{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:35:34Z","timestamp":1782488134699,"version":"3.54.5"},"reference-count":95,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T00:00:00Z","timestamp":1604880000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Alopecia is a challenging condition for both physicians and patients. Several topical, intralesional, oral, and surgical treatments have been developed in recent decades, but some of those therapies only provide partial improvement. Advanced medical therapies are medical products based on genes, cells, and\/or tissue engineering products that have properties in regenerating, repairing, or replacing human tissue. In recent years, numerous applications have been described for advanced medical therapies. With this background, those therapies may have a role in the treatment of various types of alopecia such as alopecia areata and androgenic alopecia. The aim of this review is to provide dermatologists an overview of the different advanced medical therapies that have been applied in the treatment of alopecia, by reviewing clinical and basic research studies as well as ongoing clinical trials.<\/jats:p>","DOI":"10.3390\/ijms21218390","type":"journal-article","created":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T10:47:28Z","timestamp":1605005248000},"page":"8390","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Advanced Medical Therapies in the Management of Non-Scarring Alopecia: Areata and Androgenic Alopecia"],"prefix":"10.3390","volume":"21","author":[{"given":"Antonio","family":"Martinez-Lopez","sequence":"first","affiliation":[{"name":"Dermatology Unit, Virgen de las Nieves University Hospital, Av de Madrid, 15, 18012 Granada, Spain"},{"name":"TECe19-Clinical and Translational Dermatology Investigation Group, Ibs.Granada, 18012 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4035-7955","authenticated-orcid":false,"given":"Trinidad","family":"Montero-Vilchez","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Virgen de las Nieves University Hospital, Av de Madrid, 15, 18012 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4511-408X","authenticated-orcid":false,"given":"\u00c1lvaro","family":"Sierra-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Cell Production and Tissue Engineering Unit, Virgen de las Nieves University Hospital, Andalusian Network of Design and Translation of Advanced Therapies, 18012 Granada, Spain"},{"name":"Biosanitary Institute of Granada (ibs.GRANADA), 18012 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6882-2113","authenticated-orcid":false,"given":"Alejandro","family":"Molina-Leyva","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Virgen de las Nieves University Hospital, Av de Madrid, 15, 18012 Granada, Spain"},{"name":"TECe19-Clinical and Translational Dermatology Investigation Group, Ibs.Granada, 18012 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvador","family":"Arias-Santiago","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Virgen de las Nieves University Hospital, Av de Madrid, 15, 18012 Granada, Spain"},{"name":"TECe19-Clinical and Translational Dermatology Investigation Group, Ibs.Granada, 18012 Granada, Spain"},{"name":"Cell Production and Tissue Engineering Unit, Virgen de las Nieves University Hospital, Andalusian Network of Design and Translation of Advanced Therapies, 18012 Granada, Spain"},{"name":"Biosanitary Institute of Granada (ibs.GRANADA), 18012 Granada, Spain"},{"name":"Dermatology Department, Granada School of Medicine, Granada University, 18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.adengl.2019.02.022","article-title":"Do Dermatologic Diagnosis Change in Hot vs Cold Periods of The Year? 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