracellular ATP via ligation of P2X7 receptor","volume":"109","author":"Delarasse","year":"2009","journal-title":"J. Neurochem."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"e751","DOI":"10.1038\/cddis.2013.274","article-title":"PKC-dependent ERK phosphorylation is essential for P2X7 receptor-mediated neuronal differentiation of neural progenitor cells","volume":"4","author":"Tsao","year":"2013","journal-title":"Cell Death Dis."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.cellsig.2011.11.012","article-title":"A novel role for P2X7 receptor signalling in the survival of mouse embryonic stem cells","volume":"24","author":"Thompson","year":"2012","journal-title":"Cell. Signal."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1002\/stem.1864","article-title":"P2X7 receptors mediate innate phagocytosis by human neural precursor cells and neuroblasts","volume":"33","author":"Lovelace","year":"2015","journal-title":"Stem Cells"},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/glia.20227","article-title":"Expression of P2X receptors on rat microglial cells during early development","volume":"52","author":"Xiang","year":"2005","journal-title":"Glia"},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1111\/j.1471-4159.2006.04101.x","article-title":"A role for P2X7 in microglial proliferation","volume":"99","author":"Bianco","year":"2006","journal-title":"J. Neurochem."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"11559","DOI":"10.1523\/JNEUROSCI.1042-12.2012","article-title":"Microglia proliferation is controlled by P2X7 receptors in a Pannexin-1-independent manner during early embryonic spinal cord invasion","volume":"32","author":"Rigato","year":"2012","journal-title":"J. Neurosci."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s12035-008-8028-x","article-title":"P2X7 receptors in oligodendrocytes: A novel target for neuroprotection","volume":"38","author":"Matute","year":"2008","journal-title":"Mol. Neurobiol."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1046\/j.1460-9568.2003.02567.x","article-title":"Expression of the ecto-ATPase NTPDase2 in the germinal zones of the developing and adult rat brain","volume":"17","author":"Braun","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.neuroscience.2007.07.064","article-title":"The ectonucleotidases alkaline phosphatase and nucleoside triphosphate diphosphohydrolase 2 are associated with subsets of progenitor cell populations in the mouse embryonic, postnatal and adult neurogenic zones","volume":"150","author":"Langer","year":"2007","journal-title":"Neuroscience"},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s11064-011-0577-0","article-title":"Profile of nucleotide catabolism and ectonucleotidase expression from the hippocampi of neonatal rats after caffeine exposure","volume":"37","author":"Richetti","year":"2012","journal-title":"Neurochem. Res."},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0165-0270(94)00211-X","article-title":"A re-evaluation of the ultrastructural localization of 5\u2019-nucleotidase activity in the developing rat cerebellum, with a cerium-based method","volume":"59","author":"Fenoglio","year":"1995","journal-title":"J. Neurosci. Methods"},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/cne.902960304","article-title":"Ocular dominance plasticity and developmental changes of 5\u2019-nucleotidase distributions in the kitten visual cortex","volume":"296","author":"Schoen","year":"1990","journal-title":"J. Comp. Neurol."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1460-9568.1993.tb00487.x","article-title":"Cytochemical redistribution of 5\u2032-nucleotidase in the developing cat visual cortex","volume":"5","author":"Schoen","year":"1993","journal-title":"Eur. J. Neurosci."},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s12031-014-0256-0","article-title":"Developmental increase in ecto-5\u2032-nucleotidase activity overlaps with appearance of two immunologically distinct enzyme isoforms in rat hippocampal synaptic plasma membranes","volume":"54","author":"Grkovic","year":"2014","journal-title":"J. Mol. Neurosci."},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0925-4773(99)00048-9","article-title":"Developmental expression analysis of murine autotaxin (ATX)","volume":"84","author":"Bachner","year":"1999","journal-title":"Mech. Dev."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.ijdevneu.2008.05.001","article-title":"Expression mapping of ectonucleotide pyrophosphatase\/phosphodiesterase 1-3 (E-NPP1-3) in different brain structures during rat development","volume":"26","author":"Cognato","year":"2008","journal-title":"Int. J. Dev. Neurosci."},{"key":"ref_268","doi-asserted-by":"crossref","unstructured":"Foster, B.L., Nagatomo, K.J., Nociti, F.H., Fong, H., Dunn, D., Tran, A.B., Wang, W., Narisawa, S., Millan, J.L., and Somerman, M.J. (2012). Central role of pyrophosphate in acellular cementum formation. