{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T13:15:03Z","timestamp":1761311703974,"version":"build-2065373602"},"reference-count":32,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T00:00:00Z","timestamp":1605225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["LIT213760001"],"award-info":[{"award-number":["LIT213760001"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Porous organosilica microparticles consisting of silane-derived cyclophosphazene bridges were synthesized by a surfactant-mediated sol-gel process. Starting from the substitution of hexachlorocyclotriphosphazene with allylamine, two different precursors were obtained by anchoring three or six alkoxysilane units, via a thiol-ene photoaddition reaction. In both cases, spherical, microparticles (size average of ca. 1000 nm) with large pores were obtained, confirmed by both, scanning and transmission electron microscopy. Particles synthesized using the partially functionalized precursor containing free vinyl groups were further functionalized with a thiol-containing molecule. While most other reported mesoporous organosilica particles are essentially hybrids with tetraethyl orthosilicate (TEOS), a unique feature of these particles is that structural control is achieved by exclusively using organosilane precursors. This allows an increase in the proportion of the co-components and could springboard these novel phosphorus-containing organosilica microparticles for different areas of technology.<\/jats:p>","DOI":"10.3390\/ijms21228552","type":"journal-article","created":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T08:44:02Z","timestamp":1605257042000},"page":"8552","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Hybrid Porous Microparticles Based on a Single Organosilica Cyclophosphazene Precursor"],"prefix":"10.3390","volume":"21","author":[{"given":"Vanessa","family":"Poscher","sequence":"first","affiliation":[{"name":"Institute of Polymer Chemistry, Johannes Kepler University at Linz, Altenberger Strasse 69, 4040 Linz, Austria"},{"name":"Linz Institute of Technology (LIT), Johannes Kepler University at Linz, Altenberger Strasse 69, 4040 Linz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7666-8723","authenticated-orcid":false,"given":"George S.","family":"Pappas","sequence":"additional","affiliation":[{"name":"Institute of Polymer Chemistry, Johannes Kepler University at Linz, Altenberger Strasse 69, 4040 Linz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Br\u00fcggemann","sequence":"additional","affiliation":[{"name":"Institute of Polymer Chemistry, Johannes Kepler University at Linz, Altenberger Strasse 69, 4040 Linz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5953-9084","authenticated-orcid":false,"given":"Ian","family":"Teasdale","sequence":"additional","affiliation":[{"name":"Institute of Polymer Chemistry, Johannes Kepler University at Linz, Altenberger Strasse 69, 4040 Linz, Austria"},{"name":"Linz Institute of Technology (LIT), Johannes Kepler University at Linz, Altenberger Strasse 69, 4040 Linz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1828-5839","authenticated-orcid":false,"given":"Yolanda","family":"Salinas","sequence":"additional","affiliation":[{"name":"Institute of Polymer Chemistry, Johannes Kepler University at Linz, Altenberger Strasse 69, 4040 Linz, Austria"},{"name":"Linz Institute of Technology (LIT), Johannes Kepler University at Linz, Altenberger Strasse 69, 4040 Linz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6592","DOI":"10.1021\/cr300399c","article-title":"The sol-gel route to advanced silica-based materials and recent applications","volume":"113","author":"Ciriminna","year":"2013","journal-title":"Chem. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"4364","DOI":"10.1021\/acs.chemmater.9b00221","article-title":"Degradable drug carriers: Vanishing mesoporous silica nanoparticles","volume":"31","author":"Bein","year":"2019","journal-title":"Chem. Mater."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/0021-9797(68)90272-5","article-title":"Controlled growth of monodisperse silica spheres in the micron size range","volume":"26","author":"Fink","year":"1968","journal-title":"J. Colloid Interface Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"4015","DOI":"10.2147\/IJN.S52605","article-title":"Ordered nanoporous silica as carriers for improved delivery of water insoluble drugs: A comparative study between three dimensional and two dimensional macroporous silica","volume":"8","author":"Wang","year":"2013","journal-title":"Int. J. Nanomed."},{"key":"ref_5","unstructured":"Brinker, C.J., and Scherer, G.W. (1990). Sol-Gel Science: The Physics and Chemistry of Sol-Gel Processing, Academic Press."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/359710a0","article-title":"Ordered mesoporous molecular sieves synthesized by a liquid-crystal template mechanism","volume":"359","author":"Kresge","year":"1992","journal-title":"Nature"},{"key":"ref_7","first-page":"10","article-title":"Mesoporous silica nanomaterials applications in catalysis","volume":"5","author":"Lai","year":"2013","journal-title":"J. Thermodyn. Catal."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/adfm.201902634","article-title":"Mesoporous silica nanoparticles for drug delivery","volume":"30","author":"Manzano","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/47229","article-title":"Periodic mesoporous organosilicas with organic groups inside the channel walls","volume":"402","author":"Asefa","year":"1999","journal-title":"Nature"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"9611","DOI":"10.1021\/ja9916658","article-title":"Novel mesoporous materials with a uniform distribution of organic groups and inorganic oxide in their frameworks","volume":"121","author":"Inagaki","year":"1999","journal-title":"J. Am. Chem. Soc."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1021\/ar040164a","article-title":"Past, present, and future of periodic mesoporous organosilicas\u2014The PMOs","volume":"38","author":"Hatton","year":"2005","journal-title":"Acc. Chem. Res."