{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:46:10Z","timestamp":1790700370440,"version":"4.1.0"},"reference-count":160,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T00:00:00Z","timestamp":1605139200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009160","name":"Universit\u00e9 Toulouse III - Paul Sabatier","doi-asserted-by":"publisher","award":["none"],"award-info":[{"award-number":["none"]}],"id":[{"id":"10.13039\/501100009160","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer","doi-asserted-by":"publisher","award":["none"],"award-info":[{"award-number":["none"]}],"id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fondation Toulouse Cancer-Sant\u00e9","award":["none"],"award-info":[{"award-number":["none"]}]},{"name":"Ligue R\u00e9gionale contre le Cancer (comit\u00e9 Haute-Garonne, comit\u00e9 Ari\u00e8ge)","award":["none"],"award-info":[{"award-number":["none"]}]},{"name":"Institut National de la Sant&amp;#x00E9; et de la Recherche M&amp;#x00E9;dicale","award":["none"],"award-info":[{"award-number":["none"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The Thyroid hormone Receptor Interacting Protein 12 (TRIP12) protein belongs to the 28-member Homologous to the E6-AP C-Terminus (HECT) E3 ubiquitin ligase family. First described as an interactor of the thyroid hormone receptor, TRIP12\u2019s biological importance was revealed by the embryonic lethality of a murine model bearing an inactivating mutation in the TRIP12 gene. Further studies showed the participation of TRIP12 in the regulation of major biological processes such as cell cycle progression, DNA damage repair, chromatin remodeling, and cell differentiation by an ubiquitination-mediated degradation of key protein substrates. Moreover, alterations of TRIP12 expression have been reported in cancers that can serve as predictive markers of therapeutic response. The TRIP12 gene is also referenced as a causative gene associated to intellectual disorders such as Clark\u2013Baraitser syndrome and is clearly implicated in Autism Spectrum Disorder. The aim of the review is to provide an exhaustive and integrated overview of the different aspects of TRIP12 ranging from its regulation, molecular functions and physio-pathological implications.<\/jats:p>","DOI":"10.3390\/ijms21228515","type":"journal-article","created":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T10:00:32Z","timestamp":1605175232000},"page":"8515","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["E3 Ubiquitin Ligase TRIP12: Regulation, Structure, and Physiopathological Functions"],"prefix":"10.3390","volume":"21","author":[{"given":"Manon","family":"Brunet","sequence":"first","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, INSERM Unit 1037, Centre de Recherches en Canc\u00e9rologie de Toulouse, CEDEX 1, 31 037 Toulouse, France"},{"name":"Universit\u00e9 Toulouse III-Paul Sabatier, CEDEX 9, 31 062 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Vargas","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, INSERM Unit 1037, Centre de Recherches en Canc\u00e9rologie de Toulouse, CEDEX 1, 31 037 Toulouse, France"},{"name":"Universit\u00e9 Toulouse III-Paul Sabatier, CEDEX 9, 31 062 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorian","family":"Larrieu","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, INSERM Unit 1037, Centre de Recherches en Canc\u00e9rologie de Toulouse, CEDEX 1, 31 037 Toulouse, France"},{"name":"Universit\u00e9 Toulouse III-Paul Sabatier, CEDEX 9, 31 062 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Torrisani","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, INSERM Unit 1037, Centre de Recherches en Canc\u00e9rologie de Toulouse, CEDEX 1, 31 037 Toulouse, France"},{"name":"Universit\u00e9 Toulouse III-Paul Sabatier, CEDEX 9, 31 062 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marl\u00e8ne","family":"Dufresne","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, INSERM Unit 1037, Centre de Recherches en Canc\u00e9rologie de Toulouse, CEDEX 1, 31 037 Toulouse, France"},{"name":"Universit\u00e9 Toulouse III-Paul Sabatier, CEDEX 9, 31 062 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1093\/dnares\/1.5.223","article-title":"Prediction of the Coding Sequences of Unidentified Human Genes. 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