{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:18:22Z","timestamp":1789431502226,"version":"build-2803163510"},"reference-count":99,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T00:00:00Z","timestamp":1604275200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Fundamental Research Funds for the Central Universities","award":["2662018PY043"],"award-info":[{"award-number":["2662018PY043"]}]},{"name":"Hubei Agricultural Sciences and Technology Innovation Center Team of Livestock and Poultry Genetic Improvement and Healthy Breeding","award":["2019-620-000-001-30"],"award-info":[{"award-number":["2019-620-000-001-30"]}]},{"name":"the National Project for Breeding of Transgenic Pigs","award":["2016ZX08006-002"],"award-info":[{"award-number":["2016ZX08006-002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Lipid homeostasis is essential for normal cell physiology. Generally, lipids are stored in a lipid droplet (LD), a ubiquitous organelle consisting of a neutral lipid core and a single layer of phospholipid membrane. It is thought that LDs are generated from the endoplasmic reticulum and then released into the cytosol. Recent studies indicate that LDs can exist in the nucleus, where they play an important role in the maintenance of cell phospholipid homeostasis. However, the details of nuclear lipid droplet (nLD) generation have not yet been clearly characterized. SEIPIN is a nonenzymatic protein encoded by the Berardinelli-Seip congenital lipodystrophy type 2 (BSCL2) gene. It is associated with lipodystrophy diseases. Many recent studies have indicated that SEIPIN is essential for LDs generation. Here, we review much of this research in an attempt to explain the role of SEIPIN in nLD generation. From an integrative perspective, we conclude by proposing a theoretical model to explain how SEIPIN might participate in maintaining homeostasis of lipid metabolism.<\/jats:p>","DOI":"10.3390\/ijms21218208","type":"journal-article","created":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T19:51:31Z","timestamp":1604346691000},"page":"8208","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["SEIPIN: A Key Factor for Nuclear Lipid Droplet Generation and Lipid Homeostasis"],"prefix":"10.3390","volume":"21","author":[{"given":"Yi","family":"Jin","sequence":"first","affiliation":[{"name":"Key Laboratory of Agriculture Animal Genetics, Breeding and Reproduction of the Ministry of Education &amp; Key Laboratory of Swine Genetics and Breeding of the Ministry of Agriculture and Rural Affairs, College of Animal Science, Huazhong Agricultural University, Wuhan 430070, Hubei, China"},{"name":"Bio-Medical Center of Huazhong Agricultural University, Wuhan 430070, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjie","family":"Tan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Agriculture Animal Genetics, Breeding and Reproduction of the Ministry of Education &amp; Key Laboratory of Swine Genetics and Breeding of the Ministry of Agriculture and Rural Affairs, College of Animal Science, Huazhong Agricultural University, Wuhan 430070, Hubei, China"},{"name":"Institute of Biomedical Sciences, Key Laboratory of Animal Resistance Biology of Shandong Province, College of Life Sciences, Shandong Normal University, Jinan 250014, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengxiang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Agriculture Animal Genetics, Breeding and Reproduction of the Ministry of Education &amp; Key Laboratory of Swine Genetics and Breeding of the Ministry of Agriculture and Rural Affairs, College of Animal Science, Huazhong Agricultural University, Wuhan 430070, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4600-5312","authenticated-orcid":false,"given":"Zhuqing","family":"Ren","sequence":"additional","affiliation":[{"name":"Key Laboratory of Agriculture Animal Genetics, Breeding and Reproduction of the Ministry of Education &amp; Key Laboratory of Swine Genetics and Breeding of the Ministry of Agriculture and Rural Affairs, College of Animal Science, Huazhong Agricultural University, Wuhan 430070, Hubei, China"},{"name":"Bio-Medical Center of Huazhong Agricultural University, Wuhan 430070, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Missaglia, S., Coleman, R.A., Mordente, A., and Tavian, D. 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