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Poscher, V., and Salinas, Y. (2020). Trends in degradable mesoporous organosilica-based nanomaterials for controlling drug delivery: A mini review. Materials, 13.","DOI":"10.3390\/ma13173668"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"5200","DOI":"10.1039\/C6CS00340K","article-title":"Preparation of polyphosphazenes: A tutorial review","volume":"45","author":"Rothemund","year":"2016","journal-title":"Chem. Soc. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Strasser, P., and Teasdale, I. (2020). Main-chain phosphorus-containing polymers for therapeutic applications. Molecules, 25.","DOI":"10.3390\/molecules25071716"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Teasdale, I., Br\u00fcggemann, O., and Henke, H. (2020). Polyphosphazenes for Medical Applications, De Gruyter.","DOI":"10.1515\/9783110654189"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1039\/C1PY00468A","article-title":"Bioerodible polyphosphazenes and their medical potential","volume":"3","author":"Allcock","year":"2012","journal-title":"Polym. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1039\/C5DT03047A","article-title":"The specific functionalization of cyclotriphosphazene for the synthesis of smart dendrimers","volume":"45","author":"Caminade","year":"2016","journal-title":"Dalton Trans."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"8450","DOI":"10.1039\/C8CC04242J","article-title":"Uniform poly(phosphazene-triazine) porous microspheres for highly efficient iodine removal","volume":"54","author":"Xiong","year":"2018","journal-title":"Chem. Commun."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.polymdegradstab.2016.02.009","article-title":"Durable flame retardant finishing of cotton fabrics with organosilicon functionalized cyclotriphosphazene","volume":"128","author":"Wang","year":"2016","journal-title":"Polym. Degrad. Stab."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1163\/156855501753210817","article-title":"New functionalized cyclotriphosphazenes-synthesis and application in the sol-gel process","volume":"4","author":"Christova","year":"2001","journal-title":"Des. Monomers Polym."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"122011","DOI":"10.1016\/j.polymer.2019.122011","article-title":"New hybrid materials based on cyclophosphazene and polysiloxane precursors: Synthesis and properties","volume":"186","author":"Khanin","year":"2020","journal-title":"Polymer"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"16801","DOI":"10.1002\/chem.201202748","article-title":"New liquid crystalline materials based on two generations of dendronised cyclophosphazenes","volume":"18","author":"Laguna","year":"2012","journal-title":"Chem. Eur. J."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Jiang, J., Wang, Y., Luo, Z., Qi, T., Qiao, Y., Zuo, M., and Wang, B. (2019). Design and application of highly efficient flame retardants for polycarbonate combining the advantages of cyclotriphosphazene and silicone oil. Polymers, 11.","DOI":"10.3390\/polym11071155"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1021\/acsanm.8b02247","article-title":"Surfactant-free synthesis of cyclomatrix and linear organosilica phosphazene-based hybrid nanoparticles","volume":"2","author":"Poscher","year":"2019","journal-title":"ACS Appl. Nano Mater."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"5170","DOI":"10.1002\/pola.26361","article-title":"A versatile approach to the synthesis of polyphosphazene derivatives via the thiol-ene reaction","volume":"50","author":"Qian","year":"2012","journal-title":"J. Polym. Sci. Part A Polym. Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"121933","DOI":"10.1016\/j.cej.2019.121933","article-title":"Cyclotriphosphazene-bridged periodic mesoporous organosilica-integrated cellulose nanofiber anisotropic foam with highly flame-retardant and thermally insulating properties","volume":"375","author":"Wang","year":"2019","journal-title":"Chem. Eng. J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"4467","DOI":"10.1002\/pola.26865","article-title":"Branched polyphosphazenes with controlled dimensions","volume":"51","author":"Henke","year":"2013","journal-title":"J. Polym. Sci. Part A Polym. Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"12324","DOI":"10.1039\/C5CC03736K","article-title":"Synthesis of disulfide-based biodegradable bridged silsesquioxane nanoparticles for two-photon imaging and therapy of cancer cells","volume":"51","author":"Croissant","year":"2015","journal-title":"Chem. Commun."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/pola.27002","article-title":"Water-soluble, biocompatible polyphosphazenes with controllable and pH-promoted degradation behavior","volume":"52","author":"Wilfert","year":"2014","journal-title":"J. Polym. Sci. Part A Polym. Chem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1800235","DOI":"10.1002\/adfm.201800235","article-title":"Porous porphyrin-based organosilica nanoparticles for nir two-photon photodynamic therapy and gene delivery in Zebrafish","volume":"28","author":"Jimenez","year":"2018","journal-title":"Adv. Funct. Mater."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"110132","DOI":"10.1016\/j.micromeso.2020.110132","article-title":"Pyridine-, thiol- and amine-functionalized mesoporous silicas for adsorptive removal of pharmaceuticals","volume":"299","author":"Barczak","year":"2020","journal-title":"Microporous Mesoporous Mater."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"015002","DOI":"10.1088\/1468-6996\/15\/1\/015002","article-title":"A simple method for the quantification of molecular decorations on silica particles","volume":"15","author":"Mangos","year":"2014","journal-title":"Sci. Technol. Adv. Mater."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/21\/22\/8552\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:32:53Z","timestamp":1760178773000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/21\/22\/8552"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,13]]},"references-count":32,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2020,11]]}},"alternative-id":["ijms21228552"],"URL":"https:\/\/doi.org\/10.3390\/ijms21228552","relation":{},"ISSN":["1422-0067"],"issn-type":[{"type":"electronic","value":"1422-0067"}],"subject":[],"published":{"date-parts":[[2020,11,13]]}}}