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0038393"},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/aja.1002010306","article-title":"Stage-specific expression of alkaline phosphatase during neural development in the mouse","volume":"201","author":"Narisawa","year":"1994","journal-title":"Dev. Dyn."},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/ar.1091180202","article-title":"The identification, origin, and migration of the primordial germ cells in the mouse embryo","volume":"118","author":"Chiquoine","year":"1954","journal-title":"Anat. Rec."},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/cne.20524","article-title":"Postnatal development of alkaline phosphatase activity correlates with the maturation of neurotransmission in the cerebral cortex","volume":"486","author":"Fonta","year":"2005","journal-title":"J. Comp. Neurol."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.neulet.2010.09.013","article-title":"Knockdown of tissue nonspecific alkaline phosphatase impairs neural stem cell proliferation and differentiation","volume":"485","author":"Kermer","year":"2010","journal-title":"Neurosci. Lett."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1091\/mbc.e10-09-0740","article-title":"Tissue-nonspecific alkaline phosphatase promotes axonal growth of hippocampal neurons","volume":"22","author":"Zimmermann","year":"2011","journal-title":"Mol. Biol. Cell."},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"4143","DOI":"10.1093\/hmg\/ddw248","article-title":"Neurodevelopmental alterations and seizures developed by mouse model of infantile hypophosphatasia are associated with purinergic signalling deregulation","volume":"25","author":"Engel","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/ng0995-45","article-title":"Mice lacking tissue non-specific alkaline phosphatase die from seizures due to defective metabolism of vitamin B-6","volume":"11","author":"Waymire","year":"1995","journal-title":"Nat. Genet."},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s00441-012-1455-z","article-title":"Ablation of TNAP function compromises myelination and synaptogenesis in the mouse brain","volume":"349","author":"Hanics","year":"2012","journal-title":"Cell Tissue Res."},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/j.1528-1157.1985.tb05684.x","article-title":"Is adenosine an endogenous anticonvulsant?","volume":"26","author":"Dragunow","year":"1985","journal-title":"Epilepsia"},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1002\/ana.410320504","article-title":"Adenosine: A potential mediator of seizure arrest and postictal refractoriness","volume":"32","author":"During","year":"1992","journal-title":"Ann. Neurol."},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-2999(92)90454-C","article-title":"Differential effects of various xanthines on pentylenetetrazole-induced seizures in rats: An EEG and behavioural study","volume":"222","author":"Cutrufo","year":"1992","journal-title":"Eur. J. Pharm."},{"key":"ref_280","doi-asserted-by":"crossref","unstructured":"Jailani, M., Mubarak, M., Sarkhouh, M., Al Mahrezi, A., Abdulnabi, H., Naiser, M., Alaradi, H., Alabbad, A., Hassan, M., and Kamal, A. (2020). The Effect of Low-Doses of Caffeine and Taurine on Convulsive Seizure Parameters in Rats. Behav. Sci., 10.","DOI":"10.3390\/bs10020043"},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.yebeh.2017.11.003","article-title":"Caffeine and seizures: A systematic review and quantitative analysis","volume":"80","author":"Bauer","year":"2018","journal-title":"Epilepsy Behav."},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S1734-1140(10)70243-7","article-title":"Effects of 2-chloroadenosine on cortical epileptic afterdischarges in immature rats","volume":"62","author":"Mares","year":"2010","journal-title":"Pharm. Rep."},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1007\/s00702-010-0465-9","article-title":"Anticonvulsant action of 2-chloroadenosine against pentetrazol-induced seizures in immature rats is due to activation of A1 adenosine receptors","volume":"117","year":"2010","journal-title":"J. Neural Transm. (Vienna)"},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1007\/s00702-014-1234-y","article-title":"A1 not A2A adenosine receptors play a role in cortical epileptic afterdischarges in immature rats","volume":"121","year":"2014","journal-title":"J. Neural Transm. (Vienna)"},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"656","DOI":"10.3389\/fphar.2019.00656","article-title":"Adenosine A1 Receptor Agonist 2-chloro-N6-cyclopentyladenosine and Hippocampal Excitability During Brain Development in Rats","volume":"10","author":"Fabera","year":"2019","journal-title":"Front. Pharm."},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/jnc.13130","article-title":"Hyperthermia-induced seizures alter adenosine A1 and A2A receptors and 5\u2019-nucleotidase activity in rat cerebral cortex","volume":"134","author":"Albasanz","year":"2015","journal-title":"J. Neurochem."},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s12640-018-9872-8","article-title":"Caffeine Protects Against Anticonvulsant-Induced Impaired Neurogenesis in the Developing Rat Brain","volume":"34","author":"Endesfelder","year":"2018","journal-title":"Neurotox. Res."