{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T14:39:05Z","timestamp":1782484745210,"version":"3.54.5"},"reference-count":144,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T00:00:00Z","timestamp":1604361600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Endometriosis is defined as the presence of endometrial foci, localized beyond their primary site, i.e., the uterine cavity. The etiology of this disease is rather complex. Its development is supported by hormonal, immunological, and environmental factors. During recent years, particular attention has been focused on the genetic mechanisms that may be of particular significance for the increased incidence rates of endometriosis. According to most recent studies, ESR2 and CYP19A1 genes may account for the potential risk factors of infertility associated with endometriosis. The paper presents a thorough review of the latest reports and data concerning the genetic background of the risk for endometriosis development.<\/jats:p>","DOI":"10.3390\/ijms21218235","type":"journal-article","created":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T20:00:29Z","timestamp":1604433629000},"page":"8235","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The Genetic Background of Endometriosis: Can ESR2 and CYP19A1 Genes Be a Potential Risk Factor for Its Development?"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3168-062X","authenticated-orcid":false,"given":"Beata","family":"Smolarz","sequence":"first","affiliation":[{"name":"Laboratory of Cancer Genetics, Department of Pathology, Polish Mother\u2019s Memorial Hospital Research Institute, Rzgowska 281\/289, 93-338 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Szy\u0142\u0142o","sequence":"additional","affiliation":[{"name":"Department of Operative Gynaecology and Oncological Gynaecology, Polish Mother\u2019s Memorial Hospital Research Institute, Rzgowska 281\/289, 93-338 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Romanowicz","sequence":"additional","affiliation":[{"name":"Laboratory of Cancer Genetics, Department of Pathology, Polish Mother\u2019s Memorial Hospital Research Institute, Rzgowska 281\/289, 93-338 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(04)17403-5","article-title":"Endometriosis","volume":"364","author":"Giudice","year":"2004","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nrurol.2017.58","article-title":"Pathophysiology and management of urinary tract endometriosis","volume":"14","author":"Nezhat","year":"2017","journal-title":"Nat. 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