},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"1239629","DOI":"10.1155\/2016\/1239629","article-title":"Caffeine-Induced Suppression of GABAergic Inhibition and Calcium-Independent Metaplasticity","volume":"2016","author":"Isokawa","year":"2016","journal-title":"Neural Plast."},{"key":"ref_289","doi-asserted-by":"crossref","unstructured":"Blaise, J.H., Park, J.E., Bellas, N.J., Gitchell, T.M., and Phan, V. (2018). Caffeine consumption disrupts hippocampal long-term potentiation in freely behaving rats. Physiol. Rep., 6.","DOI":"10.14814\/phy2.13632"},{"key":"ref_290","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1111\/j.1528-1157.1995.tb01610.x","article-title":"Neonatal caffeine exposure and seizure susceptibility in adult rats","volume":"36","author":"Guillet","year":"1995","journal-title":"Epilepsia"},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/0165-3806(95)00108-P","article-title":"Neonatal caffeine exposure alters seizure susceptibility in rats in an age-related manner","volume":"89","author":"Guillet","year":"1995","journal-title":"Brain Res. Dev. Brain Res."},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3390\/brainsci3010177","article-title":"Therapeutic effect of caffeine treatment immediately following neonatal hypoxic-ischemic injury on spatial memory in male rats","volume":"3","author":"Alexander","year":"2013","journal-title":"Brain Sci."},{"key":"ref_293","doi-asserted-by":"crossref","unstructured":"Winerdal, M., Urmaliya, V., Winerdal, M.E., Fredholm, B.B., Winqvist, O., and \u00c5d\u00e9n, U. (2017). Single Dose Caffeine Protects the Neonatal Mouse Brain against Hypoxia Ischemia. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0170545"},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/epi.13236","article-title":"From unwitnessed fatality to witnessed rescue: Pharmacologic intervention in sudden unexpected death in epilepsy","volume":"57","author":"Richerson","year":"2016","journal-title":"Epilepsia"},{"key":"ref_295","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.2174\/1381612825666190716111245","article-title":"P1 Receptor Agonists\/Antagonists in Clinical Trials\u2014Potential Drug Candidates of the Future","volume":"25","author":"Borah","year":"2019","journal-title":"Curr. Pharm. Des."},{"key":"ref_296","doi-asserted-by":"crossref","unstructured":"Li, F., Wang, L., Li, J.W., Gong, M., He, L., Feng, R., Dai, Z., and Li, S.Q. (2011). Hypoxia induced amoeboid microglial cell activation in postnatal rat brain is mediated by ATP receptor P2X4. BMC Neurosci., 12.","DOI":"10.1186\/1471-2202-12-111"},{"key":"ref_297","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.pneurobio.2007.12.002","article-title":"The adenosine kinase hypothesis of epileptogenesis","volume":"84","author":"Boison","year":"2008","journal-title":"Prog. Neurobiol."},{"key":"ref_298","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1093\/brain\/awh555","article-title":"Astrogliosis in epilepsy leads to overexpression of adenosine kinase, resulting in seizure aggravation","volume":"128","author":"Fedele","year":"2005","journal-title":"Brain"},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1523\/JNEUROSCI.4781-03.2004","article-title":"Overexpression of adenosine kinase in epileptic hippocampus contributes to epileptogenesis","volume":"24","author":"Gouder","year":"2004","journal-title":"J. Neurosci."},{"key":"ref_300","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.csbj.2014.12.004","article-title":"Tissue-nonspecific Alkaline Phosphatase Regulates Purinergic Transmission in the Central Nervous System During Development and Disease","volume":"13","author":"Zimmermann","year":"2015","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"ref_301","doi-asserted-by":"crossref","unstructured":"Santiago, M.F., Veliskova, J., Patel, N.K., Lutz, S.E., Caille, D., Charollais, A., Meda, P., and Scemes, E. (2011). Targeting pannexin1 improves seizure outcome. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0025178"},{"key":"ref_302","doi-asserted-by":"crossref","unstructured":"Quinlan, S., Merino-Serrais, P., Di Grande, A., Dussmann, H., Prehn, J.H.M., N\u00ed Chonghaile, T., Henshall, D.C., and Jimenez-Mateos, E.M. (2019). The Anti-inflammatory Compound Candesartan Cilexetil Improves Neurological Outcomes in a Mouse Model of Neonatal Hypoxia. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.01752"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/21\/21\/7832\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:26:11Z","timestamp":1760178371000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/21\/21\/7832"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,22]]},"references-count":302,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2020,11]]}},"alternative-id":["ijms21217832"],"URL":"https:\/\/doi.org\/10.3390\/ijms21217832","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,22]]}}}